Aifeng Zhang
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View article: Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis Open
Circular RNAs (circRNAs) are crucial regulators of gene expression, exhibiting dynamic expression patterns during both normal brain development and diverse pathological states. This study reports the elevated expression of CircPTPN4 in the…
View article: Hyperkalemia combined with carbon monoxide poisoning, should hemodialysis or hyperbaric oxygen treatment be given first?: A CARE-compliant article
Hyperkalemia combined with carbon monoxide poisoning, should hemodialysis or hyperbaric oxygen treatment be given first?: A CARE-compliant article Open
Rationale: Hyperkalemia and acute carbon monoxide (CO) poisoning are both life-threatening conditions. When these conditions coexist, there is a debate on whether hemodialysis or hyperbaric oxygen (HBO) therapy should be prioritized. Our d…
View article: Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility
Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility Open
View article: Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model
Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model Open
Background and Aims Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and impaired metabolic efficiency. This study investigates the therapeutic pote…
View article: Optimized Stratification of Recurrence Risk in Stage I Non-Small Cell Lung Cancer Via Ai Hybrid Model: A Multicenter Cohort Study
Optimized Stratification of Recurrence Risk in Stage I Non-Small Cell Lung Cancer Via Ai Hybrid Model: A Multicenter Cohort Study Open
View article: Modification of the Mohr–Coulomb Criterion and Its Application in the Cracking of Ring-Stiffened Cylinders Made of Titanium Alloy
Modification of the Mohr–Coulomb Criterion and Its Application in the Cracking of Ring-Stiffened Cylinders Made of Titanium Alloy Open
TC4 ELI alloy is widely used in the marine, medicine, and aviation fields. The failure performance of TC4 ELI alloy is significantly different from that of other metal materials, such as steels. In this paper, a modified Mohr–Coulomb crite…
View article: Study of a PST-trained voice-enabled artificial intelligence counselor for adults with emotional distress (SPEAC-2): Design and methods
Study of a PST-trained voice-enabled artificial intelligence counselor for adults with emotional distress (SPEAC-2): Design and methods Open
gov #: NCT05603923.
View article: Microglia sense and suppress epileptic neuronal hyperexcitability
Microglia sense and suppress epileptic neuronal hyperexcitability Open
Microglia are the resident immune cells of the central nervous system, undertaking surveillance role and reacting to brain homeostasis and neurological diseases. Recent studies indicate that microglia modulate epilepsy-induced neuronal act…
View article: Correction: Effects of a virtual voice-based coach delivering problem-solving treatment on emotional distress and brain function: a pilot RCT in depression and anxiety
Correction: Effects of a virtual voice-based coach delivering problem-solving treatment on emotional distress and brain function: a pilot RCT in depression and anxiety Open
View article: Effects of a virtual voice-based coach delivering problem-solving treatment on emotional distress and brain function: a pilot RCT in depression and anxiety
Effects of a virtual voice-based coach delivering problem-solving treatment on emotional distress and brain function: a pilot RCT in depression and anxiety Open
View article: [Retracted] MicroRNA‑454 inhibits non‑small cell lung cancer cells growth and metastasis via targeting signal transducer and activator of transcription‑3
[Retracted] MicroRNA‑454 inhibits non‑small cell lung cancer cells growth and metastasis via targeting signal transducer and activator of transcription‑3 Open
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell migration and invasion assay data shown in Figs. 2C and 4D were strikingly similar to data appearing in differen…
View article: Roles of the m6A Modification of RNA in the Glioblastoma Microenvironment as Revealed by Single-Cell Analyses
Roles of the m6A Modification of RNA in the Glioblastoma Microenvironment as Revealed by Single-Cell Analyses Open
Purpose Glioblastoma multiforme (GBM) is a common and aggressive form of brain tumor. The N 6 -methyladenosine (m 6 A) mRNA modification plays multiple roles in many biological processes and disease states. However, the relationship betwee…
View article: Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis
Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis Open
View article: Systemic Arterial Blood Pressure and Intracerebral Hemorrhage after Mechanical Thrombectomy in Anterior Cerebral Circulation
Systemic Arterial Blood Pressure and Intracerebral Hemorrhage after Mechanical Thrombectomy in Anterior Cerebral Circulation Open
The relationship between systemic arterial blood pressure (BP) and intracerebral hemorrhage (ICH) after mechanical thrombectomy (MT) of the cerebral artery remains unclear. This study aimed to determine the effect of BP variables on ICH af…
View article: MicroRNA-320a Promotes Epithelial Ovarian Cancer Cell Proliferation and Invasion by Targeting RASSF8
MicroRNA-320a Promotes Epithelial Ovarian Cancer Cell Proliferation and Invasion by Targeting RASSF8 Open
MicroRNAs (miRNAs) play important roles in tumorigenesis by controlling target gene expression. With opposing roles as a tumor suppressor or oncogene, microRNA-320a (miR-320a) was found to participate in tumor genesis and progression and a…
View article: On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation
On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation Open
Biomimetic nanoparticles have been reported as immune modulators in autoimmune diseases and allograft rejections by numerous researchers. However, most of the therapeutics carrying antigens, toxins or cytokines underlay the mechanism of an…
