Amany A. Sleem
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View article: Lasting Multiorgan Protective Effect of Stem Cells in Systemic Endotoxaemia
Lasting Multiorgan Protective Effect of Stem Cells in Systemic Endotoxaemia Open
Stem cells exhibit protective properties in models of systemic endotoxaemia. This study aimed to explore whether stem cells could provide a sustained protective effect against oxidative stress, inflammation, and organ tissue damage in mice…
View article: Effect of the TRPV1 Receptor Agonist Capsaicin on Electrocardiogram Parameters and Cardiac Histology in Anaesthetized Rats
Effect of the TRPV1 Receptor Agonist Capsaicin on Electrocardiogram Parameters and Cardiac Histology in Anaesthetized Rats Open
Capsaicin, the pungent principle of hot peppers of the plant genus Capsicum simulates and in large concentrations desensitizes sensory and vagal nerve fibers which express transient receptor potential cation channel vanilloid subfamily mem…
View article: The Protective Effect of Isosorbide Dinitrate or L-arginine on Acute Ethanol-induced Oxidative Stress and Histopathological Changes in Different Organs
The Protective Effect of Isosorbide Dinitrate or L-arginine on Acute Ethanol-induced Oxidative Stress and Histopathological Changes in Different Organs Open
In this study, the effects of the nitric oxide donor isosorbide dinitrate (ISDN) and the nitric oxide precursor L-arginine on oxidative stress and histopathological changes induced by 96% ethanol in the brain, liver and gastric tissue were…
View article: Sorafenib-treated hepatocellular carcinoma with or without prior direct-acting antiviral therapy for hepatitis C: outcomes and survival
Sorafenib-treated hepatocellular carcinoma with or without prior direct-acting antiviral therapy for hepatitis C: outcomes and survival Open
Background Hepatitis C virus (HCV) has been linked to lower tumor growth rates, higher sorafenib efficacy, and greater survival of patients treated for hepatocellular carcinoma (HCC). In real-world settings, we tried to elucidate the effec…
View article: Neuroprotective Effect of Magnesium Oxide/gluconate in Transient Global Cerebral Ischemia in the Rat Brain
Neuroprotective Effect of Magnesium Oxide/gluconate in Transient Global Cerebral Ischemia in the Rat Brain Open
Ischemic stroke represents a major contributor to global morbidity and mortality rates. This study aims to explore the impact of magnesium salts on oxidative stress and the degree of cerebral damage in rats subjected to transient global ce…
View article: Brain Derived Neurotrophic Factor and Neuron Specific Enolase Levels as Markers of Drugs of Abuse Induced Neuronal Injury
Brain Derived Neurotrophic Factor and Neuron Specific Enolase Levels as Markers of Drugs of Abuse Induced Neuronal Injury Open
The protein brain derived neurotrophic factor (BDNF) is a member of the neurotrophins family involved in neuronal differentiation and survival and in regulation of synaptic plasticity in brain. Neuron specific enolase (NSE) is found in the…
View article: The Effect of Repeated Administration of Cannabis on the Electrocardiogram and Cardiac Histology in Normal and Epinephrine-treated Rats
The Effect of Repeated Administration of Cannabis on the Electrocardiogram and Cardiac Histology in Normal and Epinephrine-treated Rats Open
Cannabis, recognized as the most prevalent illegal drug globally, has been linked to various acute cardiovascular incidents, including arrhythmias such as premature ventricular contractions, ventricular tachycardia, sinus arrest, and myoca…
View article: Antimicrobial, antibiofilm, cytotoxicity, and anti-DNA topoisomerase activity of Streptomyces sp. 22SH with ADME and in silico study
Antimicrobial, antibiofilm, cytotoxicity, and anti-DNA topoisomerase activity of Streptomyces sp. 22SH with ADME and in silico study Open
The genus Streptomyces has been recently proven to be a valuable and rich source of producing several bioactive compounds with substantial biological activity and applications in many fields such as medicine, environmental science, food in…
View article: The Acute Effects of Cannabis on Cardiac Arrhythmia and Myocardial Injury Induced by Epinephrine in the Rat
The Acute Effects of Cannabis on Cardiac Arrhythmia and Myocardial Injury Induced by Epinephrine in the Rat Open
Cannabis, the most common illicit substance worldwide, has been associated with acute cardiovascular events such as arrhythmia including premature ventricular contractions, ventricular tachycardia, sinus arrest, and myocardial infarction. …
View article: Effect of L-dopa or bromocryptine alone or in combination with cannabis on oxidative stress, inflammation and neurodegeneration in experimental Parkinson’s disease
Effect of L-dopa or bromocryptine alone or in combination with cannabis on oxidative stress, inflammation and neurodegeneration in experimental Parkinson’s disease Open
