Tariq Ahmad
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View article: Isolation and Characterization of a Novel Thermostable Bacteriophage Targeting Multi-Drug-Resistant Salmonella Enteritidis
Isolation and Characterization of a Novel Thermostable Bacteriophage Targeting Multi-Drug-Resistant Salmonella Enteritidis Open
(1) Background: The emergence of multidrug-resistant (MDR) Salmonella enterica poses a major threat to global public health, underscoring the urgent need for alternative therapeutic strategies. Bacteriophages represent a promising alternat…
View article: Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease
Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease Open
Background We sought to determine the prevalence, clinical impact, neutralizing capacity, and cross-reactivity of pre-existing antibodies to infliximab and adalimumab in antitumor necrosis factor (TNF) treatment-naïve patients with active …
View article: Glucagon-like peptide-1 (GLP-1) receptor agonists in inflammatory bowel disease: mechanisms, clinical implications, and therapeutic potential
Glucagon-like peptide-1 (GLP-1) receptor agonists in inflammatory bowel disease: mechanisms, clinical implications, and therapeutic potential Open
Glucagon-like peptide-1 receptor agonists are increasingly recognized for their potential dual benefit in inflammatory bowel disease (IBD), offering metabolic advantages alongside emerging anti-inflammatory, immunomodulatory, and gut barri…
View article: Clinical Utility and Cost‐Effectiveness of Pretreatment <i>NUDT15</i> Pharmacogenetic Testing to Prevent Thiopurine‐Induced Myelosuppression: A Genotype‐First Reverse Phenotyping Cohort Study Within the <scp>UK NIHR</scp> Inflammatory Bowel Disease Bioresource
Clinical Utility and Cost‐Effectiveness of Pretreatment <i>NUDT15</i> Pharmacogenetic Testing to Prevent Thiopurine‐Induced Myelosuppression: A Genotype‐First Reverse Phenotyping Cohort Study Within the <span>UK NIHR</span> Inflammatory Bowel Disease Bioresource Open
Background The clinical utility and cost‐effectiveness of pre‐thiopurine NUDT15 pharmacogenetic testing in European and admixed populations are unknown. Aims To report the prevalence, penetrance, expressivity, and pathogenicity of NUDT15 v…
View article: Effects of distributed leadership on teachers’ turnover as mediated by organizational commitment and the moderating role of teachers’ empowerment in private schools in Afghanistan
Effects of distributed leadership on teachers’ turnover as mediated by organizational commitment and the moderating role of teachers’ empowerment in private schools in Afghanistan Open
Managing teacher turnover at schools is one of the major challenges for school principals worldwide. However, it becomes more problematic for school leadership in the least developed and low-income countries. The type of school leadership …
View article: Isolation and Genomic Analysis of Escherichia coli Phage AUBRB02: Implications for Phage Therapy in Lebanon
Isolation and Genomic Analysis of Escherichia coli Phage AUBRB02: Implications for Phage Therapy in Lebanon Open
Background/Objectives: Escherichia coli (E. coli), a prevalent Gram-negative bacterium, is a frequent cause of illness. The extensive use of antibiotics has led to the emergence of resistant strains, complicating antimicrobial therapy and …
View article: Small Bowel Motility Quantified by Cine MRI to Predict Longer-Term Response in Patients with Crohn’s Disease Commencing Biological Therapy: The Motility Study
Small Bowel Motility Quantified by Cine MRI to Predict Longer-Term Response in Patients with Crohn’s Disease Commencing Biological Therapy: The Motility Study Open
Background Small bowel Crohn’s disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients is difficult and complicates treatment strategy. We aimed to determine if motil…
View article: Outcome Analysis of APACHE-II Scoring System in Predicting 30 Days Mortality in Acute Pancreatitis in Tertiary Care Hospital
Outcome Analysis of APACHE-II Scoring System in Predicting 30 Days Mortality in Acute Pancreatitis in Tertiary Care Hospital Open
Objective: To evaluate outcome analysis of Apache-II scoring system in predicting 30 days mortality in acute pancreatitis in tertiary care hospital. Study Design: Prospective longitudinal study. Place and Duration of Study: Combined Milita…
View article: CLINICAL OUTCOMES OF ENUCLEATION VERSUS MARSUPIALIZATION FOLLOWED BY ENUCLEATION IN THE MANAGEMENT OF UNICYSTIC AMELOBLASTOMA
CLINICAL OUTCOMES OF ENUCLEATION VERSUS MARSUPIALIZATION FOLLOWED BY ENUCLEATION IN THE MANAGEMENT OF UNICYSTIC AMELOBLASTOMA Open
Objectives: To compare the clinical outcome of enucleation versus marsupialization followed by enucleation in managing unicystic ameloblastoma. Material and Methods: A retrospective chart review of 40 patients equally divided into marsupia…
View article: Cross-sectional evaluation of online direct-to-public calprotectin testing
Cross-sectional evaluation of online direct-to-public calprotectin testing Open
Objective Why about a quarter of patients with inflammatory bowel disease (IBD) suffer symptoms for more than a year before their diagnosis made is unclear. Low public awareness, embarrassment and the apprehension of invasive tests are cit…
View article: Isolation and Genomic Analysis of Escherichia Phage AUBRB02: Implications for Phage Therapy in Lebanon
Isolation and Genomic Analysis of Escherichia Phage AUBRB02: Implications for Phage Therapy in Lebanon Open
We obtained a new and unique Escherichia phage, AUBRB02, from sewage water in Beirut, Lebanon, as part of this research. AUBRB02 has an incubation period of around 45 minutes, a lysis period of about 10 minutes, and a burst size of around …
