Ahmed Sayadi
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View article: The construction and validation of sub-phenotype-specific genetic risk scores in systemic lupus erythematosus: a novel approach using large-scale biobank data
The construction and validation of sub-phenotype-specific genetic risk scores in systemic lupus erythematosus: a novel approach using large-scale biobank data Open
Systemic lupus erythematosus (SLE) is an autoimmune disease with a heterogenous clinical picture. This study aimed to link genetic SLE predisposition with relevant clinical manifestations using a two-step approach. First, we identified dat…
View article: Neonatal Deep Vein Thrombosis Reveals an Inferior Vena Cava Agenesis associated with Antithrombin Deficiency: A Case Report
Neonatal Deep Vein Thrombosis Reveals an Inferior Vena Cava Agenesis associated with Antithrombin Deficiency: A Case Report Open
View article: P77 Identification of a cluster of SLE risk loci associated with levels of multiple blood biomarkers in the general population – Implication for SLE sub-phenotypes
P77 Identification of a cluster of SLE risk loci associated with levels of multiple blood biomarkers in the general population – Implication for SLE sub-phenotypes Open
Objective Genetic contribution is crucial for SLE pathogenesis, but linking risk variants to specific mechanisms in SLE is challenging. We utilize UK Biobank data and a large well defined SLE cohort to investigate associations between SLE …
View article: P13 Acquired ficolin-3 deficiency in patients with systemic lupus erythematosus
P13 Acquired ficolin-3 deficiency in patients with systemic lupus erythematosus Open
Objective Ficolin-3 is the main initiator of the lectin pathway of complement in humans. Case reports of ficolin-3 deficient patients have suggested that ficolin-3 deficiency may be enriched in patients with Systemic Lupus Erythematosus (S…
View article: O16 pQTL analysis of ficolin-3 activity reveals a link between the lectin pathway of complement and hematological disease manifestations in systemic lupus erythematosus
O16 pQTL analysis of ficolin-3 activity reveals a link between the lectin pathway of complement and hematological disease manifestations in systemic lupus erythematosus Open
Objective The complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical pathway. Ficolin-3 is the main initiator of the lectin pathway of complement in …
View article: A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile
A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile Open
View article: Repeat annotation of a chromosomal-level assembly of the Callosobruchus maculatus genome
Repeat annotation of a chromosomal-level assembly of the Callosobruchus maculatus genome Open
A curated repeat library was constructed by manually curating the most abundant interspersed repeats identified using RepeatModeler (Smit et al., 2010). The curated library was combined with a beetle-spe…
View article: Repeat annotation of a chromosomal-level assembly of the Callosobruchus maculatus genome
Repeat annotation of a chromosomal-level assembly of the Callosobruchus maculatus genome Open
A curated repeat library was constructed by manually curating the most abundant interspersed repeats identified using RepeatModeler (Smit et al., 2010). The curated library was combined with a beetle-spe…
View article: Experimental Life History Evolution Results in Sex-specific Evolution of Gene Expression in Seed Beetles
Experimental Life History Evolution Results in Sex-specific Evolution of Gene Expression in Seed Beetles Open
The patterns of reproductive timing and senescence vary within and across species owing to differences in reproductive strategies, but our understanding of the molecular underpinnings of such variation is incomplete. This is perhaps partic…
View article: S10.2 Interaction between HLA-DRB1*03:01 and stat4 is associated with increased risk of nephritis in systemic lupus erythematosus
S10.2 Interaction between HLA-DRB1*03:01 and stat4 is associated with increased risk of nephritis in systemic lupus erythematosus Open
Purpose Lupus nephritis (LN) is a major cause of morbidity in Systemic Lupus Erythematosus (SLE) and a subset of patients still develop end stage renal disease (ESRD). Genetics is important in SLE pathogenesis and today >180 SLE risk loci …
View article: A possible genomic footprint of polygenic adaptation on population divergence in seed beetles?
A possible genomic footprint of polygenic adaptation on population divergence in seed beetles? Open
Efforts to unravel the genomic basis of incipient speciation are hampered by a mismatch between our toolkit and our understanding of the ecology and genetics of adaptation. While the former is focused on detecting selective sweeps involvin…
View article: Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs Open
SUMMARY Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions. Studies of motif-mediated interactions therefore provide insight into virus-host dependencies, and reveal targets for therapeutic intervent…
View article: Extensive pan-viral mimicry of host short linear motifs hijack of the human interactome
Extensive pan-viral mimicry of host short linear motifs hijack of the human interactome Open
Code used for generating Figure 2D,E,F and supp Figure 2,3,4
View article: Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities Open
Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, current methods do not identify this important class of protein-protein interactions. Uncovering peptide mediated interactions …
View article: Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome
Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome Open
Specific protein-protein interactions are central to all processes that underlie cell physiology. Numerous studies using a wide range of experimental approaches have identified tens of thousands of human protein-protein interactions. Howev…
View article: Additional file 1 of Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity
Additional file 1 of Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity Open
Additional file 1: Table S1. Sex-specific regulation of gene expression related to the proPO activating system.
View article: Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity
Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity Open
Background Sexual selection can have major effects on mating rates and sex-specific costs of mating and may thereby influence sex-differences in immunity as well as associated host-pathogen dynamics. Yet, experimental evidence linking the …
View article: The genomic footprint of sexual conflict
The genomic footprint of sexual conflict Open
Genes with sex-biased expression show a number of unique properties and this has been seen as evidence for conflicting selection pressures in males and females, forming a genetic ‘tug-of-war’ between the sexes. However, we lack studies of …
View article: NBISweden/ReprRes_G_Arnqvist_1305: The genomic footprint of sexual conflict -- supplementary data and scripts
NBISweden/ReprRes_G_Arnqvist_1305: The genomic footprint of sexual conflict -- supplementary data and scripts Open
Scripts and additional files needed to perform the underlying analyses and create tables and plots used in Sayadi et al. The genomic footprint of sexual conflict [NBIS Reproducible research for project G_Arnqvist_1305]
View article: The Evolution of Dark Matter in the Mitogenome of Seed Beetles
The Evolution of Dark Matter in the Mitogenome of Seed Beetles Open
Animal mitogenomes are generally thought of as being economic and optimized for rapid replication and transcription. We use long-read sequencing technology to assemble the remarkable mitogenomes of four species of seed beetles. These are t…
View article: Genome size correlates with reproductive fitness in seed beetles
Genome size correlates with reproductive fitness in seed beetles Open
The ultimate cause of genome size (GS) evolution in eukaryotes remains a major and unresolved puzzle in evolutionary biology. Large-scale comparative studies have failed to find consistent correlations between GS and organismal properties,…