This study aimed to investigate whether cannabis would modulate the effects of the antiparkinsonian drugs L-dopa or bromocryptine on striatal oxidative stress, neuroinflammation, and neuronal integrity in an experimental Parkinson's diseas…
View article: Novel Antiarrhythmic and Cardioprotective Effects of Brilliant Blue G
Novel Antiarrhythmic and Cardioprotective Effects of Brilliant Blue G Open
In this study, we investigated the effects of the purinergic P2X7 receptor antagonist brilliant blue G (BBG) on cardiac arrhythmia and myocardial injury induced by intravenously (i.v.) administered epinephrine in anesthetized rats. We also…
View article: Retraction Note: Comparative study of the antioxidant, toxicity, anti-inflammatory, and wound healing activities of both Digenea simplex polysaccharides and their corresponding (ZnO–Au) bimetallic nanoparticles
Retraction Note: Comparative study of the antioxidant, toxicity, anti-inflammatory, and wound healing activities of both Digenea simplex polysaccharides and their corresponding (ZnO–Au) bimetallic nanoparticles Open
View article: Protection by L-arginine Against Epinephrine-induced Arrhythmia and Cardiotoxicity
Protection by L-arginine Against Epinephrine-induced Arrhythmia and Cardiotoxicity Open
Nitric oxide is important in control of coronary blood flow, cardiomyocyte contractility, cardiac rhythm, and thrombogenicity. We aimed to investigate the effect of the nitric oxide precursor L-arginine on cardiac arrhythmia and myocardial…
View article: Nefopam exerts anticonvulsant and neuroprotective effects in experimentally-induced status epilepticus
Nefopam exerts anticonvulsant and neuroprotective effects in experimentally-induced status epilepticus Open
Nefopam is a centrally acting, non-opiate analgesic drug used in the prevention of post-operative pain. In this study, the effect of nefopam on epileptic seizures and neuronal brain damage induced in the rat by pentylenetetrazole (PTZ) was…
View article: Monocyte chemoattractant protein-1 and cyclooxygenase enzymes in rats treated with drugs of abuse
Monocyte chemoattractant protein-1 and cyclooxygenase enzymes in rats treated with drugs of abuse Open
The CC chemokine monocyte chemoattractant protein (MCP)-1/CCL2 and cyclo-oxygenase-2 enzyme are potent mediators of neuroinflammation. We studied the effect of treatment with Cannabis sativaresin extract and/or tramadol, two common drugs o…
View article: The protective effects of methylene blue on thioacetamide-induced acute liver and brain injury
The protective effects of methylene blue on thioacetamide-induced acute liver and brain injury Open
This study aimed to investigate the potential protective effects of methylene blue (MethyB) on thioacetamide (TAA)-induced acute liver and brain injury in rats.TAA (300 mg/kg) was administrated intraperitoneally (i.p.) with or without Meth…
View article: The Effects of Nitric Oxide Synthase Inhibition on Epinephrine-Induced Arrhythmia and Myocardial Damage
The Effects of Nitric Oxide Synthase Inhibition on Epinephrine-Induced Arrhythmia and Myocardial Damage Open
We have recently reported that methylene blue (MethyB) was able to inhibit epinephrine-induced arrhythmias and cardiac muscle injury. In this study, we investigated the effect of nitric oxide synthase inhibition by NG-nitro-L-arginine meth…
View article: A Comparative GC/MS Analysis of Citrus Essential Oils: Unveiling the Potential Benefits of Herb‐Drug Interactions in Preventing Paracetamol‐Induced Hepatotoxicity
A Comparative GC/MS Analysis of Citrus Essential Oils: Unveiling the Potential Benefits of Herb‐Drug Interactions in Preventing Paracetamol‐Induced Hepatotoxicity Open
Our study aimed to test the potential of Citrus oils in protecting against paracetamol (PAR)‐induced hepatotoxicity. The essential oils of Pineapple sweet orange (OO), Murcott mandarin (MO), Red grapefruit (GO), and Oval kumquat (KO) were …
View article: Taming Food–Drug Interaction Risk: Potential Inhibitory Effects of Citrus Juices on Cytochrome Liver Enzymes Can Safeguard the Liver from Overdose Paracetamol-Induced Hepatotoxicity
Taming Food–Drug Interaction Risk: Potential Inhibitory Effects of Citrus Juices on Cytochrome Liver Enzymes Can Safeguard the Liver from Overdose Paracetamol-Induced Hepatotoxicity Open
Paracetamol overdose is the leading cause of drug-induced hepatotoxicity worldwide. Because of N-acetyl cysteine's limited therapeutic efficacy and safety, searching for alternative therapeutic substitutes is necessary. This study i…
View article: Effect of propranolol, bisoprolol and terbutaline in acute brain injury induced by malathion in the rat
Effect of propranolol, bisoprolol and terbutaline in acute brain injury induced by malathion in the rat Open
The pharmacological management of acute malathion poisoning entails besides the use of the specific antidotes atropine and oximes, the administration of other drugs for controlling associated cardiac and respiratory problems.In this study,…
View article: Effect of Andrographis paniculata in experimental models of pain and inflammation
