Aida N. Kawuma
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View article: Patient-Led Peer Support Groups Improve Anti-Hypertensive Drugs Access For Adults Living With HIV And Hypertension In Rural Uganda – A Cross-Sectional Study
Patient-Led Peer Support Groups Improve Anti-Hypertensive Drugs Access For Adults Living With HIV And Hypertension In Rural Uganda – A Cross-Sectional Study Open
Introduction: People living with HIV (PLHIV) often have poorly controlled hypertension due to medication non-adherence, primarily caused by limited access to antihypertensive drugs. Peer support groups are being explored to improve access.…
View article: Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP)
Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP) Open
Background Antimicrobial resistance (AMR) is a growing health concern, particularly in Africa, and is predicted to become the leading cause of death after cancer by 2050. Factors like overuse or inappropriate use of antibiotics contribute …
View article: Clinical lactation studies. Acting on key recommendations over the last decade
Clinical lactation studies. Acting on key recommendations over the last decade Open
Including lactating women in clinical trials is imperative to generate relevant drug exposure and safety data needed to advise on clinical use of drugs in this understudied population. Recent changes in perspectives, regulatory guidance, a…
View article: Culturally appropriate terminologies in health research: a participatory study with pregnant and breastfeeding mothers in Uganda
Culturally appropriate terminologies in health research: a participatory study with pregnant and breastfeeding mothers in Uganda Open
Background The language used in research and health programs is crucial in influencing participation and ensuring the acceptability of programs and the adoption of research outcomes. The use of alienating language may present a barrier for…
View article: 'Some parts of the consent form are written using complex scientific language’: community perspectives on informed consent for research with pregnant and lactating mothers in Uganda
'Some parts of the consent form are written using complex scientific language’: community perspectives on informed consent for research with pregnant and lactating mothers in Uganda Open
View article: Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP)
Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP) Open
Background Antimicrobial resistance (AMR) is a growing health concern, particularly in Africa, and is predicted to be the leading cause of death after cancer by 2050. Factors like overuse or inappropriate use of antibiotics, contribute to…
View article: What can pharmacokinetic modelling do for you? Rational design and interpretation of clinical studies
What can pharmacokinetic modelling do for you? Rational design and interpretation of clinical studies Open
View article: Population pharmacokinetic modeling of paired plasma–breast milk lamivudine data for estimation of infant exposure in breastfeeding mother–infant pairs
Population pharmacokinetic modeling of paired plasma–breast milk lamivudine data for estimation of infant exposure in breastfeeding mother–infant pairs Open
Around 1.2 million women living with HIV give birth annually, majority of whom will breastfeed their infants while receiving antiretroviral therapy (ART). Lamivudine, a component of first‐line ART regimens crosses from maternal plasma to b…
View article: Recruitment of pregnant and breastfeeding women in pharmacokinetic studies: strategies, opportunities, barriers, and recommendations
Recruitment of pregnant and breastfeeding women in pharmacokinetic studies: strategies, opportunities, barriers, and recommendations Open
Pregnant and breastfeeding women are often under-represented in clinical research, including pharmacokinetic studies, due to ethical and logistical challenges. This paper examines strategies to improve the recruitment and retention of this…
View article: Interim analysis, a tool to enhance efficiency of pharmacokinetic studies: Pharmacokinetics of rifampicin in lactating mother–infant pairs
Interim analysis, a tool to enhance efficiency of pharmacokinetic studies: Pharmacokinetics of rifampicin in lactating mother–infant pairs Open
Pharmacokinetic studies are important for understanding drug disposition in the human body. However, pregnant and lactating women are often excluded from primary pharmacokinetic studies and as such there is often limited dosing information…
View article: Some parts in the consent form are written using complex scientific language: Community members’ perspectives regarding terminologies used during informed consent process for research involving pregnant and lactating mothers in Uganda
Some parts in the consent form are written using complex scientific language: Community members’ perspectives regarding terminologies used during informed consent process for research involving pregnant and lactating mothers in Uganda Open
Background Appropriate language use is essential to ensure inclusion of diverse populations in research. We aimed to identify possible language-related barriers regarding the informed consent and suggest interventions to enhance goal of th…
View article: Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study Open
Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure of the breastfed infant to drugs and any related risks are sparce. Lactation studies are only rarely performed close to licensin…
View article: Attaining Equity of Access to Research: Perspective on Research in Pregnancy and Breastfeeding Following Dolores Shockley Lecture at ASCPT2024
Attaining Equity of Access to Research: Perspective on Research in Pregnancy and Breastfeeding Following Dolores Shockley Lecture at ASCPT2024 Open
Everybody deserves access to evidence‐based information to make decisions about their health. However, in many situations, clinical trial eligibility criteria mean that specific data do not exist for certain groups of individuals. These in…
View article: Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study Open
Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure of the breastfed infant to drugs and any related risks are sparce. Lactation studies are only rarely performed close to licensin…
View article: Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study Open
Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure of the breastfed infant to drugs and any related risks are sparce. Lactation studies are only rarely performed close to licensin…
View article: Determinants of early change in serum creatinine after initiation of dolutegravir‐based antiretroviral therapy in South Africa
Determinants of early change in serum creatinine after initiation of dolutegravir‐based antiretroviral therapy in South Africa Open
