Ahmad Nassr
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View article: Infective endocarditis meets native vertebral osteomyelitis: a mortality perspective
Infective endocarditis meets native vertebral osteomyelitis: a mortality perspective Open
Background: Native vertebral osteomyelitis and infective endocarditis (NVO + IE) are increasingly recognized as overlapping entities, sharing common risk factors (e.g., advanced age, immunosuppression) and similar pathogen profiles, most c…
View article: Not all Parkinsons patients with thoracolumbar spinal fusion are created equal: Highlighting the difference between long and short fusions
Not all Parkinsons patients with thoracolumbar spinal fusion are created equal: Highlighting the difference between long and short fusions Open
Background: Parkinsons disease (PD) is a devastating neuromuscular disease that has several distinct spinal syndromes in addition to common degenerative spinal disorders. Multiple studies have concluded that patients with Parkinson's disea…
View article: The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique
The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique Open
No funding was received for the present work. The original clinical trial (NCT01597518) was funded by the AO Foundation, United States Department of Defense (DOD), and the Praxis Spinal Cord Institute.
View article: Lumbar Endplate Hounsfield Units Enhance Transforaminal Lumbar Interbody Fusion Subsidence Prediction Compared to Trabecular Hounsfield Units Alone
Lumbar Endplate Hounsfield Units Enhance Transforaminal Lumbar Interbody Fusion Subsidence Prediction Compared to Trabecular Hounsfield Units Alone Open
Study Design Retrospective cohort analysis. Objective (1) Develop a novel computed tomography (CT)-based assessment of endplate bone density (EP-HU), (2) Determine if EP-HU was a stronger predictor than trabecular HU for subsidence after t…
View article: Removal of painful pelvic screws following spine fusion surgery: outcomes and complications
Removal of painful pelvic screws following spine fusion surgery: outcomes and complications Open
OBJECTIVE The purpose of this study was to evaluate the risks and benefits of removing painful pelvic/iliac screws in spine fusion surgery patients. METHODS A retrospective review identified patients who had traditional iliac and S2-alar-i…
View article: Impact of Frailty and Other Factors as Estimated by HU to Predict Response to Anabolic Bone Medications
Impact of Frailty and Other Factors as Estimated by HU to Predict Response to Anabolic Bone Medications Open
Introduction: Bone health optimization is a key component of the preoperative management of spine surgery patients, as poor bone quality increases the odds of mechanical complications. The present study aimed to achieve the following: (1) …
View article: Risk factors for early pathological fracture following stereotactic body radiation therapy for spinal metastases
Risk factors for early pathological fracture following stereotactic body radiation therapy for spinal metastases Open
OBJECTIVE The aim of this study was to determine independent risk factors for vertebral compression fracture (VCF) following stereotactic body radiation therapy (SBRT) in metastatic spine disease. METHODS Patients treated with SBRT for spi…
View article: The Paraspinal Sarcopenia at the Upper Instrumented Vertebra Is a Predictor of Discoligamentous but Not Bony Proximal Junctional Kyphosis
The Paraspinal Sarcopenia at the Upper Instrumented Vertebra Is a Predictor of Discoligamentous but Not Bony Proximal Junctional Kyphosis Open
Background/Objectives: Both poor bone quality and paraspinal sarcopenia have been suggested as risk factors for proximal junctional kyphosis (PJK) at the upper instrumented vertebra (UIV) following long-segment thoracolumbar fusion. Method…
View article: Letter to the Editor: “Which is the Superior Thoracolumbar Injury Classification Tool? TLICS Versus AOSpine 2013: A Systematic Review”
Letter to the Editor: “Which is the Superior Thoracolumbar Injury Classification Tool? TLICS Versus AOSpine 2013: A Systematic Review” Open
View article: Lumbar facet arthroplasty for spondylolisthesis and stenosis: Three-year outcomes from a prospective FDA randomized clinical trial
Lumbar facet arthroplasty for spondylolisthesis and stenosis: Three-year outcomes from a prospective FDA randomized clinical trial Open
View article: What Is the Accuracy of 16S PCR Followed by Sanger Sequencing or Next-generation Sequencing in Native Vertebral Osteomyelitis? A Systematic Review and Meta-analysis
