Ai‐Lan Lee
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EDA photochemistry using continuous flow Open
In recent years, electron donor–acceptor (EDA) complexes have emerged as sustainable, cost-effective, and inherently safer alternatives to traditional transition metal-based photocatalysts in photochemical processes. Formed via the associa…
Light-Mediated Tandem Giese/C–H Functionalizations Toward Cyclopenta[<i>b</i>]indoles Open
An efficient method for forming cyclopenta[b]indoles directly from 3-indole-α-ketoacids via tandem Giese/C-H functionalization has been developed. The use of photoactive 3-indole-α-ketoacids as radical precursors allows for the mild tandem…
View article: Cascade Reactions of Enone‐Tethered Ketones and Aldehydes with Indoles: Substrate‐Controlled Divergent Synthesis of Indenes and Indanes
Cascade Reactions of Enone‐Tethered Ketones and Aldehydes with Indoles: Substrate‐Controlled Divergent Synthesis of Indenes and Indanes Open
A cascade strategy involving the reactions of enone‐tethered ketones with indoles for the synthesis of indenes is outlined in the presence of iodine as a catalyst. Halogen bonding between molecular iodine and enones activates substrates to…
Light-Mediated Direct Decarboxylative Giese Aroylations without a Photocatalyst Open
Previous light-mediated approaches to the direct decarboxylative Giese aroylation reaction have mainly relied on the use of a photocatalyst and a reductive quenching pathway. By exploiting a mechanistically distinct oxidative protocol, we …
Direct C–H functionalisation of azoles <i>via</i> Minisci reactions Open
This review gives an overview of the C–H functionalisation of azoles via Minisci-type reactions, highlighting recent progress, existing limitations and potential areas for growth.
Direct C–H amidation of 1,3-azoles: light-mediated, photosensitiser-free <i>vs.</i> thermal Open
Direct C–H amidation of the four most important 1,3-azoles in medicinal chemistry has been developed and applied to late-stage functionalisation.
CCDC 2258061: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Direct decarboxylative Giese amidations: photocatalytic <i>vs.</i> metal- and light-free Open
A direct decarboxylative Giese amidation reaction from oxamic acids has been achieved, allowing easy access to previously inaccessible 1,4-difunctionalised compounds.
Direct Minisci-Type C–H Amidation of Purine Bases Open
A method for the C-H carboxyamidation of purines has been developed that is capable of directly installing primary, secondary, and tertiary amides. Previous Minisci-type investigations on purines were limited to alkylations and arylations.…
Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free Open
A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more…
Direct decarboxylative Giese reactions Open
This review summarizes recent progress on using carboxylic acids directly as convenient precursors for the 1,4-radical conjugate addition (Giese) reaction.
Direct C–H Functionalization of Phenanthrolines: Metal- and Light-Free Dicarbamoylations Open
A direct method for C-H dicarbamoylations of phenanthrolines has been developed, which is capable of directly installing primary, secondary as well as tertiary amides. This is a significant improvement on the previous direct method, which …
Heterogeneous photocatalysis in flow chemical reactors Open
The synergy between photocatalysis and continuous flow chemical reactors has shifted the paradigms of photochemistry, opening new avenues of research with safer and scalable processes that can be readily implemented in academia and industr…
Continuous-flow synthesis and application of polymer-supported BODIPY Photosensitisers for the generation of singlet oxygen; process optimised by in-line NMR spectroscopy Open
Commercial polystyrene Merrifield-type resins have been post-synthetically functionalised with BODIPY photosensitisers via a novel aryl ester linking strategy in continuous-flow. A unique synthetic advantage of post-synthetically modifying…
Synthesis and optoelectronic properties of benzoquinone-based donor–acceptor compounds Open
Herein, we report a mild and efficient palladium-catalyzed C–H functionalization method to synthesize a series of benzoquinone (BQ)-based charge-transfer (CT) derivatives in good yields. The optoelectronic properties of these compounds wer…
CCDC 1946937: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Silver Effect in Regiodivergent Gold-Catalyzed Hydroaminations Open
We report a silver-induced switching of regioselectivity in gold-catalyzed reactions, and we provide mechanistic evidence to suggest a true "silver effect": that is, one that is implicated in the catalytic process itself, via σ-gold π-silv…
CCDC 1832068: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 1816415: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes Open
Radiopharmaceuticals that incorporate radioactive iodine in combination with single‐photon emission computed tomography imaging play a key role in nuclear medicine, with applications in drug development and disease diagnosis. Despite this …
Auto‐Tandem Catalysis: Pd<sup>II</sup>‐Catalysed Dehydrogenation/Oxidative Heck Reaction of Cyclopentane‐1,3‐diones Open
A Pd II catalyst system has been used to successfully catalyse two mechanistically distinct reactions in a one‐pot procedure: dehydrogenation of 2,2‐disubstituted cyclopentane‐1,3‐diones and the subsequent oxidative Heck coupling. This aut…
Dual gold and photoredox catalysed C–H activation of arenes for aryl–aryl cross couplings Open
A mild and fully catalytic aryl–aryl cross coupling via gold-catalyzed C–H activation has been achieved by merging gold and photoredox catalysis.
Chirality Transfer in Gold(I)‐Catalysed Hydroalkoxylation of 1,3‐Disubstituted Allenes Open
Gold(I)‐catalysed intermolecular hydroalkoxylation of enantioenriched 1,3‐disubstituted allenes was previously reported to occur with poor chirality transfer due to rapid allene racemisation. The first intermolecular hydroalkoxylation of a…
Dual gold photoredox C(sp<sup>2</sup>)–C(sp<sup>2</sup>) cross couplings – development and mechanistic studies Open
A new oxidant- and base-free dual catalysed C(sp2)–C(sp2) coupling between arylboronic acids and aryldiazonium salts has been developed. Mechanistic investigations reveal two divergent pathways depending on the gold catalyst employed.