Explanipedia

Lactate activates trained immunity by fueling the tricarboxylic acid cycle and regulating histone lactylation Open

Huanhuan Cai, Xueyuan Chen, Yan Liu, Ying-Bo Chen, Gechang Zhong , et al. · 2025

Targeted Degradation Technology Based on the Autophagy‐Lysosomal Pathway: A Promising Strategy for Treating Preeclampsia Open

Lin Xiao, Mei Zhang, Jing Chen, Kai Zhao, Huiping Zhang , et al. · 2025

In recent years, targeted protein degradation (TPD) strategies leveraging the autophagy‐lysosomal pathway (ALP) have transcended the limitations of conventional drug molecules, emerging as a highly promising approach for selectively elimin…

PD‐1‐Enhanced Treg Cell Senescence in Advanced Maternal Age Open

Guang‐Shun Gong, Yujing Zhang, Xiaohui Hu, Xinxiu Lin, Aihua Liao · 2024

Senescence occurs earlier in the immune system than in solid organs as age increases. Regulatory T (Treg) cells are among the first cells to exhibit signs of aging. However, whether advanced‐age pregnancy involves Treg cell aging remains u…

Editorial: Autophagy: unveiling the mechanisms and implications in health and disease Open

Shi‐Bin Cheng, Xiaodi Chen, Aihua Liao · 2024

IL-27/Blimp-1 axis regulates the differentiation and function of Tim-3+ Tregs during early pregnancy Open

Sijia Zhao, Xiaohui Hu, Xinxiu Lin, Yujing Zhang, Jing Wang , et al. · 2024

Decidual regulatory T cells (Tregs) are essential for successful pregnancy outcome. A subset of Tregs, T cell immunoglobulin and mucin domain-containing protein 3-positive regulatory T cells (TregsTim-3+), plays a central role in the accep…

Hydroquinone impairs trophoblast migration and invasion via AHR-twist-IFITM1 axis Open

Anthony Maxwell, Grace Swanson, Annie Thy Nguyen, Anna Hu, Darby Richards , et al. · 2024

Interleukin-10: a novel metabolic inducer of macrophage differentiation and subsequently contributing to improved pregnancy outcomes of mice by orchestrating oxidative phosphorylation metabolism Open

Huan Wang, Liling Wang, Guangshun Gong, Xinxiu Lin, Jing Luo , et al. · 2024

Metabolism regulates the phenotype and function of macrophages. After recruitment to local tissues, monocytes are influenced by the local microenvironment and differentiate into various macrophages depending on different metabolic pathways…

Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice Open

Qing Tian, Ying Yin, Yu Tian, Yufan Wang, Y Wang , et al. · 2024

Epigenetic modifiers that accumulate in oocytes, play a crucial role in steering the developmental program of cleavage embryos and initiating life. However, the identification of key maternal epigenetic regulators remains elusive. In the f…

Ketolysis Activates T Cell Function Against Staphylococcus Aureus Infection by Fueling the Tricarboxylic Acid (TCA) Cycle and Affecting Histone Acetylation Open

Huanhuan Cai, Hao Zeng, Ying-Bo Chen, Xiaoyu Chen, Shuo Rong , et al. · 2024

TRIM34 Suppresses Hepatocellular Carcinoma Via Targeting TAK1 for K63-Linked Polyubiquitination Open

Xuan Lu, Zelong Li, Siwei Dong, Peipei Yao, Fei Chen , et al. · 2024

Macrophage memory: Types, Mechanisms, and Its Role in Health and Disease Open

Aihua Liao, Xu-Hui Fang, Zhi-Jing Li, Chunyan Liu, Gil Mor · 2023

On the basis of the mechanisms of action and characteristics of immune effects, immunity is generally divided into innate and adaptive immunity. Adaptive immunity is associated with the response to non-self entities and is characterized by…

Twist1–IRF9 Interaction Is Necessary for IFN-Stimulated Gene Anti-Zika Viral Infection Open

Yuan You, Esteban Grasso, Ayesha B. Alvero, Jennifer C. Condon, Tanya Dimova , et al. · 2023

An efficient immune defense against pathogens requires sufficient basal sensing mechanisms that can deliver prompt responses. Type I IFNs are protective against acute viral infections and respond to viral and bacterial infections, but thei…

11.4 T ultra-high static magnetic field has no effect on morphology but induces upregulation of TNF signaling pathway based on transcriptome analysis in zebrafish embryos Open

Chunyan Liu, Lu Shi, Shiyu Liu, Chao Dong, Yuanyao Chen , et al. · 2023

As magnetic resonance imaging (MRI) scanners with ultra-high field (UHF) have optimal performance, scientists have been working to develop high-performance devices with strong magnetic fields to improve their diagnostic potential. However,…

Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure Open

Anthony Maxwell, Nicholas K. Adzibolosu, Anna Hu, Yuan You, Paul M. Stemmer , et al. · 2023

The Role of Mononuclear Phagocytes in the Testes and Epididymis Open

Xu Shi, Hu Zhao, Yafei Kang, Xinyi Dong, Caiqian Yu , et al. · 2022

The mononuclear phagocytic system (MPS) is the primary innate immune cell group in male reproductive tissues, maintaining the balance of pro-inflammatory and immune tolerance. This article aims to outline the role of mononuclear macrophage…

The regulation and potential roles of m6A modifications in early embryonic development and immune tolerance at the maternal-fetal interface Open

