Ahmed Abdrabou
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View article: Revealing the anticancer potential of nano-encapsulated graviola extract on tongue carcinoma (SCC154) cell line: targeting the PI3K/AKT/mTOR pathway (in vitro study)
Revealing the anticancer potential of nano-encapsulated graviola extract on tongue carcinoma (SCC154) cell line: targeting the PI3K/AKT/mTOR pathway (in vitro study) Open
Background Graviola emerged as a promising anticancer agent, with nanotechnology enhancing drugs’ therapeutic potential. The purpose of this work was to explore graviola extract and its nano-platform’s effects on tongue carcinoma (SCC154 c…
View article: In vitro activity of meropenem-vaborbactam combinations and eravacycline against carbapenem-resistant Acinetobacter baumannii
In vitro activity of meropenem-vaborbactam combinations and eravacycline against carbapenem-resistant Acinetobacter baumannii Open
Treatment of carbapenem-resistant Acinetobacter baumannii (CRAB) presents a growing clinical challenge. This study evaluated the in vitro efficacy of eravacycline and the potential synergistic activity of meropenem-vaborbactam in combinati…
View article: Role of CD133 antibody-conjugated nanocarrier in enhancing the targetability of hepatocellular carcinoma stem cells
Role of CD133 antibody-conjugated nanocarrier in enhancing the targetability of hepatocellular carcinoma stem cells Open
This study aimed at targeting hepatic cancer stem cells (CSCs) with quercetin (Q) or kaempferol (K) loaded into poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) decorated with CD133 antibody. For this purpose, the formulated Q NPs and…
View article: Exosome mediated delivery of Epigallocatechin 3 gallate as a novel approach to alleviate psoriasis symptoms through cytokine and apoptotic pathway modulation
Exosome mediated delivery of Epigallocatechin 3 gallate as a novel approach to alleviate psoriasis symptoms through cytokine and apoptotic pathway modulation Open
View article: Anti‐Inflammatory/Antioxidant Features of Adipose Tissue Mesenchymal Stem Cells Conditioned Media for Doped TiO<sub>2</sub> Nanoparticles in Induced Inflammation
Anti‐Inflammatory/Antioxidant Features of Adipose Tissue Mesenchymal Stem Cells Conditioned Media for Doped TiO<sub>2</sub> Nanoparticles in Induced Inflammation Open
The fundamental purpose of this work is to determine the anti‐inflammatory/antioxidant activity of stem cell conditioned medium enhanced by mono‐ or dual‐doped TiO 2 nanoparticles. The transmission electron microscope, X‐ray diffraction, a…
View article: Anti-colorectal cancer activity of constructed oleogels based on encapsulated bioactive canola extract in lecithin for edible semisolid applications
Anti-colorectal cancer activity of constructed oleogels based on encapsulated bioactive canola extract in lecithin for edible semisolid applications Open
Globally, colorectal cancer ranks second in women and third in men. Hydrophilic anticancer agents have limited use in lipid systems due to their weak solubility. Therefore, this study aimed to develop oleogels based on pumpkin seed oil (R1…
View article: Copper-tin nanocomposites-loaded exosomes persuaded skin carcinoma cell apoptosis and arrested cell cycle
Copper-tin nanocomposites-loaded exosomes persuaded skin carcinoma cell apoptosis and arrested cell cycle Open
Skin cancer is one of the most prevalent ailments in men that may be provoked by sun exposure. The chemotherapeutic potential of copper (Cu)- and tin (Sn)-based substances against a range of cancers has been studied. Based on the differenc…
View article: An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells
An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells Open
View article: Hyaluronated nanoparticles deliver raloxifene to CD44-expressed colon cancer cells and regulate lncRNAs/miRNAs epigenetic cascade
Hyaluronated nanoparticles deliver raloxifene to CD44-expressed colon cancer cells and regulate lncRNAs/miRNAs epigenetic cascade Open
Background Colorectal malignant cells (CRC) are one of the world’s main causes of cancer mortality and morbidity. Notwithstanding the plenty of anti-CRC therapeutics, its prognosis remains not selective owing to cancer resistance to these …
View article: Chemical Composition and Bioactivities of Egyptian Opuntia ficus–indica Seeds Oils Obtained by Conventional and Ultrasound-assisted Extraction Techniques
Chemical Composition and Bioactivities of Egyptian Opuntia ficus–indica Seeds Oils Obtained by Conventional and Ultrasound-assisted Extraction Techniques Open
The main objective of the current work was to assess the suitability of ultrasound-assisted extraction (UAE) for the oil recovery from Opuntia ficus-indica (L.) Mill.(O.ficus indica) seeds as compared to conventional extraction technique; …
View article: Correlation Between Pre-treatment Collateral Status and Short-Term Functional Outcome in Patients With Mild to Moderate Stroke After Reperfusion Therapy in a Local Primary Stroke Center in the Southwestern Part of Saudi Arabia
Correlation Between Pre-treatment Collateral Status and Short-Term Functional Outcome in Patients With Mild to Moderate Stroke After Reperfusion Therapy in a Local Primary Stroke Center in the Southwestern Part of Saudi Arabia Open
Background Stroke is a substantial cause of disability and mortality worldwide and is characterized by the sudden onset of acute neurological deficit. During acute ischemia, cerebral collateral circulations are crucial in preserving blood …
