Ahmed H. Afifi
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View article: Chemical profile of Ficus lyrata bark extract and its therapeutic effect on non-alcoholic fatty liver disease via regulating oxidative stress, inflammation and hepatic lipogenesis
Chemical profile of Ficus lyrata bark extract and its therapeutic effect on non-alcoholic fatty liver disease via regulating oxidative stress, inflammation and hepatic lipogenesis Open
The high prevalence of non-alcoholic fatty liver disease (NAFLD) worldwide necessitates the attention and intervention of modern medical treatment options. Preliminary studies have demonstrated that Ficus Lyrata leaves can exert protective…
View article: In vivo and in silico studies on the potential role of garden cress oil in attenuating methotrexate-induced inflammation and apoptosis in liver
In vivo and in silico studies on the potential role of garden cress oil in attenuating methotrexate-induced inflammation and apoptosis in liver Open
View article: Design, synthesis, molecular docking and anticancer activity of benzothiazolecarbohydrazide–sulfonate conjugates: insights into ROS-induced DNA damage and tubulin polymerization inhibition
Design, synthesis, molecular docking and anticancer activity of benzothiazolecarbohydrazide–sulfonate conjugates: insights into ROS-induced DNA damage and tubulin polymerization inhibition Open
An innovative design strategy for the synthesis of the benzothiazole–sulfonate conjugate 6i.
View article: Garden cress oil attenuates methotrexate-induced hepatic damage by enhancing inflammation, apoptosis, and histological profile: in vivo and in silico studies
Garden cress oil attenuates methotrexate-induced hepatic damage by enhancing inflammation, apoptosis, and histological profile: in vivo and in silico studies Open
Methotrexate (MTX) has been used in high doses for cancer therapy and low doses for autoimmune diseases. It is proven that methotrexate-induced hepatotoxicity occurs even at relatively low doses. It is known that garden cress has anti-infl…
View article: Chemical composition and studying the possible neuroprotective effect of iridoids-rich fraction from Pentas lanceolata leaves using rotenone model of Parkinson’s disease in mice
Chemical composition and studying the possible neuroprotective effect of iridoids-rich fraction from Pentas lanceolata leaves using rotenone model of Parkinson’s disease in mice Open
View article: Comparative metabolomics analysis of Citrus medica var. sarcodactylis Swingle and Limonia acidissima Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects
Comparative metabolomics analysis of Citrus medica var. sarcodactylis Swingle and Limonia acidissima Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects Open
A comprehensive study of fruits and leaves extracts of Citrus medica var. sarcodactylis Swingle and Limonia acidissima L. family Rutaceae was accomplished to investigate their antiviral activity along with their zinc o…
View article: Secondary metabolites from the leaves of Terminalia myriocarpa and their α-glucosidase inhibitory potential
Secondary metabolites from the leaves of Terminalia myriocarpa and their α-glucosidase inhibitory potential Open
The objective of this study is to investigate the chemical composition of the leaves of Terminalia myriocarpa and to evaluate their α-glucosidase inhibitory activity aiming to be used as a safe antidiabetic. Consequently, 10 compounds were…
View article: Secondary metabolites from the leaves of Terminalia myriocarpa and their α-glucosidase inhibitory potential
Secondary metabolites from the leaves of Terminalia myriocarpa and their α-glucosidase inhibitory potential Open
Triterpenoids and phytosteroids from stem bark of Crataeva nurvala buch ham.Shumaia Parvin, Md. Abdul Kader, Md. Abdul Muhit, Md. Ekramul Haque, Md. Ashik Mosaddik, Mir Imam Ibne Wahed
View article: Ficus Lyrata Bark Extract Alleviates Steatosis in Obesity- Induced Non-Alcoholic Fatty Liver Disease in Rats
Ficus Lyrata Bark Extract Alleviates Steatosis in Obesity- Induced Non-Alcoholic Fatty Liver Disease in Rats Open
The authors have requested that this preprint be removed from Research Square.
View article: Metabolic Profiling of Mimusops elengi Linn. Leaves extract and in silico anti-inflammatory assessment targeting NLRP3 inflammasome
Metabolic Profiling of Mimusops elengi Linn. Leaves extract and in silico anti-inflammatory assessment targeting NLRP3 inflammasome Open
Mimusops elengi Linn. Secondary metabolites of flavonoids, phenolic acids, coumarin classes and stilbene were identified by UPLC/ESI-QTOF-HRMS/MS technique with negative ion detection. Major Mimusops elengi flavonoids included Myricitrin, …
View article: Phytochemical Profile of Phoenix rupicola T. Anderson Seeds and In Vitro Evaluation of their Estrogenic Activity using MCF-7 Cell Lines
Phytochemical Profile of Phoenix rupicola T. Anderson Seeds and In Vitro Evaluation of their Estrogenic Activity using MCF-7 Cell Lines Open
The current study aimed to investigate the phytochemical profile and the in vitro estrogenic activity of Phoenix rupicola T. Anderson seeds' extracts.Gas chromatography/ mass spectrometry (GC/MS) of the petroleum ether (seed oil) and chlor…
View article: Antiproliferative potential of moluccella laevis L. aerial parts family lamiaceae (labiatae), supported by phytochemical investigation and molecular docking study
Antiproliferative potential of moluccella laevis L. aerial parts family lamiaceae (labiatae), supported by phytochemical investigation and molecular docking study Open
The current biologically guided study aimed the in vitro investigation of cytotoxic activity, identification of the phytochemical content of Moluccella laevis L. aerial parts and supporting this activity by a molecular docking study. Aqueo…
View article: NS3/4A helicase inhibitory alkaloids from <i>Aptenia cordifolia</i> as HCV target
NS3/4A helicase inhibitory alkaloids from <i>Aptenia cordifolia</i> as HCV target Open
Chemical investigation of Aptenia cordifolia roots extract, using chromatographic and spectroscopic techniques, resulted in isolation and identification of eight known compounds.
View article: Neuroprotective activity of Ulmus pumila L. in Alzheimer's disease in rats; role of neurotrophic factors
Neuroprotective activity of Ulmus pumila L. in Alzheimer's disease in rats; role of neurotrophic factors Open
View article: Evaluation of Hepatoprotective, Antioxidant and Cytotoxic Properties of Isolated Flavonoids from Breynia disticha J.R.Forst. and G.Forst
Evaluation of Hepatoprotective, Antioxidant and Cytotoxic Properties of Isolated Flavonoids from Breynia disticha J.R.Forst. and G.Forst Open
Background and Objective: Breynia disticha J.R.Forst.and G.Forst is a tropical shrub widely grown in tropical Africa.The leaves have characteristic green, purple and pink color, found in gardens and public areas.The aim of the study was to…
View article: Sulawesins A–C, Furanosesterterpene Tetronic Acids That Inhibit USP7, from a <i>Psammocinia</i> sp. Marine Sponge
Sulawesins A–C, Furanosesterterpene Tetronic Acids That Inhibit USP7, from a <i>Psammocinia</i> sp. Marine Sponge Open
Three new furanosesterterpene tetronic acids, sulawesins A-C (1-3), were isolated from a Psammocinia sp. marine sponge, along with the known compounds ircinins-1 (4) and -2 (5). Although ircinins-1 and -2 were previously isolated as (+)- o…