Agneta Zickert
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View article: Proteomic analysis reveals angiogenesis-related plasma proteins associated with pre-eclampsia in SLE
Proteomic analysis reveals angiogenesis-related plasma proteins associated with pre-eclampsia in SLE Open
Objective Delivery of a small for gestational age (SGA) infant is a common pregnancy complication among women with SLE. Although disease activity and autoantibodies such as anti-Smith and anti-ribonucleoprotein associate with SGA, underlyi…
View article: INCIDENT CARDIOVASCULAR AND VENOUS THROMBOEMBOLIC EVENTS IN AUTOANTIBODY-DEFINED SLE CLUSTERS
INCIDENT CARDIOVASCULAR AND VENOUS THROMBOEMBOLIC EVENTS IN AUTOANTIBODY-DEFINED SLE CLUSTERS Open
PV197 / #398 Poster Topic: AS22 - SLE Heterogeneity Background/Purpose Patients with SLE are at high risk of cardiovascular (CV) and venous thromboembolic (VTE) events. Previously, we identified 4 autoantibody-defined SLE clusters,[1] asso…
View article: GENETICS AND PROTEOMICS IN AUTOANTIBODY-DEFINED SUBGROUPS OF PATIENTS WITH SLE
GENETICS AND PROTEOMICS IN AUTOANTIBODY-DEFINED SUBGROUPS OF PATIENTS WITH SLE Open
PV106 / #522 Poster Topic: AS12 - Genetics, Epigenetics, Transcriptomics Background/Purpose Using their autoantibody profile, patients with systemic lupus erythematosus (SLE) can be grouped into 4 less heterogeneous subgroups [1] Subgroup …
View article: Plasma C4d levels correlate with treatment response and renal activity in proliferative lupus nephritis
Plasma C4d levels correlate with treatment response and renal activity in proliferative lupus nephritis Open
Objective The investigation of complement factors in lupus nephritis (LN) in relation to treatment response and the impact of underlying genetics of C4. Methods Seventy-seven patients with active LN confirmed by a kidney biopsy and in whom…
View article: Altered hemostatic balance in favor of a procoagulant state in pregnant women with systemic lupus erythematosus
Altered hemostatic balance in favor of a procoagulant state in pregnant women with systemic lupus erythematosus Open
Objectives This study aimed to investigate hemostatic parameters in pregnant patients with systemic lupus erythematosus (SLE) in relation to the use of antithrombotic prophylaxis, preeclampsia (PE), and antiphospholipid antibody status. Pa…
View article: Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus
Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus Open
Objectives Adverse pregnancy outcomes are more common in women with SLE compared with healthy women, but we lack prognostic biomarkers. Plasma IFN-α protein levels are elevated in a subgroup of pregnant women with SLE, but whether this is …
View article: P146 Low CD4+ T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy
P146 Low CD4+ T cell count is related to specific anti-nuclear antibodies, IFNα protein positivity and disease activity in systemic lupus erythematosus pregnancy Open
Objective Adverse pregnancy outcomes are more common among women with systemic lupus erythematosus (SLE) compared to healthy women, but there is limited understanding on how pregnancy affects the immune system and what specific immunopatho…
View article: O34 Plasma thrombospondin-1 levels are associated with arterial and venous thrombotic events in systemic lupus erythematosus
O34 Plasma thrombospondin-1 levels are associated with arterial and venous thrombotic events in systemic lupus erythematosus Open
Background Thrombospondin-1 (TSP-1) is the most abundant protein inside platelet alpha-granules, being secreted upon their activation. The role of TSP-1 in thrombosis and hemostasis remains dubious, with conflicting data showcasing both pr…
View article: O10 Ischemic stroke subtypes in SLE-associations with a STAT4 risk genotype
O10 Ischemic stroke subtypes in SLE-associations with a STAT4 risk genotype Open
Objective Ischemic stroke is 2–3 times more common among SLE patients than in the general population, but it unknown if certain subtypes of stroke are more common in SLE patients, nor if stroke subtypes are associated with the susceptibili…
View article: O12 Immune complexes containing anti-dsDNA in patients with systemic lupus erythematosus with renal involvement – Association with renal activity and response to treatment
O12 Immune complexes containing anti-dsDNA in patients with systemic lupus erythematosus with renal involvement – Association with renal activity and response to treatment Open
Objective Immune complexes (IC) are generated and deposit in the glomeruli in systemic lupus erythematosus (SLE) patients with lupus nephritis (LN), thereby contributing to the pathogenetic process. We here evaluated anti-dsDNA in circulat…
View article: P145 Circulating interferon-α levels are elevated during pregnancy in women with SLE who deliver infants that are small for gestational age, preterm and/or have low birth weight
P145 Circulating interferon-α levels are elevated during pregnancy in women with SLE who deliver infants that are small for gestational age, preterm and/or have low birth weight Open
Objectives Adverse pregnancy outcomes (APOs) are more common among women with SLE compared to the general population and the underlying immunopathological mechanisms are largely unknown. The type I interferon (IFN) signature persists in co…
