Ahmed Alobaida
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View article: Revolutionizing Cancer Care: The Role of 3D Printing in Personalized Oncology
Revolutionizing Cancer Care: The Role of 3D Printing in Personalized Oncology Open
this review highlights the transformative role of 3D printing in modern cancer care, emphasizing its capacity to drive innovation, enable personalized treatment strategies, and enhance precision, ultimately improving therapeutic outcomes a…
View article: Microfluidic captured patient-derived circulating endothelial cells identify novel targets of pulmonary arterial hypertension
Microfluidic captured patient-derived circulating endothelial cells identify novel targets of pulmonary arterial hypertension Open
Endothelial cell (EC) dysfunction and gene expression abnormalities in pulmonary arterial hypertension (PAH) vary among patients. Existing PAH cell sources, often from lung transplant patients, are influenced by drug treatments and are ina…
View article: Bioactive principles, anti-diabetic, and anti-ulcer activities of Ducrosia anethifolia Boiss leaves from the Hail region, Saudi Arabia
Bioactive principles, anti-diabetic, and anti-ulcer activities of Ducrosia anethifolia Boiss leaves from the Hail region, Saudi Arabia Open
This work aimed to identify the bioactive constituents of Ducrosia anethifolia Boiss eaves through cold methanolic extract. The GC–MS study of cold methanolic extract showed the presence of various pharmaceutically important bioactive comp…
View article: Theoretical investigations on the liquid-phase molecular separation in isolation and purification of pharmaceutical molecules from aqueous solutions via polymeric membranes
Theoretical investigations on the liquid-phase molecular separation in isolation and purification of pharmaceutical molecules from aqueous solutions via polymeric membranes Open
We have developed ANFIS (adaptive neuro-fuzzy inference system) modeling strategy for investigations on molecular separation using membrane systems. The results can be useful for purification and isolation of pharmaceutical molecules durin…
View article: Manganese chloride (MnCl2) induced novel model of Parkinson’s disease in adult Zebrafish; Involvement of oxidative stress, neuroinflammation and apoptosis pathway
Manganese chloride (MnCl2) induced novel model of Parkinson’s disease in adult Zebrafish; Involvement of oxidative stress, neuroinflammation and apoptosis pathway Open
View article: Development of advanced method based on nanoporous membranes for separation of pharmaceutical compounds from aqueous streams: Computational simulation and analysis
Development of advanced method based on nanoporous membranes for separation of pharmaceutical compounds from aqueous streams: Computational simulation and analysis Open
In this study, we developed a novel methodology for isolation and separation of pharmaceutical compounds from aqueous solutions. Pharmaceutical pollutants are an important group of contaminants of emerging concern (CECs), which their disch…
View article: Development of GBRT Model as a Novel and Robust Mathematical Model to Predict and Optimize the Solubility of Decitabine as an Anti-Cancer Drug
Development of GBRT Model as a Novel and Robust Mathematical Model to Predict and Optimize the Solubility of Decitabine as an Anti-Cancer Drug Open
The efficient production of solid-dosage oral formulations using eco-friendly supercritical solvents is known as a breakthrough technology towards developing cost-effective therapeutic drugs. Drug solubility is a significant parameter whic…
View article: Delafloxacin-Capped Gold Nanoparticles (DFX-AuNPs): An Effective Antibacterial Nano-Formulation of Fluoroquinolone Antibiotic
Delafloxacin-Capped Gold Nanoparticles (DFX-AuNPs): An Effective Antibacterial Nano-Formulation of Fluoroquinolone Antibiotic Open
New antibiotics are seen as ‘drugs of last resort’ against virulent bacteria. However, development of resistance towards new antibiotics with time is a universal fact. Delafloxacin (DFX) is a new fluoroquinolone antibiotic that differs fro…
View article: Anti-Cancer Drug Solubility Development within a Green Solvent: Design of Novel and Robust Mathematical Models Based on Artificial Intelligence
Anti-Cancer Drug Solubility Development within a Green Solvent: Design of Novel and Robust Mathematical Models Based on Artificial Intelligence Open
Nowadays, supercritical CO2(SC-CO2) is known as a promising alternative for challengeable organic solvents in the pharmaceutical industry. The mathematical prediction and validation of drug solubility through SC-CO2 system using novel arti…
View article: Development a novel robust method to enhance the solubility of Oxaprozin as nonsteroidal anti-inflammatory drug based on machine-learning
Development a novel robust method to enhance the solubility of Oxaprozin as nonsteroidal anti-inflammatory drug based on machine-learning Open
View article: Dithymoquinone Analogues as Potential Candidate(s) for Neurological Manifestation Associated with COVID-19: A Therapeutic Strategy for Neuro-COVID
Dithymoquinone Analogues as Potential Candidate(s) for Neurological Manifestation Associated with COVID-19: A Therapeutic Strategy for Neuro-COVID Open
The COVID-19 era has prompted several researchers to search for a linkage between COVID-19 and its associated neurological manifestation. Toll-like receptor 4 (TLR-4) acts as one such connecting link. spike protein of SARS-CoV-2 can bind e…
View article: University Students' Self-Medication Practices and Pharmacists' Role: A Cross-Sectional Survey in Hail, Saudi Arabia
University Students' Self-Medication Practices and Pharmacists' Role: A Cross-Sectional Survey in Hail, Saudi Arabia Open
Background: Self-medication is an important issue for health authorities around the world. It is also a common practice among university students. Objective: This study aimed to assess the prevalence of and reasons for self-medication amon…
View article: Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance
Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance Open
Ceftriaxone has been a part of therapeutic regime for combating some of the most aggressive bacterial infections in the last few decades. However, increasing bacterial resistance towards ceftriaxone and other third generation cephalosporin…
View article: Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects
Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects Open
View article: Newer approaches and novel drugs for inhalational therapy for pulmonary arterial hypertension
Newer approaches and novel drugs for inhalational therapy for pulmonary arterial hypertension Open
Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by remodeling of small pulmonary arteries leading to increased pulmonary arterial pressure. Existing treatments acts to normalize vascular to…
View article: Pulmonary-arterial-hypertension (PAH)-on-a-chip: fabrication, validation and application
Pulmonary-arterial-hypertension (PAH)-on-a-chip: fabrication, validation and application Open
Current animal and cellular models only partially recapitulate the pathophysiology of PAH. Our PAH-on-a-chip model can mimic the major pathologies of PAH such as pulmonary arterial remodeling and sex disparity and help develop PAH therapeu…
View article: Car, A Homing Peptide, Prolongs Pulmonary Preferential Vasodilation by Increasing Pulmonary Retention and Reducing Systemic Absorption of Liposomal Fasudil
Car, A Homing Peptide, Prolongs Pulmonary Preferential Vasodilation by Increasing Pulmonary Retention and Reducing Systemic Absorption of Liposomal Fasudil Open
Here,\nwe sought to elucidate the role of CAR (a cyclic peptide)\nin the accumulation and distribution of fasudil, a drug for pulmonary\narterial hypertension (PAH), in rat lungs and in producing pulmonary\nspecific vasodilation in PAH rat…
View article: Repurposing rosiglitazone, a PPAR-γ agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH
Repurposing rosiglitazone, a PPAR-γ agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH Open