A.H. Rudresha
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View article: Pan-Immune-Inflammation Value: A Novel Marker for Chemotherapy Response in Locally Advanced Breast Cancer
Pan-Immune-Inflammation Value: A Novel Marker for Chemotherapy Response in Locally Advanced Breast Cancer Open
Neoadjuvant chemotherapy (NACT) is the cornerstone in the management of locally advanced breast cancer (LABC), aiming to reduce tumor burden and achieve pathological complete response (pCR), which correlates with improved survival outcomes…
View article: Intrathecal Trastuzumab as a Novel Simplified Therapeutic Strategy for Isolated Metastases in the Leptomeninges in HER2-Positive Breast Cancer: A Case Report and Review of Literature
Intrathecal Trastuzumab as a Novel Simplified Therapeutic Strategy for Isolated Metastases in the Leptomeninges in HER2-Positive Breast Cancer: A Case Report and Review of Literature Open
Leptomeningeal metastases is one of the dreaded complications of metastatic breast cancer, which has a very poor prognosis despite standard treatment, which includes systemic chemotherapy, targeted therapy, and radiation therapy. Intrathec…
View article: A Retrospective Study on the Use of Short-Term Combination Pharmacotherapy in Improving Weight, Appetite and Tolerance to Cytotoxic Chemotherapy in Patients with Locally Advanced Solid Cancers
A Retrospective Study on the Use of Short-Term Combination Pharmacotherapy in Improving Weight, Appetite and Tolerance to Cytotoxic Chemotherapy in Patients with Locally Advanced Solid Cancers Open
Cytotoxic chemotherapy-related toxicities pose significant challenges in the management of solid cancers, particularly in resource-limited settings. This may be because of the increased incidence of cancer precachexia and cachexia that the…
View article: Beyond Guidelines: Real World Treatment & Outcomes of Chronic Lymphocytic Leukemia at a Tertiary Indian Cancer Centre
Beyond Guidelines: Real World Treatment & Outcomes of Chronic Lymphocytic Leukemia at a Tertiary Indian Cancer Centre Open
Background: Chronic Lymphocytic Leukemia (CLL) is the most common type of leukemia diagnosed in the United States and accounts for about one-quarter of the newly diagnosed cases while it is one of the least common leukemias in India (< 5% …
View article: Clinical Profile and Outcome of Adult Classical Hodgkin’s Lymphoma: Real World Single Centre Experience
Clinical Profile and Outcome of Adult Classical Hodgkin’s Lymphoma: Real World Single Centre Experience Open
View article: Accessibility to Rituximab and its impact on treatment outcomes in major Non-Hodgkin Lymphoma subtypes: Insights from a resource-limited setting
Accessibility to Rituximab and its impact on treatment outcomes in major Non-Hodgkin Lymphoma subtypes: Insights from a resource-limited setting Open
Objective: Non- Hodgkin’s lymphoma is a relatively uncommon cancer and outcome data in Indian setting is scarce. This study aimed to evaluate the accessibility to rituximab and its impact on treatment outcomes in major non-Hodgkin's lympho…
View article: THE PROGNOSTIC SIGNIFICANCE OF CD10+ MUM1+ GCB SUBTYPE OF DIFFUSE LARGE B-CELL LYMPHOMAS
THE PROGNOSTIC SIGNIFICANCE OF CD10+ MUM1+ GCB SUBTYPE OF DIFFUSE LARGE B-CELL LYMPHOMAS Open
PURPOSE - Diffuse Large B-Cell Lymphoma can be subclassified into the prognostically distinct groups of GCB and non-GCB using the immunohistochemical Hans algorithm. However, in real life, patients classified as GCB show differing outcomes…
View article: Impact of Body Mass Index on Pathological Complete Response Following Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer – A South Indian Single-institute Experience
Impact of Body Mass Index on Pathological Complete Response Following Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer – A South Indian Single-institute Experience Open
Context: Obesity is a risk factor for the development of breast cancer. Neoadjuvant chemotherapy (NACT) is now increasingly being used in its management. Pathological complete response to NACT has proven to be a surrogate marker for improv…
View article: A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain
A Pilot Study on the Addition of Tramadol or Eutectic Mixture of Local Anesthetics (Prilocaine Plus Lignocaine) to Local Lignocaine Infiltration for Prevention of Bone Marrow Aspiration/Biopsy Associated Pain Open
