Amina Khan
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View article: 380 Neurofibromatosis Type 1 with Recurrent Extensive Orbital Plexiform Neurofibroma and Associated Glaucoma: A Case of Disfiguring Disease Managed by Exenteration
380 Neurofibromatosis Type 1 with Recurrent Extensive Orbital Plexiform Neurofibroma and Associated Glaucoma: A Case of Disfiguring Disease Managed by Exenteration Open
Introduction/Objective Neurofibromatosis Type 1 (NF1) is a common autosomal dominant neurocutaneous disorder with an incidence of approximately 1 in 3,000 live births. It is characterized by complete penetrance and variable expressivity, l…
View article: The lack of breast cancer screening programmes (Mammograms) in Pakistan
The lack of breast cancer screening programmes (Mammograms) in Pakistan Open
Breast cancer is one of the leading causes of cancer-related deaths amongst women in Pakistan and is also the most commonly diagnosed cancer among women in the country as well. With an age-standardised incidence rate of 34.6 per 100,000 wo…
View article: Bridging Global Disparities in Breast Cancer Care: External Validation Study of the MD Anderson “Nomogram To Predict Positive Sentinel Lymph Nodes After Neoadjuvant Chemotherapy” and Its Financial Implications of Axillary De-escalation in a Resource Limited Setting
Bridging Global Disparities in Breast Cancer Care: External Validation Study of the MD Anderson “Nomogram To Predict Positive Sentinel Lymph Nodes After Neoadjuvant Chemotherapy” and Its Financial Implications of Axillary De-escalation in a Resource Limited Setting Open
Axillary surgery in breast cancer has evolved from radical dissections to selective de-escalations. Identifying patients who may safely omit sentinel lymph node biopsy (SLNB) can further reduce the surgical burden, post operative complicat…
View article: Diagnostic Accuracy of Spot Urine Protein-Creatinine Ratio for Pre-Eclampsia among Females Presented to Tertiary Level Hospital with Pregnancy-Induced Hypertension
Diagnostic Accuracy of Spot Urine Protein-Creatinine Ratio for Pre-Eclampsia among Females Presented to Tertiary Level Hospital with Pregnancy-Induced Hypertension Open
Preeclampsia is main cause of fetal, maternal and newborn death globally, particularly in low- and middle-income nations. It's usually diagnosed when a pregnant woman shows indicators of hypertension and proteinuria. Objective: To determin…
View article: Maternal<i>Med12</i>safeguards trophoblast pluripotency and placental development
Maternal<i>Med12</i>safeguards trophoblast pluripotency and placental development Open
For a brief but critical period post-fertilization, the mammalian embryo is entirely dependent on maternal products inherited from the oocyte. Previous research showed that oocyte-specific loss of Med12 , an X-linked gene and Mediator comp…
View article: Impact of Passive Smoking on Low Birth Weight among Pregnant Women in Active Labor
Impact of Passive Smoking on Low Birth Weight among Pregnant Women in Active Labor Open
Passive smoking during pregnancy, also called second-hand smoke exposure or environmental tobacco smoke, pretenses a substantial threat to fetal and maternal health. Objectives: To evaluate the association between passive smoking exposure …
View article: Severe Congenital Neutropenia with ELANE gene mutation, on G-CSF therapy; a case report
Severe Congenital Neutropenia with ELANE gene mutation, on G-CSF therapy; a case report Open
Introduction/Objective Severe congenital neutropenia (SCN) is a genetic syndrome characterized by a deficiency of mature neutrophils in the bone marrow and peripheral blood. The disease is caused by various gene mutations, with ELANE gene …
View article: Myeloid neoplasm with concurrent BCR::ABL1 translocation, and JAK2 and SF3B1 co-mutations with severe fibrosis: a case report
Myeloid neoplasm with concurrent BCR::ABL1 translocation, and JAK2 and SF3B1 co-mutations with severe fibrosis: a case report Open
Introduction/Objective Myeloproliferative neoplasms (MPNs) arise from hematopoietic stem cells with somatically altered tyrosine kinase signaling. Classification of MPNs is based on hematologic, histopathologic and molecular characteristic…
View article: Myeloid Sarcoma of Conjunctiva in a patient with JAK2-positive myeloid neoplasm: two distinct myeloid neoplasms sequentially arising from a common precursor
Myeloid Sarcoma of Conjunctiva in a patient with JAK2-positive myeloid neoplasm: two distinct myeloid neoplasms sequentially arising from a common precursor Open
Introduction/Objective Myeloid sarcoma (aka granulocytic sarcoma or chloroma), a rare type of myeloid neoplasm is characterized by the presence of myelogenous blastic cells outside of the bone marrow either before, during or after the deve…
View article: Impact of SSO-ASTRO Margin Guidelines on Re-excision Rate in Breast-conserving Surgery: A Single-center Experience.
