Aihong Peng
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View article: ADIPOQ regulates lipid metabolism by activating AMPK/CPT-1 pathway to attenuate the proliferation of psoriasis lesions
ADIPOQ regulates lipid metabolism by activating AMPK/CPT-1 pathway to attenuate the proliferation of psoriasis lesions Open
View article: Heat stress increases mutation efficiency mediated by CRISPR/Cas9 in citrus
Heat stress increases mutation efficiency mediated by CRISPR/Cas9 in citrus Open
The CRISPR/Cas9 system has shown great promise in engineering targeted mutations in a genome. The efficiency of Cas9-mediated genome editing is temperature sensitive. A high-temperature regime can increase the mutation efficiency induced b…
View article: The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases
The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases Open
Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway, and plays a vital role in the regulation of cell metabolic activity, reprogramming, aging a…
View article: The role of actin cytoskeleton CFL1 and ADF/cofilin superfamily in inflammatory response
The role of actin cytoskeleton CFL1 and ADF/cofilin superfamily in inflammatory response Open
Actin remodeling proteins are important in immune diseases and regulate cell cytoskeletal responses. These responses play a pivotal role in maintaining the delicate balance of biological events, protecting against acute or chronic inflamma…
View article: Molecular mechanisms and drug therapy of metabolism disorders in psoriasis
Molecular mechanisms and drug therapy of metabolism disorders in psoriasis Open
In psoriasis, enhanced glycolysis, glutamine metabolism and altered fatty acid composition in the psoriatic lesion and plasma result in the excessive proliferation of keratinocytes and secretion of inflammatory cytokines. Altered metabolis…
View article: Downregulation of lysine 2-hydroxyisobutyrylation of ErbB3 binding protein 1 at amino acid 210 promotes keratinocyte proliferation via induction of transcription initiation factor IA-mediated rRNA synthesis
Downregulation of lysine 2-hydroxyisobutyrylation of ErbB3 binding protein 1 at amino acid 210 promotes keratinocyte proliferation via induction of transcription initiation factor IA-mediated rRNA synthesis Open
Background Psoriasis is a prevalent chronic inflammatory dermatosis characterized by the excessive proliferation of keratinocytes (KCs). Lysine 2-hydroxyisobutyrylation (Khib) is a newly identified post-translational modification that regu…
View article: CsBZIP40 confers resistance against citrus bacterial canker by repressing CsWRKY43-CsPrx53/CsSOD13 cascade mediated ROS scavenging
CsBZIP40 confers resistance against citrus bacterial canker by repressing CsWRKY43-CsPrx53/CsSOD13 cascade mediated ROS scavenging Open
As the bacterial etiologic agent causing citrus bacterial canker (CBC), Xanthomonas citri subsp. citri (Xcc) seriously impacts citrus plantation and fruit production globally. In an earlier study, we demonstrated that CsBZIP40 can positive…
View article: Production of marker-free transgenic plants from mature tissues of navel orange using a Cre/loxP site-recombination system
Production of marker-free transgenic plants from mature tissues of navel orange using a Cre/loxP site-recombination system Open
Genetic transformation with mature material as the explants could shorten the transgenic period and avoid seed dependence compared with genetic transformation using the epicotyl seedling stem segments as the receptor. Here, we constructed …
View article: Psoriatic Dermal-Derived Mesenchymal Stem Cells Induced C3 Expression in Keratinocytes
Psoriatic Dermal-Derived Mesenchymal Stem Cells Induced C3 Expression in Keratinocytes Open
Our results suggest that psoriatic DMSCs contribute to the increased C3 expression in psoriatic lesion via upregulating S100A9, providing the theoretical basis for the role of C3 and DMSCs in the pathogenesis of psoriasis.
