Hadeer A. Aglan
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View article: Role of CD133 antibody-conjugated nanocarrier in enhancing the targetability of hepatocellular carcinoma stem cells
Role of CD133 antibody-conjugated nanocarrier in enhancing the targetability of hepatocellular carcinoma stem cells Open
This study aimed at targeting hepatic cancer stem cells (CSCs) with quercetin (Q) or kaempferol (K) loaded into poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) decorated with CD133 antibody. For this purpose, the formulated Q NPs and…
View article: Preconditioning of bone marrow mesenchymal stem cells with sodium hydrosulfide enhances their therapeutic potential in type II collagen–induced arthritis rat model
Preconditioning of bone marrow mesenchymal stem cells with sodium hydrosulfide enhances their therapeutic potential in type II collagen–induced arthritis rat model Open
This study was conducted to evaluate the impact of sodium hydrogen sulfide (NaHS) on the therapeutic efficacy of bone marrow mesenchymal stem cells (BM-MSCs) in the treatment of collagen-induced arthritis (CIA) rats. MSCs were isolated and…
View article: Acquisition of durable insulin-producing cells from human adipose tissue-derived mesenchymal stem cells as a foundation for cell- based therapy of diabetes mellitus
Acquisition of durable insulin-producing cells from human adipose tissue-derived mesenchymal stem cells as a foundation for cell- based therapy of diabetes mellitus Open
View article: Optimization of differentiation protocols of dental tissues stem cells to pancreatic β-cells
Optimization of differentiation protocols of dental tissues stem cells to pancreatic β-cells Open
Background Despite the recent progress in the differentiation strategies of stem cells into pancreatic beta cell lineage, current protocols are not optimized for different cell types. The purpose of this study is to investigate and compare…
View article: The Promising Role of hypoxia-resistant insulin-producing Cells in Ameliorating Diabetes Mellitus <i>In Vivo</i>
The Promising Role of hypoxia-resistant insulin-producing Cells in Ameliorating Diabetes Mellitus <i>In Vivo</i> Open
The chosen nanomaterials were impressive in generating hypoxia-resistant IPCs that could be an inspirational strategy for curing diabetes.
View article: Efficient generation of functional pancreatic β cells from dental-derived stem cells via laminin-induced differentiation
Efficient generation of functional pancreatic β cells from dental-derived stem cells via laminin-induced differentiation Open
This study demonstrates the significant role of the implantation of IPCs generated from dental-derived stem cells in treatment of diabetes mellitus.
View article: Mesenchymal stem cells attenuate amiodarone-induced pulmonary fibrosis in rats via blockade of inflammation and TGF-B1/Smad3/ S100A4 signaling
Mesenchymal stem cells attenuate amiodarone-induced pulmonary fibrosis in rats via blockade of inflammation and TGF-B1/Smad3/ S100A4 signaling Open
Aim: This study aimed to clarify the anti-fibrotic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs), compared to conditioned media (CM), in amiodarone (AD)-induced lung fibrosis. Methods: A total of 64 Wistar rats were cat…
View article: Adipose Tissue-derived Cardiomyocytes for Enhancing Cardiac Remodeling in a Rat Model of Acute Myocardial Infarction
Adipose Tissue-derived Cardiomyocytes for Enhancing Cardiac Remodeling in a Rat Model of Acute Myocardial Infarction Open
This investigation was directed towards addressing the pivotal role of adipose tissue-derived cardiomyocytes seeded onto nanofiber (NF) in repairing the deteriorated cardiac tissue in a model of MI. Molecular analysis for MEF2C and Actn ex…
View article: Pre-Clinical Evidence for the Anti-Obesity Potential of Quercetin and Curcumin Loaded Chitosan/PEG Blended PLGA Nanoparticles
Pre-Clinical Evidence for the Anti-Obesity Potential of Quercetin and Curcumin Loaded Chitosan/PEG Blended PLGA Nanoparticles Open
This research aimed to formulate quercetin (Qu) and curcumin (CUR)-loaded PLGA NPs coated with chitosan (CS) & PEG and to explore their therapeutic effect against obesity in rats. Qu and CUR nanostructures were prepared and characterized b…
View article: Osteoblast-Based Therapy—A New Approach for Bone Repair in Osteoporosis: Pre-Clinical Setting
Osteoblast-Based Therapy—A New Approach for Bone Repair in Osteoporosis: Pre-Clinical Setting Open
View article: Modulation of bone turnover aberration: A target for management of primary osteoporosis in experimental rat model
Modulation of bone turnover aberration: A target for management of primary osteoporosis in experimental rat model Open
Osteoporosis is a skeletal degenerative disease characterised by abnormal bone turnover with scant bone formation and overabundant bone resorption. The present approach was intended to address the potency of nanohydroxyapatite (nHA), chito…
View article: Role of nanoparticles in osteogenic differentiation of bone marrow mesenchymal stem cells
Role of nanoparticles in osteogenic differentiation of bone marrow mesenchymal stem cells Open
View article: HARNESSING THE ANTIOXIDANT PROPERTY OF CERIUM AND YTTRIUM OXIDE NANOPARTICLES TO ENHANCE MESENCHYMAL STEM CELL PROLIFERATION
HARNESSING THE ANTIOXIDANT PROPERTY OF CERIUM AND YTTRIUM OXIDE NANOPARTICLES TO ENHANCE MESENCHYMAL STEM CELL PROLIFERATION Open
Objective: This work was designed to explore if cerium oxide (CeO2) and yttrium oxide (Y2O3) nanoparticles as antioxidant agents could potentiate the proliferation of mesenchymal stem cells (MSCs) derived from human dental pulp (hDPSCs).Me…
View article: Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from<i>in vivo</i>study
Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from<i>in vivo</i>study Open
The global burden of hepatocellular carcinoma is increasing; actually, it is estimated as 750,000 new cases annually. This study was initiated to emphasize the possibility that gallic acid could alleviate hepatocarcinogenesis in vivo. In t…
View article: Influence of bioactive sulfated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities
Influence of bioactive sulfated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities Open
The pronounced antitumor activity of sulfated polysaccharide-protein complexes of JCEM and EHEM is due to direct cytotoxic activity, anti-hepatocarcinogenesis, and anti-angiogenesis. In addition, JCEM, PCEM and EHEM had an immunostimulator…
View article: Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer
Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer Open
Objective: This research was conducted to explore mechanisms behind the potency of quercetin in inhibiting colon cancer induced in an experimental model. Materials and Methods: Forty adult male rats of Wistar strain were distributed into 4…
View article: Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells
Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells Open
The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions.