Explanipedia

Mycophenolate Mofetil Use for Inflammatory Bowel Disease Open

Ahmed Abomhya, Ahmed Elmoursi · 2025

Mycophenolate Mofetil (MMF) is a prodrug that gets converted to mycophenolic acid (MPA). MPA inhibits the Akt/mTOR and STAT5 pathways and has a reversible cytostatic effect on T and B lymphocytes [1]. MMF is FDA-approved for immunosuppress…

Primary biliary cholangitis, a rising health burden Open

Mohamed Elnaggar, Ismail Elkhattib, Ahmed Abomhya, James L. Boyer · 2024

Primary biliary cholangitis (PBC) is a rare immune-mediated disease, commonly affecting women in their 40s, and ultimately progressing to liver failure. The incidence and prevalence of the disease are increasing worldwide, possibly due to …

PREVALENCE AND PREDICTORS OF METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE IN A RETROSPECTIVE COHORT OF PATIENTS WITH ULCERATIVE COLITIS Open

Ahmed Elmoursi, Mohamed Ali, Ibrahim Metawea, Alaa Alareidi, Ahmed Abomhya · 2024

BACKGROUND Metabolic dysfunction associated steatotic liver disease (MASLD) is observed in both ulcerative colitis (UC) and Crohn's disease, affecting around 27.5% of cases over an average duration of 4.6 years. However, data on the preval…

IMPACT OF COVID-19 ON NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING HOSPITALIZATIONS IN 2020: A NATIONWIDE ANALYSIS Open

Khaled Elfert, Yomna Elfert, Fouad Jaber, Azizullah Beran, Ahmed Abomhya , et al. · 2023

ILEOSTOMY AND RISK OF ACUTE KIDNEY INJURY IN PATIENTS WITH CROHN'S DISEASE Open

Ahmed Abomhya, Salman Ayaz, Salman Haider · 2023

BACKGROUND Chron's disease is an inflammatory disorder that can involve any part of GI tract but most commonly involves the small intestine. Many of the patients with Cohn’s disease end up requiring surgery, and the 10-year risk of requiri…

EPITHELIAL CELLS OF ULCERATIVE COLITIS PATIENTS REQUIRE NORMAL LEVELS OF MITOCHONDRIA AND BETA-CATENIN TO UTILIZE BUTYRATE METABOLISM AND PROMOTE ULCER HEALING Open

Iyabo Erinkitola, Ahmed Abomhya, Syed Adeel Hassan, Evan Conder, Kian Rosenau , et al. · 2023

BACKGROUND Under normal conditions butyrate produced by obligate anaerobes (e.g. firmicutes) provides the dominant energy source for colonocytes via β-oxidation and the tricarboxylic acid cycle. Ulcerative Colitis (UC) is an inflammatory b…

PERIPHERAL BLOOD EXTRACELLULAR VESICLE LIPIDS AS BIOMARKERS FOR HUMAN INFLAMMATORY BOWEL DISEASE Open

Syed Adeel Hassan, Courtney Perry, Justin Thomas, Mohamed Eltaher, Mahmoud Elkammar , et al. · 2023

BACKGROUND The current paradigm in inflammatory bowel disease (IBD) diagnostics is based on peripheral biomarkers such as C-reactive protein and fecal calprotectin that achieve low sensitivity and specificity for intestinal inflammation. E…

Prevalence and Impact of Acute Pancreatitis on Hospitalization Outcomes in a Cohort of Patients With Crohn’s Disease Open

Ahmed Abomhya, Elizabeth Clemetson, Farrah Khan, Omar Tageldin, Zainab Abdulsada , et al. · 2022

In our nationwide cohort of CD patients, there was a significant association between AP and worse hospitalization outcomes. Additionally, we found independent associations for having AP that may help identify patients at high risk.

P1553: PREVALENCE AND IMPACT OF IRON DEFICIENCY ANEMIA IN A COHORT OF PATIENTS WITH CROHN’S DISEASE Open

Ahmed Abomhya, Waqqas Tai, Waleed Saadedeen, Oluwabunmi Ajala, Z. Abdulsada , et al. · 2022

Background: Iron deficiency anemia (IDA) is the most common cause of anemia worldwide. Crohn’s disease (CD) is a chronic inflammatory disease that affects the digestive system and is associated with a significant risk of chronic blood loss…

P494: MYELOID LEUKEMIA IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES: A RETROSPECTIVE COHORT STUDY Open

Ahmed Abomhya, Ansari Yaasir Ahmed Abdul Razzaq, Simon Lukose · 2022

Background: Inflammatory bowel diseases include ulcerative colitis and Crohn’s disease and affect around 3.1 million adults in the United States (US). The data on the risk of myeloid leukemia among patients with IBD are limited and there h…

P1672: ARTERIAL EMBOLISM IN A NATIONWIDE COHORT OF PATIENTS WITH INFLAMMATORY BOWEL DISEASES Open

Ahmed Abomhya, Z. Abdulsada, Hewa Hamad · 2022

Background: Inflammatory bowel disease (IBD) patients are at a significantly high risk of thromboembolism events. Arterial embolism is a rare but dire condition with only a few reported cases among IBD patients. Systemic chronic inflammati…

COVID-19 and liver diseases, what we know so far Open

Mohamed Y. El‐Naggar, Ahmed Abomhya, Ismail Elkhattib, Nabila Dawoud, Rajkumar Doshi · 2022

Coronavirus disease 2019 (COVID-19) pneumonia outbreak started in December 2019. On March 12, 2020, the World Health Organization (WHO) declared that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constitutes a pandemic, …

Burden and Predictors of Non-Alcoholic Fatty Liver Disease in a Retrospective Cohort of Patients With Crohn’s Disease Open

Ahmed Abomhya, Mohammed Mahmoodurrahman, Salman Ayaz, Hossam Hamad, Farrah Khan · 2022

NAFLD is associated with worse hospitalization outcomes in patients with CD. Study findings suggest the need for early identification and effective management of NAFLD predictors to reduce complications.

