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View article: P12.30.A EPIDEMIOLOGY AND TREATMENT PATTERNS IN MIDH OLIGODENDROGLIOMAS AND DIFFUSE ASTROCYTOMAS: A LONGITUDINAL NATIONWIDE COHORT PERSPECTIVE
P12.30.A EPIDEMIOLOGY AND TREATMENT PATTERNS IN MIDH OLIGODENDROGLIOMAS AND DIFFUSE ASTROCYTOMAS: A LONGITUDINAL NATIONWIDE COHORT PERSPECTIVE Open
BACKGROUND Treatment of IDH-mutant (mIDH) gliomas, including oligodendrogliomas and diffuse astrocytomas, typically involve surgery, radiotherapy, and/or chemotherapy (RT/CT). Immediate post-surgery RT/CT is not indicated for all patients …
View article: Evaluating work activity and societal burden in patients with grade 2 IDH-mutant glioma
Evaluating work activity and societal burden in patients with grade 2 IDH-mutant glioma Open
Background IDH-mutant (mIDH) gliomas affect relatively young and otherwise healthy patients with high workforce participation. Management typically involves surgery, radiotherapy, and/or chemotherapy (RT/CT), although immediate post-surger…
View article: Prognostic Value of Systemic Immune Inflammation Index in Squamous Cell Lung Cancer
Prognostic Value of Systemic Immune Inflammation Index in Squamous Cell Lung Cancer Open
Background/Objectives: Squamous cell lung cancer (SCC) presents a significant treatment challenge due to its poor prognosis and limited therapeutic options. In many resource-limited countries, access to advanced molecular testing is often …
View article: Mixed effect model confirms increased risk of image changes with increasing linear energy transfer in proton therapy of gliomas
Mixed effect model confirms increased risk of image changes with increasing linear energy transfer in proton therapy of gliomas Open
14% of patients developed IC following PT. Lesion-weighted and mixed effect models resulted in similar model performance confirming increased risk of IC with increasing LET. The beam arrangement seems to influence the risk of IC and needs …
View article: Predictive factors for biochemical relapse in non-metastatic prostate cancer following primary radiotherapy
Predictive factors for biochemical relapse in non-metastatic prostate cancer following primary radiotherapy Open
<p><strong>Aim</strong> To investigate the predictors of biochemical relapse (BCR) among patients with non-metastatic prostate cancer treated with radiotherapy as the first-line therapy. <br /><strong>…
View article: Selection for proton radiotherapy of grade 1–3 glioma patients
Selection for proton radiotherapy of grade 1–3 glioma patients Open
Higher degree of agreement was reached. Age and ΔDmean to the residual brain significantly predicted the choice of radiation modality. We have developed a decision support model which may aid in the selection of patients with glioma grade …
View article: A prospective clinical study of the influence of oral protein intake on [18F]FET-PET uptake and test–retest repeatability in glioma
A prospective clinical study of the influence of oral protein intake on [18F]FET-PET uptake and test–retest repeatability in glioma Open
View article: Mixed Effect Model Confirms Increased Risk of Image Changes with Increasing Linear Energy Transfer in Proton Therapy of Gliomas
Mixed Effect Model Confirms Increased Risk of Image Changes with Increasing Linear Energy Transfer in Proton Therapy of Gliomas Open
View article: Added prognostic value of DCE blood volume imaging in patients with suspected recurrent or residual glioblastoma—A hybrid [18F]FET PET/MRI study
Added prognostic value of DCE blood volume imaging in patients with suspected recurrent or residual glioblastoma—A hybrid [18F]FET PET/MRI study Open
Background Magnetic resonance imaging (MRI) cerebral blood volume (CBV) measurements improve the diagnosis of recurrent gliomas. The study investigated the prognostic value of dynamic contrast-enhanced (DCE) CBV imaging in treated IDH wild…
View article: BIOM-24. PREDICTION OF DISTANT RECURRENCE IN GLIOBLASTOMA PATIENTS TREATED WITH STANDARD THERAPY
BIOM-24. PREDICTION OF DISTANT RECURRENCE IN GLIOBLASTOMA PATIENTS TREATED WITH STANDARD THERAPY Open
BACKGROUND Infiltrative growth is a hallmark of glioblastoma (GBM) and is a major factor in therapeutic failure. We aimed to identify clinical and molecular factors associated with distance recurrence in glioblastoma patients treated with …
View article: Prediction of dose-sparing by protons assessed by a knowledge-based planning tool in radiotherapy of brain tumours
Prediction of dose-sparing by protons assessed by a knowledge-based planning tool in radiotherapy of brain tumours Open