Hong Liu, Jie Zheng, Aihua Liao · 2022

The immune microenvironment at the maternal-fetal interface was determined by the crosstalk between the trophoblast and maternal-derived cells, which dynamically changed during the whole gestation. Trophoblasts act as innate immune cells a…

Comparing Mouse and Human Tissue-Resident γδ T Cells Open

Guanyu Qu, Shengli Wang, Zhenlong Zhou, Dawei Jiang, Aihua Liao , et al. · 2022

Circulating immune cell compartments have been extensively studied for decades, but limited access to peripheral tissue and cell yield have hampered our understanding of tissue-based immunity, especially in γδ T cells. γδ T cells are a uni…

Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy* Open

Jiahui Ding, Anthony Maxwell, Nicholas K. Adzibolosu, Anna Hu, Yuan You , et al. · 2022

Pregnancy is a unique condition where the maternal immune system is continuously adapting in response to the stages of fetal development and signals from the environment. The placenta is a key mediator of the fetal/maternal interaction by …

Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss Open

Liling Wang, Huan Wang, Jing Luo, Ting Xie, Gil Mor , et al. · 2022

Rationale: Recurrent pregnancy loss (RPL) is a distressing disorder that seriously affects the physical and psychological health of women. RPL is also a sentinel risk marker for future obstetric complications and warrants in-depth i…

Human leukocyte antigens: the unique expression in trophoblasts and their crosstalk with local immune cells Open

Xinxiu Lin, Yingming Xie, Sijia Zhao, Chunyan Liu, Gil Mor , et al. · 2022

Trophoblasts differentiate and form the placenta during pregnancy in a complex and finely orchestrated process, which is dependent on the establishment of maternal-fetal immune tolerance and the proper function of trophoblasts. Trophoblast…

Intrinsic Sexual Dimorphism in the Placenta Determines the Differential Response to Benzene Exposure Open

Anthony Maxwell, Nicholas K. Adzibolosu, Anna Hu, Yuan You, Paul M. Stemmer , et al. · 2022

Immunologic Memory in Pregnancy: Focusing on Memory Regulatory T Cells Open

Yujing Zhang, Li Shen, Tao Zhang, Kahindo P. Muyayalo, Jing Luo , et al. · 2022

A successful pregnancy requires the maternal immune system to tolerate an allogeneic fetus. The incidence of preeclampsia and other complications related to impaired fetal tolerance is lower during the second pregnancy than during the firs…

Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy Open

Lu Gao, Qian‐Han Xu, Lina Ma, Jing Luo, Kahindo P. Muyayalo , et al. · 2021

Lactic acid (LA) metabolism in the tumor microenvironment contributes to the establishment and maintenance of immune tolerance. This pathway is characterized in tumor associated macrophages. However, the role and pathway of LA metabolism a…

TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion Open

Yuan You, Patrick Stelzl, Dana N. Joseph, Paulomi Aldo, Anthony Maxwell , et al. · 2021

Successful implantation requires the coordinated migration and invasion of trophoblast cells from out of the blastocyst and into the endometrium. This process relies on signals produced by cells in the maternal endometrium. However, the re…

Placenta‐derived interferon‐stimulated gene 20 controls ZIKA virus infection Open

Jiahui Ding, Paulomi Aldo, Cai M. Roberts, Paul R. Stabach, Hong Liu , et al. · 2021

C-Type Natriuretic Peptide Plays an Anti-Inflammatory Role in Rat Epididymitis Induced by UPEC Open

Chunlei Mei, Yafei Kang, Chenlu Zhang, Chunyu He, Aihua Liao , et al. · 2021

Human epididymitis is mainly caused by retrograde urinary tract infection with uropathogenic Escherichia coli ( UPEC ). This disease is an important factor (accounting for 20–30%) causing male infertility. C-type natriuretic peptide (CNP),…

Pregnancy Induces an Immunological Memory Characterized by Maternal Immune Alterations Through Specific Genes Methylation Open

Xiaobo Huang, Liling Wang, Sijia Zhao, Hong Liu, Si Chen , et al. · 2021

During pregnancy, the maternal immune system undergoes major adaptive modifications that are necessary for the acceptance and protection of the fetus. It has been postulated that these modifications are temporary and limited to the time of…

Systemic Characterization of Novel Immune Cell Phenotypes in Recurrent Pregnancy Loss Open

Hong Liu, Xinxiu Lin, Xiaobo Huang, Donghui Huang, Su Song , et al. · 2021

Recurrent pregnancy loss (RPL) is a disturbing disease in women, and 50% of RPL is reported to be associated with immune dysfunction. Most previous studies of RPL focused mainly on the relationship between RPL and either T cells or natural…

An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19? Open

Sijia Zhao, Ting Xie, Li Shen, Hong Liu, Liling Wang , et al. · 2021

The coronavirus disease 2019 (COVID-19) pandemic has been raging around the world since January 2020. Pregnancy places the women in a unique immune scenario which may allow severe COVID‐19 disease. In this regard, the potential unknown eff…

Essential Role of Placenta Derived Interferon Stimulated Gene 20 Against ZIKA Virus Infection Open

Jiahui Ding, Paulomi Aldo, Cai M. Roberts, Paul R. Stabach, Hong Liu , et al. · 2021

Zika virus is a positive-sense single-stranded RNA virus, which can be transmitted across the placenta and leads to adverse effects on fetal development during pregnancy. The severity of these complications highlights the importance of pre…

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