Mairaj Ahmed Ansari
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View article: Natural Building Blocks for Structured World Models: Theory, Evidence, and Scaling
Natural Building Blocks for Structured World Models: Theory, Evidence, and Scaling Open
The field of world modeling is fragmented, with researchers developing bespoke architectures that rarely build upon each other. We propose a framework that specifies the natural building blocks for structured world models based on the fund…
View article: Mycobacterium tuberculosis antigen containing-exosomes reinforce BCG vaccine efficacy by augmenting long term protection and memory response against experimental tuberculosis in BALB-C mice.
Mycobacterium tuberculosis antigen containing-exosomes reinforce BCG vaccine efficacy by augmenting long term protection and memory response against experimental tuberculosis in BALB-C mice. Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb.) , inflicts one third of the humanity. Despite the availability of effective drug regimens, complete eradication of M.tb. remains challenging due to prolong treatment duration.…
View article: Profiling HIV1-host protein–protein interaction networks in patient-derived exosome proteins: impact on pathophysiology and innate immune pathways
Profiling HIV1-host protein–protein interaction networks in patient-derived exosome proteins: impact on pathophysiology and innate immune pathways Open
These findings are a step ahead in comprehending the pathophysiology of HIV1 and the innate immune response pathways, providing excellent opportunities to explore further exosome-based biomarkers for theranostic approaches.
View article: Public Health, Risk Perception, and Governance Challenges in the 2025 Los Angeles Wildfires: Evidence from a Community-Based Survey
Public Health, Risk Perception, and Governance Challenges in the 2025 Los Angeles Wildfires: Evidence from a Community-Based Survey Open
The January 2025 wildfires in Southern California, notably the Palisades and Eaton Fires, were among the most catastrophic in the state's history, leading to nearly 18,000 structural losses, extensive evacuations, and considerable public h…
View article: Improving Treatments for Oral Diseases,Head and Neck Cancers, as well as Developing New Technologies
Improving Treatments for Oral Diseases,Head and Neck Cancers, as well as Developing New Technologies Open
Head and neck cancers, encompassing malignancies of the oral cavity, pharynx, and larynx, represent a considerable worldwide health concern, with over 890,000 new cases and 450,000 deaths each year. Notwithstanding progress in conventional…
View article: Remote Ischemic Post-Conditioning (RIC) Mediates Anti-Inflammatory Signaling via Myeloid AMPKα1 in Murine Traumatic Optic Neuropathy (TON)
Remote Ischemic Post-Conditioning (RIC) Mediates Anti-Inflammatory Signaling via Myeloid AMPKα1 in Murine Traumatic Optic Neuropathy (TON) Open
Traumatic optic neuropathy (TON) has been regarded a vision-threatening condition caused by either ocular or blunt/penetrating head trauma, which is characterized by direct or indirect TON. Injury happens during sports, vehicle accidents a…
View article: A comparative study on clinical features and COVID-19 severity in pediatric patients and adults
A comparative study on clinical features and COVID-19 severity in pediatric patients and adults Open
Introduction Coronavirus disease (COVID-19) has emerged as a global threat affecting diverse populations. While the severity of the disease is often associated with comorbidities and inflammation, pediatric patients generally experience a …
View article: Editorial: Prophylactic efficacy and safety of COVID-19 vaccines in preventing disease caused by various SARS CoV-2 variants
Editorial: Prophylactic efficacy and safety of COVID-19 vaccines in preventing disease caused by various SARS CoV-2 variants Open
EDITORIAL article Front. Cell. Infect. Microbiol., 13 March 2024Sec. Clinical Microbiology Volume 14 - 2024 | https://doi.org/10.3389/fcimb.2024.1384601
View article: Apigenin enhances sorafenib anti-tumour efficacy in hepatocellular carcinoma
Apigenin enhances sorafenib anti-tumour efficacy in hepatocellular carcinoma Open
In conclusion, Apigenin could enhance the therapeutic efficacy of Sorafenib against liver cancer and may be a promising therapeutic approach for treating HCC. However, further research is imperative to gain more in-depth mechanistic insigh…
View article: Systems-wide view of host-pathogen interactions across COVID-19 severities using integrated omics analysis
Systems-wide view of host-pathogen interactions across COVID-19 severities using integrated omics analysis Open
The mechanisms explaining the variability in COVID-19 clinical manifestations (mild, moderate, and severe) are not fully understood. To identify key gene expression markers linked to disease severity, we employed an integrated approach, co…
View article: Unveiling common markers in COVID-19: ADAMTS2, PCSK9, and OLAH emerged as key differential gene expression profiles in PBMCs across diverse disease conditions
Unveiling common markers in COVID-19: ADAMTS2, PCSK9, and OLAH emerged as key differential gene expression profiles in PBMCs across diverse disease conditions Open
Diverse COVID-19 severity levels and a spectrum of clinical manifestations underscore the need to comprehend the underlying genetic mechanisms. Such knowledge is essential for improving disease management and therapeutic approaches. This …
View article: Estrogen-mediated modulation of sterile inflammatory markers and baroreflex sensitivity in ovariectomized female Wistar rats
Estrogen-mediated modulation of sterile inflammatory markers and baroreflex sensitivity in ovariectomized female Wistar rats Open
Estrogen mediates cardioprotection by improving baroreflex sensitivity in ovariectomized Wistar rats through modulation of the NO pathway.
