Explanipedia

A TLR4-HSP70 efferocytic program in thymic macrophages sustains thymic homeostasis and T cell output Open

Andri L. Lemarquis, Daniel Ghazarian, Brianna Gipson, Aihua Huang, Scott E. James , et al. · 2025

T cell reconstitution is essential for immune recovery after hematopoietic cell transplantation (HCT) and requires a functional thymus to generate naïve T cells. However, thymic regenerative failure remains poorly understood and lacks ther…

1291 Evaluation of whole blood preservation strategies for high-dimensional mass cytometry in clinical immune monitoring Open

Carly L. Lancaster, M. W. Coughlin, Aihua Huang, Justin A. Jarrell, Ramji Srinivasan , et al. · 2025

Bioinformatics-based identification of differentially expressed genes in endometrial carcinoma: implications for early diagnosis and prognostic stratification Open

Liang Gao, Donglan Yuan, Aihua Huang, Hua Qian · 2025

Introduction This study aims to identify differentially expressed genes (DEGs) in endometrial carcinoma (EC) through bioinformatics analysis and investigate their roles in early diagnosis and prognosis. Methods EC-related gene datasets wer…

Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells Open

Aihua Huang, Yali Kong, Kan Wang, Milton L. Brown, David Mu · 2025

Breast cancer is one of the most common cancers globally. Unfortunately, many patients with breast cancer develop resistance to chemotherapy and tumor recurrence, which is primarily driven by breast cancer stem cells (BCSCs). BCSCs behave …

Genome and transcriptome wide association study identify candidate genes regulating folate levels in maize Open

Chenglin Zou, Meng Yang, Aihua Huang, Runxiu Mo, Ruining Zhai , et al. · 2025

Background Maize ( Zea mays L.) serves as a crucial dietary source of folate for humans. However, the genetic regulatory mechanisms underlying the natural variation of folate in maize remain poorly understood. Here, we integrated multi-omi…

Geographic atrophy: Understanding the relationship between structure and function Open

Aihua Huang, Zhichao Wu, Georg Ansari, Leon von der Emde, Maximilian Pfau , et al. · 2025

The complex relationship between structural and functional measures in GA reflects underlying pathophysiological mechanisms and has important implications for clinical trial endpoints and patient management. Multimodal assessment incorpora…

Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway Open

Tianwang Guan, Zhenxing Lu, Rundong Tai, Shuai Guo, Zhaowenbin Zhang , et al. · 2025

Diabetes and chemotherapy frequently give rise to severe cardiovascular complications, including chemotherapy-induced cardiotoxicity and diabetes-associated vascular remodeling. Nevertheless, the precise epidemiological features of these c…

Measuring Dynamic Stomatal Opening at Milli-Scale: Toward In-Field Distributive Deployment Open

Qingze Zou, Ziyan Zhang, Shuangliang Li, Dengmeng Li, Aihua Huang , et al. · 2025

Identification of the arl1 locus controlling leaf rolling and its application in maize breeding Open

Meng Yang, Aihua Huang, Ru Wen, Shuyun Tian, Runxiu Mo , et al. · 2025

Synchronous Cardiac and Central Nervous System Diffuse Large B-Cell Lymphoma Open

Jack Bradbury, Cassandra Spanos, Michael Shipton, Penny McKelvie, Aihua Huang · 2024

FOXP3 targets KIF5A to increase lactate production and promote docetaxel resistance in lung adenocarcinoma Open

Liangliang Dong, Chan Feng, Wenwen Cheng, Aihua Huang, Kejing Ying · 2024

A prominent cause of cancer-related fatalities with a poor prognosis is lung adenocarcinoma (LUAD). KIF5A, a crucial member of the kinesin superfamily, is linked to drug resistance in malignancies. This work aims to investigate the mechani…

Physiological Characteristic Changes and Transcriptome Analysis of Maize (Zea mays L.) Roots under Drought Stress Open

Chenglin Zou, Hua Tan, Kaijian Huang, Ruining Zhai, Meng Yang , et al. · 2024

Water deficit is a key limiting factor for limiting yield in maize (Zea mays L.). It is crucial to elucidate the molecular regulatory networks of stress tolerance for genetic enhancement of drought tolerance. The mechanism of drought toler…

Impact of Social Media on Employee Innovation Performance: The Mediating Role of Knowledge Acquisition and Moderating Role of Status Hierarchy Open

Li Yang, Shanshi Liu, Shuo Huang, Aihua Huang · 2024

From the perspective of Knowledge Acquisition(KA) and based on the communication visibility theory, this paper uses multi-level regression analysis to explore the impact mechanism of social media use on Employee Innovation Performance(EIP)…

Identification of immune-related hub genes contributing to the pathogenesis, diagnosis, and remission of ulcerative colitis by integrated bioinformatic analyses Open

Lingna Zhou, Qianru Gu, Aihua Huang, Guoxiang Fu, Xiaotong Hu , et al. · 2023

The inflammatory disease ulcerative colitis (UC) is multifaceted, immune-mediated, chronic, and relapsing, which is considered to be mainly driven by dysregulated mucosal immune response. The remission of the inflammatory response is a mar…

Analysis of neoadjuvant chemotherapy for breast cancer: a 20-year retrospective analysis of patients of a single institution Open

Danzhi Chen, Qinchuan Wang, Minjun Dong, Fei Chen, Aihua Huang , et al. · 2023

Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting <span>PIEZO1</span>/calpain/autophagy signaling pathway in the basal forebrain Open