Effect of Andrographis paniculata in experimental models of pain and inflammation Open
We investigated the effect of a standardized extract of the plant Andrographis paniculata in carrageenan induced paw oedema and in acute thermal, electric and visceral inflammatory pain models in rats.The effects of the extract on spontane…
View article: The effect of the imidazoline receptor agonist rilmenidine on visceral and thermal nociceptive pain in mice
The effect of the imidazoline receptor agonist rilmenidine on visceral and thermal nociceptive pain in mice Open
The effect of the centrally acting imidazoline agonist rilmenidine was examined in acute visceral and thermal nociceptive pain models, Porsolt's forced swimming test and rotarod test in mice.Rilmenidine given intraperitoneally (i.p.) at do…
View article: Cardioprotection by methylene Blue Against Epinephrine-Induced Cardiac Arrhythmias and Myocardial Injury
Cardioprotection by methylene Blue Against Epinephrine-Induced Cardiac Arrhythmias and Myocardial Injury Open
Methylene blue is used in the treatment of vasoplegic syndrome after cardiac surgery, anaphylaxis, and septic shock refractory to epinephrine and fluid resuscitation. In this study, we investigated the potential protective effect of methyl…
View article: The Protection by Vitamin E Against Tramadol-Induced Proconvulsant Effects and Brain Damage in Pentylenetetrazole-Induced Status Epilepticus in Rats
The Protection by Vitamin E Against Tramadol-Induced Proconvulsant Effects and Brain Damage in Pentylenetetrazole-Induced Status Epilepticus in Rats Open
We investigated the effect of the opioid analgesic tramadol on the development of epileptic seizures and neuronal injury and the possible modulatory effect of vitamin E (Vit E) in rats with pentylenetetrazole (PTZ)-induced status epileptic…
View article: RETRACTED ARTICLE: Comparative study of the antioxidant, toxicity, anti-inflammatory, and wound healing activities of both Digenea simplex polysaccharides and their corresponding (ZnO–Au) bimetallic nanoparticles
RETRACTED ARTICLE: Comparative study of the antioxidant, toxicity, anti-inflammatory, and wound healing activities of both Digenea simplex polysaccharides and their corresponding (ZnO–Au) bimetallic nanoparticles Open
The development of green nanoparticle synthesis has multiple benefits over conventional physico-chemical techniques and provides a wide range of medical and biological applications. This study aims to synthesize zinc oxide nanoparticles (Z…
View article: Potential therapeutic effects of isolated polysaccharides from some edible plant wastes: Characterization and bioactivities
Potential therapeutic effects of isolated polysaccharides from some edible plant wastes: Characterization and bioactivities Open
Polysaccharides have various effects and exhibit several bioactivities that possess an enormous influence on healthcare due to their therapeutic beneficial and comparatively low toxicity.The study is focusing in investigation of the chemic…
View article: Citric Acid Administration Protects Against Insulin-Induced Hypoglycemic Brain and Liver Injury
Citric Acid Administration Protects Against Insulin-Induced Hypoglycemic Brain and Liver Injury Open
We aimed to investigate the effect of treatment with citric acid on oxidative stress and tissue injury in brain and liver of rats subjected to hypoglycaemia. Rats received intraperitoneal injections of insulin (5 IU/kg) followed 30 min lat…
View article: Inhibition Of Pentylenetetrazole-Induced Seizures And Neuronal Injury By Brilliant Blue G: Role Of Oxidative Stress, And Brain Derived Neurotrophic Factor
Inhibition Of Pentylenetetrazole-Induced Seizures And Neuronal Injury By Brilliant Blue G: Role Of Oxidative Stress, And Brain Derived Neurotrophic Factor Open
We aimed to investigate the effect of the P2X7 purinergic receptor antagonist brilliant blue G (BBG) on epileptic seizures, brain oxidative stress and neuronal injury induced in rats by pentylenetetrazole (PTZ). Rats received repeated intr…
View article: Acrocarpus fraxinifolius Wight and Arn. Bark; phenolics, toxicity studies, antioxidant and anti-inflammatory activities
Acrocarpus fraxinifolius Wight and Arn. Bark; phenolics, toxicity studies, antioxidant and anti-inflammatory activities Open
The purpose of the survey was to determine acute & chronic toxicity; in vivo antioxidant and anti-inflammatory actions of the different extracts of A. fraxinifolius Wight and Arn bark; along with estimation of the phenolic, flavonoidal con…
View article: Methylene Blue Protects Against Acute Ethanol-Induced Oxidative Stress and Organ Damage
Methylene Blue Protects Against Acute Ethanol-Induced Oxidative Stress and Organ Damage Open
Ethanol (EtOH) intake is an important global health problem which affects many organs such as the brain, liver and stomach. The aim of the study was to examine the effect of the redox dye methylene blue (MethyB) on oxidative stress and his…