Alexander Ghanem
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View article: EFFICACY OF VONOPRAZAN VERSUS ESOMEPRAZOLE IN TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE
EFFICACY OF VONOPRAZAN VERSUS ESOMEPRAZOLE IN TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE Open
View article: Evaluation of safety and efficacy of warfarin therapy by using Time in Therapeutic Range in patients receiving warfarin in Assiut University Hospital
Evaluation of safety and efficacy of warfarin therapy by using Time in Therapeutic Range in patients receiving warfarin in Assiut University Hospital Open
View article: Erratum zu: Stellungnahme zur kritischen Bewertung der Nationalen VersorgungsLeitlinie zur chronischen koronaren Herzerkrankung
Erratum zu: Stellungnahme zur kritischen Bewertung der Nationalen VersorgungsLeitlinie zur chronischen koronaren Herzerkrankung Open
View article: The secreted Nimrod NimB1 negatively regulates early steps of apoptotic cell phagocytosis in <i>Drosophila</i>
The secreted Nimrod NimB1 negatively regulates early steps of apoptotic cell phagocytosis in <i>Drosophila</i> Open
Efferocytosis, the efficient clearance of apoptotic cells (ACs) by phagocytes, is vital for maintaining tissue homeostasis. Here, we reveal the role of the secreted protein NimB1 in reducing apoptotic cell recognition and binding in the ea…
View article: Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons
Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons Open
The elimination of superfluous neurons via apoptosis and subsequent glial phagocytosis is crucial for the development of the central nervous system (CNS). In Drosophila, two glial phagocytic receptors, six-microns-under (SIMU) and Draper, …
View article: Programming of neural progenitors of the adult subependymal zone towards a glutamatergic neuron lineage by neurogenin 2
Programming of neural progenitors of the adult subependymal zone towards a glutamatergic neuron lineage by neurogenin 2 Open
View article: Glossar zu Prozesszeiten und Kennzahlen im Herzkatheterlabor
Glossar zu Prozesszeiten und Kennzahlen im Herzkatheterlabor Open
Zusammenfassung Der demografische Wandel sowie innovative Fortschritte in der interventionellen Kardiologie führen zu Veränderungen in der Qualität der medizinischen Versorgung von Patienten mit kardiovaskulären Erkrankungen. Ein erfolgrei…
View article: Digitale Leitlinien des 21. Jahrhunderts
Digitale Leitlinien des 21. Jahrhunderts Open
Zusammenfassung Bislang werden klinische Leitlinien als verallgemeinerte Darstellungen klinischen Wissens verstanden, die nach bester verfügbarer Evidenz die Anforderungen an die Versorgung von Patienten in spezifischen Patientensituatione…
View article: Interventionelle Therapie und multidisziplinäre Managementstrategien für die akute Lungenembolie
Interventionelle Therapie und multidisziplinäre Managementstrategien für die akute Lungenembolie Open
View article: L’anatomie du temps
L’anatomie du temps Open
Une charge de travail élevée, une contrainte temporelle, la croissance exponentielle des connaissances dans le domaine médical et la confrontation permanente à des situations existentielles marquent le quotidien professionnel des médecins.…
View article: Die Anatomie der Zeit
Die Anatomie der Zeit Open
Eine hohe Arbeitsbelastung, Zeitdruck, exponentieller Wissenszuwachs im medizinischen Bereich und die ständige Konfrontation mit existenziellen Situationen prägen den Arbeitsalltag von Medizinerinnen und Medizinern. Diese Komplexität kann…
View article: Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury
Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury Open
View article: Results from the “Me & My Heart” (eMocial) Study: a Randomized Evaluation of a New Smartphone-Based Support Tool to Increase Therapy Adherence of Patients with Acute Coronary Syndrome
Results from the “Me & My Heart” (eMocial) Study: a Randomized Evaluation of a New Smartphone-Based Support Tool to Increase Therapy Adherence of Patients with Acute Coronary Syndrome Open
View article: Inhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice
Inhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice Open
Aims: Oxidative stress and inflammation contribute to atherogenesis. Rac1 GTPase regulates pro-oxidant NADPH oxidase activity, reactive oxygen species (ROS) formation, actin cytoskeleton organization and monocyte adhesion. We investigated …
View article: High-Yield Human Induced Pluripotent Stem Cell-Derived Monocytes and Macrophages Are Functionally Comparable With Primary Cells
High-Yield Human Induced Pluripotent Stem Cell-Derived Monocytes and Macrophages Are Functionally Comparable With Primary Cells Open
Macrophages are pivotal effectors of host immunity and regulators of tissue homeostasis. Understanding of human macrophage biology has been hampered by the lack of reliable and scalable models for cellular and genetic studies. Human induce…
View article: Use of Pre- and Intensified Postprocedural Physiotherapy in Patients with Symptomatic Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement Study (the 4P-TAVR Study)
Use of Pre- and Intensified Postprocedural Physiotherapy in Patients with Symptomatic Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement Study (the 4P-TAVR Study) Open
Background. Physiotherapy prior to open-heart surgery lowers the rate of pneumonia and length of the hospital stay. Pneumonia is a major contributor to short-term mortality following transcatheter aortic valve replacement (TAVR). Hence, we…
View article: Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling
Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling Open
View article: Design and rationale for the “Me & My Heart” (eMocial) study: A randomized evaluation of a new smartphone‐based support tool to increase therapy adherence of patients with acute coronary syndrome
Design and rationale for the “Me & My Heart” (eMocial) study: A randomized evaluation of a new smartphone‐based support tool to increase therapy adherence of patients with acute coronary syndrome Open
A novel smartphone‐based patient support tool was developed to increase the adherence to antiplatelet therapy and lifestyle changes in patients after coronary angioplasty for acute coronary syndrome (ACS). The eMocial study ( ClinicalTrial…
View article: Cryo EM structure of the rabies virus ribonucleoprotein complex
Cryo EM structure of the rabies virus ribonucleoprotein complex Open
View article: Treatment with mononuclear cell populations improves post-infarction cardiac function but does not reduce arrhythmia susceptibility
Treatment with mononuclear cell populations improves post-infarction cardiac function but does not reduce arrhythmia susceptibility Open
Transplantation of different MNC populations after myocardial infarction improves left ventricular function similar to effects of eCMs. Prevention of inducible ventricular arrhythmia is only seen after transplantation of eCMs.
