Shabana I. Khan
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View article: Frequency of Malignancy in Patients with Solitary Thyroid Nodule
Frequency of Malignancy in Patients with Solitary Thyroid Nodule Open
Background: The thyroid gland is the largest endocrine gland in the human body and the most frequent site of primary endocrine malignancies. Solitary thyroid nodules (STNs) are clinically significant because of their malignant potential, w…
View article: Quaternion Toeplitz matrices and their fundamental properties
Quaternion Toeplitz matrices and their fundamental properties Open
Toeplitz matrices are characterized by their constant diagonals, have been extensively studied in various settings, including over real and complex numbers. However, their study over quaternions is quite sparse. In this paper, we investiga…
View article: Study the Association of Serum Lipid Profile with Hypertension in Kingdom of Saudi Arabia- A Case Control Study
Study the Association of Serum Lipid Profile with Hypertension in Kingdom of Saudi Arabia- A Case Control Study Open
Introduction: The highest rates of morbidity and mortality in Saudi Arabia are caused by heart disease, which is significantly increased by hypertension and dyslipidemia. The aim of this research was to compare the lipid profiles of hypert…
View article: Factors Associated with Thyroid Malignancy among Patients Presenting with Thyroid Nodule
Factors Associated with Thyroid Malignancy among Patients Presenting with Thyroid Nodule Open
Background: Thyroid nodules are increasingly detected worldwide, and while most are benign, a meaningful proportion harbor malignancy. Regional differences in incidence and mortality suggest contributions from demographic, environmental, a…
View article: CORRELATION OF SERUM URIC ACID LEVEL WITH LEVEL OF URINARY ALBUMIN IN PATIENTS WITH DIABETIC NEPHROPATHY
CORRELATION OF SERUM URIC ACID LEVEL WITH LEVEL OF URINARY ALBUMIN IN PATIENTS WITH DIABETIC NEPHROPATHY Open
Background: Diabetic nephropathy is a leading cause of chronic kidney disease worldwide, contributing significantly to morbidity and mortality among individuals with diabetes mellitus. Uric acid, a final product of purine metabolism, has b…
View article: Aminoquinoline-Pyrimidine-Based Alkyl-Piperazine Tethered Hybrids: Synthesis, Antiplasmodial Activity, and Mechanistic Studies
Aminoquinoline-Pyrimidine-Based Alkyl-Piperazine Tethered Hybrids: Synthesis, Antiplasmodial Activity, and Mechanistic Studies Open
Though great progress has been made to eliminate malaria globally, effective and inexpensive strategies to design new antimalarials are still required due to the problem of drug resistance to the currently used antimalarials. Herein, in co…
View article: Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde
Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde Open
View article: A Combined Approach for Rapid Dereplication of Herb–Drug Interaction Causative Agents in Botanical Extracts─A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe
A Combined Approach for Rapid Dereplication of Herb–Drug Interaction Causative Agents in Botanical Extracts─A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe Open
Despite promising preliminary biology, natural products isolation efforts may be confounded when the active compound is not isolated during bioassay-guided purification or classical pharmacognostic research investigations. A more rational …
View article: Immulina® mitigates the development of illness when administered during the prodromal period of influenza viral infection in mice (Part 2)
Immulina® mitigates the development of illness when administered during the prodromal period of influenza viral infection in mice (Part 2) Open
This study, together with our previous paper, indicate that Immulina® was most effective at enhancing immune antiviral resilience if administered before or soon after initial infection. The data generated can be used to guide additional re…
View article: Interaction of Phyllanthus Amarus Extract and Lignans with Human Xenobiotic-Receptors, Cytochrome-P450s and Abc-Transporters
Interaction of Phyllanthus Amarus Extract and Lignans with Human Xenobiotic-Receptors, Cytochrome-P450s and Abc-Transporters Open
View article: Antioxidant, cytotoxic and anti-inflammatory properties of Anthemis tricolor Boiss. through a series of cellular assays and inhibition of Turkish Macrovipera lebetina obtusa venom induced inflammation in rat
Antioxidant, cytotoxic and anti-inflammatory properties of Anthemis tricolor Boiss. through a series of cellular assays and inhibition of Turkish Macrovipera lebetina obtusa venom induced inflammation in rat Open
Background and Aims: Venom of Macrovipera lebetina obtusa (Viperidae), Turkey’s biggest viper, is highly toxic to humans and causes inflammation. In Anatolian traditional medicine, many Anthemis L. species are used in wound healing and aga…
View article: Is Baikiain in Tara Flour a Causative Agent for the Adverse Events Associated with the Recalled Frozen French Lentil & Leek Crumbles Food Product? - A Working Hypothesis
Is Baikiain in Tara Flour a Causative Agent for the Adverse Events Associated with the Recalled Frozen French Lentil & Leek Crumbles Food Product? - A Working Hypothesis Open
The French Lentil & Leek Crumbles frozen food product was recently recalled due to reports of gastrointestinal issues. So far, 393 adverse illness complaints and 133 hospitalizations have been reported from consumption of this food, and th…
View article: Cannabinoid and Opioid Receptor Affinity and Modulation of Cancer-Related Signaling Pathways of Machaeriols and Machaeridiols from Machaerium Pers.