View article: MiR34a Regulates Neuronal MHC Class I Molecules and Promotes Primary Hippocampal Neuron Dendritic Growth and Branching
MiR34a Regulates Neuronal MHC Class I Molecules and Promotes Primary Hippocampal Neuron Dendritic Growth and Branching Open
In the immune system, Major Histocompatibility Complex class I (MHC-I) molecules are located on the surface of most nucleated cells in vertebrates where they mediate immune responses. Accumulating evidence indicates that MHC-I molecules ar…
View article: Safety and efficacy of remote ischemic postconditioning after thrombolysis in patients with stroke
Safety and efficacy of remote ischemic postconditioning after thrombolysis in patients with stroke Open
Objective: To determine the effect of remote ischemic post-conditioning (RIPC) on acute ischemic stroke (AIS) patients undergoing intravenous thrombolysis (IVT). Methods: A single-center, randomized controlled trial was performed with AIS …
View article: 76 Prognostic potential of electrocardiographic parameters in patients with multiple myeloma
76 Prognostic potential of electrocardiographic parameters in patients with multiple myeloma Open
Background Patients with multiple myeloma (MM) can develop cardiac abnormalities, predisposing them to the development of heart failure, arrhythmia or infarction with poor prognosis. The purpose of this study is to evaluate the prognostic …
View article: 128 Systemic arterial blood pressure and intracerebral hemorrhage after mechanical thrombectomy in anterior cerebral circulation
128 Systemic arterial blood pressure and intracerebral hemorrhage after mechanical thrombectomy in anterior cerebral circulation Open
Background and Purpose The relationship between systemic arterial blood pressure (BP) and intracerebral hemorrhage (ICH) after mechanical thrombectomy (MT) of cerebral artery remains unclear. This study aimed to determine the effect of BP …
View article: Personalized application of three different concentrations of iodinated contrast media in coronary computed tomography angiography
Personalized application of three different concentrations of iodinated contrast media in coronary computed tomography angiography Open
No study has evaluated the impact of different iodinated contrast media on coronary contrast enhancement, using an injection protocol according to body surface area (BSA). Thus, the present study aimed to examine the usefulness and safety …
View article: Table of Contents
Table of Contents Open
View article: miR-218 Expressed in Endothelial Progenitor Cells Contributes to the Development and Repair of the Kidney Microvasculature
miR-218 Expressed in Endothelial Progenitor Cells Contributes to the Development and Repair of the Kidney Microvasculature Open
View article: Neuronal NLRC5 regulates MHC class I expression in Neuro‐2a cells and also during hippocampal development
Neuronal NLRC5 regulates MHC class I expression in Neuro‐2a cells and also during hippocampal development Open
Major histocompatibility Complex class I (MHC I) molecules are ubiquitously expressed, being found in most nucleated cells, where they are central mediators of both the adaptive and innate immune responses. Recent studies have shown that M…
View article: Differentiating weight-restored anorexia nervosa and body dysmorphic disorder using neuroimaging and psychometric markers
Differentiating weight-restored anorexia nervosa and body dysmorphic disorder using neuroimaging and psychometric markers Open
Anorexia nervosa (AN) and body dysmorphic disorder (BDD) are potentially life-threatening conditions whose partially overlapping phenomenology-distorted perception of appearance, obsessions/compulsions, and limited insight-can make diagnos…
View article: Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice
Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice Open
ADAM10, a member of the disintegrin and metalloproteinase domain-containing protein (ADAM) family, has been reported to mediate proteolytic shedding of cell surface proteins. An increasing body of evidence indicates that ADAM10 is involved…
View article: Efficacy and Safety of Le-Mai Particle in Patients with Angina Pectoris
Efficacy and Safety of Le-Mai Particle in Patients with Angina Pectoris Open
This study aimed to verify the efficacy and safety of the Le-Mai particle in patients with angina pectoris. Randomized controlled trials (RCTs) were searched from numerous databases. Clinical symptom improvement was served as the primary e…
View article: Von Mises Strain as a Risk Marker for Vulnerability of Carotid Plaque: Preliminary Clinical Evaluation of Cerebral Infarction
Von Mises Strain as a Risk Marker for Vulnerability of Carotid Plaque: Preliminary Clinical Evaluation of Cerebral Infarction Open
View article: Prognostic Value of Long Noncoding RNA CRNDE as a Novel Biomarker in Solid Cancers: An Updated Systematic Review and Meta-Analysis
Prognostic Value of Long Noncoding RNA CRNDE as a Novel Biomarker in Solid Cancers: An Updated Systematic Review and Meta-Analysis Open
Background: Long noncoding RNA colorectal neoplasia differentially expressed (CRNDE) has been reported to exhibit a potential oncogenic role in the development of human cancers. However, the clinical value of CRNDE expression in var…
View article: Exosome-mediated microRNA-138 and vascular endothelial growth factor in endometriosis through inflammation and apoptosis via the nuclear factor-κB signaling pathway
Exosome-mediated microRNA-138 and vascular endothelial growth factor in endometriosis through inflammation and apoptosis via the nuclear factor-κB signaling pathway Open
Endometriosis (Ems) is a condition that refers to the ectopic implantation and growth of endometrial tissue outside the uterine cavity. The aim of the present study was to investigate the role of microRNA‑138 (miR‑138) in Ems and the possi…