Marco Agostini
YOU?
Author Swipe
The Search for Predictive Biomarkers in Response to Immune Checkpoint Inhibitors and Associated Adverse Events Open
The introduction of immune checkpoint inhibitors (ICIs) as a part of immunotherapy represented a therapeutic breakthrough in the landscape of cancer treatment. The action of these inhibitors consists of blocking certain inhibitory receptor…
View article: Isoforms of Phosphorylated Tau as Potential Biomarkers for Alzheimer’s Disease: The Contribution of Mass Spectrometry-Based Proteomics
Isoforms of Phosphorylated Tau as Potential Biomarkers for Alzheimer’s Disease: The Contribution of Mass Spectrometry-Based Proteomics Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, heterogeneous at the molecular level and characterized by diverse and complex pathological features. Such features are known to accumulate silently in the brain over yea…
View article: Colorectal cancer peritoneal metastasis is promoted by tissue-specific fibroblasts that can arise in response to various local disorders
Colorectal cancer peritoneal metastasis is promoted by tissue-specific fibroblasts that can arise in response to various local disorders Open
Peritoneal membrane injury induces the activation of local fibroblasts and tissue remodelling, which ultimately can progress to fibrosis. Metastasis of colorectal cancer (CRC) to the abdominal cavity results in such peritoneal damage. Pati…
View article: Programmed Cell Death Ligand as a Biomarker for Response to Immunotherapy: Contribution of Mass Spectrometry-Based Analysis
Programmed Cell Death Ligand as a Biomarker for Response to Immunotherapy: Contribution of Mass Spectrometry-Based Analysis Open
Immune checkpoint inhibition is a major component in today’s cancer immunotherapy. In recent years, the FDA has approved a number of immune checkpoint inhibitors (ICIs) for the treatment of melanoma, non-small-cell lung, breast and gastroi…
View article: Proteomic Investigation of Immune Checkpoints and Some of Their Inhibitors
Proteomic Investigation of Immune Checkpoints and Some of Their Inhibitors Open
Immune checkpoints are crucial molecules for the maintenance of antitumor immune responses. The activation or inhibition of these molecules is dependent on the interactions between receptors and ligands; such interactions can provide inhib…
View article: IMMUNOREACT 7: Regular aspirin use is associated with immune surveillance activation in colorectal cancer
IMMUNOREACT 7: Regular aspirin use is associated with immune surveillance activation in colorectal cancer Open
Background Long‐term daily use of aspirin reduces incidence and mortality due to colorectal cancer (CRC). This study aimed to analyze the effect of aspirin on the tumor microenvironment, systemic immunity, and on the healthy mucosa surroun…
View article: Recent Advancements in Hydrogel Biomedical Research in Italy
Recent Advancements in Hydrogel Biomedical Research in Italy Open
Hydrogels have emerged as versatile biomaterials with remarkable applications in biomedicine and tissue engineering. Here, we present an overview of recent and ongoing research in Italy, focusing on extracellular matrix-derived, natural, a…
View article: Will Liquid Biopsy Deliver the Expected Breakthrough in Clinical Oncology? Contribution of Mass Spectrometry-Based Proteomics
Will Liquid Biopsy Deliver the Expected Breakthrough in Clinical Oncology? Contribution of Mass Spectrometry-Based Proteomics Open
Analysis of liquid biopsy samples can reveal a wealth of molecular as well as cellular entities circulating in various body fluids. These entities include circulating tumor cells, circulating cell-free and tumor DNA, RNA, and proteins. Det…
View article: Profile of matrix‐entrapped extracellular vesicles of microenvironmental and infiltrating cell origin in decellularized colorectal cancer and adjacent mucosa
Profile of matrix‐entrapped extracellular vesicles of microenvironmental and infiltrating cell origin in decellularized colorectal cancer and adjacent mucosa Open
Cellular elements that infiltrate and surround tumours and pre‐metastatic tissues have a prominent role in tumour invasion and growth. The extracellular vesicles specifically entrapped and stored within the extracellular matrix (ECM‐EVs) m…
View article: Mass Spectrometry Investigation of Some ATP-Binding Cassette (ABC) Proteins
Mass Spectrometry Investigation of Some ATP-Binding Cassette (ABC) Proteins Open
Drug resistance remains one of the main causes of poor outcome in cancer therapy. It is also becoming evident that drug resistance to both chemotherapy and to antibiotics is driven by more than one mechanism. So far, there are at least eig…
View article: Liquid electron ionization-mass spectrometry as a novel strategy for integrating normal-phase liquid chromatography with low and high-resolution mass spectrometry
Liquid electron ionization-mass spectrometry as a novel strategy for integrating normal-phase liquid chromatography with low and high-resolution mass spectrometry Open
First proof of concept of the coupling between normal-phase liquid chromatography and electron ionization mass spectrometry using a Liquid Electron Ionization (LEI) interface.