Zi‐qing Zhang, Yan Lü, Hao Zhang, Suhe Dong, Ya‐tong Wu , et al. · 2023

Aims To verify the hypothesis that an enriched environment (EE) alleviates sleep deprivation‐induced fear memory impairment by modulating the basal forebrain (BF) PIEZO1/calpain/autophagy pathway. Methods Eight‐week‐old male mice were hous…

Determination of Ten Flavonoids in the Raw and Fermented Fructus Aurantii by Quantitative Analysis of Multicomponents via a Single Marker (QAMS) Based on UPLC Open

Ting Yang, Ying‐Ying Huang, Qinru Li, Qijian Xu, Yangbing Fang , et al. · 2023

Fermented Fructus Aurantii (FFA) is widely used in South China for the treatment of functional dyspepsia. Naringin, neohesperidin, and other flavonoids are the main pharmacodynamic components of FFA. A new method is presented for the simul…

Deep Learning-Based Recognition of Cervical Squamous Interepithelial Lesions Open

Huimin An, Liya Ding, Mengyuan Ma, Aihua Huang, Yi Gan , et al. · 2023

Cervical squamous intraepithelial lesions (SILs) are precursor lesions of cervical cancer, and their accurate diagnosis enables patients to be treated before malignancy manifests. However, the identification of SILs is usually laborious an…

Postpartum stress urinary incontinence: a clinical study of 6,302 cases in Jiangsu Province Open

Xiaoxia Chang, Ling Ling, Hong-Ju Gao, Yumei Jiang, Meiqin Jiang , et al. · 2023

Objectives: To investigate the prevalence and influencing factors of stress urinary incontinence (SUI) within 6–8 weeks postpartum in Jiangsu Province. Material and methods: We designed a multi-center cross-sectional study involving seven …

Effect of Fetal-type Posterior cerebral artery on cerebral infarction and collateral circulation Open

Fan Bai, Bei Hou, Hui Liu, Lei Zhu, Shanshan Guo , et al. · 2023

We studied 57 patients with cerebral infarction and Fetal-type Posterior cerebral artery (FTP)\, confirmed by MRA and CTA. 26 cases (45.61%) of Complete Fetal-type Posterior cerebral artery (cFTP), 21 cases (36.84%) of Partial Fetal-type P…

Analysis of neoadjuvant chemotherapy for breast cancer: A 20-year retrospective analysis of patients of a single institution Open

Danzhi Chen, Qinchuan Wang, Minjun Dong, Fei Chen, Aihua Huang , et al. · 2023

Background Neoadjuvant chemotherapy has been widely applied in operable breast cancer patients. This study aim to identify the predictive factors of overall survival(OS) and recurrence free survival (RFS) in breast cancer patients who rece…

Serum interleukin-6 levels are increased in post-herpetic neuralgia: a single-center retrospective study Open

Ding Lin, Changyang Zhong, Quanlong Jiang, Aihua Huang, Yuan Liu · 2023

Additional file 1 of Analysis of neoadjuvant chemotherapy for breast cancer: a 20-year retrospective analysis of patients of a single institution Open

Danzhi Chen, Qinchuan Wang, Minjun Dong, Fei Chen, Aihua Huang , et al. · 2023

Supplementary Material 1

SNP-based bulk segregant analysis revealed disease resistance QTLs associated with northern corn leaf blight in maize Open

Ruining Zhai, Aihua Huang, Runxiu Mo, Chenglin Zou, Xinxing Wei , et al. · 2022

Maize ( Zea mays L.) is the most important food security crop worldwide. Northern corn leaf blight (NCLB), caused by Exserohilum turcicum , severely reduces production causing millions of dollars in losses worldwide. Therefore, this study …

Exosomal lncRNA ATB Derived from Ovarian Cancer Cells Promotes Angiogenesis via Regulating miR-204-3p/TGF&beta;R2 Axis Open

Donglan Yuan, Ting Guo, Dandan Zhu, Hongshan Ge, Yinling Zhao , et al. · 2022

Donglan Yuan,1,&ast; Ting Guo,2,&ast; DanDan Zhu,1 Hongshan Ge,1 Yinling Zhao,1 Aihua Huang,1 Xiaosu Wang,1 Xiuhong Cao,3 CuiQin He,1 Hua Qian,1 Hong Yu4 1Department of Obstetrics and Gynecology, Taizhou Peopleâs Hospital Affilia…

LncRNA-MSC-AS1 inhibits the ovarian cancer progression by targeting miR-425-5p Open

Yinling Zhao, Donglan Yuan, Dandan Zhu, Tianhui Xu, Aihua Huang , et al. · 2021

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer Open

Jing‐Jing Yang, Yulu Zhou, Shuduo Xie, Ji Wang, Zhaoqing Li , et al. · 2021

Background Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer. Targeting ferroptosis…

Metformin Induces Ferroptosis byInhibiting UFMylation of SLC7A11 in Breast Cancer Open

Jingjing Yang, Yulu Zhou, Shuduo Xie, Wang Ji, Zhaoqing Li , et al. · 2021

Background Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer. Targeting ferroptosis…

LncRNA-MSC-AS1 inhibits the ovarian cancer progression by targeting miR-425-5p Open

Yinling Zhao, Donglan Yuan, Dandan Zhu, Tianhui Xu, Aihua Huang , et al. · 2021

Background Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) were reported to be aberrantly expressed and related to the pathogenesis of ovarian cancer. However, the role and regulatory mechanism of MSC-AS1 in ovarian cancer has yet to…

Splenic laceration following endoscopic retrograde cholangiopancreatography: A literature review and our experience Open

Kan Wang, Yanfei Fang, Aihua Huang, Min Gao · 2020

Aihua Huang YOU? Author Swipe