View article: P58 Menopausal age and the effect of menopause on disease activity in SLE
P58 Menopausal age and the effect of menopause on disease activity in SLE Open
Objective To investigate menopausal age in women with SLE and controls, and to assess if SLE-related measurements, blood lipid levels, and hs-CRP differed with menopausal status among SLE patients. Methods In a cross-sectional study, we co…
View article: LP-016 Anti-histone and anti-nucleosome antibodies, rather than anti-dsDNA antibodies are associated with interferon-induced biomarkers in Sudanese and Swedish SLE patients
LP-016 Anti-histone and anti-nucleosome antibodies, rather than anti-dsDNA antibodies are associated with interferon-induced biomarkers in Sudanese and Swedish SLE patients Open
Background In SLE, anti-dsDNA often exists together with autoantibodies against other chromatin components, like histones and nucleosomes. These antibodies can induce cytokines including interferon-alpha. Methods We have measured ANA speci…
View article: Occurrence and localization of FOXP3 + cells in kidney biopsies in lupus nephritis and ANCA-associated vasculitis
Occurrence and localization of FOXP3 + cells in kidney biopsies in lupus nephritis and ANCA-associated vasculitis Open
The study aims to increase the understanding regarding the role of regulatory T cells (Tregs) in lupus nephritis (LN) and ANCA-associated vasculitis (AAV) by comparing their localization in renal tissue and changes following immunosuppress…
View article: Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus
Low-density granulocytes are related to shorter pregnancy duration but not to interferon alpha protein blood levels in systemic lupus erythematosus Open
Background An increased risk of pregnancy complications is seen in women with systemic lupus erythematosus (SLE), but the specific immunopathological drivers are still unclear. Hallmarks of SLE are granulocyte activation, type I interferon…
View article: AB0673 SERUM 25 (OH) VITAMIN D LEVELS AND BONE MINERAL DENSITY IN SYSTEMIC LUPUS ERYTHEMATOSUS
AB0673 SERUM 25 (OH) VITAMIN D LEVELS AND BONE MINERAL DENSITY IN SYSTEMIC LUPUS ERYTHEMATOSUS Open
Background Several disease- and treatment-related factors, such as proinflammatory cytokines, corticosteroid treatment, lupus nephritis, and impaired renal function affect serum vitamin D levels and cause accelerated osteoporosis in patien…
View article: PO.8.176 Inflammation in blood and placenta in SLE pregnancies
PO.8.176 Inflammation in blood and placenta in SLE pregnancies Open
Background Adverse pregnancy outcomes, including preterm birth and preeclampsia, are more prevalent in women with SLE compared to healthy women. The immunopathological mechanisms causing these complications are largely unknown and we need …
View article: Interleukin (IL) 16: a candidate urinary biomarker for proliferative lupus nephritis
Interleukin (IL) 16: a candidate urinary biomarker for proliferative lupus nephritis Open
Objective Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE). The pathogenesis is incompletely understood and diagnostic biomarkers are scarce. We investigated interleukin (IL) 16 as a potential biomarker …
View article: Anti-phosphatidylserine/prothrombin antibodies and thrombosis associate positively with HLA-DRB1*13 and negatively with HLA-DRB1*03 in SLE
Anti-phosphatidylserine/prothrombin antibodies and thrombosis associate positively with HLA-DRB1*13 and negatively with HLA-DRB1*03 in SLE Open
Objectives Emerging evidence demonstrates that aPS-PT associate with thrombotic events. Genetic predisposition, including HLA-DRB1 alleles, is known to contribute to the occurrence of conventional aPL [anti-β2glycoprotein-I (anti-β2GPI) an…
View article: Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding <i>HLA‐DRB1</i> Genotype Associations and Immunological and Clinical Manifestations
Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding <i>HLA‐DRB1</i> Genotype Associations and Immunological and Clinical Manifestations Open
Objective The heterogeneity of systemic lupus erythematosus (SLE) constitutes clinical and therapeutical challenges. We therefore studied whether unrecognized disease subgroups can be identified by using autoantibody profiling together wit…
View article: Myocardial infarctions, subtypes and coronary atherosclerosis in SLE: a case–control study
Myocardial infarctions, subtypes and coronary atherosclerosis in SLE: a case–control study Open
Objective Patients with SLE have increased risk of myocardial infarction (MI). Few studies have investigated the characteristics of SLE-related MIs. We compared characteristics of and risk factors for MI between SLE patients with MI (MI-SL…
View article: Associations with thrombosis are stronger for antiphosphatidylserine/prothrombin antibodies than for the Sydney criteria antiphospholipid antibody tests in SLE
Associations with thrombosis are stronger for antiphosphatidylserine/prothrombin antibodies than for the Sydney criteria antiphospholipid antibody tests in SLE Open
Objectives Antiphosphatidylserine/prothrombin complex antibodies (aPS/PT) are risk factors for thrombosis, yet further validation of their clinical relevance in different ethnic groups is required. We investigated the performance of aPS/PT…