Ai‐Hong Yang
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View article: Design, synthesis, biological evaluation, and X‐ray single crystal structure of novel computer‐aided‐drug‐designbased α‐mangostin derivatives: Multifunctional ligands against Alzheimer's disease
Design, synthesis, biological evaluation, and X‐ray single crystal structure of novel computer‐aided‐drug‐designbased α‐mangostin derivatives: Multifunctional ligands against Alzheimer's disease Open
Multifunctional ligand design strategy may be a promising approach for the treatment of Alzheimer's disease (AD). α‐Mangostin (α‐M), a natural small molecule with anti‐AD properties, was used as the lead compound for the design and synthes…
View article: Carrier-free nanoparticles—new strategy of improving druggability of natural products
Carrier-free nanoparticles—new strategy of improving druggability of natural products Open
There are abundant natural products resources and extensive clinical use experience in China. However, the active components of natural products generally have problems such as poor water solubility and low bioavailability, which limit the…
View article: Anticancer effect of a combination of cisplatin and matrine on cervical cancer U14 cells and U14 tumor-bearing mice, and possible mechanism of action involved
Anticancer effect of a combination of cisplatin and matrine on cervical cancer U14 cells and U14 tumor-bearing mice, and possible mechanism of action involved Open
Purpose: To investigate the anticancer effects of cisplatin (DDP) in combination with matrine on cervical cancer U14 cell tumor-bearing mice.
Methods: The cell proliferation of cervical cancer U14 cells treated with DDP (25, 20, 15, 10 an…
View article: Synthesis, Single Crystal Characterization and Anti-AD Activities of a Novel Complex of Cu(II) with <i>in Situ</i> Formed Protonated Chrysin Derivative Ligand
Synthesis, Single Crystal Characterization and Anti-AD Activities of a Novel Complex of Cu(II) with <i>in Situ</i> Formed Protonated Chrysin Derivative Ligand Open
View article: Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease
Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease Open
View article: Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy
Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy Open
View article: Anti-depressant effect of curcumin-loaded guanidine-chitosan thermo-sensitive hydrogel by nasal delivery
Anti-depressant effect of curcumin-loaded guanidine-chitosan thermo-sensitive hydrogel by nasal delivery Open
Curcumin, a polyphenol compound extracted from the roots of turmeric plants, possesses anti-depressant effect by regulating the levels of neuroendocrine immunological factors. The purpose of this study was to investigate the anti-de…
View article: Simultaneous Evaluation of Inhibition on Human CYP450 of Asarum Volatile Oil by a Cocktail Approach
Simultaneous Evaluation of Inhibition on Human CYP450 of Asarum Volatile Oil by a Cocktail Approach Open
In this study, the cocktail method was used to study the inhibitory effect of the volatile oil components including asarinin, methyl eugenol, asarone, safrole and myristicin on the CYP450 enzymes. Five kinds of probe substrates metabolized…
View article: Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole
Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole Open
1. Safrole is the main component of the volatile oil in Xixin, which has a strong antifungal effect. However, safrole has been shown to be associated with the development of hepatocellular carcinoma. Methylenedioxyphenyl and allyl-benzene …
View article: CCDC 774610: Experimental Crystal Structure Determination
CCDC 774610: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 888446: Experimental Crystal Structure Determination
CCDC 888446: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 748264: Experimental Crystal Structure Determination
CCDC 748264: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 748309: Experimental Crystal Structure Determination
CCDC 748309: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 702820: Experimental Crystal Structure Determination
CCDC 702820: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …