Agnete Overgaard
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View article: Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats Open
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders. A less explored topic concerns the use of repeated low doses of psychedelics, at a dose t…
View article: Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH
Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH Open
Non‐alcoholic steatohepatitis (NASH) has emerged as a major challenge for public health because of high global prevalence and lack of evidence‐based therapies. Most animal models of NASH lack sufficient validation regarding disease progres…
View article: Automated Image Analyses of Glomerular Hypertrophy in a Mouse Model of Diabetic Nephropathy
Automated Image Analyses of Glomerular Hypertrophy in a Mouse Model of Diabetic Nephropathy Open
Background Glomerular hypertrophy is a hallmark of kidney injury in metabolically induced renal diseases such as obesity-associated glomerulopathies and diabetic nephropathy (DN). Methods Using light sheet fluorescent microscopy (LSFM) and…
View article: Chronic paroxetine blunts stress response and normalizes adverse behavioral effects seen acutely in nulliparous rats
Chronic paroxetine blunts stress response and normalizes adverse behavioral effects seen acutely in nulliparous rats Open
Selective serotonin reuptake inhibitors (SSRI) are widely used antidepressants and their effect is partly mediated by restoring stress axis dynamics, which may depend on sex and hormonal states. In the present study, we investigate the eff…
View article: Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene <i>Egr3</i>
Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene <i>Egr3</i> Open
Serotonin 2A receptors (5-HT 2A Rs) mediate the effects of hallucinogenic drugs and antipsychotic medications, and are reduced in schizophrenia patients’ brains. However, the mechanisms that regulate 5-HT 2A R expression remain poorly unde…
View article: Data for: Paroxetine blunts the swim stress-induced corticosterone response and increases depressive-like behavior in a rat model of postpartum depression
Data for: Paroxetine blunts the swim stress-induced corticosterone response and increases depressive-like behavior in a rat model of postpartum depression Open
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View article: Ovariectomy Drives Asynchronous Changes in Serotonin Receptor 2A and Transporter Availability in Rats
Ovariectomy Drives Asynchronous Changes in Serotonin Receptor 2A and Transporter Availability in Rats Open
Ovarian hormones have potent effects on key features of the serotonergic neurotransmission.This includes effects that may counterbalance each other, e.g.postsynaptic receptor changes and change in serotonin transporter (SERT) levels, which…