Aijun Pan
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View article: Therapeutic effect and mechanism of inhaled nitric oxide on septic lung injury in mice
Therapeutic effect and mechanism of inhaled nitric oxide on septic lung injury in mice Open
View article: Early Warning Models Using Machine Learning to Predict Sepsis-Associated Chronic Critical Illness: A Study Based on the Medical Information Mart for Intensive Care Database
Early Warning Models Using Machine Learning to Predict Sepsis-Associated Chronic Critical Illness: A Study Based on the Medical Information Mart for Intensive Care Database Open
Background Patients with chronic critical illness (CCI) experience poor prognoses and incur high medical costs. However, there is currently limited clinical awareness of sepsis-associated CCI, resulting in insufficient vigilance. Therefore…
View article: Identification of immune characteristic biomarkers and therapeutic targets in cuproptosis for sepsis by integrated bioinformatics analysis and single-cell RNA sequencing analysis
Identification of immune characteristic biomarkers and therapeutic targets in cuproptosis for sepsis by integrated bioinformatics analysis and single-cell RNA sequencing analysis Open
View article: Use of pus metagenomic next-generation sequencing for efficient identification of pathogens in patients with sepsis
Use of pus metagenomic next-generation sequencing for efficient identification of pathogens in patients with sepsis Open
The positive detection rate of blood metagenomic next-generation sequencing (mNGS) was still too low to meet clinical needs, while pus from the site of primary infection may be advantageous for identification of pathogens. To assess the va…
View article: Carbapenem is not always the best choice in the treatment of septic shock
Carbapenem is not always the best choice in the treatment of septic shock Open
Background Septic shock is a global public health burden. In addition to the improvement of the level of individual care, the improvement of the overall hospital quality control management is also an essential key aspect of the Surviving S…
View article: Diagnostic Value and Clinical Application of Metagenomic Next-Generation Sequencing for Infections in Critically Ill Patients
Diagnostic Value and Clinical Application of Metagenomic Next-Generation Sequencing for Infections in Critically Ill Patients Open
mNGS might be a promising technology to provide precision medicine for critically ill patients with infection.
View article: Identification of immune-related lncRNA in sepsis by construction of ceRNA network and integrating bioinformatic analysis
Identification of immune-related lncRNA in sepsis by construction of ceRNA network and integrating bioinformatic analysis Open
View article: Prevention of urinary tract infection using a silver alloy hydrogel-coated catheter in critically ill patients: A single-center prospective randomized controlled study
Prevention of urinary tract infection using a silver alloy hydrogel-coated catheter in critically ill patients: A single-center prospective randomized controlled study Open
View article: Expert consensus on blood pressure management in critically ill patients
Expert consensus on blood pressure management in critically ill patients Open
View article: Comparison of endotracheal aspirate and bronchoalveolar lavage fluid metagenomic next-generation sequencing in severe pneumonia: a nested, matched case–control study
Comparison of endotracheal aspirate and bronchoalveolar lavage fluid metagenomic next-generation sequencing in severe pneumonia: a nested, matched case–control study Open
View article: Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Noninferiority Trial
Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Noninferiority Trial Open
OBJECTIVES: To determine the effectiveness and safety of ciprofol for sedating patients in ICUs who required mechanical ventilation (MV). DESIGN: A multicenter, single-blind, randomized, noninferiority trial. SETTING: Twenty-one centers ac…
View article: Additional file 6 of Identification of immune-related lncRNA in sepsis by construction of ceRNA network and integrating bioinformatic analysis
Additional file 6 of Identification of immune-related lncRNA in sepsis by construction of ceRNA network and integrating bioinformatic analysis Open
Supplementary Material 6
View article: Effect of ICU quality control indicators on VAP incidence rate and mortality: a retrospective study of 1267 hospitals in China
Effect of ICU quality control indicators on VAP incidence rate and mortality: a retrospective study of 1267 hospitals in China Open
View article: Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019 (COVID-19)
Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019 (COVID-19) Open
View article: Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019
Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019 Open
This consensus focuses on severe and critical coronavirus disease 2019 (COVID-19) mainly based on the consideration that mortality of severe and critical cases is higher than mild and moderate cases of COVID-19. Severe patients usually dev…
View article: Comparison of endotracheal aspirate and bronchoalveolar lavage fluid metagenomic next-generation sequencing in severe pneumonia: a nested, matched case-control study