Objectives Bone marrow aspiration although being a common procedure is associated with significant pain and its reduction remains an unmet need. We evaluated the use of tramadol and eutectic mixture of local anesthetics (prilocaine plus li…
View article: Expression of Aberrant Markers and its Association with Remission Postinduction Therapy in Acute Lymphoblastic Leukaemia and Acute Myeloid Leukaemia
Expression of Aberrant Markers and its Association with Remission Postinduction Therapy in Acute Lymphoblastic Leukaemia and Acute Myeloid Leukaemia Open
Introduction: Haematological malignancies contribute to a significant number (8.2%) among cancer patientsin India. Bursa-Acute Lymphoblastic Leukaemia (B-ALL), Thymus-Acute Lymphoblastic Leukaemia (T-ALL) and Acute Myeloid Leukaemia (AML) …
View article: Follicular lymphoma transforming to DLBCL and reverting back to follicular lymphoma at relapse—a case report
Follicular lymphoma transforming to DLBCL and reverting back to follicular lymphoma at relapse—a case report Open
We have presented a case of FL that has transformed to DLBCL after 10 years of diagnosis. After HT, she was treated with CHOP chemotherapy and the patient relapsed again after 3 years with follicular lymphoma histology. This case highlight…
View article: Ewing’s Sarcoma of the Vulva: An Uncommon Tumor in an Uncommon Site
Ewing’s Sarcoma of the Vulva: An Uncommon Tumor in an Uncommon Site Open
Extraskeletal Ewing's sarcoma (EES) is an uncommon, aggressive, round cell tumor. It accounts to 16% among Ewing's sarcoma (ES). The most commonly involved sites are soft tissues of trunk or lower extremities, paravertebral tissues, chest …
View article: Nested Stromal and Epithelial Tumor of the Liver: An Unusual Nonhepatocytic Entity
Nested Stromal and Epithelial Tumor of the Liver: An Unusual Nonhepatocytic Entity Open
Nested stromal-epithelial tumor (NSET) of the liver is an extremely rare, nonhepatocytic, nonbiliary tumor of the liver. To the best of our knowledge, 41 cases have been reported in literature. We report the 42nd case. The reported tumors …
View article: Metastatic hormone receptor-positive breast cancer in CDK 4/6 era
Metastatic hormone receptor-positive breast cancer in CDK 4/6 era Open
Background: The treatment landscape of metastatic hormone receptor (HR) positive breast cancer has been changed in recent years. Availability of CDK 4/6 inhibitor and other hormone therapy has changed the treatment algorithm for these pati…
View article: Primary mucinous carcinomas of the lung: Clinical characteristics and treatment outcomes
Primary mucinous carcinomas of the lung: Clinical characteristics and treatment outcomes Open
IMA is rarely diagnosed on needle biopsies due to insufficient tissue. They mimic pneumonia on imaging, thus delaying diagnosis. EGFR mutations, ALK, and ROS1 translocations are usually negative making them ineligible for tyrosine kinase i…
View article: A prospective study to assess response to neoadjuvant hormonal therapy in postmenopausal women with hormone-receptor positive breast cancer at a regional cancer centre in South India
A prospective study to assess response to neoadjuvant hormonal therapy in postmenopausal women with hormone-receptor positive breast cancer at a regional cancer centre in South India Open
View article: Comparison between CHOP like regimens and DAEPOCH with or without Rituximab in adult high grade B cell lymphoma NOS; A retrospective study from a tertiary cancer hospital in South India
Comparison between CHOP like regimens and DAEPOCH with or without Rituximab in adult high grade B cell lymphoma NOS; A retrospective study from a tertiary cancer hospital in South India Open
View article: Differences in disease characteristics and survival outcomes of follicular lymphoma in young adults and older population: An institutional analysis
Differences in disease characteristics and survival outcomes of follicular lymphoma in young adults and older population: An institutional analysis Open
View article: A study in recurrent small cell lung cancer patients, comparing weekly paclitaxel, irinotecan and temozolomide in second-line: A prospective study from a south Indian tertiary cancer hospital
A study in recurrent small cell lung cancer patients, comparing weekly paclitaxel, irinotecan and temozolomide in second-line: A prospective study from a south Indian tertiary cancer hospital Open
View article: Retrospective review of metastatic carcinoma of cervix from a tertiary cancer institute of south India
