Explanipedia

Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci Open

Aihua Lin, Linn Rødevand, Ida E. Sønderby, Oleksandr Frei, Shahram Bahrami , et al. · 2025

Objective Deficits in social communication and social interaction are core features of autism spectrum disorder (ASD), and studies suggest that loneliness and social isolation are common. ASD has a strong genetic basis, but the genetic arc…

Integrating Network Pharmacology, Molecular Docking, Dynamics Simulation and Experimental Validation to Decipher the Antipyretic Mechanisms of Xiaochaihu Granules Open

Miner Gu, Hong Liu, Cong Bi, W. Situ, Haifeng Du , et al. · 2025

Xiaochaihu granules (XCHG), a traditional Chinese herbal formulation, have demonstrated clinical efficacy in fever management, but their precise mode of action remains unclear. Our investigation employed an integrative methodology combinin…

Factors associated with chronic calcineurin inhibitor nephrotoxicity in children with minimal-change disease Open

Bei Jin, Ziji Lu, Cheng Cheng, Yuxin Pei, Lizhi Chen , et al. · 2025

MCD children who developed CNI resistance were susceptible to chronic CNI nephrotoxicity. Urinary NAG might be a valuable biomarker for CNI nephrotoxicity prediction in MCD children.

Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma Open

Ye‐Lin Liang, Xu Liu, Liangfang Shen, Guangyuan Hu, Guorong Zou , et al. · 2025

Importance Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demon…

The green development in China through the lens of complex cybernetics: Insight for a new era Open

Aihua Lin, Pierluigi Toma, Zhang Min-feng, Giulio Fusco · 2024

Measuring the level of green development is far from being a well-assessed problem, due to both the broad meaning of green development and the presence of randomness in environmental changes. In this paper, we develop the sustainable devel…

Corrigendum to “COVID-19 VACCINES MAY ALSO BOOST IMMUNITY TO SEASONAL CORONAVIRUSES AND INFLUENZA” [International Journal of Infectious Diseases Volume 134, Supplement 1 (2023), Page S11] Open

Vennila Gopal, O. Teng, Aihua Lin, Paul Anantharajah Tambyah, R. Chee Seong · 2024

The authors regret the authorship and affiliations in the originally published article were incorrect. The correct details are: V Gopal1, O Teng1, AML Quek1,2, RCS Seet1,2, PA Tambyah1,3 1National University of Singapore, Medicine, Singapo…

Corrigendum to “Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders” [Psychoneuroendocrinology 157 (2023) 106368] Open

Guy Hindley, Ole Kristian Drange, Aihua Lin, Gleda Kutrolli, Alexey Shadrin , et al. · 2024

Correction to: Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci Open

Piotr Jahołkowski, Guy Hindley, Alexey Shadrin, Markos Tesfaye, Shahram Bahrami , et al. · 2023

Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors Open

Linn Rødevand, Zillur Rahman, Guy Hindley, Olav B. Smeland, Oleksandr Frei , et al. · 2023

These findings indicate a genetic propensity to smoking and a reduced genetic risk of obesity among individuals with schizophrenia. The bidirectional effects of the shared loci with the other CVD risk factors may imply differences in genet…

Bidirectional genetic overlap between autism spectrum disorder and cognitive traits Open

Sigrun Hope, Alexey Shadrin, Aihua Lin, Shahram Bahrami, Linn Rødevand , et al. · 2023

Autism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational attainment (EDU)…

Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa Open

Lasse Bang, Shahram Bahrami, Guy Hindley, Olav B. Smeland, Linn Rødevand , et al. · 2023

Anorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and related traits ha…

Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders Open

Guy Hindley, Ole Kristian Drange, Aihua Lin, Gleda Kutrolli, Alexey Shadrin , et al. · 2023

C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders. Recent findings have suggested a protective effect of the genetic liability to elevated CRP on schizophrenia risk and a causative effect on depression…

COVID-19 VACCINES MAY ALSO BOOST IMMUNITY TO SEASONAL CORONAVIRUSES AND INFLUENZA. Open

Vennila Gopal, O. Teng, Aihua Lin, Paul Anantharajah Tambyah, R. Chee Seong · 2023

Intro: The incidence of seasonal influenza reduced significantly during the COVID-19 pandemic, only to rebound in 2022. Although the global rollout of COVID-19 vaccines has significantly reduced the number of patients with severe COVID-19 …

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis Open

Markos Tesfaye, Piotr Jahołkowski, Guy Hindley, Alexey Shadrin, Zillur Rahman , et al. · 2023

Associations between serum trace elements and the risk of nasopharyngeal carcinoma: a multi-center case-control study in Guangdong Province, southern China Open

Xinyu Ge, Shang-Hang Xie, Hao Wang, Xin Ye, Wenjie Chen , et al. · 2023

Background Associations between trace elements and nasopharyngeal carcinoma (NPC) have been speculated but not thoroughly examined. Methods This study registered a total of 225 newly diagnosed patients with NPC and 225 healthy controls mat…

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy Open

Guy Hindley, Alexey Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng , et al. · 2023

Personality and cognitive function are heritable mental traits whose genetic foundations may be distributed across interconnected brain functions. Previous studies have typically treated these complex mental traits as distinct constructs. …

Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts Open

Nadine Parker, Weiqiu Cheng, Guy Hindley, Kevin S. O’Connell, Sandeep Karthikeyan , et al. · 2023

The findings indicate shared genetic underpinnings for cortical brain structure and blood immune markers, with implications for neurodevelopment and understanding the etiology of brain-related disorders.

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities Open

Nils Eiel Steen, Zillur Rahman, Attila Szabó, Guy Hindley, Nadine Parker , et al. · 2023

Background Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-wide association studies (GWAS) have identified genetic variants associated with SCZ and immune-related phenotypes. Here, we use cutting edge statistical tool…

Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci Open

Piotr Jahołkowski, Guy Hindley, Alexey Shadrin, Markos Tesfaye, Shahram Bahrami , et al. · 2023

Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. We applied a conditional/conjunctio…

Supplementary Method from Prognostic Value of Deep Learning PET/CT-Based Radiomics: Potential Role for Future Individual Induction Chemotherapy in Advanced Nasopharyngeal Carcinoma Open