Aiguo Liu
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View article: Homoharringtonine added to CLAG regimen improves outcome of pediatric Relapsed/Refractory AML: A multicenter prospective study
Homoharringtonine added to CLAG regimen improves outcome of pediatric Relapsed/Refractory AML: A multicenter prospective study Open
Induction The prognosis of refractory/relapsed (R/R) Acute myeloid leukemia (AML) is dismal. Regimens including cladribine, cytarabine, and granulocyte-stimulating factor (CLAG) resulted in excellent outcomes with a 50-62.7% complete remis…
View article: CAR-exosomes derived from immune cells: an emerging nanoscale vanguard in overcoming tumor immunotherapy hurdles
CAR-exosomes derived from immune cells: an emerging nanoscale vanguard in overcoming tumor immunotherapy hurdles Open
Chimeric Antigen Receptor (CAR)-engineered cell therapies excel against hematologic malignancies, however, their efficacy in solid tumors is hampered by toxicity, poor tumor infiltration, immunosuppressive microenvironments, limited persis…
View article: A Multicenter Study of Acute Abdomen in Children With Acute Lymphoblastic Leukemia: <scp>CCCG</scp>‐<scp>ALL</scp>‐2015
A Multicenter Study of Acute Abdomen in Children With Acute Lymphoblastic Leukemia: <span>CCCG</span>‐<span>ALL</span>‐2015 Open
Objective Acute abdomen presents a significant challenge in the treatment of childhood acute lymphoblastic leukemia (ALL), potentially leading to treatment failure and treatment‐related mortality. Results from the multicenter study of CCCG…
View article: Blinatumomab in pediatric B-acute lymphoblastic leukemia
Blinatumomab in pediatric B-acute lymphoblastic leukemia Open
Blinatumomab, a bispecific T-cell engager, has demonstrated substantial clinical benefits in treating pediatric patients with relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). Approved by FDA for several indications, …
View article: Identification of Crucial Genes Associated With MYCN‐Driven Neuroblastoma Based on Single‐Cell Analysis and Machine Learning
Identification of Crucial Genes Associated With MYCN‐Driven Neuroblastoma Based on Single‐Cell Analysis and Machine Learning Open
Background Neuroblastoma (NB) with MYCN amplification is strongly correlated with high‐risk stratification and poor prognosis. However, the underlying mechanisms remain incompletely understood. Elucidating these pathways is critical for ad…
View article: CACA clinical guideline of holistic psychosocial care for cancer patients
CACA clinical guideline of holistic psychosocial care for cancer patients Open
The CACA clinical guidelines for psychosocial care provide a framework and systematic recommendations for addressing psychological issues in patients with cancer, as well as for meeting the psychosocial needs of cancer patients and their f…
View article: Disulfidptosis in pediatric AML: a multi-omics approach to risk stratification and potential therapeutic strategy
Disulfidptosis in pediatric AML: a multi-omics approach to risk stratification and potential therapeutic strategy Open
View article: Efficacy and Safety of Letermovir for Cytomegalovirus Prophylaxis Following Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients
Efficacy and Safety of Letermovir for Cytomegalovirus Prophylaxis Following Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients Open
Letermovir is both effective and safe for CMV prophylaxis in pediatric patients following HCT, especially in patients with more risk factors of csCMVi. Grade II-IV GvHD increases the risk of csCMVi, while letermovir prophylaxis reduces the…
View article: [Factors associated with prognosis and treatment failure in children with acute lymphoblastic leukemia].
[Factors associated with prognosis and treatment failure in children with acute lymphoblastic leukemia]. Open
The prognosis of children with ALL is related to risk stratification, immunophenotyping, relapse status, and occurrence of severe adverse events. Among these factors, relapse is the primary cause of treatment failure. Actively preventing r…
View article: Relationship between albumin-corrected anion gap and non-alcoholic fatty liver disease: a cross-sectional analysis of NHANES 2017–2018
Relationship between albumin-corrected anion gap and non-alcoholic fatty liver disease: a cross-sectional analysis of NHANES 2017–2018 Open
Objectives The objective of this study was to examine the correlation between the albumin-corrected anion gap (ACAG) and non-alcoholic fatty liver disease (NAFLD) using data from the National Health and Nutrition Examination Survey (NHANES…
View article: Progress of porous tantalum surface-modified biomaterial coatings in bone tissue engineering
Progress of porous tantalum surface-modified biomaterial coatings in bone tissue engineering Open
View article: A novel tantalum scaffold promoting osteoporotic osseointegration by controlled immune regulation
A novel tantalum scaffold promoting osteoporotic osseointegration by controlled immune regulation Open
Implant failure due to osteoporosis remains a significant clinical challenge that requires further investigation and resolution. The immunomodulatory properties of bone implant materials are of great significance for the regulation of bone…
View article: Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study
Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study Open
Objectives This study aimed to investigate the relationship between albumin-corrected anion gap (ACAG) and lumbar spine bone mineral density (BMD) in a diverse population, assessing how variations in ACAG levels correlate with changes in l…
View article: Application and progress of 3D printed biomaterials in osteoporosis
Application and progress of 3D printed biomaterials in osteoporosis Open
Osteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and bone formation. Conventional treatments, such as pharmaceutical drugs and hormone replacement therapy, often yield suboptimal…
View article: Pediatric pancreatic acinar cell carcinoma with a non-canonical BRAF-KMT2C fusion and a classic SND1-BRAF fusion: a case report and literature review
Pediatric pancreatic acinar cell carcinoma with a non-canonical BRAF-KMT2C fusion and a classic SND1-BRAF fusion: a case report and literature review Open
View article: Application of Light-Responsive Nanomaterials in Bone Tissue Engineering