Click to increase image sizeClick to decrease image size Disclosure statementThe authors have nothing to disclose.Data availability statementCorresponding author can be contacted for access to data and will provide data upon reasonable req…
View article: P11.32.A GLIOBLASTOMA NOMOGRAM: PREDICTING THE LOCATION OF FIRST PROGRESSION AFTER LONG-COURSE CHEMORADIOTHERAPY BASED ON A NATIONAL COHORT
P11.32.A GLIOBLASTOMA NOMOGRAM: PREDICTING THE LOCATION OF FIRST PROGRESSION AFTER LONG-COURSE CHEMORADIOTHERAPY BASED ON A NATIONAL COHORT Open
BACKGROUND Glioblastoma (GBM) is known for its high local failure rate, as well as its migration, leading to these possible locations of disease progression: 1. Local-only; lesion of progression is connected to the initial tumour location …
View article: JS09.8.A COMPARATIVE PROGNOSTIC VALUE OF O-(2-[18F]-FLUOROETHYL)-L-TYROSINE PET IMAGING AND DCE MRI BLOOD VOLUME IMAGING IN PATIENTS WITH SUSPECTED RECURRENT IDH-WILDTYPE HIGH-GRADE GLIOMA
JS09.8.A COMPARATIVE PROGNOSTIC VALUE OF O-(2-[18F]-FLUOROETHYL)-L-TYROSINE PET IMAGING AND DCE MRI BLOOD VOLUME IMAGING IN PATIENTS WITH SUSPECTED RECURRENT IDH-WILDTYPE HIGH-GRADE GLIOMA Open
BACKGROUND Quantitative blood volume (BV) imaging using dynamic T1-weighted contrast enhanced (DCE) perfusion MRI may be of diagnostic value in patients with suspected recurrent high-grade glioma, but the association of DCE BV measurements…
View article: The impact of short-course hypofractionated radiotherapy on multimodality treatment utilisation, compliance, and outcome in glioblastoma patients: a Danish patterns of care study
The impact of short-course hypofractionated radiotherapy on multimodality treatment utilisation, compliance, and outcome in glioblastoma patients: a Danish patterns of care study Open
In Denmark, the use of short-course HFRT significantly increased in recent years. Nonetheless, the overall utilisation of RT and chemotherapy did not increase on a population level. Nor did survival change. In contrast, compliance with bot…
View article: The impact of short-course hypofractionated radiotherapy on multimodality treatment utilisation, compliance, and outcome in glioblastoma patients: a Danish patterns of care study
The impact of short-course hypofractionated radiotherapy on multimodality treatment utilisation, compliance, and outcome in glioblastoma patients: a Danish patterns of care study Open
The aim of this retrospective registry-based Danish patterns of care study was (1) to evaluate the real-world utilisation of short-course hypofractionated radiotherapy (HFRT) in glioblastoma (GBM) patients over time, and (2) to evaluate th…
View article: The Neurogenome study: Comprehensive molecular profiling to optimize treatment for Danish glioblastoma patients
The Neurogenome study: Comprehensive molecular profiling to optimize treatment for Danish glioblastoma patients Open
Background Glioblastoma is an aggressive brain cancer with no possibility for cure. Treatment and survival have only improved slightly since 2005 when the current regime was implemented. The limited improvements in the treatment of gliobla…
View article: P11.32.A EGFR expression and non-methylated MGMT predict distant recurrence in glioblastoma patients treated with standard therapy
P11.32.A EGFR expression and non-methylated MGMT predict distant recurrence in glioblastoma patients treated with standard therapy Open
Background Infiltrative growth within the central nervous system is hallmark of glioblastoma (GBM) at time of diagnosis. Targeting infiltrative glioma cells by adding chemotherapy to local treatment (surgical resection and radiotherapy) ha…
View article: Diagnostic yield of simultaneous dynamic contrast-enhanced magnetic resonance perfusion measurements and [18F]FET PET in patients with suspected recurrent anaplastic astrocytoma and glioblastoma
Diagnostic yield of simultaneous dynamic contrast-enhanced magnetic resonance perfusion measurements and [18F]FET PET in patients with suspected recurrent anaplastic astrocytoma and glioblastoma Open
View article: 9p21.3 Microdeletion involving <i>CDKN2A/2B</i> in a young patient with multiple primary cancers and review of the literature
9p21.3 Microdeletion involving <i>CDKN2A/2B</i> in a young patient with multiple primary cancers and review of the literature Open
Germline pathogenic variants in CDKN2A predispose to various cancers, including melanoma, pancreatic cancer, and neural system tumors, whereas CDKN2B variants are associated with renal cell carcinoma. A few case reports have described hete…
