Aïcha Soumaré
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View article: Obstetric Complications in the General ICU at CHU Gabriel Touré, Bamako Management and Prognostic Factors
Obstetric Complications in the General ICU at CHU Gabriel Touré, Bamako Management and Prognostic Factors Open
Introduction: Obstetric complications remain a major cause of maternal morbidity and mortality in sub-Saharan Africa, particularly when intensive care is required. This study aimed to analyse the epidemiological, clinical, therapeutic and …
View article: Handgrip strength reference values and determinants of muscle weakness in French adults: results from the NutriNet-Santé study
Handgrip strength reference values and determinants of muscle weakness in French adults: results from the NutriNet-Santé study Open
The reference values provide reference data for French adults, and these data should be useful in identifying populations at risk of low muscle strength and sarcopenia.
View article: Early norepinephrine for patients with septic shock: an updated systematic review and meta-analysis with trial sequential analysis
Early norepinephrine for patients with septic shock: an updated systematic review and meta-analysis with trial sequential analysis Open
Early norepinephrine introduction in septic shock is associated with reduced mortality, decreased fluid volume administered at 6 h, faster time to achieve MAP target and more mechanical ventilation-free days. However, the trial sequential …
View article: Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification
Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification Open
INTRODUCTION An integrative polygenic risk score (iPRS) capturing the neurodegenerative and vascular contribution to dementia could identify high‐risk individuals and improve risk prediction. METHODS We developed an iPRS for dementia (iPRS…
View article: Author response: Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies
Author response: Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies Open
View article: Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies
Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies Open
Background: Clonal hematopoiesis of indeterminate potential (CHIP) was initially linked to a twofold increase in atherothrombotic events. However, recent investigations have revealed a more nuanced picture, suggesting that CHIP may confer …
View article: Author response: Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: an analysis in prospective studies
Author response: Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: an analysis in prospective studies Open
View article: Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: an analysis in prospective studies
Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: an analysis in prospective studies Open
Background Clonal hematopoiesis of indeterminate potential (CHIP) was initially linked to a twofold increase in atherothrombotic events. However, recent investigations have revealed a more nuanced picture, suggesting that CHIP may confer o…
View article: White matter hyperintensity spatial patterns: risk factors and clinical correlates
White matter hyperintensity spatial patterns: risk factors and clinical correlates Open
INTRODUCTION White matter hyperintensities (WMH), a major cerebral small vessel disease marker, may arise from different pathologies depending on their location. We explored clinical and genetic correlates of agnostically derived spatial W…
View article: Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia
Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia Open
Importance Vascular disease is a treatable contributor to dementia risk, but the role of specific markers remains unclear, making prevention strategies uncertain. Objective To investigate the causal association between white matter hyperin…
View article: Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies
Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies Open
Background: Clonal hematopoiesis of indeterminate potential (CHIP) was initially linked to a twofold increase in atherothrombotic events. However, recent investigations have revealed a more nuanced picture, suggesting that CHIP may confer …
View article: Comprehensive Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: A Thorough Analysis in prospective studies
Comprehensive Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: A Thorough Analysis in prospective studies Open
Background Clonal hematopoiesis of indeterminate potential (CHIP) was initially linked to a twofold increase in atherothrombotic events. However, recent investigations have revealed a more nuanced picture, suggesting that CHIP may confer o…
View article: Reviewer #1 (Public Review): Comprehensive Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: A Thorough Analysis in prospective studies
Reviewer #1 (Public Review): Comprehensive Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: A Thorough Analysis in prospective studies Open
Clonal hematopoiesis of indeterminate potential (CHIP) was initially linked to a twofold increase in atherothrombotic events. However, recent investigations have revealed a more nuanced picture, suggesting that CHIP may confer only a modes…
View article: Cohort Profile: Dementia Risk Prediction Project (DRPP)
Cohort Profile: Dementia Risk Prediction Project (DRPP) Open
International audience
View article: Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: an analysis in prospective studies
Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: an analysis in prospective studies Open
Background Clonal hematopoiesis of indeterminate potential (CHIP) was initially linked to a twofold increase in atherothrombotic events. However, recent investigations have revealed a more nuanced picture, suggesting that CHIP may confer o…
View article: Prediction of Dementia Using Machine Learning Methods within a Large Pooled Consortia: The Dementia Risk Prediction Pooling (DRPP) Consortium
Prediction of Dementia Using Machine Learning Methods within a Large Pooled Consortia: The Dementia Risk Prediction Pooling (DRPP) Consortium Open
Background Machine learning models have been used to create accurate prediction models for dementia. However, many suffer from overfitting and external validation often results in decreased performance. Pooling data from various sources fo…
View article: Risk Prediction of Dementia in Middle‐aged and Older Adults: The Dementia Risk Prediction Pooling (DRPP) Consortium
Risk Prediction of Dementia in Middle‐aged and Older Adults: The Dementia Risk Prediction Pooling (DRPP) Consortium Open
Background Several risk prediction equations exist for the incidence of Alzheimer’s Disease and related dementias (ADRD); however, current equations are based on studies of older individuals, with limited follow‐up time and covariates, and…
View article: Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics
Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics Open
Importance There is increasing recognition that vascular disease, which can be treated, is a key contributor to dementia risk. However, the contribution of specific markers of vascular disease is unclear and, as a consequence, optimal prev…
View article: Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate
Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate Open
Cerebral small vessel disease is a leading cause of stroke and a major contributor to cognitive decline and dementia, but our understanding of specific genes underlying the cause of sporadic cerebral small vessel disease is limited. We rep…
View article: Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes
Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes Open
View article: Prevalence, Severity, and Clinical Management of Brain Incidental Findings in Healthy Young Adults: MRi-Share Cross-Sectional Study
Prevalence, Severity, and Clinical Management of Brain Incidental Findings in Healthy Young Adults: MRi-Share Cross-Sectional Study Open
Background and Objectives: Young adults represent an increasingly large proportion of healthy volunteers in brain imaging research, but descriptions of incidental findings (IFs) in this age group are scarce. We aimed to assess the prevalen…
View article: Cerebral small vessel disease genomics and its implications across the lifespan
Cerebral small vessel disease genomics and its implications across the lifespan Open
View article: High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage
High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage Open
View article: Association of variants in<i>HTRA1</i>and<i>NOTCH3</i>with MRI-defined extremes of cerebral small vessel disease in older subjects
Association of variants in<i>HTRA1</i>and<i>NOTCH3</i>with MRI-defined extremes of cerebral small vessel disease in older subjects Open
We report a composite extreme phenotype design using distribution of white matter hyperintensities and brain infarcts in a population-based cohort of older persons for gene-mapping of cerebral small vessel disease. We demonstrate its appli…
View article: Perceived parental support in childhood and adolescence and suicidal ideation in young adults: a cross-sectional analysis of the i-Share study
Perceived parental support in childhood and adolescence and suicidal ideation in young adults: a cross-sectional analysis of the i-Share study Open
Students that perceived low levels of past parental support had a higher risk of suicidal ideation. Past perceived parental support appeared to be a potent marker of suicidal risk in young adults. This marker should be routinely collected …
View article: Response to: ‘Uric acid and incident dementia: a population-based cohort study’ by Lee and Song
Response to: ‘Uric acid and incident dementia: a population-based cohort study’ by Lee and Song Open
View article: Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study
Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study Open
View article: Orthostatic Hypotension and Risk of Incident Dementia
Orthostatic Hypotension and Risk of Incident Dementia Open
Several studies indicate a potential link between orthostatic hypotension (OH) and incident dementia but without substantial evidence to date. Our objective is to study the association between OH and dementia in a cohort of elderly individ…
View article: Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study
Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study Open
In a large population-based sample of older community-dwelling persons with up to 13 y of follow-up, we observed that higher LDL-C and TC concentrations were associated with an increased risk of AD. This result was independent of vascular …
View article: Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study
Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study Open
Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises f…