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View article: An electrochemical CRISPR/Cas12a biosensing platform utilizing Fe<sub>3</sub>O<sub>4</sub>/α-Fe<sub>2</sub>O<sub>3</sub> nanosheets for highly sensitive detection of EGFR-19Del
An electrochemical CRISPR/Cas12a biosensing platform utilizing Fe<sub>3</sub>O<sub>4</sub>/α-Fe<sub>2</sub>O<sub>3</sub> nanosheets for highly sensitive detection of EGFR-19Del Open
A sensitive electrochemical biosensing platform CRISPR based was developed for the detection of EGFR-19Del. In this work, the trans-cleavage activity of target-induced CRISPR/Cas12a was investigated by monitoring the electrical signal chan…
View article: Label-free electrochemical biosensor with magnetically induced self-assembly for the detection of cancer antigen 125
Label-free electrochemical biosensor with magnetically induced self-assembly for the detection of cancer antigen 125 Open
Magnetically induced self-assembly technology was used to construct a label-free electrochemical biosensor based on magnetic Mg0.5Cu0.5Fe2O4-Au nanocomposites for the sensitive detection of cancer antigen 125 (CA125). To aim for this, Mg0.…
View article: Symmetry dual functional pyrimidine-BODIPY probes for imaging targeting and activity study
Symmetry dual functional pyrimidine-BODIPY probes for imaging targeting and activity study Open
Nondestructive diagnosis of tumor has always been the goal of scientists. Fluorescent dyes have become the rising star in the field of cancer diagnosis because of their excellent characteristics. Therefore, in this work, fluorescence probe…
View article: Meta-analysis of the association between sclerostin level and adverse clinical outcomes in patients undergoing maintenance haemodialysis
Meta-analysis of the association between sclerostin level and adverse clinical outcomes in patients undergoing maintenance haemodialysis Open
Background: Studies regarding the relationship of sclerostin (Scl) with clinical outcomes in patients undergoing maintenance haemodialysis have yielded controversial findings. This meta-analysis was performed to investigate the predictive …
View article: Klotho Inhibits Unilateral Ureteral Obstruction-Induced Endothelial-to-Mesenchymal Transition via TGF-β1/Smad2/Snail1 Signaling in Mice
Klotho Inhibits Unilateral Ureteral Obstruction-Induced Endothelial-to-Mesenchymal Transition via TGF-β1/Smad2/Snail1 Signaling in Mice Open
This study aimed to evaluate repression of Klotho on unilateral ureteral obstruction (UUO)-induced renal fibrosis and endothelial-to-mesenchymal transition (EndoMT) in mice. Renal fibrosis model was established by UUO in C57BL/6 male mice.…
View article: 1,25(OH)<sub>2</sub>D<sub>3</sub> Activates Autophagy to Protect against Oxidative Damage of INS-1 Pancreatic Beta Cells
1,25(OH)<sub>2</sub>D<sub>3</sub> Activates Autophagy to Protect against Oxidative Damage of INS-1 Pancreatic Beta Cells Open
Diabetes mellitus is a serious disease endangering human health worldwide. Vitamin D (Vit D) is a well-characterized regulator of calcium-phosphorus metabolism that also exerts other biological effects extending far beyond mineral homeosta…
View article: Dynamic Hierarchical Self-Assemble Small Molecule Structure Hexabenzocoronene for the High-Performance Anodes Lithium Ion Storage
Dynamic Hierarchical Self-Assemble Small Molecule Structure Hexabenzocoronene for the High-Performance Anodes Lithium Ion Storage Open
View article: Ginsenoside-Rg1 Protects against Renal Fibrosis by Regulating the Klotho/TGF-β1/Smad Signaling Pathway in Rats with Obstructive Nephropathy
Ginsenoside-Rg1 Protects against Renal Fibrosis by Regulating the Klotho/TGF-β1/Smad Signaling Pathway in Rats with Obstructive Nephropathy Open
Ginsenoside-Rg1 (G-Rg1) is an agent isolated from Panax ginseng that exerts anti-fibrotic effects; however, the mechanism is still unclear. Herein, we investigated whether G-Rg1 administration can mitigate or reverse unilateral ureteral ob…