Aiden Telfser
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View article: Macrophages direct location-dependent recall of B cell memory to vaccination
Macrophages direct location-dependent recall of B cell memory to vaccination Open
Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell receptor upon boosting and re-exposure to antigen. We show in mouse models that lymph no…
View article: A semi‐automated <scp>ASC</scp> speck assay to evaluate pyrin inflammasome activation
A semi‐automated <span>ASC</span> speck assay to evaluate pyrin inflammasome activation Open
Objective To develop a rapid functional assay to validate variants of uncertain significance (VUS) in the MEFV gene. Methods Overactivity of the pyrin inflammasome pathway and ASC speck oligomerisation in response to stimulation with low c…