View article: Safety and feasibility of interventional left atrial appendage closure without contrast agent
Safety and feasibility of interventional left atrial appendage closure without contrast agent Open
Interventional LAAC with the Amulet device can be performed safely without the use of contrast agent. This approach might help to enhance the use of LAAC in patients at high risk of contrast-induced nephropathy and procedural stroke.
View article: 2117Cerebral protection during catheter ablation of ventricular tachycardia in patients with ischemic heart disease
2117Cerebral protection during catheter ablation of ventricular tachycardia in patients with ischemic heart disease Open
View article: Empfehlungen zur extrakorporalen kardiopulmonalen Reanimation (eCPR)
Empfehlungen zur extrakorporalen kardiopulmonalen Reanimation (eCPR) Open
View article: Anatomical projections of the dorsomedial hypothalamus to the periaqueductal grey and their role in thermoregulation: a cautionary note
Anatomical projections of the dorsomedial hypothalamus to the periaqueductal grey and their role in thermoregulation: a cautionary note Open
The DMH is known to regulate brown adipose tissue (BAT) thermogenesis via projections to sympathetic premotor neurons in the raphe pallidus, but there is evidence that the periaqueductal gray (PAG) is also an important relay in the descend…
View article: Cerebral Protection During Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Heart Disease
Cerebral Protection During Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Heart Disease Open
Background Catheter ablation of ventricular tachycardia ( VT ) is associated with the risk of cerebral embolism. The origin of periprocedural brain embolism in the setting of VT ablation is often unknown and strategies to avoid it are spar…
View article: Optical coherence tomography-guided versus angiography-guided implantation of everolimus-eluting bioresorbable vascular scaffolds: Comparison of coverage, apposition and clinical outcome. The ALSTER-OCT ABSORB registry
Optical coherence tomography-guided versus angiography-guided implantation of everolimus-eluting bioresorbable vascular scaffolds: Comparison of coverage, apposition and clinical outcome. The ALSTER-OCT ABSORB registry Open
Optical coherence tomography analysis at 6-months following EE-BVS-implantation finds almost 90% of struts to be covered. No difference between OCT vs. angiography-guided EE-BVS-implantation was observed. OCT at 6-months was not able to pr…
View article: 997Embolic debris captured by a cerebral protection system during catheter ablation of ventricular tachycardia in patients with ischemic heart disease
997Embolic debris captured by a cerebral protection system during catheter ablation of ventricular tachycardia in patients with ischemic heart disease Open
View article: XXes Journées francophones de virologie
XXes Journées francophones de virologie Open
Les complexes de réplication des virus à ARN négatif sont dépourvus de toute activité de vérification de leur fidélité.Ainsi, à chaque cycle de réplication, un certain nombre d'erreurs se produit et génère des populations génétiquement div…
View article: Neuronal LRP4 regulates synapse formation in the developing CNS
Neuronal LRP4 regulates synapse formation in the developing CNS Open
The low-density lipoprotein receptor-related protein 4 (LRP4) is essential in muscle fibers for the establishment of the neuromuscular junction. Here, we show that LRP4 is also expressed by embryonic cortical and hippocampal neurons, and t…
View article: Identification of Two Classes of Somatosensory Neurons That Display Resistance to Retrograde Infection by Rabies Virus
Identification of Two Classes of Somatosensory Neurons That Display Resistance to Retrograde Infection by Rabies Virus Open
Glycoprotein-deleted rabies virus-mediated monosynaptic tracing has become a standard method for neuronal circuit mapping, and is applied to virtually all parts of the rodent nervous system, including the spinal cord and primary sensory ne…