Aidan Douglas
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View article: YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast
YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast Open
YAP1 signaling is essential for development but its specific roles in early embryogenesis remain poorly understood. To shed light on this, we analyzed YAP1’s role in regulating the pluripotency of the mammalian epiblast, using scRNAseq app…
View article: A retinoic acid:YAP1 signaling axis controls atrial lineage commitment
A retinoic acid:YAP1 signaling axis controls atrial lineage commitment Open
In cardiac progenitor cells (CPCs), retinoic acid (RA) signaling induces atrial lineage gene expression and acquisition of an atrial cell fate. To achieve this, RA coordinates a complex regulatory network of downstream effectors that is no…
View article: A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment
A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment Open
Vitamin A/Retinoic Acid (Vit A/RA) signaling is essential for heart development. In cardiac progenitor cells (CPCs), RA signaling induces the expression of atrial lineage genes while repressing ventricular genes, thereby promoting the acqu…