Ahmad Awada
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View article: Comprehensive analysis of the role of <i>ASC1</i> and <i>APE2</i> introns on cellular fitness, transcription, and post‐transcriptional dynamics
Comprehensive analysis of the role of <i>ASC1</i> and <i>APE2</i> introns on cellular fitness, transcription, and post‐transcriptional dynamics Open
A splicing‐competent intron has been found to affect the expression of a gene at almost every step between transcription and translation. In this investigation, we performed a comprehensive analysis of the role of an intron from two yeast …
View article: Atrial fibrillation ablation: Is the Ice Age definitively over?
Atrial fibrillation ablation: Is the Ice Age definitively over? Open
View article: Avelumab-based neoadjuvant therapy in patients with muscle-invasive bladder cancer (AURA Oncodistinct-004): a phase 2 multicenter clinical trial
Avelumab-based neoadjuvant therapy in patients with muscle-invasive bladder cancer (AURA Oncodistinct-004): a phase 2 multicenter clinical trial Open
Background Immunotherapy is becoming a standard of care for non-metastatic muscle-invasive bladder cancer (MIBC). The optimal chemotherapy partner for chemo-immunotherapy combinations remains unknown. We evaluated the efficacy and safety o…
View article: Should We Revisit the Clinical Value of Fractional Flow Reserve in the Era of Coronary Microvascular Dysfunction?
Should We Revisit the Clinical Value of Fractional Flow Reserve in the Era of Coronary Microvascular Dysfunction? Open
The understanding of coronary artery disease is evolving, with more attention given currently to the microcirculation compartment. Coronary microvascular dysfunction (CMD) is defined by any structural or functional alteration of the corona…
View article: Pulmonary vein isolation durability with fluoroscopy or 3D mapping-guided radiofrequency balloon ablation: a mandated remap study
Pulmonary vein isolation durability with fluoroscopy or 3D mapping-guided radiofrequency balloon ablation: a mandated remap study Open
Background Effective balloon positionnking during pulmonary vein isolation (PVI) with a radiofrequency balloon (RFB) is crucial for optimal energy delivery, maximising lesion formation, and preventing gaps. Traditionally, fluoroscopy is us…
View article: Final results from the phase Ia/Ib study of the novel bromodomain and extra-terminal domain inhibitor, BI 894999, in patients with advanced solid tumors or diffuse large B-cell lymphoma
Final results from the phase Ia/Ib study of the novel bromodomain and extra-terminal domain inhibitor, BI 894999, in patients with advanced solid tumors or diffuse large B-cell lymphoma Open
View article: Infective Endocarditis of the TAVI Prosthesis: Emerging New Challenges
Infective Endocarditis of the TAVI Prosthesis: Emerging New Challenges Open
A 74-year-old patient presented to the emergency department with aggravating asthenia and persistent fever over the course of the last 2 weeks. He benefited 3 years prior from a self-expandable transcatheter aortic valve implantation (TAVI…
View article: Metastatic Gestational Trophoblastic Neoplasia Leading to Acute Respiratory Failure and Death: A Case Report – About a Particularly Challenging Management in the Intensive Care Unit, and Exploring the Potential of Pembrolizumab in Treating Frail, Pretreated Gestational Trophoblastic Neoplasia
Metastatic Gestational Trophoblastic Neoplasia Leading to Acute Respiratory Failure and Death: A Case Report – About a Particularly Challenging Management in the Intensive Care Unit, and Exploring the Potential of Pembrolizumab in Treating Frail, Pretreated Gestational Trophoblastic Neoplasia Open
Introduction: Gestational trophoblastic disease (GTD) includes rare tumors from abnormal fertilization, ranging from benign hydatidiform moles to malignant choriocarcinomas (CCs) and rare placental-site trophoblastic tumors. Management of …
View article: Recurrence and survival in high-intermediate risk endometrial cancers with isolated tumor cell lymph node metastasis
Recurrence and survival in high-intermediate risk endometrial cancers with isolated tumor cell lymph node metastasis Open
In this retrospective study, there was no significant difference in survival for patients with HIR endometrial cancer and ITC SLNs treated with either EBRT/VBT or CRT. Patients with three or more HIR risk factors remain at risk for recurre…
View article: Supplementary Data1 from Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer
Supplementary Data1 from Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer Open
Supplementary methods and results
View article: Data from Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer
Data from Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer Open
Purpose:IL1 pathway upregulation is implicated in pancreatic ductal adenocarcinoma (PDAC) progression, therapy resistance, and survival. Nadunolimab is an IL1 receptor accessory protein (IL1RAP)–targeting antibody with enhanced antibody-de…
View article: 37P Lymphocyte subpopulation balances as a blood biomarker for immune-related adverse events in patients receiving immune checkpoint inhibitors
37P Lymphocyte subpopulation balances as a blood biomarker for immune-related adverse events in patients receiving immune checkpoint inhibitors Open
info:eu-repo/semantics/published
View article: 29P Prognostic value of systemic inflammatory index and platelet-to-lymphocyte ratio in muscle-invasive bladder cancer patients treated with neoadjuvant chemo-immunotherapy in the AURA trial
29P Prognostic value of systemic inflammatory index and platelet-to-lymphocyte ratio in muscle-invasive bladder cancer patients treated with neoadjuvant chemo-immunotherapy in the AURA trial Open
View article: Further mobility enhancements for 5G-advanced and beyond
Further mobility enhancements for 5G-advanced and beyond Open
The study on mobility is an inherent part of any generation of cellular technology. It is aimed at ensuring robust, reliable, and interruption-free handover of the mobile user connection. Such continuous improvement is necessary as the ser…