Cannabinoid and Opioid Receptor Affinity and Modulation of Cancer-Related Signaling Pathways of Machaeriols and Machaeridiols from Machaerium Pers. Open
Machaeriols and machaeridiols are unique hexahydrodibenzopyran-type aralkyl phytocannabinoids isolated from Machaerium Pers. Earlier studies of machaeriol A (1) and B (2) did not show any affinity for cannabinoid receptor 1 (CB1 or CNR1), …
View article: Machine learning and traditional QSAR modeling methods: a case study of known PXR activators
Machine learning and traditional QSAR modeling methods: a case study of known PXR activators Open
Pregnane X receptor (PXR), extensively expressed in human tissues related to digestion and metabolism, is responsible for recognizing and detoxifying diverse xenobiotics encountered by humans. To comprehend the promiscuous nature of PXR an…
View article: In Vitro Metabolism and CYP-Modulating Activity of Lavender Oil and Its Major Constituents
In Vitro Metabolism and CYP-Modulating Activity of Lavender Oil and Its Major Constituents Open
The application of essential oils has historically been limited to topical (massage therapy) and inhalational (aromatherapy) routes of administration. More recently, however, evaluation of the therapeutic effects of essential oils has expa…
View article: CCDC 2169157: Experimental Crystal Structure Determination
CCDC 2169157: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Interactions of <i>Phyllanthus Amarus</i> Extract and its Lignans with Xenobioticsensing Receptors (PXR and AHR), Cytochrome P450 Enzymes (CYP3A4 and CYP1A2) and ABC Transporters (P-GP and BCRP)
Interactions of <i>Phyllanthus Amarus</i> Extract and its Lignans with Xenobioticsensing Receptors (PXR and AHR), Cytochrome P450 Enzymes (CYP3A4 and CYP1A2) and ABC Transporters (P-GP and BCRP) Open
View article: Antiplasmodial and antimicrobial activities of e <i>nt</i> -abietane diterpenoids from the roots of <i>Suregada zanzibariensis</i>
Antiplasmodial and antimicrobial activities of e <i>nt</i> -abietane diterpenoids from the roots of <i>Suregada zanzibariensis</i> Open
The root extract of Suregada zanzibariensis Baill. afforded six previously described ent-abietane diterpenoids, namely 7-oxo-ent-abieta-5(6),8(14),13(15)-trien-16,12-olide (1), mangiolide (2), 8,14β
View article: CCDC 2149671: Experimental Crystal Structure Determination
CCDC 2149671: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Expanding the scope of novel 1,2,3-triazole derivatives as new antiparasitic drug candidates
Expanding the scope of novel 1,2,3-triazole derivatives as new antiparasitic drug candidates Open
We have previously shown that prenyl and aliphatic 1,2,3-triazoles displayed antiparasitic and antimycobacterial activity. Herein, new series of analogues were prepared looking for antimalarial drug candidates.
View article: Screening of medicinal plants for possible herb-drug interactions through modulating nuclear receptors, drug-metabolizing enzymes and transporters
Screening of medicinal plants for possible herb-drug interactions through modulating nuclear receptors, drug-metabolizing enzymes and transporters Open
View article: CCDC 2153609: Experimental Crystal Structure Determination
CCDC 2153609: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2153596: Experimental Crystal Structure Determination
CCDC 2153596: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Computational Tools to Expedite the Identification of Potential PXR Modulators in Complex Natural Product Mixtures: A Case Study with Five Closely Related Licorice Species
Computational Tools to Expedite the Identification of Potential PXR Modulators in Complex Natural Product Mixtures: A Case Study with Five Closely Related Licorice Species Open
The genus Glycyrrhiza, comprising approximately 36 spp., possesses complex structural diversity and is documented to possess a wide spectrum of biological activities. Understanding and finding the mechanisms of efficacy or safety fo…
View article: Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers
Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers Open
Primaquine (PQ) is a racemic drug used in treatment of malaria for six decades. Recent studies suggest that the two enantiomers of PQ are differentially metabolized in animals, and this results in different pharmacological and toxicologica…
View article: A Multitarget Approach to Evaluate the Efficacy of Aquilaria sinensis Flower Extract against Metabolic Syndrome
A Multitarget Approach to Evaluate the Efficacy of Aquilaria sinensis Flower Extract against Metabolic Syndrome Open
Aquilaria sinensis (Lour.) Spreng is known for its resinous secretion (agarwood), often secreted in defense against injuries. We investigated the effects of A. sinensis flower extract (AF) on peroxisome proliferator-activated receptors alp…
View article: Screening of Medicinal Plants for Possible Herb-Drug Interactions Through Modulating Nuclear Receptors, Drug-Metabolizing Enzymes and Transporters
Screening of Medicinal Plants for Possible Herb-Drug Interactions Through Modulating Nuclear Receptors, Drug-Metabolizing Enzymes and Transporters Open
View article: Anti-inflammatory and cytotoxic specialised metabolites from the leaves of Glandularia × hybrida
Anti-inflammatory and cytotoxic specialised metabolites from the leaves of Glandularia × hybrida Open
View article: Anti-hyperglycemic and anti-hyperlipidemic effects of a methanolic extract of Debregeasia salicifolia in Alloxan-induced diabetic albino mice
Anti-hyperglycemic and anti-hyperlipidemic effects of a methanolic extract of Debregeasia salicifolia in Alloxan-induced diabetic albino mice Open
Diabetes mellitus (DM), an endocrine syndrome characterized by high blood glucose levels due to abrogated insulin activity. The existing treatments for DM have side effects and varying degrees of efficacy. Therefore, it is paramount that n…
View article: Rational Design of a Cu Chelator That Mitigates Cu‐Induced ROS Production by Amyloid Beta
Rational Design of a Cu Chelator That Mitigates Cu‐Induced ROS Production by Amyloid Beta Open
Alzheimer's disease severely perturbs transition metal homeostasis in the brain leading to the accumulation of excess metals in extracellular and intraneuronal locations. The amyloid beta protein binds these transition metals, ultimately c…