Comparison of endotracheal aspirate and bronchoalveolar lavage fluid metagenomic next-generation sequencing in severe pneumonia: a nested, matched case-control study Open
Objectives: To compare clinical outcomes in patients with severe pneumonia according to the diagnostic strategy used. Methods: In this retrospective, nested, case-control study, patients with severe pneumonia who had undergone endotracheal…
View article: Correction to: Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial
Correction to: Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial Open
View article: Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial
Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial Open
Background Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficientl…
View article: Correction to: Association between hospital and ICU structural factors and patient outcomes in China: a secondary analysis of the National Clinical Improvement System Data in 2019
Correction to: Association between hospital and ICU structural factors and patient outcomes in China: a secondary analysis of the National Clinical Improvement System Data in 2019 Open
View article: Association between hospital and ICU structural factors and patient outcomes in China: a secondary analysis of the National Clinical Improvement System Data in 2019
Association between hospital and ICU structural factors and patient outcomes in China: a secondary analysis of the National Clinical Improvement System Data in 2019 Open
View article: Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial
Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial Open
View article: Active Implementation of an Evidence-Based Nutrition Guideline for Critically Ill Patients Versus Standard Care: A Cluster Randomised, Multicentre, Controlled Trial
Active Implementation of an Evidence-Based Nutrition Guideline for Critically Ill Patients Versus Standard Care: A Cluster Randomised, Multicentre, Controlled Trial Open
View article: Long-term application of hydroxychloroquine could not prevent the infection of COVID-19
Long-term application of hydroxychloroquine could not prevent the infection of COVID-19 Open
Introduction: Current pandemic of the coronavirus induced disease 2019 (COVID-19) presents an urgent issue to the world due to lack of vaccine and medication. Hydroxychloroquine (HCQ) has generated a lot of controversies whether it is effe…
View article: Diagnostic Value of Metagenomic Next-Generation Sequencing for the Detection of Pathogens in Bronchoalveolar Lavage Fluid in Ventilator-Associated Pneumonia Patients
Diagnostic Value of Metagenomic Next-Generation Sequencing for the Detection of Pathogens in Bronchoalveolar Lavage Fluid in Ventilator-Associated Pneumonia Patients Open
Objective : To evaluate the diagnostic performance of metagenomic next-generation sequencing (mNGS) using bronchoalveolar lavage fluid (BALF) in patients with ventilator-associated pneumonia (VAP). Methods : BALF samples of 72 patients wit…
View article: Metagenomic next-generation sequencing technology for detection of pathogens in blood of critically ill patients
Metagenomic next-generation sequencing technology for detection of pathogens in blood of critically ill patients Open
Detection of blood pathogens by mNGS has good applicability for critically ill patients who cannot be diagnosed by BC in the early stages of infection, and mNGS should be performed as early as possible to obtain higher pathogen detection r…
View article: Reply to Wang et al.: Tocilizumab treatment should be used in a timely manner, at suitable dose, and in suitable patients
Reply to Wang et al.: Tocilizumab treatment should be used in a timely manner, at suitable dose, and in suitable patients Open
The global agri-food system is simultaneously a major contributor to, and severely affected by, climate change. Agroecological farming systems can contribute to creating resilient agri-food systems. Based on a multiyear qualitative case st…
View article: Reply to Yang et al.: Tocilizumab treatment in COVID-19 patients needs the assessment of the disease severity and timely intervention
Reply to Yang et al.: Tocilizumab treatment in COVID-19 patients needs the assessment of the disease severity and timely intervention Open
Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms gi…
View article: Successful cure of a patient with urosepsis using a combination of extracorporeal membrane oxygenation and continuous renal replacement therapy: A case report and literature review
Successful cure of a patient with urosepsis using a combination of extracorporeal membrane oxygenation and continuous renal replacement therapy: A case report and literature review Open
View article: Analysis of the intestinal microbiota in COVID-19 patients and its correlation with the inflammatory factor IL-18
Analysis of the intestinal microbiota in COVID-19 patients and its correlation with the inflammatory factor IL-18 Open
The ongoing global pandemic of COVID-19 disease, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mainly infect lung epithelial cells, and spread mainly through respiratory droplets. However, recent studies …
View article: Table of Contents
Table of Contents Open