Explanipedia

Teriflunomide treatment for relapsing-remitting multiple sclerosis: An experience from Saudi Arabia Open

Morad Aljinaid, Osama Khojah, Layan Fahad Arshad, Raghad Algahtani, Ziyad Alghweinem , et al. · 2025

Multiple sclerosis (MS) is a disease of the central nervous system in which the immune system attacks the myelin sheath that covers nerve fibers. It is an immune-mediated chronic inflammatory disease. Teriflunomide is a once-daily oral dis…

The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology Open

Ahmad Abulaban, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Mustafa M Shokr , et al. · 2025

Role of liver X receptor in multiple sclerosis: A long furtive life behind a barrier Open

Ahmad Abulaban, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Eman Ahmed, Mohamed Fawzy , et al. · 2025

Liver X receptors (LXRs) are nuclear receptors that function as transcription factors regulating cholesterol metabolism and are implicated in multiple sclerosis (MS) pathogenesis. This mini-review aims to elucidate the potential role of LX…

The Possible Role of Metformin and Fibroblast Growth Factor‐21 in Multiple Sclerosis Neuropathology: Birds of a Feather Flock Together Open

Ahmad Abulaban, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Eman Ahmed, Mubarak Alruwaili , et al. · 2025

Multiple sclerosis (MS) is a progressive demyelinating disease of the CNS, characterized by inflammation, the formation of CNS plaques, and damage to the neuronal myelin sheath (Graphical abstract). Fibroblast growth factor 21 (FGF21) is i…

Do people with multiple sclerosis in Saudi Arabia want to know their prognosis? A cross-sectional nationwide study Open

Yaser Al Malik, Awad S. Alharbi, Mohammed A Alfurayh, Abdulaziz Aldalaan, Abdulazeez Alzailaie , et al. · 2025

While more than half of pwMS are curious about their prognosis, only about one-third have optimal discussions about LTP with neurologists. Many desire information on prognostic tools. Further research is needed to assess patients' knowledg…

Administration and Monitoring Burden of High-Efficacy Disease-Modifying Therapies for Multiple Sclerosis: A Delphi Consensus of Clinical Experts from Saudi Arabia Open

Seraj Makkawi, Ahmad Abulaban, Yaser Al Malik, Ebtesam Alshehri, Ahmed Althobaiti , et al. · 2025

Consensus guidelines on the diagnosis and management of myasthenia gravis by the Saudi Arabia Neuromuscular and Electrodiagnostic Medicine and neuromuscular specialists from the Gulf Cooperation Council region Open

Ali Alshehri, Mohammed H. Alanazy, Majed Alabdali, Ahmad R. Abuzinadah, Aysha A. Alshareef , et al. · 2025

The introduction of numerous therapeutic advancements in the management of myasthenia gravis (MG) may add difficulties in clinical decision-making, especially when no recommendations tailored to the local context are available. For this re…

Patterns of multiple sclerosis presentation to the emergency department Open

Seraj Makkawi, Alaa Maglan, Osama Khojah, Faris Allaf, Saeed Alamoudi , et al. · 2024

Background Multiple sclerosis (MS) patients are no strangers to the emergency department (ED) due to the relapsing and progressive nature of the disease and the associated complications. This study aimed to identify patterns of ED visits a…

Role of fenofibrate in multiple sclerosis Open

Ahmad Abulaban, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Engy Elekhnawy, Asma Alanazi , et al. · 2024

Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the central nervous system (CNS). The underlying pathophysiology of MS is the destruction of myelin sheath by immune cells. The formation of myelin plaq…

Life-Saving Treatments for Spinal Muscular Atrophy Open

Victor Diego Armengol, Basil T. Darras, Ahmad Abulaban, Ali Alshehri, Nina Barišić , et al. · 2023

Overall, this survey highlights the global inequality in managing patients with SMA. The spread of newborn screening is essential in ensuring improved access to care for patients with SMA. With the advancement of neurotherapeutics, more ge…

