Ahmed R. Sofy
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View article: cfDNA Key genomic markers in HCV-Induced hepatocellular carcinoma in Egyptian patients
cfDNA Key genomic markers in HCV-Induced hepatocellular carcinoma in Egyptian patients Open
View article: Binding affinities and antiviral activities of Allicin and Glycyrrhizin against SARS-CoV-2: Molecular docking and in-vitro approaches
Binding affinities and antiviral activities of Allicin and Glycyrrhizin against SARS-CoV-2: Molecular docking and in-vitro approaches Open
View article: Magnetized water mitigates AlCl3-induced oxidative stress and Alzheimer's-like neurotoxicity in rats
Magnetized water mitigates AlCl3-induced oxidative stress and Alzheimer's-like neurotoxicity in rats Open
View article: Biochemical, Hematologic and Oxidative Stress Biomarkers Investigation in Infected Native Breed Calves with Foot and Mouth Disease virus Serotype A
Biochemical, Hematologic and Oxidative Stress Biomarkers Investigation in Infected Native Breed Calves with Foot and Mouth Disease virus Serotype A Open
View article: Potential use of SAP-4 as a destructive and biofilm stripper against disobedient Staphylococcus aureus (SA) and methicillin-resistant S. aureus (MRSA) isolates
Potential use of SAP-4 as a destructive and biofilm stripper against disobedient Staphylococcus aureus (SA) and methicillin-resistant S. aureus (MRSA) isolates Open
View article: Anti-Herpes Effect and Mode of Action of Hesperidin as a Safe and Promising Alternative Antiviral
Anti-Herpes Effect and Mode of Action of Hesperidin as a Safe and Promising Alternative Antiviral Open
View article: Uncovering and evaluating coconut oil-loaded silica nanoemulsion as anti-viral, bacterial, and fungal: synthesis, fabrication, characterization, and biosafety profiles
Uncovering and evaluating coconut oil-loaded silica nanoemulsion as anti-viral, bacterial, and fungal: synthesis, fabrication, characterization, and biosafety profiles Open
Background Coconut oil, a natural component abundant in terpenoids, possesses various physiological functions. The global concern over the spread of viral infections and antimicrobial-resistant bacteria and fungi has highlighted the need f…
View article: Combating Multidrug Resistance: The Potential of Antimicrobial Peptides and Biofilm Challenges
Combating Multidrug Resistance: The Potential of Antimicrobial Peptides and Biofilm Challenges Open
The escalating crisis of antibiotic resistance represents a formidable challenge to global public health, necessitating urgent and innovative solutions. This review delves into the multifaceted nature of antibiotic resistance, emphasizing …
View article: Exploring biosurfactant from Halobacterium jilantaiense as drug against HIV and zika virus: fabrication, characterization, cytosafety property, molecular docking, and molecular dynamics simulation
Exploring biosurfactant from Halobacterium jilantaiense as drug against HIV and zika virus: fabrication, characterization, cytosafety property, molecular docking, and molecular dynamics simulation Open
Biosurfactants are surface-active molecules with unique qualities and various uses. Many microorganisms produce secondary metabolites with surface-active characteristics that serve various antiviral functions. The HIV and Zika viruses were…
View article: Survival factors affecting the infectivity of hepatitis A virus isolated from Egypt
Survival factors affecting the infectivity of hepatitis A virus isolated from Egypt Open
Background: The physicochemical properties of viruses affect both how well they spread and how long they may survive in different environments. It would be helpful to have a complete understanding of the tools to break or limit the chain o…
View article: Mesenchymal stem cell transplantation in burn wound healing: uncovering the mechanisms of local regeneration and tissue repair
Mesenchymal stem cell transplantation in burn wound healing: uncovering the mechanisms of local regeneration and tissue repair Open
Burn injuries pose a significant healthcare burden worldwide, often leading to long-term disabilities and reduced quality of life. To explore the impacts of the transplantation of mesenchymal stem cells (MSCs) on the healing of burns and t…
View article: Synergistic Effects of Kaolin and Silicon Nanoparticles for Ameliorating Deficit Irrigation Stress in Maize Plants by Upregulating Antioxidant Defense Systems
Synergistic Effects of Kaolin and Silicon Nanoparticles for Ameliorating Deficit Irrigation Stress in Maize Plants by Upregulating Antioxidant Defense Systems Open
Water deficit is a significant environmental stress that has a negative impact on plant growth and yield. In this research, the positive significance of kaolin and SiO2 nanoparticles in moderating the detrimental effects of water deficit o…
View article: Diversity and Distribution Characteristics of Viruses from Soda Lakes
