Explanipedia

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells Open

Tom Dendooven, Mina Ebrahimi, Ália dos Santos, Warre Dhondt, Oliver Knowles , et al. · 2025

In eukaryotic cells, LINC complexes physically bridge the two nuclear membranes to cytoskeletal filaments, transmitting mechanical forces to the nucleus. Due to their dynamic and membrane-embedded nature, their architecture in native membr…

A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ channel KtrAB Open

Janina Stautz, David Griwatz, Susann Kaltwasser, Ahmad Reza Mehdipour, Sophie Ketter , et al. · 2025

K + homeostasis is crucial for bacterial survival. The bacterial K+ channel KtrAB is regulated by the binding of ADP and ATP to the cytosolic RCK subunits KtrA. While the ligand-induced conformational changes in KtrA are well described, th…

Stability convergence in natural antibodies with ultra-long hypervariable loops Open

Marcel Passon, Matja Zalar, Thomas Nehls, Stefaan C. De Smedt, Frederik Lermyte , et al. · 2025

Antibodies bind to antigens with hypervariable loops called complementarity-determining regions (CDRs). In contrast to conventional antibodies, a subset of bovine antibodies has an ultra-long CDR (ulCDR) composed of up to 70 residues folde…

Molecular dynamics of membrane partitioning of nifedipine prior to binding calcium channel Cav1.1 Open

Warre Dhondt, Louis Vanduyfhuys, Ahmad Reza Mehdipour · 2025

An increasing number of ligand-bound membrane protein structures reveal ligand-binding sites on the lipid-exposed surface of the protein within the membrane bilayer. Binding events to such sites have previously been studied using molecular…

The mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake Open

Imre Gonda, Simona Sorrentino, Laura Galazzo, Nicolas P. Lichti, Fabian Arnold , et al. · 2025

MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes Open

Katharina E. J. Jungnickel, Océane Guelle, Miharu Iguchi, Wentao Dong, Vadim Kotov , et al. · 2024

Robotic-inspired approach to multi-domain membrane receptor conformation space: theory and SARS-CoV-2 spike protein case study Open

Alen T. Mathew, Mateusz Sikora, Gerhard Hummer, Ahmad Reza Mehdipour · 2024

1 Summary The spike protein of SARS-CoV-2 is a highly flexible membrane receptor that triggers the translocation of the virus into cells by attaching to the human receptors. Like other type I membrane receptors, this protein has several ex…

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23 Open

Yehudi Bloch, Jan Félix, Romain Merceron, Mathias Provost, Royan Alipour Symakani , et al. · 2024

MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes Open

Katharina E. J. Jungnickel, Océane Guelle, Miharu Iguchi, Wentao Dong, Vadim Kotov , et al. · 2023

Summary Lysosomal degradation of macromolecules in lysosomes produces diverse small metabolites exported by specific transporters for reuse in biosynthetic pathways. Here, we deorphanized the Major Facilitator Superfamily Domain Containing…

GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery Open

Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank , et al. · 2023

As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of…

Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors Open

Clara Lettl, Franziska Schindele, Ahmad Reza Mehdipour, Thomas Steiner, Diana Ring , et al. · 2023

Dissecting the conformational complexity and mechanism of a bacterial heme transporter Open

Di Wu, Ahmad Reza Mehdipour, Franziska Finke, Hojjat Ghasemi Goojani, Roan R. Groh , et al. · 2023

Author Correction: Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level Open

Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic , et al. · 2023

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level Open

Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic , et al. · 2022

Force-tuned Avidity of Spike Variant-ACE2 Interactions viewed on the Single-Molecule Level - MD simulations Dataset Open

Rong Zhou, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic , et al. · 2022

Models of SARS-CoV-2 virus spike protein bound to 1-3 of ACE2 receptors embedded in lipid nanodisks. Systems include all files in GROMACS format needed to reproduce simulations performed in the "Force-tuned Avidity of Spike Variant-ACE2 In…

Force-tuned Avidity of Spike Variant-ACE2 Interactions viewed on the Single-Molecule Level - MD simulations Dataset Open

Rong Zhou, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic , et al. · 2022

Models of SARS-CoV-2 virus spike protein bound to 1-3 of ACE2 receptors embedded in lipid nanodisks. Systems include all files in GROMACS format needed to reproduce simulations performed in the "Force-tuned Avidity of Spike Variant-ACE2 In…

