Ai Peng
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View article: TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation
TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation Open
Cells adapt to nutrient limitation by activating catabolic and inhibiting anabolic pathways, yet prolonged stress may lead to cell death. How cells orchestrate metabolic adaptation and cell death to nutrient stress is poorly understood. We…
View article: Altered fecal microbial and metabolic profiles reveal potential mechanisms underlying anemia in patients with chronic renal failure
Altered fecal microbial and metabolic profiles reveal potential mechanisms underlying anemia in patients with chronic renal failure Open
The gut microbiomes communicate with the kidney and may play a crucial role in the development of anemia in patients with chronic renal failure (CRF). However, the alterations in microbiota and their association with functional metabolites…
View article: Delineating circulating lymphocyte subsets in the transition from gout remission to recurrence
Delineating circulating lymphocyte subsets in the transition from gout remission to recurrence Open
Objectives Lymphocytes and their subsets are implicated in both the onset and remission of gout. However, the specific roles in gout recurrence and complete remission remain unclear. This study aimed to characterize lymphocyte immunophenot…
View article: Development and validation of multi-center serum creatinine-based models for noninvasive prediction of kidney fibrosis in chronic kidney disease
Development and validation of multi-center serum creatinine-based models for noninvasive prediction of kidney fibrosis in chronic kidney disease Open
This study presents a validated, noninvasive, multi-center Scr-based machine learning model for assessing kidney fibrosis severity in CKD. The integration of a clinical nomogram and ML approach offers a novel, practical alternative to biop…
View article: A new LF for Switched Systems with Sampled Control
A new LF for Switched Systems with Sampled Control Open
This study introduces a novel looped-function (LF) approach for evaluating the stability of linear switching systems under sampled-triggered control. The method introduced a novel stability of system and based on the discrete-time Lyapunov…
View article: Single-cell transcriptomics reveals variations in monocytes and Tregs between gout flare and remission
Single-cell transcriptomics reveals variations in monocytes and Tregs between gout flare and remission Open
Gout commonly manifests as a painful, self-limiting inflammatory arthritis. Nevertheless, the understanding of the inflammatory and immune responses underlying gout flares and remission remains ambiguous. Here, based on single-cell RNA-Seq…
View article: Rattling-like behavior and band convergence induced ultra-low lattice thermal conductivity in MgAl2Te4 monolayer
Rattling-like behavior and band convergence induced ultra-low lattice thermal conductivity in MgAl2Te4 monolayer Open
Inspired by the excellent stability of exhibited by experimentally synthesized two-dimensional (2D) MoSi2N4 layered material, the thermal and electronic transport, and thermoelectric (TE) properties of MgAl2Te4 monolayer are systematically…
View article: Ethnic disparities in bidirectional causal effects between serum uric acid concentrations and kidney function: Trans-ethnic Mendelian randomization study
Ethnic disparities in bidirectional causal effects between serum uric acid concentrations and kidney function: Trans-ethnic Mendelian randomization study Open
This trans-ethnic Mendelian randomization study confirmed the bidirectional causal effects between SUA concentrations and kidney function and highlighted the importance of considering ethnic disparities in clinical treatments.
View article: Association Study of Esomeprazole Pharmacokinetics and <i>CYP2C19</i> Gene Polymorphisms
Association Study of Esomeprazole Pharmacokinetics and <i>CYP2C19</i> Gene Polymorphisms Open
To investigate the association between esomeprazole pharmacokinetics and CYP2C19 gene polymorphisms in a cohort of 95 healthy Chinese participants. A cohort of 95 participants was assembled and stratified into 2 distinct groups, receiving …
View article: MSU crystal deposition contributes to inflammation and immune responses in gout remission
MSU crystal deposition contributes to inflammation and immune responses in gout remission Open
As a prominent feature of gout, monosodium urate (MSU) crystal deposition induces gout flares, but its impact on immune inflammation in gout remission remains unclear. Using single-cell RNA sequencing (scRNA-seq), we characterize the trans…
View article: Robust Alternating Multilayered Cellulose Nanofiber Composite Membranes Fabricated by High-Efficiency Ca 2+ -Precomplexed Vacuum-Assisted Self- Assembly towards Electromagnetic Interference Shielding
Robust Alternating Multilayered Cellulose Nanofiber Composite Membranes Fabricated by High-Efficiency Ca 2+ -Precomplexed Vacuum-Assisted Self- Assembly towards Electromagnetic Interference Shielding Open
One-dimensional cellulose nanofiber (CNF) is prone to constructing connected nanofiber networks in vacuum-assisted self-assembly due to intense hydrogen bonds, which exhibits great superiority in fabricating electromagnetic interference (E…
View article: Real-time and accurate calibration detection of gout stones based on terahertz and Raman spectroscopy
Real-time and accurate calibration detection of gout stones based on terahertz and Raman spectroscopy Open
Gout is a metabolic disease that can result in the formation of gout stones. It is essential to promptly identify and confirm the type of gout stone to alleviate pain and inflammation in patients and prevent complications associated with g…
View article: Trend of clinical trials of new drugs for rare diseases in China in recent 10 years
Trend of clinical trials of new drugs for rare diseases in China in recent 10 years Open
Background Rare disease is a general term for a disease that affects a small number of people but recognized as a global public health priority. Governments worldwide are paying more and more attention to the academical research and drug i…
View article: Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis
Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis Open
Importance Baseline findings from the China Dialysis Calcification Study (CDCS) revealed a high prevalence of vascular calcification (VC) among patients with end-stage kidney disease; however, data on VC progression were limited. Objective…
View article: Joint Application of Multiple Inflammatory Cytokines in Diagnosis of Gout Flare
Joint Application of Multiple Inflammatory Cytokines in Diagnosis of Gout Flare Open
The joint application of multiple inflammatory cytokines can better distinguish acute gout from remission gout compared with peripheral blood cells.
