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View article: Elucidating the role of APOE ε4 gene variants in the clinical manifestation of Parkinson's disease
Elucidating the role of APOE ε4 gene variants in the clinical manifestation of Parkinson's disease Open
Introduction Parkinson's Disease (PD) is the most common movement disorder, and remains a major cause of mortality and morbidity worldwide. Studies have uncovered the potential role of the Apolipoprotein (APOE) gene in PD, although results…
View article: Association of rare <i>APOE</i> missense variants with Alzheimer's disease in the Japanese population
Association of rare <i>APOE</i> missense variants with Alzheimer's disease in the Japanese population Open
Background Little is known about the rare missense variants (RMVs) of APOE in East Asians, including the Japanese, and their association with Alzheimer's disease (AD) and lipid metabolism. Objective To identify APOE RMVs in the Japanese po…
View article: <i>APOE</i> rare missense variants in Japan
<i>APOE</i> rare missense variants in Japan Open
Background APOE is well recognized to be the most influential susceptibility gene for Alzheimer’s disease (AD). For the wild‐type allele, e3 , it is known that the e4 allele is a risk for AD, while the e2 allele is protective. Recently, ge…
View article: Association of rare<i>APOE</i>missense variants with Alzheimer's disease in the Japanese population
Association of rare<i>APOE</i>missense variants with Alzheimer's disease in the Japanese population Open
Background: APOE is a major susceptibility gene for Alzheimer's disease (AD). Recent studies in Europe and the US have identified rare missense variants (RMVs) in APOE which are significantly associated with AD. However, little is known re…