The prevalence of major depression and generalized anxiety disorder in patients with multiple sclerosis in Saudi Arabia: a cross-sectional multicentered study Open

Anas M Alswat, Bsaim A. Altirkistani, Anas R. Alserihi, Osama K. Baeshen, Eythar Alrushid , et al. · 2023

Background Multiple sclerosis (MS) is an autoimmune disease characterized by chronic, progressive neurodegeneration of the central nervous system (CNS), and it is the most common inflammatory neurological disease affecting young adults. Gi…

Utility of Initial Arterial Blood Gas in Neuromuscular versus Non-Neuromuscular Acute Respiratory Failure in Intensive Care Unit Patients Open

Ahmad R. Abuzinadah, Asma Khaled Almalki, Rinad Zuwaimel Almuteeri, Rahaf Hassan Althalabi, Hanin Abdullah Sahli , et al. · 2022

Background: The arterial blood gas (ABG) parameters of patients admitted to intensive care units (ICUs) with acute neuromuscular respiratory failure (NMRF) and non-NMRF have not been defined or compared in the literature. Methods: We retro…

Adherence of Saudi women with epilepsy to folic acid intake in the preconceptional period in two tertiary care hospitals in Riyadh: A cross sectional study Open

Ali Alanazi, Ahmed A. Al‐Qahtani, Mohammad N. Alfahadi, Saleh Alduhayan, Abdulaziz Alfadhel , et al. · 2022

Severe ataxia uncovered Hodgkin’s lymphoma: do not forget CT neck when looking for covert malignancy Open

Naim Izet Kajtazi, Ehtesham Khalid, Juman Al Ghamdi, Ahmad Abulaban, Majed Alhameed · 2021

A 53-year-old woman without medical problems presented with 5-month history of dizziness, difficulty speaking, severe ataxia, which worsened a day before admission to inability to stand unsupported. An extensive workup was initiated to fin…

Managing multiple sclerosis in the Covid19 era: a review of the literature and consensus report from a panel of experts in Saudi Arabia Open

Mohammed Aljumah, Ahmad Abulaban, Hani Aggad, Reem Al Bunyan, Mona Alkhawajah , et al. · 2021

Disease-modifying therapies (DMT) for relapsing-remitting MS (RRMS) act on the immune system, suggesting a need for caution during the SARS-CoV2/Covid-19 pandemic. A group of experts in MS care from Saudi Arabia convened to consider the im…

Guillain-Barré Syndrome as a Complication of COVID-19 Open

Adeel Zubair, Aarij Zubair, Kunal Desai, Ahmad Abulaban, Bhaskar Roy · 2021

Coronavirus disease 2019 (COVID-19) is associated with multiple neurological complications including Guillain-Barre syndrome (GBS).While there are reports of COVID-19 -related GBS cases, much remain unknown. We report two cases…

The lateralization of clinical findings might not affect the clinical outcome in multiple sclerosis Open

Ahmad Abulaban · 2020

To the Editor With great interest, I have read the data published recently by Varoglu and Balkuv.[1][1] They raised an interesting clinical question about the outcome and lateralization of clinical findings in patients with Multiple Scle…

Transcriptomic and clonal characterization of T cells in the human central nervous system Open

Jenna L. Pappalardo, Le Zhang, Maggie Pecsok, Kelly Perlman, Chrysoula Zografou , et al. · 2020

We have profiled cerebrospinal fluid T cells in healthy individuals and patients with MS using single-cell RNA and TCR sequencing.