Retrospective review of metastatic carcinoma of cervix from a tertiary cancer institute of south India Open
View article: A pilot study on comparative efficacy of tramadol or eutectic mixture of local anaesthetics (prilocaine plus lignocaine) in preventing bone marrow aspiration associated pain
A pilot study on comparative efficacy of tramadol or eutectic mixture of local anaesthetics (prilocaine plus lignocaine) in preventing bone marrow aspiration associated pain Open
View article: Efficacy of olanzapine combination in prevention of nausea & vomiting in highly emetogenic chemotherapy
Efficacy of olanzapine combination in prevention of nausea & vomiting in highly emetogenic chemotherapy Open
View article: Primary Adrenal Leiomyosarcoma: An Extremely Rare Mesenchymal Tumor
Primary Adrenal Leiomyosarcoma: An Extremely Rare Mesenchymal Tumor Open
Leiomyosarcoma is a soft-tissue neoplasm of smooth muscle origin. Primarily, it occurs in the myometrium, retroperitoneum, or dermis of the extremities; primary leiomyosarcoma of the adrenal gland is very rare. Till date, only 30 patients …
View article: HIV/AIDS-related lymphoma: perspective from a regional cancer center in India
HIV/AIDS-related lymphoma: perspective from a regional cancer center in India Open
ARL is a heterogeneous disease. Histologic subtype is a major determinant of the clinical outcome. ADL has significantly lower CD4 counts than those of NADL. There is an urgent and unmet need for uniform management guidelines for improving…
View article: Metastatic Synovial Sarcoma: Experience from a Tertiary Care Center from India
Metastatic Synovial Sarcoma: Experience from a Tertiary Care Center from India Open
Background: Synovial sarcoma represents 8% of all soft-tissue sarcoma (STS). It is a high-grade STS, and 50% of patients develop metastasis. The most common site of metastasis is the lungs, lymph nodes followed by bones. Ifosfamide-based c…
View article: Efficacy of a Reduced-dose Rasburicase: Single-institution Experience in India
Efficacy of a Reduced-dose Rasburicase: Single-institution Experience in India Open
Background: Tumor lysis syndrome (TLS) is an oncological emergency associated with life-threatening metabolic abnormalities. Hyperuricemia is a feature of TLS and is treated with hydration, urine alkalinization, and allopurinol. Rasburicas…
View article: Pattern of Bone Marrow Involvement by Solid Tumors: Experience from a Tertiary Care Center from South India
Pattern of Bone Marrow Involvement by Solid Tumors: Experience from a Tertiary Care Center from South India Open
Background: Bone marrow involvement by solid tumor implicates advanced disease and dismal prognosis. Bone marrow aspiration and biopsy are routinely performed as staging workup for certain small round cell tumors and also for unexplained c…
View article: Evaluation of safety and efficacy of minocycline combined with tyrosine kinase inhibitors in patients of EGFR mutated metastatic lung cancer
Evaluation of safety and efficacy of minocycline combined with tyrosine kinase inhibitors in patients of EGFR mutated metastatic lung cancer Open
Background: Tyrosine Kinase Inhibitors (TKI) are used in the first line management of metastatic Non-Small cell lung cancer in the presence of EGFR activating driver mutations. Skin rash is one of the most common side effects associated wi…
View article: Modified Epirubicin, cisplatin, and 5-FU regimen as first-line chemotherapy in metastatic gastric or gastroesophageal junction adenocarcinoma: A Phase II study
Modified Epirubicin, cisplatin, and 5-FU regimen as first-line chemotherapy in metastatic gastric or gastroesophageal junction adenocarcinoma: A Phase II study Open
Background: Epirubicin, cisplatin, and 5-FU (ECF) is one of the most commonly used first-line chemotherapy regimens in metastatic gastric cancer. However, due to protracted infusion schedule, need for special infusion pumps, and catheter-r…
View article: Selective cyclin-dependent kinase 4/6 inhibitors as anticancer drugs: Moving beyond hormone receptor-positive breast cancer
Selective cyclin-dependent kinase 4/6 inhibitors as anticancer drugs: Moving beyond hormone receptor-positive breast cancer Open
The cyclin D-cyclin-dependent kinase (CDK) 4/6 pathway controls the cell cycle machinery by regulating the G1-to-S-phase transition. Dysregulation of this pathway, resulting in increased cellular proliferation, is frequently observed in a …