Cryo‐EM structures of pentameric autoinducer‐2 exporter from Escherichia coli reveal its transport mechanism Open

R.A. Khera, Ahmad Reza Mehdipour, Jani Reddy Bolla, Joerg Kahnt, Sonja Welsch , et al. · 2022

GlycoVHH: Introducing N-glycans on the camelid VHH antibody scaffold - Optimal sites and use for macrophage delivery Open

Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank , et al. · 2022

As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics. To further increase the versatility of…

Dissecting the conformational complexity and flipping mechanism of a prokaryotic heme transporter Open

Di Wu, Ahmad Reza Mehdipour, Franziska Finke, Hojjat Ghasemi Goojani, Roan R. Groh , et al. · 2022

Iron-bound cyclic tetrapyrroles (hemes) are key redox-active cofactors in membrane-integrated oxygen reductases and other bioenergetic enzymes. However, the mechanisms of heme transport and insertion into respiratory chain complexes remain…

Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter Open

Elisabeth Lambert, Ahmad Reza Mehdipour, Alexander Schmidt, Gerhard Hummer, Camilo Pérez · 2022

The structure of the Aquifex aeolicus MATE family multidrug resistance transporter and sequence comparisons suggest the existence of a new subfamily Open

Jiangfeng Zhao, Hao Xie, Ahmad Reza Mehdipour, Schara Safarian, Ulrich Ermler , et al. · 2021

Significance Multidrug and toxic compound extrusion (MATE) transporters play a significant role in the active export of drugs and toxic compounds in pathogens. The transport mechanism is still not fully understood. A comprehensive phylogen…

Cryo-EM structures of pentameric autoinducer-2 exporter from E. coli reveal its transport mechanism Open

R.A. Khera, Ahmad Reza Mehdipour, Jani Reddy Bolla, Joerg Kahnt, Sonja Welsch , et al. · 2021

Bacteria utilize small extracellular molecules to communicate in order to collectively coordinate their behaviors in response to the population density. Autoinducer-2 (AI-2), a universal molecule for both intra- and inter-species communica…

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB Open

Schara Safarian, Helen K. Opel‐Reading, Di Wu, Ahmad Reza Mehdipour, Kiel Hards , et al. · 2021

Evidence for a ‘trap-and-flip’ mechanism in a proton-dependent lipid transporter Open

Elisabeth Lambert, Ahmad Reza Mehdipour, Alexander Schmidt, Gerhard Hummer, Camilo Pérez · 2021

Transport of lipids across membranes is fundamental for diverse biological pathways in cells. Multiple ion-coupled transporters participate in lipid translocation, but their mechanisms remain largely unknown. Major facilitator superfamily …

Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection Open

Rukmini Mukherjee, Anshu Bhattacharya, Denisa Bojková, Ahmad Reza Mehdipour, Dong Hyuk Shin , et al. · 2021

Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike Open

Ahmad Reza Mehdipour, Gerhard Hummer · 2021

Significance The SARS-CoV-2 virus infects cells by docking the spike protein at its surface to a receptor protein exposed on human cells. Both receptor and spike are covered by sugars. With molecular dynamics simulations, we show that suga…

Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection Open

Dong Hyuk Shin, Anshu Bhattacharya, Yi-Lin Cheng, Marta Campos Alonso, Ahmad Reza Mehdipour , et al. · 2020

Legionella pneumophila causes a severe pneumonia known as Legionnaires’ disease. During the infection, Legionella injects more than 300 effector proteins into host cells. Among them are enzymes involved in altering the host-ubiquitination …

Author response: Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection Open

Dong Hyuk Shin, Anshu Bhattacharya, Yi-Lin Cheng, Marta Campos Alonso, Ahmad Reza Mehdipour , et al. · 2020

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity Open

Dong Hyuk Shin, Rukmini Mukherjee, Diana Grewe, Denisa Bojková, Kheewoong Baek , et al. · 2020

Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike Open

Ahmad Reza Mehdipour, Gerhard Hummer · 2020

Binding of the spike protein of SARS-CoV-2 to the human angiotensin converting enzyme 2 (ACE2) receptor triggers translocation of the virus into cells. Both the ACE2 receptor and the spike protein are heavily glycosylated, including at sit…

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