View article: Nanotherapy: New Approach for Impeding Hepatic Cancer Microenvironment via Targeting Multiple Molecular Pathways
Nanotherapy: New Approach for Impeding Hepatic Cancer Microenvironment via Targeting Multiple Molecular Pathways Open
The present approach provides new mechanistic insights into the powerful anti-hepatic cancer advantage of the novel nanoprototypes which is correlated with modulating critical signal transduction pathways implicated in tumor microenviromen…
View article: In Vitro Anti-Colorectal Cancer and Anti-Microbial Effects of Pinus roxburghii and Nauplius graveolens Extracts Modulated by Apoptotic Gene Expression
In Vitro Anti-Colorectal Cancer and Anti-Microbial Effects of Pinus roxburghii and Nauplius graveolens Extracts Modulated by Apoptotic Gene Expression Open
The use of phytochemicals is gaining increasing attention for treating cancer morbidity with minimal burden side effects. This study evaluated the cytotoxicity and antimicrobial activities of Pinus roxburghii branch (P. roxburghii) and Nau…
View article: Implication of extrinsic and intrinsic apoptotic pathways in the targeted therapy of hepatocellular carcinoma using aptamer-labeled viramidine nanoparticles
Implication of extrinsic and intrinsic apoptotic pathways in the targeted therapy of hepatocellular carcinoma using aptamer-labeled viramidine nanoparticles Open
View article: Inhibition of induced-hepatic cancer in vivo through IQGAP1-shRNA gene therapy and modulation of TRAIL-induced apoptosis pathway
Inhibition of induced-hepatic cancer in vivo through IQGAP1-shRNA gene therapy and modulation of TRAIL-induced apoptosis pathway Open
Background Liver cancer is the deadliest malignancy among common tumors. It is the top cause of cancer-related deaths in Egypt, and it is characterized by increasing occurrence among the population. The objective of this study was to deter…
View article: Functional nanoemulsion and nanocomposite microparticles as an anticolorectal cancer and antimicrobial agent: applied in yogurt
Functional nanoemulsion and nanocomposite microparticles as an anticolorectal cancer and antimicrobial agent: applied in yogurt Open
Great concern for human health has led the food industry to focus on functional products. Microparticles based on nanoemulsions (M1) and nanocomposites (M2) were developed to deliver vital agents against colorectal cancer and microbial inf…
View article: Evaluation of Particulate Autogenous Bone Graft Harvested by Auto Chip Maker versus Milling of Block Bone Graft (Experimental Study with Biochemical and Genetic Assessment)
Evaluation of Particulate Autogenous Bone Graft Harvested by Auto Chip Maker versus Milling of Block Bone Graft (Experimental Study with Biochemical and Genetic Assessment) Open
Background:The mode of harvesting autogenous bone grafts can affect the quality of harvested bone and viability.The present study was carried out to evaluate cellular viability, differentiation and proliferative power in autogenous bone gr…
View article: Pinus roxburghii and Nauplius graveolens Extracts Elevate Apoptotic Gene Markers in C26 Colon Carcinoma Cells Induced in a BALB/c Mouse Model
Pinus roxburghii and Nauplius graveolens Extracts Elevate Apoptotic Gene Markers in C26 Colon Carcinoma Cells Induced in a BALB/c Mouse Model Open
The present study aimed to evaluate the chemopreventive potential of Pinus roxburghii branch (P. roxburghii) and Nauplius graveolens (N. graveolens) extracts against human colorectal cancer (CRC) induced by C26 murine cells in a BALB/c mou…
View article: Frankincense essential oil nanoemulsion specifically induces lung cancer apoptosis and inhibits survival pathways
Frankincense essential oil nanoemulsion specifically induces lung cancer apoptosis and inhibits survival pathways Open
View article: The use of ultrasound (UAE) and microwaves (MAE) to improve the extraction of pharmaceutically active materials from the fruit of the prickly pear (Opuntia ficus-indica)
The use of ultrasound (UAE) and microwaves (MAE) to improve the extraction of pharmaceutically active materials from the fruit of the prickly pear (Opuntia ficus-indica) Open
Background Conventional extraction methods have many limitations and drawbacks, including, prolonged extraction time, present safety concern and environmental risks, with low quality extracts. We report the use of ultrasonic (UAE) and micr…
View article: Hyaluronic acid-exposed nanoparticles delivered raloxifene against colon cancerous cells and orcasterated epigenetics
Hyaluronic acid-exposed nanoparticles delivered raloxifene against colon cancerous cells and orcasterated epigenetics Open
Colorectal cancer (CRC) is one of the world's mortality causes. Despite recent breakthroughs in treatment, the prognosis for CRC remains poor due to drug resistance. Raloxifene (RX) was recently licensed for the prevention of CRC. We propo…
View article: Newly Synthesized Punicalin and Punicalagin Nano-Prototypes Induce Breast Cancer Cytotoxicity Through ROS-Mediated Apoptosis
Newly Synthesized Punicalin and Punicalagin Nano-Prototypes Induce Breast Cancer Cytotoxicity Through ROS-Mediated Apoptosis Open
PN and PNG nano-prototypes of PLGA decorated with CS and PEG enhanced the anti-cancer activity through induction of cytotoxicity, reactive oxygen species (ROS)-mediated apoptosis.
