Andrew Harrison
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View article: Instructional review of key factors to achieve successful outcomes when using low-intensity pulsed ultrasound in fracture repair
Instructional review of key factors to achieve successful outcomes when using low-intensity pulsed ultrasound in fracture repair Open
Low-intensity pulsed ultrasound (LIPUS) treatment of fractures has been available to the orthopaedic community for nearly three decades; however, it is still considered an experimental treatment by some clinicians, even though there is a w…
View article: Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients
Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients Open
Pain relief from hyaluronic acid injections was sustained for on average 466.8 days post initial treatment. Patients who received subsequent 3rd, 4th, and 5th injections also experienced extended duration of benefit. Patients with grades 2…
View article: <p>NASHA hyaluronic acid for the treatment of shoulder osteoarthritis: a prospective, single-arm clinical trial</p>
NASHA hyaluronic acid for the treatment of shoulder osteoarthritis: a prospective, single-arm clinical trial Open
Background: Osteoarthritis of the shoulder or glenohumeral joint is a painful condition that can be debilitating. Intra-articular injection with hyaluronic acid should be considered for patients not responding adequately to physical therap…
View article: Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity
Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity Open
Low-intensity pulsed ultrasound (LIPUS) is a therapy used clinically to promote healing. Using live-cell imaging we show that LIPUS stimulation, acting through integrin-mediated cell-matrix adhesions, rapidly induces Rac1 activation associ…
View article: Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): A systematic review and meta-analysis
Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): A systematic review and meta-analysis Open
LIPUS treatment can be an alternative to surgery for established nonunions. Given that no spontaneous healing of established nonunions is expected, and that it is challenging to test the efficacy of LIPUS for nonunion by randomized clinica…
View article: Mode & mechanism of low intensity pulsed ultrasound (LIPUS) in fracture repair
Mode & mechanism of low intensity pulsed ultrasound (LIPUS) in fracture repair Open
It has been 30years since the first level one clinical trial demonstrated low intensity pulsed ultrasound (LIPUS) could accelerate fracture repair. Since 1994 numerous investigations have been performed on the effect of LIPUS. The majority…