Ahnika Kline
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View article: A Cell-Free DNA Plasma Next-Generation Sequencing Test—Is It Worth the Cost?
A Cell-Free DNA Plasma Next-Generation Sequencing Test—Is It Worth the Cost? Open
Background: The Karius Test (KT), a microbial cell-free DNA next-generation sequencing assay, is increasingly utilized in challenging infectious syndromes. However, its real-world clinical utility and cost-effectiveness remain uncertain. M…
View article: Current Clinical Laboratory Challenges to Widespread Adoption of Phage Therapy in the United States
Current Clinical Laboratory Challenges to Widespread Adoption of Phage Therapy in the United States Open
The resurgence of phage therapy in Western societies has been in direct response to recent increases in antimicrobial resistance (AMR) that have ravaged many societies. While phage therapy as a concept has been around for over 100 years, i…
View article: P-1358. Understanding Fungal Infections and Trends in Fungal Resistance: A Single Center Evaluation
P-1358. Understanding Fungal Infections and Trends in Fungal Resistance: A Single Center Evaluation Open
Background Invasive fungal infections cost the US health care system billions and are challenging to treat. In 2021 alone, the CDC estimates that fungal infections contributed to over $7 billion in direct medical costs and over 7,000 death…
View article: Neurological manifestations of nontuberculous mycobacteria in adults: case series and review of the literature
Neurological manifestations of nontuberculous mycobacteria in adults: case series and review of the literature Open
Introduction Nontuberculous mycobacteria (NTM) mediated infections are important to consider in cases with neuroinflammatory presentations. We aimed to characterize cases of NTM with neurological manifestations at the National Institutes o…
View article: A simple solid media assay for detection of synergy between bacteriophages and antibiotics
A simple solid media assay for detection of synergy between bacteriophages and antibiotics Open
The emergence of antibiotic-resistant bacteria (ARB) has necessitated the development of alternative therapies to deal with this global threat. Bacteriophages (viruses that target bacteria) that kill ARB are one such alternative. Although …
View article: 826. Decision to Treat <i>Pneumocystis Jirovecii</i> Pneumonia by Combining Molecular Diagnostics and Patient Specific Factors
826. Decision to Treat <i>Pneumocystis Jirovecii</i> Pneumonia by Combining Molecular Diagnostics and Patient Specific Factors Open
Background Pneumocystis jirovecii pneumonia (PJP) diagnosis on immunocompromised patients with or without HIV has changed over time. Molecular methods have substituted microscopic methods that can be subjective, labor intensive, and requir…
View article: A simple solid media assay for detection of synergy between bacteriophages and antibiotics
A simple solid media assay for detection of synergy between bacteriophages and antibiotics Open
The emergence of antibiotic resistant bacteria (ARB) has necessitated the development of alternative therapies to deal with this global threat. Bacteriophages (viruses that target bacteria) that kill ARB are one such alternative. While pha…
View article: Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia
Epidemiologic, clinical, and serum markers may improve discrimination between bacterial and viral etiologies of childhood pneumonia Open
Background Discrimination of bacterial and viral etiologies of childhood community-acquired pneumonia (CAP) is often challenging. Unnecessary antibiotic administration exposes patients to undue risks and may engender antimicrobial resistan…
View article: Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study
Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study Open
Objective To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach. Design ‘Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)’ study was an o…
View article: Case Commentary: Long-Term Fosmanogepix Use in a Transplant Recipient with Disseminated Aspergillosis Caused by Azole-Resistant Aspergillus calidoustus
Case Commentary: Long-Term Fosmanogepix Use in a Transplant Recipient with Disseminated Aspergillosis Caused by Azole-Resistant Aspergillus calidoustus Open
Aspergillus calidoustus is an emerging, azole-resistant, cryptic Aspergillus species in immunosuppressed patients that often features extrapulmonary involvement and carries high mortality. The case presented by J.
View article: Approach to Identifying Causative Pathogens of Community-Acquired Pneumonia in Children Using Culture, Molecular, and Serology Tests
Approach to Identifying Causative Pathogens of Community-Acquired Pneumonia in Children Using Culture, Molecular, and Serology Tests Open
Determining the causative pathogen(s) of community-acquired pneumonia (CAP) in children remains a challenge despite advances in diagnostic methods. Currently available guidelines generally recommend empiric antimicrobial therapy when the s…
View article: Dacron swab and PBS are acceptable alternatives to flocked swab and viral transport media for SARS-CoV-2
Dacron swab and PBS are acceptable alternatives to flocked swab and viral transport media for SARS-CoV-2 Open
View article: 277. Identification and Antifungal Susceptibility of Candida Species Isolated from Bloodstream Infections Over a 14-Year Period
277. Identification and Antifungal Susceptibility of Candida Species Isolated from Bloodstream Infections Over a 14-Year Period Open
Background Invasive infections caused by Candida species are associated with significant morbidity and mortality. Historically, C. albicans has been the predominant species recovered from patients with candidemia. However, the changing epi…