View article: Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study
Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study Open
ObjectiveTo determine the diagnostic accuracy of calprotectin to diagnose inflammatory bowel disease (IBD) in children in whom general practitioners (GPs) suspected IBD.DesignProspective observational cohort study of a new calprotectin-bas…
View article: Perlindungan Hak Cipta terhadap Pengubahan Aransemen Musik Berdasarkan Undang- Undang Nomor 28 Tahun 2014
Perlindungan Hak Cipta terhadap Pengubahan Aransemen Musik Berdasarkan Undang- Undang Nomor 28 Tahun 2014 Open
This research discusses the protection of copyright in relation to the alteration of musical arrangements based on Law Number 28 of 2014. The research utilizes a normative research method (legal research) to examine the legal protection of…
View article: Real-world effectiveness of upadacitinib in Crohn’s disease: a UK multicentre retrospective cohort study
Real-world effectiveness of upadacitinib in Crohn’s disease: a UK multicentre retrospective cohort study Open
Background Upadacitinib is a Janus kinase inhibitor, which has recently been approved for treating Crohn’s disease. There are limited real-world studies on the outcomes of upadacitinib in Crohn’s disease. Objective Our aim was to evaluate …
View article: Defining predictors of responsiveness to advanced therapies in Crohn’s disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine
Defining predictors of responsiveness to advanced therapies in Crohn’s disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine Open
Introduction Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic dev…
View article: P580 Iron deficiency anaemia and quality of life in Inflammatory Bowel Disease: Prospective cohort study of ferric derisomaltose on quality of life and work productivity in patients with IBD
P580 Iron deficiency anaemia and quality of life in Inflammatory Bowel Disease: Prospective cohort study of ferric derisomaltose on quality of life and work productivity in patients with IBD Open
Background Iron-deficiency anaemia is a frequent complication of inflammatory bowel disease (IBD), affecting approximately 10% of patients at any one time. Quality of life scores in patients with IBD and anaemia are similar to those report…
View article: OP01 PROFILE: a multi-centre, randomised, open-label, biomarker-stratified clinical trial of treatment strategies for patients with newly-diagnosed Crohn’s disease
OP01 PROFILE: a multi-centre, randomised, open-label, biomarker-stratified clinical trial of treatment strategies for patients with newly-diagnosed Crohn’s disease Open
Background Clinical outcomes differ substantially between patients with Crohn’s disease and there is variability in how newly-diagnosed patients are managed. Recent interest has focused on developing biomarkers to predict outcomes and guid…
View article: OP11 Exploring the potential clinical utility of NUDT15 pharmacogenetic testing in clinical practice: a ‘focused reverse phenotyping’ study in the UK IBD Bioresource
OP11 Exploring the potential clinical utility of NUDT15 pharmacogenetic testing in clinical practice: a ‘focused reverse phenotyping’ study in the UK IBD Bioresource Open
Background In a previous study we recruited patients with inflammatory bowel disease (IBD) and a history of thiopurine induced myelosuppression (TIM) and identified associated variants in NUDT15. This widely used phenotype-first approach, …
View article: P371 Calprotectin Testing: A Methods Comparison Study
P371 Calprotectin Testing: A Methods Comparison Study Open
Background In conventional laboratory-based Enzyme Linked Immunosorbant Assays (ELISA) for calprotectin measurement, raw stool is returned to and manually processed by testing laboratories. The OCS-Pledia calprotectin test uses the same st…
View article: P234 Online direct-to-public calprotectin testing in the UK: what is out there in 2023?
P234 Online direct-to-public calprotectin testing in the UK: what is out there in 2023? Open
Background The longest component of the time-to-diagnosis is the interval between symptom onset and an individual seeking help. Recent reports in patients with sexually transmitted infections and hepatitis C, who also suffer health related…
View article: P852 Metataxonomic and metabolomic profiling to predict response to anti-TNF therapy in Crohn’s Disease
P852 Metataxonomic and metabolomic profiling to predict response to anti-TNF therapy in Crohn’s Disease Open
Background The composition of the gut microbiota is associated with response to treatments in inflammatory bowel disease1. We sought to identify gut microbial and metabolomic biomarkers associated with response to anti-TNF therapy in Crohn…
View article: P823 Real-world effectiveness of upadacitinib in Crohn's disease; a UK multicentre retrospective cohort study
P823 Real-world effectiveness of upadacitinib in Crohn's disease; a UK multicentre retrospective cohort study Open
Background Upadacitinib is a Janus kinase inhibitor which has recently been approved for the treatment of Crohn’s disease. There are limited real-world studies on the outcomes of upadacitinib in Crohn’s disease. Our aim was to evaluate the…
View article: Adolescent Testicular Adrenal Rest Tumors: A Case Report and Review of the Literature
Adolescent Testicular Adrenal Rest Tumors: A Case Report and Review of the Literature Open
Testicular Adrenal Rest Tumors (TARTs) are intratesticular masses linked to congenital adrenal hyperplasia (CAH) and the oversecretion of adrenocorticotropic hormone. We present a case of a 17-year-old male patient with CAH who exhibited u…