Ahmed Al Sarkhy
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View article: Gut virome profile in new onset treatment naïve Saudi children with ulcerative colitis
Gut virome profile in new onset treatment naïve Saudi children with ulcerative colitis Open
Background: Gut microbiome imbalance is well established in ulcerative colitis (UC) in Western populations. Significantly less is known about the gut virome and whether geography impacts the UC-associated microbiome. The aim of this study …
View article: The outcome of functional constipation in Saudi children
The outcome of functional constipation in Saudi children Open
Background. Understanding the outcome of functional constipation (FC) for both patients and physicians is essential, yet it has been infrequently reported worldwide. The objective of this report was to update the outcomes of FC in Saudi ch…
View article: Gut fungal profile in new onset treatment-naïve ulcerative colitis in Saudi children
Gut fungal profile in new onset treatment-naïve ulcerative colitis in Saudi children Open
Background: Although the role of fungi in gut inflammation in IBD has been suggested, data are still limited in ulcerative colitis (UC). Our aim was to describe the gut fungal profile in a pediatric UC in Saudi Arabia. Methods: Fecal sampl…
View article: Saudi consensus guidance for the diagnosis and management of inflammatory bowel disease in children and adolescents
Saudi consensus guidance for the diagnosis and management of inflammatory bowel disease in children and adolescents Open
The management of inflammatory bowel disease (IBD) in children and adolescents is challenging. Clear evidence-based guidelines are required for this population. This article provides recommendations for managing IBD in Saudi children and a…
View article: Bacterial dysbiosis in newly diagnosed treatment naïve pediatric ulcerative colitis in Saudi Arabia
Bacterial dysbiosis in newly diagnosed treatment naïve pediatric ulcerative colitis in Saudi Arabia Open
Background: The role of microbiota in the pathogenesis of ulcerative colitis (UC) has been increasingly recognized. However, most of the reports are from Western populations. In Middle Eastern countries, including Saudi Arabia, little is k…
View article: Gut microbiota predicts the diagnosis of ulcerative colitis in Saudi children
Gut microbiota predicts the diagnosis of ulcerative colitis in Saudi children Open
BACKGROUND Ulcerative colitis (UC) is an immune-mediated chronic inflammatory condition with a worldwide distribution. Although the etiology of this disease is still unknown, the understanding of the role of the microbiota is becoming incr…
View article: Clinical profile of functional constipation in Saudi children
Clinical profile of functional constipation in Saudi children Open
BACKGROUND: Functional constipation (FC) is a common condition in children, and information on the clinical characteristics of FC in Saudi children is scarce. OBJECTIVE: Describe the clinical profile of FC in Saudi children. DESIGN: Retros…
View article: Prevalence of functional gastrointestinal disorders in Saudi infants and toddlers: A cross-sectional multicenter study
Prevalence of functional gastrointestinal disorders in Saudi infants and toddlers: A cross-sectional multicenter study Open
Background: Functional gastrointestinal disorders (FGIDs) are common pediatric problems, but their prevalence in Saudi Arabia is unknown. We aimed to assess the prevalence of FGIDs and risk factors among children in six regions of Saudi Ar…
View article: Multichannel intraesophageal impedance with pH metry in Saudi children
Multichannel intraesophageal impedance with pH metry in Saudi children Open
Background: Multichannel Intraesophageal Impedance with pH (MII-pH) provides complete characterization of gastroesophageal reflux (GER). The aim of this study was to report our experience in this relatively new technique, emphasizing the c…
View article: Clinical and laboratory features of biliary atresia and patterns of management practices: Saudi national study (2000–2018)
Clinical and laboratory features of biliary atresia and patterns of management practices: Saudi national study (2000–2018) Open
Background: We utilized the data from the Saudi national biliary atresia (BA) study (2000–2018) to describe the clinical, biochemical, imaging, and histopathological features of BA and the perioperative clinical practices among local pedia…
View article: Frequency and Predictive Factors for Spontaneous Normalization of Anti-Tissue Transglutaminase-IgA Serology among Saudi Children with Type 1 Diabetes Mellitus: A Cohort Study
Frequency and Predictive Factors for Spontaneous Normalization of Anti-Tissue Transglutaminase-IgA Serology among Saudi Children with Type 1 Diabetes Mellitus: A Cohort Study Open
Asymptomatic patients with T1DM with mild elevation of anti-TTG-IgA need not be rushed for invasive endoscopy or exposed to an un-needed gluten-free diet but should rather have a regular follow-up of their celiac serology.