View article: Pre-Clinical Evidence for the Anti-Obesity Potential of Quercetin and Curcumin Loaded Chitosan/PEG Blended PLGA Nanoparticles
Pre-Clinical Evidence for the Anti-Obesity Potential of Quercetin and Curcumin Loaded Chitosan/PEG Blended PLGA Nanoparticles Open
This research aimed to formulate quercetin (Qu) and curcumin (CUR)-loaded PLGA NPs coated with chitosan (CS) & PEG and to explore their therapeutic effect against obesity in rats. Qu and CUR nanostructures were prepared and characterized b…
View article: Synthesis and Cytotoxic Activity of New N-(Arylglycyl)succinohydrazide and their Sugar hydrazone derivatives
Synthesis and Cytotoxic Activity of New N-(Arylglycyl)succinohydrazide and their Sugar hydrazone derivatives Open
Hydrazones have pronounced properties that allow them promising for a range of synthetic applications.In the current study, new acid hydrazide compounds incorporating substituted arylglyl and succinyl moieties were prepared via multistep p…
View article: THERAPEUTIC EFFICACY OF CURCUMA AND POMELO LOADED CHITOSAN NANOPARTICLES IN INTESTINAL MURINE TRICHINELLOSIS
THERAPEUTIC EFFICACY OF CURCUMA AND POMELO LOADED CHITOSAN NANOPARTICLES IN INTESTINAL MURINE TRICHINELLOSIS Open
The majority of the medications used to treat trichinellosis had little bio-availability and a elevated resistance level. This work compared the usage of Curcuma longa extract, pomelo peels extract, and their chitosan (CS) nanoparticles (N…
View article: Cytotoxic, apoptotic, and genetic evaluations of Nigella sativa essential oil nanoemulsion against human hepatocellular carcinoma cell lines
Cytotoxic, apoptotic, and genetic evaluations of Nigella sativa essential oil nanoemulsion against human hepatocellular carcinoma cell lines Open
Background Phytochemicals and plant extracts are showing promising anticancer potentials. In the current study, the volatile faction (essential oil) of Nigella sativa seeds was evaluated against some hepatocellular carcinoma (HCC). The ess…
View article: Therapeutic Efficacy of Kumquat-Loaded Chitosan Nanoparticles against Toxoplasmosis in mice model
Therapeutic Efficacy of Kumquat-Loaded Chitosan Nanoparticles against Toxoplasmosis in mice model Open
The goal of this study was to compare the effects of kumquat extract and its chitosan nanoparticles on biochemical, histopathological, and parasitological factors in mice infected with Toxoplasma gondii versus spiramycin and control groups…
View article: Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis
Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis Open
The synergistic influence between TQ which induced the DR5 and TRAIL, facilitating the connection between TRAIL and its receptors on the cancerous cell membrane. Hence, the proposed combination therapy induced the ROS-mediated apoptotic st…
View article: Combination Therapy of TRAIL and Thymoquinone Induce Breast Cancer Cell Cytotoxicity-Mediated Apoptosis and Cell Cycle Arrest
Combination Therapy of TRAIL and Thymoquinone Induce Breast Cancer Cell Cytotoxicity-Mediated Apoptosis and Cell Cycle Arrest Open
In conclusion, there is a synergistic effect between TRAIL and TQ playing a therapeutic role in killing resistant breast cancer cells.
View article: Preliminary study on the toxicological impacts of Pinus roxburghii and Nauplius graveolens extracts on albino mice
Preliminary study on the toxicological impacts of Pinus roxburghii and Nauplius graveolens extracts on albino mice Open
The objective of this study was to evaluate the potential toxicity of methanolic extracts of Pinus roxburghii branch (P.roxburghii) and Nauplius graveolens (N.graveolens).Single oral dosage was administered to male mice at increasing conce…