Explanipedia

Adaptation and Validation of a Risk Assessment Tool for Candidozyma auris in a Saudi Arabian Hospital Open

Fatimah Alshahrani, Abba Amsami Elgujja, Sarah Alsubaie, Salah Ezreqat, Ahmed Albarrag , et al. · 2025

Objective This study aimed to employ a risk assessment tool adapted from a validated MRSA risk assessment tool to identify individuals at substantial risk of C. auris within the hospital setting. Method This study 'adapted' the MRSA risk a…

Risk Factors for Candidozyma auris Among Admitted Patients in Riyadh, Saudi Arabia (2020–2022) Open

Fatimah Alshahrani, Abba Amsami Elgujja, Sarah Alsubaie, Salah Ezreqat, Ahmed Albarrag , et al. · 2025

These findings are similar to those of other studies in that certain identified risk factors contribute to infection or colonization with C. auris.

Lipopolysaccharide-Binding Protein (LBP) and Inflammatory Biomarkers in SARS-CoV-2 Hospitalized Patients Open

Aldanah Alshathri, Iman Abdullah Bindayel, Wajude Alabdullatif, Ali Alhijji, Ahmed Albarrag · 2025

Background/Objectives: Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic with far-reaching impacts on human activities. Moreover, direct viral damage and uncontrolled inflammation have…

Production, Biochemical Characterization, and Application of Laccase from Halophilic Curvularia lunata MLK46 Recovered from Mangrove Rhizosphere Open

Malak Alshammary, Essam Kotb, Ibtisam Ababutain, Amira H. Alabdalall, Sumayh A. Aldakeel , et al. · 2025

Laccase production was evaluated in 108 fungal isolates recovered from the eastern coast of Saudi Arabia, a critical element in environmental biodegradation and biotransformation. The most active isolate was identified as Curvularia lunata…

Genomic surveillance of Methicillin Resistant <i>Staphylococcus aureus</i> in Saudi Arabia Open

Mohammed Alarawi, Musaad A. Altammami, Mohammed H. Abutarboush, Maxat Kulmanov, Dalal M. Alkuraythi , et al. · 2025

Methicillin-resistant Staphylococcus aureus (MRSA) surveillance in regions with mass gatherings presents unique challenges for public health systems. Saudi Arabia, hosting millions of pilgrims annually, provides a distinctive setting for s…

Unexpected Efficacy of Albumin-Bound Glycerol Monolaurate Against Multidrug-Resistant Bacterial Isolates: A Time-Kill Assay Study Open

Mona A. Alrabiah, Amina A. Hassan, Murad A. Mubaraki, Ahmed Albarrag, Mohamed A. Dkhil , et al. · 2025

Current findings suggest that HSA-bound GML could be developed as a novel broad-spectrum antimicrobial agent targeting multidrug-resistant pathogens. Future research should focus on formulation optimization, in vivo efficacy studies, and p…

Production, biological characterization, and applications of natural pigments from filamentous fungi Open

Albandari Alyami, Amira H. Alabdalall, Hanen Chakroun, Sumayh A. Aldakeel, Ahmed Albarrag , et al. · 2025

Natural dyes are gaining prominence as safer, bioactive alternatives to synthetic colorants, with microbial production offering efficient and cost-effective methods. This study isolated and evaluated pigment-producing fungi from Saudi Arab…

Adoption and Use of a Risk Assessment Tool for Identifying and Controlling the Spread of Candida Auris among Admitted Patients at a Saudi Arabian Hospital Open

Fatimah Alshahrani, Abba Amsami Elgujja, Sarah Alsubaie, Salah Ezreqat, Ahmed Albarrag , et al. · 2024

Background : The emergence of Candida auris (C. auris) , a multidrug-resistant fungal pathogen, poses a significant healthcare challenge, necessitating robust risk-assessment strategies for effective infection control in hospital settings.…

Adoption and Use of a Risk Assessment Tool for Identifying and Controlling the Spread of Candida Auris among Admitted Patients at a Saudi Arabian Hospital Open

Fatimah Alshahrani, Abba Amsami Elgujja, Sarah Alsubaie, Salah Ezreqat, Ahmed Albarrag , et al. · 2024

Background The emergence of Candida auris (C. auris) , a multidrug-resistant fungal pathogen, poses a significant healthcare challenge, necessitating robust risk assessment strategies for effective infection control in hospital settings. O…

Descriptive View on Candida Auris Occurrence in a Tertiary Health Institution in Riyadh, Saudi Arabia Open

Fatimah Alshahrani, Abba Amsami Elgujja, Sarah Alsubaie, Salah Ezreqat, Ahmed Albarrag , et al. · 2023