View article: A national study on the inter-observer variability in the delineation of organs at risk in the brain
A national study on the inter-observer variability in the delineation of organs at risk in the brain Open
Except for the caudal definition of the spinal cord, the variances observed in the contours of OARs in the brain were generally low and consistent. Surface mapping revealed sub-regions of higher variance for some organs. The data set is be…
View article: Treatment plan comparison of proton vs photon radiotherapy for lower-grade gliomas
Treatment plan comparison of proton vs photon radiotherapy for lower-grade gliomas Open
View article: P14.69 Trends in postoperative chemoradiotherapy for Glioblastoma patients: a Danish cohort study
P14.69 Trends in postoperative chemoradiotherapy for Glioblastoma patients: a Danish cohort study Open
BACKGROUND Postoperative chemoradiotherapy (CRT), using conventional radiotherapy (convRT), has a key role in the treatment of glioblastoma (GBM) supported by level 1A evidence. In the past decade, evidence supporting hypofractionated radi…
View article: A Prognostic Model for Glioblastoma Patients Treated With Standard Therapy Based on a Prospective Cohort of Consecutive Non-Selected Patients From a Single Institution
A Prognostic Model for Glioblastoma Patients Treated With Standard Therapy Based on a Prospective Cohort of Consecutive Non-Selected Patients From a Single Institution Open
Background Glioblastoma patients administered standard therapies, comprising maximal surgical resection, radiation therapy with concomitant and adjuvant temozolomide, have a variable prognosis with a median overall survival of 15–16 months…
View article: A national study on the inter-observer variability in the delineation of organs at risk in the brain
A national study on the inter-observer variability in the delineation of organs at risk in the brain Open
The Danish Neuro Oncology Group (DNOG) has established national consensus guidelines for the delineation of organs at risk (OAR) structures based on published literature. This study was conducted to finalise these guidelines and evaluate t…
View article: A national study on the inter-observer variability in the delineation of organs at risk in the brain
A national study on the inter-observer variability in the delineation of organs at risk in the brain Open
The Danish Neuro Oncology Group (DNOG) has established national consensus guidelines for the delineation of organs at risk (OAR) structures based on published literature. This study was conducted to finalise these guidelines and evaluate t…
View article: Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers
Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers Open
Gliosarcoma (GS) constitutes a minor fraction of primary glioblastoma (GBM), which is the most frequent malignant brain tumor in adults. Despite the fact that malignant gliomas are highly invasive, extracranial metastases are very rarely s…
View article: P05.27 Reirradiation of brain metastases with stereotactic radiosurgery
P05.27 Reirradiation of brain metastases with stereotactic radiosurgery Open
Little is known about the outcome following a second course of stereotactic radiosurgery (SRS) for recurrence of brain metastases (BM) at the previously irradiated site. We retrospectively analyzed overall survival (OS) and the clinical fa…
View article: NIMG-05. REPEATABILITY OF FET-PET SCANNING AND THE INFLUENCE OF PROTEIN INTAKE IN GLIOMA
NIMG-05. REPEATABILITY OF FET-PET SCANNING AND THE INFLUENCE OF PROTEIN INTAKE IN GLIOMA Open
BACKGROUND: O-(2-18F-fluoroethyl)-L-tyrosine positron-emission-tomography (FET-PET) scanning is used in routine clinical management and evaluation of glioma brain tumours. Clinical guidelines recommend fasting 4-6 hours before a FET-PET sc…
View article: PO-0642: Influence of Introduction of VMAT and FET-PET on Treatment Outcomes for Glioblastoma Patients
PO-0642: Influence of Introduction of VMAT and FET-PET on Treatment Outcomes for Glioblastoma Patients Open
View article: RTHP-20. EVALUATION OF RADIATION THERAPY TECHNOLOGY AND DOSIMETRY IMPACT ON TREATMENT OUTCOME FOR GLIOBLASTOMA PATIENTS
RTHP-20. EVALUATION OF RADIATION THERAPY TECHNOLOGY AND DOSIMETRY IMPACT ON TREATMENT OUTCOME FOR GLIOBLASTOMA PATIENTS Open
We sought to assess the impact of the clinical introduction of new radiation therapy technologies on the outcome for glioblastoma patients. Newly diagnosed glioblastoma patients receiving 60 Gy with concomitant and adjuvant temozolomide in…