What Is the Accuracy of 16S PCR Followed by Sanger Sequencing or Next-generation Sequencing in Native Vertebral Osteomyelitis? A Systematic Review and Meta-analysis Open
Background Identifying a microorganism in patients with native vertebral osteomyelitis presents diagnostic challenges. Microorganism identification through culture-based methods is constrained by prolonged processing times and sensitivity …
View article: Culture-Negative Native Vertebral Osteomyelitis: A Narrative Review of an Underdescribed Condition
Culture-Negative Native Vertebral Osteomyelitis: A Narrative Review of an Underdescribed Condition Open
The incidence of culture-negative NVO (CN-NVO) cases is increasing, presenting significant diagnostic and therapeutic challenges due to the inability to isolate causative organisms with conventional microbiological methods. Factors influen…
View article: Wide variability of the definitions used for native vertebral osteomyelitis: walking the path for a unified diagnostic framework with a meta-epidemiological approach
Wide variability of the definitions used for native vertebral osteomyelitis: walking the path for a unified diagnostic framework with a meta-epidemiological approach Open
View article: Paraspinal Sarcopenia and Lower Hounsfield Units are Independent Predictors of Increased Risk for Proximal Junctional Complications Following Thoracolumbar Fusions Terminating in the Upper Thoracic Spine
Paraspinal Sarcopenia and Lower Hounsfield Units are Independent Predictors of Increased Risk for Proximal Junctional Complications Following Thoracolumbar Fusions Terminating in the Upper Thoracic Spine Open
Study Design Retrospective cohort study. Objective The impact of paraspinal sarcopenia following fusions that extend to the upper thoracic spine remain unknown. The purpose of the present study was to assess the impact of sarcopenia on the…
View article: It is time for a unified definition of native vertebral osteomyelitis: a framework proposal
It is time for a unified definition of native vertebral osteomyelitis: a framework proposal Open
In recent years, there has been a notable increase in research output on native vertebral osteomyelitis (NVO), coinciding with a rise in its incidence. However, clinical outcomes remain poor, due to frequent relapse and long-term sequelae.…
View article: Riluzole for Degenerative Cervical Myelopathy
Riluzole for Degenerative Cervical Myelopathy Open
Importance The modified Japanese Orthopaedic Association (mJOA) scale is the most common scale used to represent outcomes of degenerative cervical myelopathy (DCM); however, it lacks consideration for neck pain scores and neglects the mult…
View article: Biomechanical analysis of lumbar decompression technique and the effect on spinal instability: a narrative review
Biomechanical analysis of lumbar decompression technique and the effect on spinal instability: a narrative review Open
View article: Lumbar Facet Arthroplasty Versus Fusion for Grade-I Degenerative Spondylolisthesis with Stenosis
Lumbar Facet Arthroplasty Versus Fusion for Grade-I Degenerative Spondylolisthesis with Stenosis Open
Background: The comparative effectiveness of decompression plus lumbar facet arthroplasty versus decompression plus instrumented lumbar spinal fusion in patients with lumbar spinal stenosis and grade-I degenerative spondylolisthesis is unk…
View article: Significant Reduction in Bone Density as Measured by Hounsfield Units in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis
Significant Reduction in Bone Density as Measured by Hounsfield Units in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis Open
Background: Multisegmental pathologic autofusion occurs in patients with ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH). It may lead to reduced vertebral bone density due to stress shielding. Methods: This …
View article: The Predictors of Incidental Durotomy in Patients Undergoing Pedicle Subtraction Osteotomy for the Correction of Adult Spinal Deformity
The Predictors of Incidental Durotomy in Patients Undergoing Pedicle Subtraction Osteotomy for the Correction of Adult Spinal Deformity Open
Background: Pedicle subtraction osteotomy (PSO) is a powerful tool for sagittal plane correction in patients with rigid adult spinal deformity (ASD); however, it is associated with high intraoperative blood loss and the increased risk of d…
View article: CORR Insights®: Does A Hinged Operating Table Facilitate Sagittal Correction in Transforaminal Lumbar Interbody Fusion With Smith-Peterson Osteotomy? A Radiographic Analysis