Application of Light-Responsive Nanomaterials in Bone Tissue Engineering Open
The application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially in promoting bone healing and regeneration. With a deeper understanding of the mechanisms of bone defects and healing dis…
View article: A Tumor Microenvironment-triggered Biomineralized Nanoplatform Synergizes with Lypressin for Tumor Blockade Therapy
A Tumor Microenvironment-triggered Biomineralized Nanoplatform Synergizes with Lypressin for Tumor Blockade Therapy Open
View article: The Prognostic and Risk Factors for Children With High‐Risk Mature B‐Cell Non‐Hodgkin's Lymphoma: A Retrospective Multicenter Study
The Prognostic and Risk Factors for Children With High‐Risk Mature B‐Cell Non‐Hodgkin's Lymphoma: A Retrospective Multicenter Study Open
Backgrounds and Aims Our previous study (CCCG‐BNHL‐2015) reported the treatment strategies and outcomes of pediatric B‐cell non‐Hodgkin's lymphoma (B‐NHL) in China which showed that children in low‐risk groups already have a dramatically f…
View article: Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report
Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report Open
Background Imerslund-Gräsbeck syndrome (IGS) is an autosomal recessive disorder characterized by selective vitamin B12 malabsorption, resulting in vitamin B12 deficiency and impaired reabsorption of proximal tubular proteins.This case high…
View article: Clinical analysis of immune reconstitution after chemotherapy in children with acute lymphoblastic leukemia
Clinical analysis of immune reconstitution after chemotherapy in children with acute lymphoblastic leukemia Open
View article: Osteopontin-driven partial epithelial-mesenchymal transition governs the development of middle ear cholesteatoma
Osteopontin-driven partial epithelial-mesenchymal transition governs the development of middle ear cholesteatoma Open
Cholesteatoma is a common disease of the middle ear. Currently, surgical removal is the only treatment option and patients face a high risk of relapse. The molecular basis of cholesteatoma remains largely unknown. Here, we show that Osteop…
View article: Case report: Genetic analysis of a novel intronic inversion variant in the SPTB gene associated with hereditary spherocytosis
Case report: Genetic analysis of a novel intronic inversion variant in the SPTB gene associated with hereditary spherocytosis Open
Background: Hereditary spherocytosis (HS) is a congenital haemolytic anaemia attributed to dysregulation or abnormal quantities of erythrocyte membrane proteins. Currently, the most common erythrocytic gene, spectrin β ( SPTB ), variants a…
View article: Imerslund-Gräsbeck Syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report
Imerslund-Gräsbeck Syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report Open
Background Imerslund-Gräsbeck syndrome (IGS) is an autosomal recessive disorder characterized by selective vitamin B12 malabsorption, resulting in vitamin B12 deficiency and impaired reabsorption of proximal tubular proteins.This case high…
View article: Prognostic prediction by 18F-FDG-PET/CT parameters in patients with neuroblastoma: a systematic review and meta-analysis
Prognostic prediction by 18F-FDG-PET/CT parameters in patients with neuroblastoma: a systematic review and meta-analysis Open
Purpose Neuroblastoma is a solid malignant tumor with high malignancy and high risk for metastasis. The prognosis of neuroblastoma ranges from spontaneous regression to insensitivity to therapies and widespread metastasis. There is a non-i…
View article: Updates on Hearing Loss and its Rehabilitation
Updates on Hearing Loss and its Rehabilitation Open
This book provides a comprehensive overview of hearing loss and its rehabilitation. It contains valuable contributions from experts organized into two sections on hearing loss and its etiology and management, and precision medicine. This b…
View article: Presbycusis: A Coordinated and Personalized Approach According to Different Frailty Phenotypes
Presbycusis: A Coordinated and Personalized Approach According to Different Frailty Phenotypes Open
Age-related hearing loss (ARHL) is the most common sensory impairment. Older people with ARHL may vary in their profiles and usually manifest heterogeneous phenotypes, including in combination with presbyastasis, tinnitus, different frailt…
View article: Effect of the tyrosine kinase inhibitors on the growth in children with Philadelphia chromosome–positive acute lymphoblastic leukemia: a case–control study
Effect of the tyrosine kinase inhibitors on the growth in children with Philadelphia chromosome–positive acute lymphoblastic leukemia: a case–control study Open
This study was supported by the National Natural Science Foundation of China (grant 81670136 [JCai and JT]), the fourth round of Three-Year Public Health Action Plan (2015-2017; GWIV-25 [SS]), Shanghai Health Commission Clinical Research P…
View article: Data from Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor–Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells
Data from Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor–Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells Open
Growing evidence shows an association between chronic liver inflammation and hepatocellular carcinoma (HCC) development. STAT3, which is associated with inflammation and cellular transformation, is constitutively activated in human HCC tis…
View article: Data from Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor–Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells
Data from Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor–Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells Open
Growing evidence shows an association between chronic liver inflammation and hepatocellular carcinoma (HCC) development. STAT3, which is associated with inflammation and cellular transformation, is constitutively activated in human HCC tis…
View article: Supplementary Figures 1-3 from Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor–Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells
Supplementary Figures 1-3 from Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor–Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells Open
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