Background Candida auris is an emerging multidrug-resistant fungal pathogen that represents a serious threat to healthcare settings currently. Objective: Its objective was to determine the prevalence of C. auris in the hospital since its i…

Effectiveness of COVID-19 vaccines against ICU admission during Omicron surge in Saudi Arabia: a nationwide retrospective cohort study Open

Raghib Abu-Saris, Emad Almohammadi, Ahmed Albarrag · 2023

Descriptive View on Candida Auris Occurrence in a Tertiary Health Institution in Riyadh, Saudi Arabia Open

Fatimah Alshahrani, Abba Amsami Elgujja, Sarah Alsubaie, Salah Ezreqat, Ahmed Albarrag , et al. · 2023

Background Candida auris is an emerging multidrug-resistant fungal pathogen that represents a serious threat to healthcare settings currently. Objective: Its objective was to determine the prevalence of C. auris in the hospital since its i…

Screening for chitin degrading bacteria in the environment of Saudi Arabia and characterization of the most potent chitinase from Streptomyces variabilis Am1 Open

Essam Kotb, Amira H. Alabdalall, Azzah I. Alghamdi, Ibtisam Ababutain, Sumayh A. Aldakeel , et al. · 2023

Forty-six promising chitinolytic isolates were recovered during a screening for chitinolytic bacteria in the environment of Saudi Arabia. The top three isolates belonged to the genus Streptomyces . Streptomyces variabilis Am1 was able to e…

Chemokine Levels among Patients with Middle East Respiratory Syndrome Coronavirus Infection Open

Abdulkarim Alhetheel, Ahmed Albarrag, Zahid Shakoor, Ali M. Somily, Mazin Barry , et al. · 2023

Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with significant morbidity and mortality due to intense pulmonary inflammation. Enhanced chemokine-mediated leukocyte infiltration in lungs has been linked with unfavora…

Correlation of Plasma 25(OH)D3 and Vitamin D Binding Protein Levels with COVID-19 Severity and Outcome in Hospitalized Patients Open

Wajude Alabdullatif, Ahmad T. Almnaizel, Ali Alhijji, Aldanah Alshathri, Ahmed Albarrag , et al. · 2023

Background: The Coronavirus Disease-19 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a worldwide pandemic. The severity of COVID-19 varies greatly across infected individuals. Possi…

Impact of MERS-CoV and SARS-CoV-2 Viral Infection on Immunoglobulin-IgG Cross-Reactivity Open

Joud Mohammed Alkhalifah, Waleed Seddiq, Mohammed Alshehri, Abdulkarim Alhetheel, Ahmed Albarrag , et al. · 2023

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has posed a considerable threat to public health and global economies. SARS-CoV-2 has largely affected a vast world population and was declared a COVID-19 pandemic outbreak, with…

Bioethanol Production from Lignocellulosic Biomass Using Aspergillus niger and Aspergillus flavus Hydrolysis Enzymes through Immobilized S. cerevisiae Open

Amira H. Alabdalall, Asma A. Almutari, Sumayh A. Aldakeel, Ahmed Albarrag, Lena A. Aldakheel , et al. · 2023

Lignocellulose, the main component of a plant cell wall, is a potential renewable bioenergy source. It is composed of cellulose, hemicellulose, and lignin structures. Cellulose is a linear polysaccharide that is hydrolyzed chemically or en…

Differential expression of carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) and dipeptidyl peptidase‐4 (DPP4) with detection of Middle East respiratory syndrome-coronavirus in peripheral blood Open

Abdulkarim Alhetheel, Ahmed Albarrag, Zahid Shakoor, Ali M. Somily, Mazin Barry , et al. · 2022

Increased expression levels of CD66e (CEACAM5) may contribute to increased susceptibility of PBMCs to MERS-CoV infection and disease progression.

Development and Validation of Reverse Transcriptase Loop-Mediated Isothermal Amplification (RT-LAMP) as a Simple and Rapid Diagnostic Tool for SARS-CoV-2 Detection Open

Ahmad M. Aldossary, Essam A. Tawfik, Musaad A. Altammami, Azzam A. Alquait, Rayan Y. Booq , et al. · 2022

Since the COVID-19 pandemic outbreak in the world, many countries have searched for quick diagnostic tools to detect the virus. There are many ways to design diagnostic assays; however, each may have its limitations. A quick, sensitive, sp…

Effective treatment of resistant opportunistic fungi associated with immuno-compromised individuals using silver biosynthesized nanoparticles Open