CORR Insights®: Does A Hinged Operating Table Facilitate Sagittal Correction in Transforaminal Lumbar Interbody Fusion With Smith-Peterson Osteotomy? A Radiographic Analysis Open
1Professor of Orthopedic Surgery and Neurosurgery, Mayo Clinic School of Medicine, Rochester, MN, USA A. Nassr, Mayo Clinic, Department of Orthopedics, 200 First Street Southwest, Rochester, MN 55905, USA, Email: [email protected] This COR…
View article: Iatrogenic vertebral artery injury with concomitant contralateral idiopathic vertebral artery dissection managed with intravascular intervention: a case report
Iatrogenic vertebral artery injury with concomitant contralateral idiopathic vertebral artery dissection managed with intravascular intervention: a case report Open
Surgeons should be aware of the possibility, while rare, that an occult injury to the non-injured artery is always a possibility if significant deformity correction or alignment change has occurred during cervical spine surgery. Working cl…
View article: Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial
Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial Open
Riluzole is a sodium-glutamate antagonist that attenuates neurodegeneration in amyotrophic lateral sclerosis (ALS). It has shown favorable results in promoting recovery in pre-clinical models of traumatic spinal cord injury (tSCI) and in e…
View article: Do Patients Accurately Recall Their Preoperative Symptoms After Elective Orthopedic Procedures?
Do Patients Accurately Recall Their Preoperative Symptoms After Elective Orthopedic Procedures? Open
Patient-reported outcome measures are a frequent tool used to assess orthopedic surgical outcomes. However, recall bias is a potential limitation of these tools when used retrospectively, as they rely on patients to accurately recall their…
View article: Sacropelvic Fixation with S2-Alar-Iliac (S2AI) Screws Via CT-guided Navigation
Sacropelvic Fixation with S2-Alar-Iliac (S2AI) Screws Via CT-guided Navigation Open
Sacropelvic fixation is frequently used for the correction of complex pediatric spine deformities. S2-alar-iliac (S2AI) screws are a powerful method to obtain iliac fixation. Advantages include a medialized starting point that requires les…
View article: En bloc resection of a high cervical chordoma followed by reconstruction with a free vascularized fibular graft: illustrative case
En bloc resection of a high cervical chordoma followed by reconstruction with a free vascularized fibular graft: illustrative case Open
BACKGROUND Wide excision of chordoma provides better local control than intralesional resection or definitive radiotherapy. The en bloc excision of high cervical chordomas is a challenging endeavor because of the complex anatomy of this re…
View article: A Prospective Study of Lumbar Facet Arthroplasty in the Treatment of Degenerative Spondylolisthesis and Stenosis
A Prospective Study of Lumbar Facet Arthroplasty in the Treatment of Degenerative Spondylolisthesis and Stenosis Open
Study Design: Prospective randomized Food and Drug Administration investigational device exemption clinical trial. Objective: The purpose of the present study is to report the 1-year clinical and radiographic outcomes and safety profile of…
View article: Association between lower Hounsfield units and proximal junctional kyphosis and failure at the upper thoracic spine
Association between lower Hounsfield units and proximal junctional kyphosis and failure at the upper thoracic spine Open
OBJECTIVE The aim of this study was to analyze risk factors and avoidance techniques for proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) in the upper thoracic spine with an emphasis on bone mineral density (BMD) as…
View article: The Effect of Preoperative Mental Health Status on Outcomes After Anterior Cervical Discectomy and Fusion
The Effect of Preoperative Mental Health Status on Outcomes After Anterior Cervical Discectomy and Fusion Open
Clinicians should be aware of the effects of poor mental health status on clinical outcomes in patients undergoing anterior cervical fusion, but can still expect significant clinical improvements after surgery.
View article: Rheumatoid Arthritis in Spine Surgery: A Systematic Review and Meta-Analysis
Rheumatoid Arthritis in Spine Surgery: A Systematic Review and Meta-Analysis Open
Study Design Systematic Review and Meta-analysis Objective The purpose of this study is to synthesize recommendations for perioperative medical management of RA patients and quantify outcomes after spine surgery when compared to patients w…