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View article: Late-stage benzenoid-to-troponoid skeletal modification of the cephalotanes exemplified by the total synthesis of harringtonolide
Late-stage benzenoid-to-troponoid skeletal modification of the cephalotanes exemplified by the total synthesis of harringtonolide Open
Skeletal modifications enable elegant and rapid access to various derivatives of a compound that would otherwise be difficult to prepare. They are therefore a powerful tool, especially in the synthesis of natural products or drug discovery…
View article: Late-Stage “Benzenoid-to-Troponoid” Skeletal Modification of the Cephalotanes: Total Synthesis of Harringtonolide and Computational Analysis
Late-Stage “Benzenoid-to-Troponoid” Skeletal Modification of the Cephalotanes: Total Synthesis of Harringtonolide and Computational Analysis Open
Inspired by the biosynthesis of the cephalotane natural products, we envisioned that a “single-atom insertion” into the framework of the benzenoid subfamily would provide access to the troponoid congeners — representing the reverse of the …
View article: Formalization of Drug Dose Titration Procedures
Formalization of Drug Dose Titration Procedures Open
View article: Modelling and assessing one- and two-drug dose titrations
Modelling and assessing one- and two-drug dose titrations Open
In health-care, there is a need to quantify medical errors. Among these errors, we observe wrong dose prescriptions. Drug dose titration (DT) is the process by which dosage is progressively adjusted to the patient till a steady dose is rea…
View article: Towards the Classification of Self-Sovereign Identity Properties
Towards the Classification of Self-Sovereign Identity Properties Open
Self-Sovereign Identity (SSI) is a novel and emerging, decentralized digital identity approach that enables entities to control and manage their digital identifiers and associated identity data fully while enhancing trust, privacy, securit…
View article: An Ontology to Support Automatic Drug Dose Titration
An Ontology to Support Automatic Drug Dose Titration Open
Drug dose titration (DT) is the clinical process of progressively adjusting the dose of a medication for the maximum benefit of the patient. Several DT clinical models exist based on the elementary concepts of null, initial, and maximal do…
View article: Synergy of Blockchain Technology and Data Mining Techniques for Anomaly Detection
Synergy of Blockchain Technology and Data Mining Techniques for Anomaly Detection Open
Blockchain and Data Mining are not simply buzzwords, but rather concepts that are playing an important role in the modern Information Technology (IT) revolution. Blockchain has recently been popularized by the rise of cryptocurrencies, whi…
View article: Modelling and Assessment of One-Drug Dose Titration
Modelling and Assessment of One-Drug Dose Titration Open
In health-care, medical errors are quantified. Among them, wrong dose prescriptions occur. Drug dose titration (DT) is the process by which dosage is progressively adjusted to the patient till a steady dose is reached. Depending on the cli…
View article: Supporting the Sustainability of Natural Fiber-Based Value Chains of SMEs through Digitalization
Supporting the Sustainability of Natural Fiber-Based Value Chains of SMEs through Digitalization Open
SMEs represent a significant share of business companies in Europe. Their limitations might be overcome by using value chains, resulting in successful development and growth also within traditionally low-digitalized, natural fiber-based do…
View article: Correlation Between Students' Background and the Knowledge on Conceptual Database Modelling
Correlation Between Students' Background and the Knowledge on Conceptual Database Modelling Open
Students taking a Databases Course have different pre-knowledge of Conceptual Database Modelling. At the beginning of the course, they were asked to self-evaluate their knowledge of database design concepts. We have compared the results of…
View article: How to reduce gender biases in selection and recruitment processes
How to reduce gender biases in selection and recruitment processes Open
View article: A Model of Perception of Privacy, Trust, and Self-Disclosure on Online Social Networks
A Model of Perception of Privacy, Trust, and Self-Disclosure on Online Social Networks Open
Online Social Networks are used widely, raising new issues in terms of privacy, trust, and self-disclosure. For a better understanding of these issues for Facebook users, a model was built that includes privacy value, privacy risk, trust, …
View article: Correlation Between Students’ Background and the Knowledge on Conceptual Database Modelling
Correlation Between Students’ Background and the Knowledge on Conceptual Database Modelling Open
View article: A Systematic Review of the Use of Blockchain in Healthcare
A Systematic Review of the Use of Blockchain in Healthcare Open
Blockchain technology enables a decentralized and distributed environment with no need for a central authority. Transactions are simultaneously secure and trustworthy due to the use of cryptographic principles. In recent years, blockchain …
View article: A Systematic Review of the Use of Blockchain in Healthcare
A Systematic Review of the Use of Blockchain in Healthcare Open
Blockchain technology enables a decentralized and distributed environment with no need for a central authority. Transactions are simultaneously secure and trustworthy due to the use of cryptographic principles. In recent years, blockchain …
View article: Sensors and Functionalities of Non-Invasive Wrist-Wearable Devices: A Review
Sensors and Functionalities of Non-Invasive Wrist-Wearable Devices: A Review Open
Wearable devices have recently received considerable interest due to their great promise for a plethora of applications. Increased research efforts are oriented towards a non-invasive monitoring of human health as well as activity paramete…
View article: Experimental study on the effectiveness of a teaching approach using barker or Bachman notation for conceptual database design
Experimental study on the effectiveness of a teaching approach using barker or Bachman notation for conceptual database design Open
Relational databases are one of the pillars of information systems and as a consequence conceptual and logical design can be seen as the foundation of almost every application regardless of the platform. Nevertheless, little research has b…
View article: EduCTX: A Blockchain-Based Higher Education Credit Platform
EduCTX: A Blockchain-Based Higher Education Credit Platform Open
Blockchain technology enables the creation of a decentralized environment where transactions and data are not under the control of any third party organization. Any transaction ever completed is recorded in a public ledger in a verifiable …