Ahmed K. Oraby
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View article: A single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein
A single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein Open
View article: A Single Amino Acid Mutation Alters the Neutralization Epitopes in the Respiratory Syncytial Virus Fusion Glycoprotein
A Single Amino Acid Mutation Alters the Neutralization Epitopes in the Respiratory Syncytial Virus Fusion Glycoprotein Open
Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization. All current available RSV therapeutics, including antibody prophylaxis and adult vaccination, target the RSV fusion glycoprotein (RSV-F). The seven neutraliz…
View article: Structure-Based Discovery of Allosteric Inhibitors Targeting a New Druggable Site in the Respiratory Syncytial Virus Polymerase
Structure-Based Discovery of Allosteric Inhibitors Targeting a New Druggable Site in the Respiratory Syncytial Virus Polymerase Open
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory infections for which effective treatment options remain limited. Herein, we employed a computational structure-based design strategy aimed at identifying potent…
View article: A Single Amino Acid Mutation Alters the Neutralization Epitopes in the Respiratory Syncytial Virus Fusion Glycoprotein
A Single Amino Acid Mutation Alters the Neutralization Epitopes in the Respiratory Syncytial Virus Fusion Glycoprotein Open
Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization. All current available RSV therapeutics including antibody prophylaxis and adult vaccination target the RSV fusion glycoprotein (RSV-F).The seven neutralizati…
View article: CCHFV entry via LDLR keeps it ‘ticking’?
CCHFV entry via LDLR keeps it ‘ticking’? Open
View article: Mapping respiratory syncytial virus fusion protein interactions with the receptor IGF1R and the impact of alanine-scanning mutagenesis on viral infection
Mapping respiratory syncytial virus fusion protein interactions with the receptor IGF1R and the impact of alanine-scanning mutagenesis on viral infection Open
Respiratory syncytial virus (RSV) has two main surface glycoproteins, the attachment glycoprotein (G) and the fusion (F) protein, which together mediate viral entry. Attachment is mediated by the RSV-G protein, while the RSV-F protein make…
View article: Micellization thermodynamics as a function of the temperature of a cationic zwitterionic dodecyl phosphocholine and anionic sodium dodecyl sulfate mixed micelles with fluorometry
Micellization thermodynamics as a function of the temperature of a cationic zwitterionic dodecyl phosphocholine and anionic sodium dodecyl sulfate mixed micelles with fluorometry Open
As fluorescence parameters such as lifetime, quantum yield, anisotropy and polarisation quantum are extremely sensitive to fluorophores’ microenvironmental changes, changes in the properties of the fluorescence probe have been widely used …
View article: Respiratory Syncytial Virus Evolution by Adaptation
Respiratory Syncytial Virus Evolution by Adaptation Open
Respiratory syncytial virus (RSV) infection is the most common cause of infant hospitalizations worldwide, and in the absence of an RSV vaccine, antibody prophylaxis is the only means of protection. The two types of RSV, RSVA and RSVB, sha…
View article: Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs
Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs Open
Deregulation and changes in energy metabolism are emergent and important biomarkers of cancer cells. The uptake of hexoses in cancer cells is mediated by a family of facilitative hexose membrane-transporter proteins known as Glucose Transp…
View article: A Novel Small Molecule Inhibits Hepatitis C Virus Propagation in Cell Culture
A Novel Small Molecule Inhibits Hepatitis C Virus Propagation in Cell Culture Open
The discovery of curative antiviral drugs for a chronic disease such as HCV infection has encouraged drug discovery in the context of other viruses for which no curative drugs currently exist. Since we currently face a novel virus that has…
View article: CCDC 1577438: Experimental Crystal Structure Determination
CCDC 1577438: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1577437: Experimental Crystal Structure Determination
CCDC 1577437: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Correction: Metal ion binding properties of a bimodal triazolyl-functionalized calix[4]arene on a multi-array microcantilever system. Synthesis, fluorescence and DFT computation studies
Correction: Metal ion binding properties of a bimodal triazolyl-functionalized calix[4]arene on a multi-array microcantilever system. Synthesis, fluorescence and DFT computation studies Open
Correction for ‘Metal ion binding properties of a bimodal triazolyl-functionalized calix[4]arene on a multi-array microcantilever system. Synthesis, fluorescence and DFT computation studies’ by Abdullah N. Alodhayb et al., RSC Adv., 2016, …