View article: Determinants of Severity due to Covid-19 Among Young Adults
Determinants of Severity due to Covid-19 Among Young Adults Open
Background Coronavirus disease (COVID-19) is an emerging infectious disease affecting people of all ages, races, and countries, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The disease has been shown to be more…
View article: Effect of an Integrated Physiotherapy Protocol on Knee Osteoarthritis Patients: A Preliminary Study
Effect of an Integrated Physiotherapy Protocol on Knee Osteoarthritis Patients: A Preliminary Study Open
Background: Exercise therapy can potentially relieve symptoms and improve functional status of the knee osteoarthritis population. Despite the proved practical benefits, there is no standard, comprehensive physiotherapeutic protocol availa…
View article: Systems-Wide View of Host-Pathogen Interactions Across COVID-19 Severities Using Integrated Omics Analysis
Systems-Wide View of Host-Pathogen Interactions Across COVID-19 Severities Using Integrated Omics Analysis Open
View article: COVID-19 Pandemic and Vaccines Update on Challenges and Resolutions
COVID-19 Pandemic and Vaccines Update on Challenges and Resolutions Open
The coronavirus disease (COVID-19) is caused by a positive-stranded RNA virus called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), belonging to the Coronaviridae family. This virus originated in Wuhan City, China, and becam…
View article: The Immunomodulatory CEA Cell Adhesion Molecule 6 (CEACAM6/CD66c) Is a Protein Receptor for the Influenza A Virus
The Immunomodulatory CEA Cell Adhesion Molecule 6 (CEACAM6/CD66c) Is a Protein Receptor for the Influenza A Virus Open
To establish a productive infection in host cells, viruses often use one or multiple host membrane glycoproteins as their receptors. For Influenza A virus (IAV) such a glycoprotein receptor has not been described, to date. Here we show tha…
View article: HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi’s Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity
HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi’s Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity Open
ROS play important roles in several cellular processes, and increased ROS cause several adverse effects. KSHV infection of endothelial cells induces ROS, which facilitate virus entry by amplifying the infection-induced host cell signaling …
View article: Correction for Ansari et al., “Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells”
Correction for Ansari et al., “Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells” Open
View article: Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency
Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency Open
View article: The immunomodulatory CEA cell adhesion molecule 6 (CEACAM6/CD66c) is a candidate receptor for the influenza A virus
The immunomodulatory CEA cell adhesion molecule 6 (CEACAM6/CD66c) is a candidate receptor for the influenza A virus Open
To establish a productive infection in host cells, viruses often use one or multiple host membrane glycoprotein as their receptors. For Influenza A virus (IAV) such a glycoprotein receptor has not been described, to date. Here we show that…
View article: Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses
Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses Open
IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune response DNA sensor and induces the IL-1β and antiviral type-1 interferon-β (IFN-β) c…
View article: ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi’s Sarcoma-Associated Herpesvirus
ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi’s Sarcoma-Associated Herpesvirus Open
Kaposi's sarcoma-associated herpesvirus (KSHV) binding to the endothelial cell surface heparan sulfate is followed by sequential interactions with α3β1, αVβ3 and αVβ5 integrins and Ephrin A2 receptor tyrosine kinase (EphA2R). These interac…
View article: Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency
Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency Open
IFI16 (interferon gamma-inducible protein 16) recognizes nuclear episomal herpesvirus (Kaposi's sarcoma-associated herpesvirus [KSHV], Epstein-Barr virus [EBV], and herpes simplex virus 1 [HSV-1]) genomes and induces the inflammasome and i…
View article: ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells
ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells Open
Kaposi's sarcoma-associated herpesvirus (KSHV) enters human dermal microvascular endothelial cells (HMVEC-d), its natural in vivo target cells, by lipid raft-dependent macropinocytosis. The internalized viral envelope fuses with the macrop…
View article: Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses
Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses Open
The IL-1β and type I interferon-β (IFN-β) molecules are important inflammatory cytokines elicited by the eukaryotic host as innate immune responses against invading pathogens and danger signals. Recently, a predominantly nuclear gamma-inte…
View article: BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses
BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses Open
The innate immune system pattern recognition receptors (PRR) are the first line of host defenses recognizing the various pathogen- or danger-associated molecular patterns and eliciting defenses by regulating the production of pro-inflammat…