Iron Deficiency Anemia: An Overlooked Complication of Crohn’s Disease Open

Ahmed Abomhya, Waqqas Tai, Salman Ayaz, Farrah Khan, Waleed Saadedeen , et al. · 2022

In a large nationwide cohort of patients hospitalized for CD, we observed a significant burden of IDA. Additionally, we found a significant association between IDA and worse hospitalization outcomes.

CROHN’S DISEASE AND ACUTE PANCREATITIS; ASSOCIATION, OUTCOMES, AND PREDICTORS OF 90-DAY READMISSION WITH ACUTE PANCREATITIS. INSIGHTS FROM THE NATIONWIDE READMISSION DATABASE Open

Ahmed Abomhya, Elizabeth Clemeston, Vijay Gayam, Farrah Khan, Denzil Etienne · 2022

INTRODUCTION It’s a controversy if pancreatitis can be considered one of the extraintestinal manifestations of Crohn’s disease (CD). (Barthet et al AJG) CD patients have a fourfold increase in the risk of acute pancreatitis (AP) compared t…

AUPHOS, A NOVEL THERAPEUTIC THAT IMPROVES MITOCHONDRIAL FUNCTION AND AMELIORATES CHRONIC COLITIS Open

Rana Mohamed, James Warinner, Lesley Wempe, Margarita Avdiushko, Tatiana Goretsky , et al. · 2022

BACKGROUND Inflammatory Bowel Disease (IBD) involves an interplay of gut microbiota, intestinal epithelium and immune responses. Recent data suggest that decreased mitochondrial gene function plays an active role in the pathophysiology of …

NEW OXPHOS REGULATING COMPOUND – AUPHOS – INCREASES MITOCHONDRIAL COMPLEXES EXPRESSION IN MURINE AND HUMAN INTESTINAL EPITHELIAL CELLS Open

Ahmed El-Sayed, Ahmed Abomhya, Margarita Avdiushko, Neeraj Kapur, Samuel G. Awuah , et al. · 2022

INTRODUCTION Mitochondrial dysfunction in intestinal epithelial cells (IEC) is a critical driver in the failure to heal chronic ulceration in IBD(1). OXPHOS is important for differentiation and cell polarity in repairing IEC(2,3). The deve…

OXPHOS DRIVES CRYPT FISSIONING REQUIRED FOR HEALING OF IBD ULCERS Open

Ahmed Abomhya, Tatiana Goretsky, Neeraj Kapur, Courtney Perry, Margarita Avdiushko , et al. · 2022

INTRODUCTION The failure of ulcers healing is a characteristic feature of IBD. Mitochondrial dysfunction in intestinal epithelial cells (IEC) occurs in IBD and is linked to worse clinical outcomes in pediatric Crohn’s and ulcerative coliti…

BURDEN OF NON-ALCOHOLIC FATTY LIVER DISEASE AMONG PATIENTS WITH CROHN’S DISEASE: ANALYSIS OF THE NATIONWIDE READMISSION DATABASE Open

Ahmed Abomhya, Mohammed Mahmoodurrahman, Daniel Mozell, Salman Ayaz, Hossam Hamad · 2022

INTRODUCTION Non-alcoholic fatty liver disease (NAFLD) is a spectrum that ranges from hepatic steatosis to Non-alcoholic steatohepatitis (NASH). NASH can lead to liver fibrosis, cirrhosis, and hepatocellular carcinoma. (Chao CY et al. Worl…

AUPHOS, A “FIRST-IN CLASS“ ORAL AGENT FOR CORRECTING METABOLIC DYSFUNCTION IN IBD Open

Lesley Wempe, Rana Mohamed, James Warinner, Tatiana Goretsky, Margarita Avdiushko , et al. · 2022

BACKGROUND Mucosal repair is the goal of medical therapy in IBD. Prospective inception cohort pediatric studies suggest that suppression of mitochondrial genes lead to unfavorable clinical outcomes in ulcerative colitis (UC) and Crohn’s di…

NEW OXPHOS REGULATING COMPOUND – AUPHOS – INCREASES MITOCHONDRIAL COMPLEXES EXPRESSION IN MURINE AND HUMAN INTESTINAL EPITHELIAL CELLS Open

Ahmed K. Elsayed, Ahmed Abomhya, Margarita Avdiushko, Neeraj Kapur, Samuel G. Awuah , et al. · 2022

AUPHOS, A “FIRST-IN CLASS” ORAL AGENT FOR CORRECTING METABOLIC DYSFUNCTION IN IBD Open