Diversity and Distribution Characteristics of Viruses from Soda Lakes Open
Viruses are the most abundant living things and a source of genetic variation. Despite recent research, we know little about their biodiversity and geographic distribution. We used different bioinformatics tools, MG-RAST, genome detective …
View article: Foliar Application of Chitosan and Phosphorus Alleviate the Potato virus Y-Induced Resistance by Modulation of the Reactive Oxygen Species, Antioxidant Defense System Activity and Gene Expression in Potato
Foliar Application of Chitosan and Phosphorus Alleviate the Potato virus Y-Induced Resistance by Modulation of the Reactive Oxygen Species, Antioxidant Defense System Activity and Gene Expression in Potato Open
Viruses pose a serious threat to the sustainable production of economically important crops around the world. In the past 20 years, potato virus Y (PVY) emerged as a relatively new and very serious problem in potatoes, even though it is th…
View article: N- or/and P-deprived Coccomyxa chodatii SAG 216–2 extracts instigated mercury tolerance of germinated wheat seedlings
N- or/and P-deprived Coccomyxa chodatii SAG 216–2 extracts instigated mercury tolerance of germinated wheat seedlings Open
Purpose This research studies the alleviation potential of N- or/and P- deprived Coccomyxa chodatii SAG 216–2 extracts as biostimulants on mercury stress (10 and 30 mg L −1 ) of wheat seedlings. Materials The study includes the interactive…
View article: Antiviral and Antibacterial Properties of synthesis Silver Nanoparticles with Nigella arvensis Aqueous Extract
Antiviral and Antibacterial Properties of synthesis Silver Nanoparticles with Nigella arvensis Aqueous Extract Open
As a result of the emergence of new virus strains and the emergence of microorganisms resistant to various antibiotic synthetics, virus infections pose significant global health challenges, so the need for new therapeutic drugs rises as ne…
View article: MORINGA OLEIFERA CRUDE EXTRACT AND THE REFERENCE M2-CHANNEL BLOCKER AMANTADINE AS ANTIVIRALS AGAINST THE EGYPTIAN H5N8 ISOLATE, SPECIFICALLY INFLUENZA A/CHICKEN/EGYPT/Q16684C/2019 (H5N8) VIRUS.
MORINGA OLEIFERA CRUDE EXTRACT AND THE REFERENCE M2-CHANNEL BLOCKER AMANTADINE AS ANTIVIRALS AGAINST THE EGYPTIAN H5N8 ISOLATE, SPECIFICALLY INFLUENZA A/CHICKEN/EGYPT/Q16684C/2019 (H5N8) VIRUS. Open
Despite that great effort is currently running in the direction of vaccine and drug development, limited number of therapeutics are currently approved against seasonal influenza virus.To limit the spread of the transmission of highly patho…
View article: Development and Evaluation of an Inactivated Influenza A(H5N8) Vaccine
Development and Evaluation of an Inactivated Influenza A(H5N8) Vaccine Open
Highly pathogenic avian influenza viruses are circulating in lots of avian species, causing major outbreaks in both wild and domestic poultry. Since its first emergence in 2014, clade 2.3.4.4 H5N8 viruses widely spread in the world resulti…
View article: Hydrogen Sulfide Modulates Salinity Stress in Common Bean Plants by Maintaining Osmolytes and Regulating Nitric Oxide Levels and Antioxidant Enzyme Expression
Hydrogen Sulfide Modulates Salinity Stress in Common Bean Plants by Maintaining Osmolytes and Regulating Nitric Oxide Levels and Antioxidant Enzyme Expression Open
The purpose of the present study is to investigate the role of hydrogen sulfide (H 2 S), in improving resistance to common bean salt stress. Method shows that common bean seeds were soaked in water and in two concentrations of sodium hydro…
View article: A polishing the harmful effects of Broad Bean Mottle Virus infecting broad bean plants by enhancing the immunity using different potassium concentrations
A polishing the harmful effects of Broad Bean Mottle Virus infecting broad bean plants by enhancing the immunity using different potassium concentrations Open
Broad bean mottle virus (BBMV) infects a wide range of hosts, resulting in significant production reductions. The lack of adequate and effective control methods involves implementing novel BBMV control strategies. Herein, we demonstrate th…
View article: Production of biosurfactant by Bacillus megaterium and its correlation with lipid peroxidation of Lactuca sativa
Production of biosurfactant by Bacillus megaterium and its correlation with lipid peroxidation of Lactuca sativa Open
The biosurfactant-producing bacterial isolate was isolated from an oil-contaminated water sample. This study aimed to determine the production of biosurfactant and its effect on the plant growth via the biosorption of some heavy metals. Th…
View article: Discovery of Polyvalent Myovirus (vB_STM-2) Phage as a Natural Antimicrobial System to Lysis and Biofilm Removal of Salmonella Typhimurium Isolates from Various Food Sources