Precision Medicine: Steps along the Road to Combat Human Cancer Open

Samuel F. Nassar, Khadir Raddassi, Baljit K. Ubhi, Joseph Doktorski, Ahmad Abulaban · 2020

The diagnosis and treatment of diseases such as cancer is becoming more accurate and specialized with the advent of precision medicine techniques, research and treatments. Reaching down to the cellular and even sub-cellular level, diagnost…

Multiple Sclerosis Patients Knowledge in Saudi Arabia Open

Ahmad Abulaban, Abdulrahman Altowairqi, Haitham Altowairqi, Abdulmajeed Almutairi, Saif Altalhi , et al. · 2019

Patients with MS in SA have less knowledge in the disease`s types, workups, and treatment efficacy. While in contrast, they have more awareness of the disease`s pathophysiology. Patient`s awareness programs should aid more knowledge among …

Exploring the outcome of multiple sclerosis among Saudi adult patients Open

Azhar Alanazi, Jinan R. Al-Rashoud, Jumanah Aljahani, Ahlam Falah Alotaibi, Alaa Althubaiti , et al. · 2019

Majority of patients had a favorable outcome that was linked with the use of DMT, compliance, early diagnosis, and absence of attacks.

Renal dysfunction as a predictor of acute stroke outcomes Open

Danah K. AboAlSamh, Ahmad Abulaban, Ismail A. Khatri, Ali M. Al-Khathaami · 2017

Estimated glomerular filtration rate is a possible predictor of stroke severity, disability and mortality.

Changing opinions about research by Saudi medical students Open

Ahmad Abulaban, Abdulrahman Alharbi, Osama BinDajam, Mohammed Al Jarbou, Hatem Alharbi , et al. · 2017

Most students in five Saudi universities expressed enthusiasm for participating in a research project, but only a few of them had sufficient knowledge on basic research. There was considerable improvement in students' perception of researc…

Intravenous Versus Nonintravenous Benzodiazepines for the Cessation of Seizures: A Systematic Review and Meta‐analysis of Randomized Controlled Trials Open

Abdussalam Alshehri, Ahmad Abulaban, Rakan Bokhari, Suleiman Kojan, Majid Alsalamah , et al. · 2017

Background The acquisition of intravenous ( IV ) access in the actively convulsing patient is difficult. This often delays the administration of the IV benzodiazepine ( BDZ ) necessary for seizure cessation. Delays in seizure cessation are…

Spinal Cord Schistosomiasis: Two Different Outcomes Open

Mohammed Alsomaili, Ahmad Abulaban · 2016

Spinal cord schistosomiasis is difficult to diagnose in nonendemic areas. We report the clinical profile of 2 young Saudi males who presented with myelopathy. The first patient arrived at our hospital relatively late, i.e. 3 months followi…

Clinical and genetic features of anoctaminopathy in Saudi Arabia Open

Saeed Bohlega, Dorothy M. Monies, Ahmad Abulaban, Hatem Murad, Hindi Al‐Hindi , et al. · 2015

The prevalence of LGMD2L is approximately 3.1% in a Saudi Arabian native LGMD cohort. Slowly progressive, late onset, and asymmetrical weakness was the salient features in these 2 families. The genetic findings were novel and will add to t…

The significance of sonic hedgehog immunohistochemical expression in colorectal carcinoma Open

Jaudah Al‐Maghrabi, Doaa Al Ghamdi, Wafaey Gomaa, Ahmad Abulaban, Mahmoud Al-Ahwal , et al. · 2015

Colorectal carcinoma is a significant source of major morbidity and mortality. Sonic hedgehog (Shh) is expressed in normal gastrointestinal tract mucosa and in many malignancies. The purpose of the present study is to investigate the relat…

Neurophobia among medical students. Open

Ahmad Abulaban, Tahir Obeid, Hussein Algahtani, Suleiman Kojan, Ali M. Al-Khathaami , et al. · 2015

Most of the students had an unfavorable attitude toward neurology on the Likert scale. New strategies are needed to change students` attitude toward this demanding specialty.

Factors potentially influencing academic performance among medical students Open

Abd Rahman Ahmad, Ahmad Abulaban, Lana Al Shawwa, Anas Merdad, Sara S. Baghlaf , et al. · 2015

Excellent medical students have many different characteristics. For example, they do not use social networking for prolonged periods of time, and they have strong motivation and study enjoyment. Further studies are needed to examine whethe…

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