View article: Association between Pancreatoblastoma and Familial Adenomatous Polyposis: Review of the Literature with an Additional Case
Association between Pancreatoblastoma and Familial Adenomatous Polyposis: Review of the Literature with an Additional Case Open
Background: Adult pancreatoblastoma (PBL) is a rare pancreatic malignancy, with recent evidence suggesting a possible link to familial adenomatous polyposis (FAP). This study aims to review the latest evidence and explore a possible associ…
View article: Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers
Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers Open
Mass spectrometry-based proteomics is a key player in research efforts to characterize aberrant epigenetic alterations, including histone post-translational modifications and DNA methylation. Data generated by this approach complements and…
View article: IMMUNOREACT 6: weak immune surveillance characterizes early-onset rectal cancer
IMMUNOREACT 6: weak immune surveillance characterizes early-onset rectal cancer Open
Background Colon cancer in young patients is often associated with hereditary syndromes; however, in early-onset rectal cancer, mutations of these genes are rarely observed. The aim of this study was to analyse the features of the local im…
View article: Supplementary Materials and Methods, Figures 1 - 2, Table 1 from NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells
Supplementary Materials and Methods, Figures 1 - 2, Table 1 from NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells Open
PDF file - 146KB, Figure S1. Notch2/3 neutralization impairs Notch signaling in CRC cells. Figure S2. Study of the Msi-1 promoter activity in vitro. Table S1: primer sequences.
View article: Data from NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells
Data from NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells Open
MUSASHI-1 (MSI-1) is a well-established stem cell marker in both normal and malignant colon cells and it acts by positively regulating the NOTCH pathway through inactivation of NUMB, a NOTCH signaling repressor. To date, the mechanisms of …
View article: Supplementary Materials and Methods, Figures 1 - 2, Table 1 from NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells
Supplementary Materials and Methods, Figures 1 - 2, Table 1 from NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells Open
PDF file - 146KB, Figure S1. Notch2/3 neutralization impairs Notch signaling in CRC cells. Figure S2. Study of the Msi-1 promoter activity in vitro. Table S1: primer sequences.
View article: Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine
Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine Open
Ovarian cancer (OC) has the highest mortality rate of all gynecological malignancies due to the high prevalence of advanced stages of diagnosis and the high rate of recurrence. Furthermore, the heterogeneity of OC tumors contributes to the…
View article: Data from NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells
Data from NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells Open
MUSASHI-1 (MSI-1) is a well-established stem cell marker in both normal and malignant colon cells and it acts by positively regulating the NOTCH pathway through inactivation of NUMB, a NOTCH signaling repressor. To date, the mechanisms of …
View article: Mass Spectrometry Contribution to Pediatric Cancers Research
Mass Spectrometry Contribution to Pediatric Cancers Research Open
For over four decades, mass spectrometry-based methods have provided a wealth of information relevant to various challenges in the field of cancers research. These challenges included identification and validation of novel biomarkers for v…