Aims Dolutegravir increases serum creatinine by inhibiting its renal tubular secretion and elimination. We investigated determinants of early changes in serum creatinine in a southern African cohort starting first‐line dolutegravir‐based a…
View article: PA-727 Physiologically-based pharmacokinetic modelling of drug-drug interactions between ritonavir-boosted atazanavir and rifampicin in pregnancy
PA-727 Physiologically-based pharmacokinetic modelling of drug-drug interactions between ritonavir-boosted atazanavir and rifampicin in pregnancy Open
Background Ritonavir-boosted atazanavir (ATV/r) and rifampicin are mainstays of second-line antiretroviral and multiple anti-TB regimens, respectively. Rifampicin is a strong inducer of CYP3A4, the main enzyme involved in atazanavir metabo…
View article: Prevalence and factors associated with suboptimal adherence to dolutegravir-based regimens among people living with HIV in a specialized clinic in Kampala, Uganda
Prevalence and factors associated with suboptimal adherence to dolutegravir-based regimens among people living with HIV in a specialized clinic in Kampala, Uganda Open
Background Suboptimal adherence to dolutegravir is up to 31% globally. In Uganda, 54% of people living with HIV(PLHIV) on first-line Antiretroviral Therapy (ART) were taking dolutegravir-based regimens. This study aimed to determine the pr…
View article: Pharmacokinetics of antimalarial drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Pharmacokinetics of antimalarial drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study Open
Background: Data surrounding the exposure of the breastfed infant to drugs and any associated risks are sparse. Drugs usually are transferred to milk in small quantities, and many have been used without obviously noticeable infant toxicity…
View article: A systematic review on maternal-to-infant transfer of drugs through breast milk during the treatment of malaria, tuberculosis, and neglected tropical diseases
A systematic review on maternal-to-infant transfer of drugs through breast milk during the treatment of malaria, tuberculosis, and neglected tropical diseases Open
Background Exclusive breastfeeding of infants under 6 months of age is recommended by the World Health Organization. In 2021, over 300 million combined incident cases of malaria, tuberculosis, and neglected tropical diseases (NTDs) were re…
View article: A commentary on establishing a local centre of excellence for research and training in pharmacometrics: Lessons from the pharmacometrics Africa–Uganda chapter
A commentary on establishing a local centre of excellence for research and training in pharmacometrics: Lessons from the pharmacometrics Africa–Uganda chapter Open
Pharmacometrics involves the development and application of mathematical models, informed by knowledge on pharmacology, physiology and the disease process, to characterize the interactions between drugs and patients. It is applied to study…
View article: Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study Open
Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure of the breastfed infant to drugs and any related risks are sparce. Lactation studies are only rarely performed close to licens…
View article: Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study Open
Informed consent forms are ethical documents required for study participation.
View article: Population pharmacokinetics of tenofovir given as either tenofovir disoproxil fumarate or tenofovir alafenamide in an African population
Population pharmacokinetics of tenofovir given as either tenofovir disoproxil fumarate or tenofovir alafenamide in an African population Open
Tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are prodrugs of the nucleotide analogue tenofovir, which acts intracellularly to inhibit HIV replication. Whereas TDF converts to tenofovir in plasma and may cause kidney …
View article: A commentary on establishing a local centre of excellence for research and training in Pharmacometrics: Lessons from the Pharmacometrics Africa -Uganda Chapter.
A commentary on establishing a local centre of excellence for research and training in Pharmacometrics: Lessons from the Pharmacometrics Africa -Uganda Chapter. Open
Pharmacometrics, the mathematical approaches to describe the transfer of drug through different biological compartments, are essential tools in clinical pharmacology research. The ethical necessity to study drugs accurately in the populati…
View article: Pharmacogenetics of tenofovir clearance among Southern Africans living with HIV
Pharmacogenetics of tenofovir clearance among Southern Africans living with HIV Open
Background Tenofovir is a component of preferred combination antiretroviral therapy (ART) regimens in Africa. Few pharmacogenetic studies have been conducted on tenofovir exposure in Africa, where genetic diversity is greatest. Objective W…
View article: Establishing a local centre of excellence for research and training in pharmacometrics: Lessons from the Pharmacometrics Africa -Uganda chapter
Establishing a local centre of excellence for research and training in pharmacometrics: Lessons from the Pharmacometrics Africa -Uganda chapter Open
Pharmacometrics Africa is a not-for-profit company registered in South Africa as an established platform for interested groups to establish and run open-access quantitative clinical pharmacology educational programs in partnership with loc…
View article: Pharmacokinetics of drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Pharmacokinetics of drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study Open
Background: Data surrounding the exposure of the breastfed infant to drugs and any associated risks are sparse. Drugs are transferred to milk in small quantities, and many have been used without obviously noticeable infant toxicity for man…
View article: Drug–drug interaction between rifabutin and dolutegravir: A population pharmacokinetic model
Drug–drug interaction between rifabutin and dolutegravir: A population pharmacokinetic model Open
Rifampicin, a potent enzyme inducer, causes marked reduction of dolutegravir exposure. Rifabutin, a less potent enzyme inducer, may offer an alternative to rifampicin. We aimed to characterize the population pharmacokinetics of dolutegravi…
View article: Pharmacokinetic and pharmacogenetic associations with dolutegravir neuropsychiatric adverse events in an African population
Pharmacokinetic and pharmacogenetic associations with dolutegravir neuropsychiatric adverse events in an African population Open
Background Dolutegravir has been associated with neuropsychiatric adverse events (NPAEs), but relationships between dolutegravir concentrations and NPAEs are unclear. Objectives To determine in an African population whether a concentration…