Aidong Yuan
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View article: Posttranscriptional regulation of neurofilament proteins and tau in health and disease
Posttranscriptional regulation of neurofilament proteins and tau in health and disease Open
Neurofilament and tau proteins are neuron-specific cytoskeletal proteins that are enriched in axons, regulated by many of the same protein kinases, interact physically, and are the principal constituents of neurofibrillary lesions in major…
View article: Autophagy is a novel pathway for neurofilament protein degradation <i>in vivo</i>
Autophagy is a novel pathway for neurofilament protein degradation <i>in vivo</i> Open
How macroautophagy/autophagy influences neurofilament (NF) proteins in neurons, a frequent target in neurodegenerative diseases and injury, is not known. NFs in axons have exceptionally long half-lives in vivo enabling formation of …
View article: Long non-coding RNA Gm37494 alleviates osteoarthritis chondrocyte injury via the microRNA-181a-5p/GABRA1 axis
Long non-coding RNA Gm37494 alleviates osteoarthritis chondrocyte injury via the microRNA-181a-5p/GABRA1 axis Open
Objective This study was conducted to investigate the effect of long non-coding RNA (lncRNA) Gm37494 on osteoarthritis (OA) and its related molecular mechanism. Methods The cartilage tissues were obtained from OA patients, and an OA mouse …
View article: Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies
Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies Open
Biomarkers of neurodegeneration and neuronal injury have the potential to improve diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy. Neurofilament proteins (NfPs) are well suited as biomarkers in these cont…
View article: Application of Magnetic Resonance Diffusion Tensor Imaging in the Clinical Diagnosis of Disc Herniation after Lumbar Spine Injury
Application of Magnetic Resonance Diffusion Tensor Imaging in the Clinical Diagnosis of Disc Herniation after Lumbar Spine Injury Open
Magnetic resonance diffusion-weighted imaging (DTI) provides a unique perspective on the pathophysiological and microstructural changes during spinal cord injury, with high spatial specificity; meanwhile, NM reflects the conduction and int…
View article: Comparison of the ROI-C cage and Zero-P device used in anterior cervical discectomy and fusion: a minimum 2-year follow-up study
Comparison of the ROI-C cage and Zero-P device used in anterior cervical discectomy and fusion: a minimum 2-year follow-up study Open
Background: Anterior cervical discectomy and fusion (ACDF) has been considered the gold-standard procedure for treating symptomatic cervical spondylosis refractory to conservative management. The aim of this study was to compare the clinic…
View article: Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors
Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors Open
View article: Neurofilaments and Neurofilament Proteins in Health and Disease
Neurofilaments and Neurofilament Proteins in Health and Disease Open
SUMMARYNeurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments (IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M [neurofilament middle]; NF-H [neurofilament heavy]; an…
View article: Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders
Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders Open
View article: Dissociation of Axonal Neurofilament Content from Its Transport Rate
Dissociation of Axonal Neurofilament Content from Its Transport Rate Open
The axonal cytoskeleton of neurofilament (NF) is a long-lived network of fibrous elements believed to be a stationary structure maintained by a small pool of transported cytoskeletal precursors. Accordingly, it may be predicted that NF con…