View article: Gut microbiota predicts the diagnosis of celiac disease in Saudi children
Gut microbiota predicts the diagnosis of celiac disease in Saudi children Open
The excellent predictive power of the combination of the fecal bacterial and viral microbiota with mucosal bacteria alone indicates a potential role in the diagnosis of difficult cases of CeD. Bacteroides intestinalis and Burkhol…
View article: Predictors of biliary atresia outcome: Saudi National Study (2000 – 2018)
Predictors of biliary atresia outcome: Saudi National Study (2000 – 2018) Open
Background: Outcomes in biliary atresia (BA) have been well-documented in large national cohorts from Europe, North America, and East Asia. Understanding the challenges that preclude success of the Kasai portoenterostomy (KPE) is the key t…
View article: Gut virome profile in healthy Saudi children
Gut virome profile in healthy Saudi children Open
Background: The role of viruses is well known in health and disease. The aim of this report was to describe the profile of viruses in the gut of healthy Saudi children. Methods: In 20 randomly selected school age children from Riyadh, stoo…
View article: Microbiota profile of new-onset celiac disease in children in Saudi Arabia
Microbiota profile of new-onset celiac disease in children in Saudi Arabia Open
View article: The Epidemiology and Outcome of Biliary Atresia: Saudi Arabian National Study (2000–2018)
The Epidemiology and Outcome of Biliary Atresia: Saudi Arabian National Study (2000–2018) Open
Background The epidemiology and outcomes of biliary atresia (BA) have been well-documented in national cohorts from two main ethnicities, namely, the Asian Orientals and Caucasians, with incidence ranging from 1 in 5,000 to 1 in 9,000 live…
View article: Intestinal microbiota profile in healthy Saudi children
Intestinal microbiota profile in healthy Saudi children Open
Background: Knowledge of microbiota in health is essential for clinical research on the role of microbiota in disease. We aimed to characterize the intestinal microbiota in healthy Saudi children. Methods: In this community-based study, st…
View article: Viral dysbiosis in children with new-onset celiac disease
Viral dysbiosis in children with new-onset celiac disease Open
Viruses are common components of the intestinal microbiome, modulating host bacterial metabolism and interacting with the immune system, with a possible role in the pathogenesis of immune-mediated diseases such as celiac disease (CeD). The…
View article: Tricho-hepato-enteric syndrome
Tricho-hepato-enteric syndrome Open
Background: Trichohepatoenteric syndrome (THES) is a very rare disorder that is characterized by intractable congenital diarrhea, woolly hair, intrauterine growth restriction, facial dysmorphism, and short stature. Our knowledge of THES is…
View article: Bacterial dysbiosis predicts the diagnosis of Crohn's disease in Saudi children
Bacterial dysbiosis predicts the diagnosis of Crohn's disease in Saudi children Open
Background: Studies have reached different conclusions regarding the accuracy of dysbiosis in predicting the diagnosis of Crohn's disease (CD). The aim of this report is to assess the utility of mucosal and fecal microbial dysbiosis as pre…
View article: Barriers to the delivery of enteral nutrition in pediatric intensive care units
Barriers to the delivery of enteral nutrition in pediatric intensive care units Open
Background and Aim: According to previously reported studies in the literature, a significant number of patients do not receive enteral nutrition in pediatric intensive care unit (PICU) because of avoidable barriers. Optimal nutrition is a…
View article: Social media usage pattern and its influencing factors among celiac patients and their families
Social media usage pattern and its influencing factors among celiac patients and their families Open
Celiac patients are highly involved in social media activities for purposes related to their disease. We encourage healthcare providers to be available online to provide trustable and high-quality educational materials.
View article: Capsule Endoscopy Complements Magnetic Resonance Enterography and Endoscopy in Evaluating Small Bowel Crohn’s Disease
Capsule Endoscopy Complements Magnetic Resonance Enterography and Endoscopy in Evaluating Small Bowel Crohn’s Disease Open
Aims Wireless capsule endoscopy (WCE) and magnetic resonance enterography (MRE) are increasingly utilized to evaluate the small bowel (SB) in Crohn’s disease (CD). The primary aims were to compare the ability of WCE and MRE to detect SB in…
View article: Diagnostic delay of pediatric inflammatory bowel disease in Saudi Arabia
Diagnostic delay of pediatric inflammatory bowel disease in Saudi Arabia Open
Long diagnostic delay in IBD was mainly due to the longer delay in gastroenterologist consultation. Review of the referral system is needed to focus on measures to reduce long delays in diagnosis. The ileal location as a risk factor in CD …
View article: Efficacy and safety of endoscopic dilatation in the management of esophageal strictures in children
Efficacy and safety of endoscopic dilatation in the management of esophageal strictures in children Open
Endoscopic dilatation is a safe and effective intervention in the management of esophageal strictures in children, with minimal complications when conducted by experts.
View article: Glycogenic hepatopathy, an underdiagnosed cause of relapsing hepatitis in uncontrolled type 1 diabetes mellitus
Glycogenic hepatopathy, an underdiagnosed cause of relapsing hepatitis in uncontrolled type 1 diabetes mellitus Open
Glycogenic hepatopathy is a rare condition that causes significant hepatomegaly and elevated liver enzyme levels in uncontrolled type 1 diabetic patients. It develops due to excessive accumulation of glycogen in the hepatocytes. It is typi…
View article: Socioeconomic Impacts of Gluten-Free Diet among Saudi Children with Celiac Disease
Socioeconomic Impacts of Gluten-Free Diet among Saudi Children with Celiac Disease Open
There is significant negative socio-economic impact of GFD on children with CD & their families. Health care providers should be aware of these psycho-social difficulties and be well trained to provide a proper education and psychological …
View article: Clinical Characteristics of Celiac Disease and Dietary Adherence to Gluten-Free Diet among Saudi Children
Clinical Characteristics of Celiac Disease and Dietary Adherence to Gluten-Free Diet among Saudi Children Open
CD has similar clinical presentations among Saudi children compared to other parts of the ward; however, the adherence to GFD is relatively poor. Younger age at diagnosis and shorter duration since the diagnosis were associated with a bett…