View article: Randomized controlled trial of nalfurafine for refractory pruritus in hemodialysis patients
Randomized controlled trial of nalfurafine for refractory pruritus in hemodialysis patients Open
Chronic kidney disease-associated pruritus (CKD-aP) is very common and sometimes refractory to treatment in hemodialysis patients. In a trial conducted in Japan, nalfurafine, effectively reduced itching of treatment-resistant CKD-aP. Our p…
View article: Trend of clinical trials of new drugs for rare diseases in China in recent 10 years
Trend of clinical trials of new drugs for rare diseases in China in recent 10 years Open
Background: Rare disease is a general term for a disease that affects a small number of people but be recognized as a global public health priority. Governments worldwide are paying more and more attention to the academical research and dr…
View article: Additional file 1 of Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity
Additional file 1 of Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity Open
Additional file 1: Additional Tables 1–10. Additional tables are separated in sheets in a single excel file. The first line in each sheet contains the title of each additional table. Supplementary Table 1. Post-hoc multiple analysis for st…
View article: Burden of kidney disease among patients with peritoneal dialysis versus conventional in-centre haemodialysis: A randomised, non-inferiority trial
Burden of kidney disease among patients with peritoneal dialysis versus conventional in-centre haemodialysis: A randomised, non-inferiority trial Open
Background: Little is known about the impact of haemodialysis (HD) and peritoneal dialysis (PD) on health-related quality of life (HRQoL). We compared HRQoL between conventional in-centre HD and home-based PD in 1082 newly diagnosed kidney…
View article: Body Mass Index Is Associated with Proteinuria in Stage 2-3a but not Stage 3b-4 CKD Patients: An Observational Cross-sectional Study
Body Mass Index Is Associated with Proteinuria in Stage 2-3a but not Stage 3b-4 CKD Patients: An Observational Cross-sectional Study Open
Background: To investigate the relationship between body mass index (BMI) and proteinuria in stage 2-4 chronic kidney disease (CKD) patients. Methods: This study conducted a multicenter, cross-sectional study of 804 stage 2-4 CKD patients.…
View article: Quantitative proteomics by iTRAQ-PRM based reveals the new characterization for gout
Quantitative proteomics by iTRAQ-PRM based reveals the new characterization for gout Open
Background Gout is a common and complex form of immunoreactive arthritis based on hyperuricemia, while the symptoms would turn to remission or even got worse. So, it is hard to early identify whether an asymptomatic hyperuricemia (AHU) pat…
View article: Quantitative Proteomics by iTRAQ-PRM based Reveals the New Characterization for Gout.
Quantitative Proteomics by iTRAQ-PRM based Reveals the New Characterization for Gout. Open
Background: Gout is a common and complex form of immunoreactive arthritis based on hyperuricemia, while the symptoms would turn to remission or even got worse. So, it is hard to early identify whether an asymptomatic hyperuricemia (AHU) pa…
View article: Quantitative Proteomics by iTRAQ-PRM based Reveals the New Characterization for Gout.
Quantitative Proteomics by iTRAQ-PRM based Reveals the New Characterization for Gout. Open
BackgroundGout is a common and complex form of immunoreactive arthritis based on hyperuricemia, while the symptoms would turn to remission or even got worse. So, it is hard to early identify whether an asymptomatic hyperuricemia (AHU) pati…
View article: Additional file 1 of Quantitative proteomics by iTRAQ-PRM based reveals the new characterization for gout
Additional file 1 of Quantitative proteomics by iTRAQ-PRM based reveals the new characterization for gout Open
Additional file 1: Table S1. Details of differentially proteins. Table S2. The mapped signaling pathways of the differentially expressed proteins between AG and control. Table S3. The mapped signaling pathways of the differentially express…