Impact of SSO-ASTRO Margin Guidelines on Re-excision Rate in Breast-conserving Surgery: A Single-center Experience. Open
Implementation of the SSO-ASTRO margin guidelines led to a notable decrease in the overall re-excision rate in our data set. These findings suggest that continued adherence to the guidelines may lead to a further reduction in the re-excisi…
View article: A rare case of EBV-positive gray zone lymphoma
A rare case of EBV-positive gray zone lymphoma Open
Introduction/Objective Gray zone lymphoma (GZL) is a rare and novel category of lymphoid neoplasms, first described in 2005. It is derived from B-cells and exhibits characteristics that fall between diffuse large B-cell lymphoma (DLBCL) an…
View article: EBV positive plasmacytoma in immunocompetent patients: A diagnostically challenging rare entity
EBV positive plasmacytoma in immunocompetent patients: A diagnostically challenging rare entity Open
Introduction/Objective Epstein-Barr Virus (EBV)-positive plasmacytoma is a rare entity that shows morphological and immunophenotypic overlap with plasmablastic lymphoma and can cause a diagnostic dilemma. Here we discuss a unique case of E…
View article: Differential roles of cyclooxygenase enzymes in the regulation of murine juvenile undifferentiated spermatogonia
Differential roles of cyclooxygenase enzymes in the regulation of murine juvenile undifferentiated spermatogonia Open
Background Acetaminophen and ibuprofen are widely administered to babies due to their presumed safety as over‐the‐counter drugs. However, no reports exist on the effects of cyclooxygenase inhibitors on undifferentiated spermatogonia and sp…
View article: 1299 Puerperal Shoulder Pain: A Rare Case of Glenohumeral Joint Septic Arthritis
1299 Puerperal Shoulder Pain: A Rare Case of Glenohumeral Joint Septic Arthritis Open
Introduction Native glenohumeral joint septic arthritis is a rare manifestation of an occult bacteraemia. Without urgent diagnosis and intervention, septic arthritis can lead to rapid cartilaginous and joint destruction. We report an unusu…
View article: Benchmarking Excellence: Evaluating Advanced Breast Carcinoma Care in Pakistan's Largest Cancer Hospital Against the National Institute for Health and Care Excellence (NICE) Guidelines
Benchmarking Excellence: Evaluating Advanced Breast Carcinoma Care in Pakistan's Largest Cancer Hospital Against the National Institute for Health and Care Excellence (NICE) Guidelines Open
Introduction Breast cancer is the most common type of cancer worldwide, and even with all the screening and education, great numbers of diagnoses are made in advanced stages. Additionally, patients in remission always remain at risk of rel…
View article: Non-invasive blood glucometer
Non-invasive blood glucometer Open
Roughly 18 million individuals experience the ill effects of diabetes mellitus, otherwise called diabetes, just in the United States which is 5 % of the aggregate populace. It is the seventh driving reason for death. By 2020, the cost rela…
View article: EDUCATION AND COGNITIVE ABILITY: EXPLORING DIRECT AND INDIRECT EFFECTS IN THE UNITED STATES AND MEXICO
EDUCATION AND COGNITIVE ABILITY: EXPLORING DIRECT AND INDIRECT EFFECTS IN THE UNITED STATES AND MEXICO Open
Education positively relates with cognition, which may be explained by enhanced cognitive reserve. However, education may also impact cognition indirectly by improving health, health behaviors, and life-course socioeconomic status (SES). T…
View article: Papillary Carcinoma of Breast: Clinicopathological Characteristics, Management, and Survival
Papillary Carcinoma of Breast: Clinicopathological Characteristics, Management, and Survival Open
Objective. To study clinicopathological features, treatment strategies, and prognosis of papillary carcinoma of breast. Material and Methods. Data from 58 patients were retrospectively reviewed from January 2010 to December 2016. Four type…
View article: Follicular Lymphoma of Breast: a Case Report from Pakistan
Follicular Lymphoma of Breast: a Case Report from Pakistan Open
Introduction: Breast Lymphoma (BL) is a rare breast tumor and accounts for less than 1% of all breast malignancies. It is further categorized into primary breast lymphoma and secondary breast lymphoma. This manuscript presents a case repor…
View article: 40 Frail patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention have more adverse angiographic features but no difference in rate of complete revascularisation compared to non-frail patients