View article: CsLOB1 regulates susceptibility to citrus canker through promoting cell proliferation in citrus
CsLOB1 regulates susceptibility to citrus canker through promoting cell proliferation in citrus Open
Summary Citrus sinensis lateral organ boundary 1 (CsLOB1) was previously identified as a critical disease susceptibility gene for citrus bacterial canker, which is caused by Xanthomonas citri subsp. citri (Xcc). However, the molecular mech…
View article: Overexpression of Salicylic Acid Carboxyl Methyltransferase (CsSAMT1) Enhances Tolerance to Huanglongbing Disease in Wanjincheng Orange (Citrus sinensis (L.) Osbeck)
Overexpression of Salicylic Acid Carboxyl Methyltransferase (CsSAMT1) Enhances Tolerance to Huanglongbing Disease in Wanjincheng Orange (Citrus sinensis (L.) Osbeck) Open
Citrus Huanglongbing (HLB) disease or citrus greening is caused by Candidatus Liberibacter asiaticus (Las) and is the most devastating disease in the global citrus industry. Salicylic acid (SA) plays a central role in regulating plant defe…
View article: The regulation of dermal mesenchymal stem cells on keratinocytes apoptosis
The regulation of dermal mesenchymal stem cells on keratinocytes apoptosis Open
Dermal mesenchymal stem cells (DMSCs) are progenitor cells with the capacity of self-renewal, multilineage differentiation, and immunomodulation, which were reported to induce the proliferation of keratinocytes, however the regulation on k…
View article: CitGVD: a comprehensive database of citrus genomic variations
CitGVD: a comprehensive database of citrus genomic variations Open
Citrus is one of the most important commercial fruit crops worldwide. With the vast genomic data currently available for citrus fruit, genetic relationships, and molecular markers can be assessed for the development of molecular breeding a…
View article: Overexpressing GH3.1 and GH3.1L reduces susceptibility to Xanthomonas citri subsp. citri by repressing auxin signaling in citrus (Citrus sinensis Osbeck)
Overexpressing GH3.1 and GH3.1L reduces susceptibility to Xanthomonas citri subsp. citri by repressing auxin signaling in citrus (Citrus sinensis Osbeck) Open
The auxin early response gene Gretchen Hagen3 (GH3) plays dual roles in plant development and responses to biotic or abiotic stress. It functions in regulating hormone homeostasis through the conjugation of free auxin to amino acids. In ci…
View article: Overexpressing <i>CsGH3.1</i> and <i>CsGH3.1L</i> reduces susceptibility to <i>Xanthomonas citri</i> subsp. <i>citri</i> by repressing auxin signaling in citrus (<i>Citrus sinensis</i> Osbeck)
Overexpressing <i>CsGH3.1</i> and <i>CsGH3.1L</i> reduces susceptibility to <i>Xanthomonas citri</i> subsp. <i>citri</i> by repressing auxin signaling in citrus (<i>Citrus sinensis</i> Osbeck) Open
The auxin early response gene Gretchen Hagen3 ( GH3 ) plays dual roles in plant development and responses to biotic or abiotic stress. It functions in regulating hormone homeostasis through the conjugation of free auxin to amino acids. In …
View article: Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived Streptomyces sp.
Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived Streptomyces sp. Open
Four angucycline glycosides were previously characterized from marine-derived Streptomyces sp. OC1610.4. Further investigation of this strain cultured on different fermentation media from that used previously resulted in the isolation of t…
View article: Strepantibins A–C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated <i>Streptomyces</i> sp.
Strepantibins A–C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated <i>Streptomyces</i> sp. Open
Two new p-terphenyls, strepantibins A and B (1 and 2), along with the first representative of a naturally occurring bisphenyltropone, strepantibin C (3), were characterized from a Streptomyces sp. associated with the larvae of the mud daub…
View article: Angucycline Glycosides from an Intertidal Sediments Strain Streptomyces sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells
Angucycline Glycosides from an Intertidal Sediments Strain Streptomyces sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells Open
Four angucycline glycosides including three new compounds landomycin N (1), galtamycin C (2) and vineomycin D (3), and a known homologue saquayamycin B (4), along with two alkaloids 1-acetyl-β-carboline (5) and indole-3-acetic acid (6), we…
View article: Angucycline Glycosides from an Intertidal Sediments Strain Streptomyces sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells
Angucycline Glycosides from an Intertidal Sediments Strain Streptomyces sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells Open
Four angucycline glycosides including three new compounds landomycin N (1), galtamycin C (2) and vineomycin D (3), and a known homologue saquayamycin B (4), along with two alkaloids 1-acetyl-β-carboline (5) and indole-3-acetic acid (6), we…
View article: Identification and Expression Analysis of Multiple Ferric Chelate Reductases in Citrus junos
Identification and Expression Analysis of Multiple Ferric Chelate Reductases in Citrus junos Open
Ferric chelate reductase (FRO) is a critical enzyme for iron absorption in strategy I plants, reducing Fe 3+ to Fe 2+ . To identify FRO family genes in the local Citrus junos cultivar Ziyang Xiangcheng and to reveal their expression model,…
View article: Engineering canker‐resistant plants through <scp>CRISPR</scp> /Cas9‐targeted editing of the susceptibility gene <i> Cs <scp>LOB</scp> 1 </i> promoter in citrus
Engineering canker‐resistant plants through <span>CRISPR</span> /Cas9‐targeted editing of the susceptibility gene <i> Cs <span>LOB</span> 1 </i> promoter in citrus Open
Summary Citrus canker, caused by Xanthomonas citri subsp. citri ( Xcc ), is severely damaging to the global citrus industry. Targeted editing of host disease‐susceptibility genes represents an interesting and potentially durable alternativ…
View article: Cloning and Expression Analysis of Citrus Genes CsGH3.1 and CsGH3.6 Responding to Xanthomonas axonopodis pv. citri Infection
Cloning and Expression Analysis of Citrus Genes CsGH3.1 and CsGH3.6 Responding to Xanthomonas axonopodis pv. citri Infection Open
View article: Characterization of transgenic Poncirus trifoliata overexpressing the ferric chelate reductase gene CjFRO2 from Citrus junos
Characterization of transgenic Poncirus trifoliata overexpressing the ferric chelate reductase gene CjFRO2 from Citrus junos Open
Iron deficiency chlorosis occurs frequently in calcareous soils. The transformation of plants with ferric chelate reductase genes (FROs) provides a potential strategy to alleviate plant chlorosis under iron deficiency. A CjFRO2 gene isolat…