View article: [Retracted] Sequential use of protein kinase inhibitors potentiates their toxicity to melanoma cells: A rationale to combine targeted drugs based on protein expression inhibition profiles
[Retracted] Sequential use of protein kinase inhibitors potentiates their toxicity to melanoma cells: A rationale to combine targeted drugs based on protein expression inhibition profiles Open
Following the publication of this article, a concerned reader drew to the Editor's attention that there appeared to be the duplication of a pair of western blots in each of Figs. 4 and 6, with the possibility of the bands in question havin…
View article: Ectopic ACTH-Dependent Cushing’s Syndrome Emerging at a Late Stage of a Mixed Histology Neuroendocrine Neoplasm: A Case Report
Ectopic ACTH-Dependent Cushing’s Syndrome Emerging at a Late Stage of a Mixed Histology Neuroendocrine Neoplasm: A Case Report Open
Introduction: Neuroendocrine neoplasms encompass well-differentiated tumors (NETs) and poorly differentiated carcinomas (neuroendocrine carcinomas [NECs]), which are distinguished by their clinical behavior and molecular characteristics. T…
View article: Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer
Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer Open
Purpose: IL1 pathway upregulation is implicated in pancreatic ductal adenocarcinoma (PDAC) progression, therapy resistance, and survival. Nadunolimab is an IL1 receptor accessory protein (IL1RAP)–targeting antibody with enhanced antibody-d…
View article: 12P Prognostic value of PD-L1 expression and neutrophil-to-lymphocyte ratio to neoadjuvant chemo-immunotherapy in muscle-invasive urothelial carcinoma patients from the AURA trial
12P Prognostic value of PD-L1 expression and neutrophil-to-lymphocyte ratio to neoadjuvant chemo-immunotherapy in muscle-invasive urothelial carcinoma patients from the AURA trial Open
View article: Therapeutic Prospects of Abemaciclib for Patients with Endometrial Cancer
Therapeutic Prospects of Abemaciclib for Patients with Endometrial Cancer Open
Endometrial cancer (EC) is a common gynecologic malignancy with a rising incidence due to obesity, comorbid conditions, and related lifestyle factors. The standard of care for primary disease consists of surgical resection with/without che…
View article: Tumor-Infiltrating Lymphocyte Scoring in Neoadjuvant-Treated Breast Cancer
Tumor-Infiltrating Lymphocyte Scoring in Neoadjuvant-Treated Breast Cancer Open
Neoadjuvant chemotherapy (NAC) is now the standard of care for patients with locally advanced breast cancer (BC). TIL scoring is prognostic and adds predictive value to the residual cancer burden evaluation after NAC. However, NAC induces …
View article: BMRK-01 EXTERNALLY VALIDATED PREDICTIVE NOMOGRAM FOR BRAIN METASTASIS IN EARLY-STAGE BREAST CANCER
BMRK-01 EXTERNALLY VALIDATED PREDICTIVE NOMOGRAM FOR BRAIN METASTASIS IN EARLY-STAGE BREAST CANCER Open
BACKGROUND Brain metastasis presents a significant concern for early-stage breast cancer (ESBC) patients, impacting their survival and overall well-being. Constructing a predictive nomogram based on primary tumor characteristics offers a w…
View article: Correction: Krayem et al. Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance. Cancers 2020, 12, 512
Correction: Krayem et al. Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance. Cancers 2020, 12, 512 Open
In the original article [...]
View article: Retraction: Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma
Retraction: Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma Open
SCOPUS: ar.j
View article: Correction: Surgery of the primary tumor in patients with de novo metastatic breast cancer: a nationwide population-based retrospective cohort study in Belgium
Correction: Surgery of the primary tumor in patients with de novo metastatic breast cancer: a nationwide population-based retrospective cohort study in Belgium Open
View article: RACH-less Handover with Early Timing Advance Acquisition for Outage Reduction
RACH-less Handover with Early Timing Advance Acquisition for Outage Reduction Open
For fifth-generation (5G) and 5G-Advanced networks, outage reduction within the context of reliability is a key objective since outage denotes the time period when a user equipment (UE) cannot communicate with the network. Earlier studies …
View article: Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer
Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer Open
Forchlorfenuron (FCF) is a widely used plant cytokinin that enhances fruit quality and size in agriculture. It also serves as a crucial pharmacological tool for the inhibition of septins. However, the precise target of FCF has not yet been…
View article: All.Can Belgium’s CB Working Group in the starting-blocks
All.Can Belgium’s CB Working Group in the starting-blocks Open
All.Can Belgium is a multi-stakeholder, not-for-profit organization dedicated to improving the efficiency of cancer care by putting the needs and well-being of patients at the heart of its priorities. In this spirit, All. Can Belgium bring…
View article: Correction: Krayem et al. The Benefit of Reactivating p53 under MAPK Inhibition on the Efficacy of Radiotherapy in Melanoma. Cancers 2019, 11, 1093
Correction: Krayem et al. The Benefit of Reactivating p53 under MAPK Inhibition on the Efficacy of Radiotherapy in Melanoma. Cancers 2019, 11, 1093 Open
In the original article [...]
View article: Optimal use of granulocyte colony-stimulating factor prophylaxis to improve survival in cancer patients receiving treatment
Optimal use of granulocyte colony-stimulating factor prophylaxis to improve survival in cancer patients receiving treatment Open
View article: Surgery of the primary tumor in patients with de novo metastatic breast cancer: a nationwide population-based retrospective cohort study in Belgium
Surgery of the primary tumor in patients with de novo metastatic breast cancer: a nationwide population-based retrospective cohort study in Belgium Open