40 Frail patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention have more adverse angiographic features but no difference in rate of complete revascularisation compared to non-frail patients Open
Introduction Over half of patients that present with non-ST elevation acute coronary syndrome (NSTEACS) are older than 70 years, with these adults having a higher incidence of frailty. There is little data describing the angiographic featu…
View article: 209 Breast Lymphoma Treatment Outcomes in a Pakistani Population: 20 Years of Experience at a Single Centre
209 Breast Lymphoma Treatment Outcomes in a Pakistani Population: 20 Years of Experience at a Single Centre Open
Background Breast lymphomas constitute a rare disease entity. To date, limited relevant data have been reported. We therefore here present a review of breast lymphoma patients treated at a single centre over 20-year period, focusing on his…
View article: 210 Prognosis of Breast Cancer in Very Young Age (Less Than 30 Years)
210 Prognosis of Breast Cancer in Very Young Age (Less Than 30 Years) Open
Background Breast cancer diagnosed at younger age has aggressive biology being triple negative and high grade and associated with poor prognosis. Method Retrospectively data of 121 patients age 30 years or younger registered during the yea…
View article: Bronchogenic Cyst in the Cervical Region: A Rare Entity – A Case Report and Review of the Literature
Bronchogenic Cyst in the Cervical Region: A Rare Entity – A Case Report and Review of the Literature Open
Bronchogenic cysts originate from the tracheobronchial bud, which arises from the embryonic foregut. Congenital bronchogenic cysts in the cervical region, especially in the thyroid or perithyroidal area, are extremely rare. Moreover, disti…
View article: Post operative chronic breast seroma with mammary fistula: A case report
Post operative chronic breast seroma with mammary fistula: A case report Open
Introduction:
\nA breast seroma can develop after trauma to the breast or following procedures such as breast surgery or radiation therapy. Most often, seromas are reabsorbed by the body over a period of several weeks, but in some cases, t…
View article: Modifying Surgical Practice in the Times of Current COVID-19 Pandemic
Modifying Surgical Practice in the Times of Current COVID-19 Pandemic Open
In the times of current coronavirus disease 2019 (COVID-19) pandemic, the surgical practice is suffering. The present report summarises the impact of this pandemic on our surgical services and the changes that have been promulgated for the…
View article: Predictive Factors Involved in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer and Impact of Response on 5 Years Disease Free Survival and Overall Survival
Predictive Factors Involved in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer and Impact of Response on 5 Years Disease Free Survival and Overall Survival Open
Objective: To evaluate all the known factors that may play a role in predicting response to Neoadjuvant chemotherapy in breast cancer and to see impact of response on five years’ disease free survival (DFS) and Overallsurvival (OS). Materi…
View article: Research in Somalia: Opportunities for Cooperation
Research in Somalia: Opportunities for Cooperation Open
Research cooperation between Somalia and Sweden began in 1982, but was interrupted in the early 1990s due to the civil war. As Somalia gradually starts the process of institution-building and shifting towards a federal system, the Swedish …
View article: Small cell carcinoma of breast, Case report of a rare tumor.
Small cell carcinoma of breast, Case report of a rare tumor. Open
Introduction: Small cell carcinoma of the breast is an exceedingly rare tumour with a few cases reported in the literature. The microscopic and immunohistochemical patterns are very similar to small cell carcinoma of the lung. Thus, most o…
View article: THE ROLE OF INTRAOPERATIVE FROZEN SECTION OF SENTINEL LYMPH NODES IN UPFRONT BREAST CONSERVATION CANCER SURGERY
THE ROLE OF INTRAOPERATIVE FROZEN SECTION OF SENTINEL LYMPH NODES IN UPFRONT BREAST CONSERVATION CANCER SURGERY Open
Objective: Sentinel lymph node biopsy is the standard of care in clinically negative axilla in breast cancer patients for which frozen section (FS) is routinely performed intraoperatively. The objective of this study was to justify the use…