Abobakr Almansob, Ali H. Bahkali, Ahmed Albarrag, Mohammad Alshomrani, Abdulwahab Z. Binjomah , et al. · 2022

SARS-CoV-2 Reinfection Rate and Outcomes in Saudi Arabia: A National Retrospective Study Open

Maram Alotaibi, Ines Krissaane, Ahad Al Seraihi, Jumanah Alshenaifi, Mohammad Hassan Qahtani , et al. · 2022

Correlation of Gut Microbiota, Vitamin D Status, and Pulmonary Function Tests in Children With Cystic Fibrosis Open

Hadeel Albedewi, Iman Abdullah Bindayel, Ahmed Albarrag, Hanaa Banjar · 2022

Background Children with cystic fibrosis (CF) are expected to have suboptimal serum vitamin D status and altered gut microbiota. The altered gut microbiota is hypothesized to have a pro-inflammatory effect that further complicates the exis…

DNA Barcoding of Potential Mosquito Disease Vectors (Diptera, Culicidae) in Jazan Region, Saudi Arabia Open

Elsiddig Noureldin, Denise Tan, Ommer Daffalla, Hatim Almutairi, Jaber Ghzwani , et al. · 2022

The conventional morphological characterization of mosquito species remains heavily used for species identification in Jazan, Saudi Arabia. It requires substantial expertise and time, as well as having difficulty in confirming identity of …

Degradation of 2,6-dicholorophenol by Trichoderma longibraciatum Isolated from an industrial Soil Sample in Dammam, Saudi Arabia Open

Amira H. Alabdalall, F. Aldakheel, Ibtisam Ababutain, Hanen Chakroun, Azzah I. Alghamdi , et al. · 2022

2,6-Dichlorophenol (2,6-DCP) is an aromatic compound with industrial importance in making insecticides, herbicides, and other organic compounds. However, it poses serious health and ecological problems. Microbial degradation of 2,6-DCP has…

SARS-CoV-2 Reinfection Rate and Outcomes in Saudi Arabia: A National Retrospective Study Open

Maram Alotaibi, Ines Krissaane, Ahad Al Seraihi, Jumanah Alshenaifi, Mohammed Hassan Qahtani , et al. · 2022

Disseminated histoplasmosis in a heart transplant recipient from Saudi Arabia: A case report Open

Maha Al‐Amri, Ahmed Albarrag, Haitham Khogeer, Jehad Alburaiki, Magid Halim , et al. · 2021

Histoplasma is endemic in North and Central America. We describe a case of disseminated histoplasmosis in a heart transplant recipient outside the known endemic areas. A 68-year-old gentleman known to have dilated cardiomyopathy. He underw…

Molecular characterization of carbapenem-resistant <i>Enterobacterales</i> in thirteen tertiary care hospitals in Saudi Arabia Open

Hail M. Al-Abdely, Raed AlHababi, Hebah Mahmoud Dada, Hala M. Roushdy, Mishaal Mohammed Alanazi , et al. · 2021

BACKGROUND: Carbapenems are the antibiotics of last-resort for the treatment of bacterial infections caused by multidrug-resistant organisms. The emergence of resistance is a critical and worrisome problem for clinicians and patients. Carb…

SARS-CoV-2 Direct real-time Polymerase Chain Reaction Testing in Laboratories With Shortage Challenges Open

Taghreed A. Alaifan, Asmaa M. Altamimi, Dalia Obeid, Turki M. Alshehri, Shaihana Almatrrouk , et al. · 2021

Aim: In our study, we propose the use of direct real-time polymerase chain reaction (RT-PCR), this test does not require extraction or a preheating step, which saves a lot of cost, labor, processing time and provides a solution for supply …

Assessment of knowledge, perception and attitude towards antibiotic resistance among medical interns in Saudi Arabia Open

Ahmed Albarrag, Nawaf Zaid Almeshari, Abdullah Ameen Alfraih, Abdullah H Alshathry, Abdulaziz Mohammed Alzaydan , et al. · 2021

Background: Antibiotic resistance is a well-established medical fact that affects the clinical course of many infections. There are many risk factors that can contribute to antibiotic resistance clinically. Therefore, it is important to un…

Comparing the RealStar® SARS-CoV-2 Modified Protocol with Original Protocol to Detect SARS-CoV-2 Open

Asmaa M. Altamimi, Taghreed A. Alaifan, Turki M. Alshehri, Ahmed Albarrag · 2021

Background: The use of effective, consistent, and sensitive PCR assays is a foundation to truly identify the virus during this pandemic related to SARS-CoV-2. The SARS-COV-2 laboratory diagnosis depends highly on the RT-PCR technique. This…

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