Discovery of Polyvalent Myovirus (vB_STM-2) Phage as a Natural Antimicrobial System to Lysis and Biofilm Removal of Salmonella Typhimurium Isolates from Various Food Sources Open
New and natural antimicrobials as an alternative control system are now an urgent need to overcome stubborn bacterial infections. Salmonella Typhimurium has become the most frequent serovar responsible for salmonellosis in humans around th…
View article: Preparation of Zinc Oxide Nanoparticles using Aspergillus niger as Antimicrobial and Anticancer Agents
Preparation of Zinc Oxide Nanoparticles using Aspergillus niger as Antimicrobial and Anticancer Agents Open
In the current study, zinc oxide nanoparticles (ZnO-NP) were prepared using extracellular extracts of Aspergillus niger. Hence, the morphological structure, optical, and surface features of the synthesized nanoparticles were studied by X-r…
View article: Antibacterial and Antifungal Activity of Green-synthesized Silver Nanoparticles Using Spinacia oleracea leaves Extract
Antibacterial and Antifungal Activity of Green-synthesized Silver Nanoparticles Using Spinacia oleracea leaves Extract Open
In this study, silver nanoparticles (AgNPs) were green synthesized using aqueous leaf extracts of green spinach that have been used as antimicrobial agents. The antimicrobial efficacy was evaluated against bacterial and fungal strains. The…
View article: Characterization and Full Genome Sequence of Novel KPP-5 Lytic Phage against Klebsiella pneumoniae Responsible for Recalcitrant Infection
Characterization and Full Genome Sequence of Novel KPP-5 Lytic Phage against Klebsiella pneumoniae Responsible for Recalcitrant Infection Open
Klebsiella pneumoniae is a hazardous opportunistic pathogen that is involved in many serious human diseases and is considered to be an important foodborne pathogen found in many food types. Multidrug resistance (MDR) K. pneumoniae strains …
View article: Ameliorating the Adverse Effects of Tomato mosaic tobamovirus Infecting Tomato Plants in Egypt by Boosting Immunity in Tomato Plants Using Zinc Oxide Nanoparticles
Ameliorating the Adverse Effects of Tomato mosaic tobamovirus Infecting Tomato Plants in Egypt by Boosting Immunity in Tomato Plants Using Zinc Oxide Nanoparticles Open
Tomato mosaic virus (ToMV) is one of the economically damageable Tobamovirus infecting the tomato in Egypt that has caused significant losses. It is therefore of great interest to trigger systemic resistance to ToMV. In this endeavor, we a…
View article: Molecular Characterization of the Alfalfa mosaic virus Infecting Solanum melongena in Egypt and the Control of Its Deleterious Effects with Melatonin and Salicylic Acid
Molecular Characterization of the Alfalfa mosaic virus Infecting Solanum melongena in Egypt and the Control of Its Deleterious Effects with Melatonin and Salicylic Acid Open
During the spring of 2019, distinct virus-like symptoms were observed in the Kafr El-Sheikh Governorate in Egypt in naturally infected eggplants. Leaves of affected plants showed interveinal leaf chlorosis, net yellow, chlorotic sectors, m…
View article: Polyvalent Phage CoNShP-3 as a Natural Antimicrobial Agent Showing Lytic and Antibiofilm Activities against Antibiotic-Resistant Coagulase-Negative Staphylococci Strains
Polyvalent Phage CoNShP-3 as a Natural Antimicrobial Agent Showing Lytic and Antibiofilm Activities against Antibiotic-Resistant Coagulase-Negative Staphylococci Strains Open
Synthetic antimicrobials have a negative impact on food quality and consumer health, which is why natural antimicrobials are urgently needed. Coagulase-negative staphylococci (CoNS) has gained considerable importance for food poisoning and…
View article: Improving Regulation of Enzymatic and Non-Enzymatic Antioxidants and Stress-Related Gene Stimulation in Cucumber mosaic cucumovirus-Infected Cucumber Plants Treated with Glycine Betaine, Chitosan and Combination
Improving Regulation of Enzymatic and Non-Enzymatic Antioxidants and Stress-Related Gene Stimulation in Cucumber mosaic cucumovirus-Infected Cucumber Plants Treated with Glycine Betaine, Chitosan and Combination Open
Cucumber mosaic cucumovirus (CMV) is a deadly plant virus that results in crop-yield losses with serious economic consequences. In recent years, environmentally friendly components have been developed to manage crop diseases as alternative…
View article: Evaluation of Antibacterial and Antibiofilm Activity of New Antimicrobials as an Urgent Need to Counteract Stubborn Multidrug-resistant Bacteria
Evaluation of Antibacterial and Antibiofilm Activity of New Antimicrobials as an Urgent Need to Counteract Stubborn Multidrug-resistant Bacteria Open
The biggest problem in the world today is antimicrobial resistance, which undermines human health and increases morbidity and mortality associated with life-threatening serious diseases. Scientists from different fields are therefore exami…