Aijun Sun
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View article: Age‐Dependent Metabolic Signatures in Mouse Oocytes Revealed by Single‐Cell Raman Spectroscopy and High‐Resolution Imaging
Age‐Dependent Metabolic Signatures in Mouse Oocytes Revealed by Single‐Cell Raman Spectroscopy and High‐Resolution Imaging Open
The decline in oocyte quality with maternal age poses significant challenges for fertility and embryonic development. Traditional methods for assessing oocyte quality rely on invasive techniques that limit their applicability. In this stud…
View article: ERK-METTL3 axis acts as a novel regulator of antiviral innate immunity combating pseudorabies virus infection
ERK-METTL3 axis acts as a novel regulator of antiviral innate immunity combating pseudorabies virus infection Open
The ERK-mediated phosphorylation of the core m 6 A methyltransferase METTL3 has been linked to the regulation of embryonic stem cell differentiation and tumorigenesis. However, its role in the antiviral innate immune response remains uncle…
View article: RAB5B: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer
RAB5B: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer Open
Background The RAB5B protein belongs to the RAB family and is primarily localized to early endosomes. It regulates the endocytic pathway through its GTPase activity, thereby affecting various aspects such as cell signaling and metabolic re…
View article: Correction: Myeloid Zinc Finger 1: insights into its oncogenic potential, prognostic value, and impact on immune microenvironment across cancers
Correction: Myeloid Zinc Finger 1: insights into its oncogenic potential, prognostic value, and impact on immune microenvironment across cancers Open
[This corrects the article DOI: 10.3389/fimmu.2025.1591912.].
View article: Panel Testing of <scp>BRAF</scp> Mutation, <scp>RAS</scp> Mutation, and <scp>RET</scp>/<scp>PTC</scp> Rearrangements or <scp>RET</scp> Mutation Using Fine‐Needle Aspiration Specimens in Evaluation of Thyroid Carcinoma
Panel Testing of <span>BRAF</span> Mutation, <span>RAS</span> Mutation, and <span>RET</span>/<span>PTC</span> Rearrangements or <span>RET</span> Mutation Using Fine‐Needle Aspiration Specimens in Evaluation of Thyroid Carcinoma Open
Objective Thyroid carcinoma (TC) is a common malignancy of the endocrine system. This research investigates the value of multiple gene detection in evaluating the pathological features of TC. Methods This retrospective study includes sampl…
View article: Myeloid Zinc Finger 1: insights into its oncogenic potential, prognostic value, and impact on immune microenvironment across cancers
Myeloid Zinc Finger 1: insights into its oncogenic potential, prognostic value, and impact on immune microenvironment across cancers Open
Background Myeloid Zinc Finger 1 ( MZF1 ) is a zinc finger transcription factor gene that regulates gene expression by recognizing and binding to specific DNA sequences. Preliminary studies have suggested that MZF1 plays a pivotal role in …
View article: FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination
FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination Open
Mitochondrial dysfunction is related to etiopathogenesis and progression of heart failure (HF). The underlying molecular mechanisms are not fully understood. Transcription factor FOXM1 plays an essential role in cardiovascular development.…
View article: Exploration of SUSD3 in pan-cancer: studying its role, predictive analysis, and biological significance in various malignant tumors in humans
Exploration of SUSD3 in pan-cancer: studying its role, predictive analysis, and biological significance in various malignant tumors in humans Open
Background The SUSD3 protein, marked by the Sushi domain, plays a key role in cancer progression, with its expression linked to tumor advancement and patient prognosis. Altered SUSD3 levels could serve as a predictive biomarker for cancer …
View article: Metabolic Homeostasis of Immune Cells Modulates Cardiovascular Diseases
Metabolic Homeostasis of Immune Cells Modulates Cardiovascular Diseases Open
Recent investigations into the mechanisms underlying inflammation have highlighted the pivotal role of immune cells in regulating cardiac pathophysiology. Notably, these immune cells modulate cardiac processes through alternations in intra…
View article: Ubiquitin proteasome system in cardiac fibrosis
Ubiquitin proteasome system in cardiac fibrosis Open
The UPS primarily impacts cardiac fibrosis through modulation of the TGF-β signaling pathway targeting key molecules involved, including the TGF-β receptors, Smad2/3/4 complexes, and inhibitory Smad7, thereby influencing fibrotic processes…
View article: Long-term outcomes in hospitalized heart failure patients in China: results from the China National Heart Failure (CN-HF) registry study
Long-term outcomes in hospitalized heart failure patients in China: results from the China National Heart Failure (CN-HF) registry study Open
Background There is a paucity of data on the long-term outcomes of heart failure (HF) patients in China. We aimed to investigate the incidence of cardiovascular (CV) death or rehospitalization due to worsening HF (WHF) and other outcomes a…
View article: Investigation on the Different Needs of Practicing Doctors for Continuing Medical Education under the Three-Level Medical System in China
Investigation on the Different Needs of Practicing Doctors for Continuing Medical Education under the Three-Level Medical System in China Open
Background: To explore the needs of obstetricians and gynecologists (OB-GYNs) for training methods and contents, under China’s three-level diagnosis and treatment system. Methods: Epidemiological investigation was adopted, and network ques…
View article: TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway
TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway Open
Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure (HF). TEAD1 has been shown to be essential for heart development and homeostasis. However, fibro…
View article: Global burden of adolescent and young adult cardiovascular diseases and risk factors: Results from Global Burden of Disease Study 2019
Global burden of adolescent and young adult cardiovascular diseases and risk factors: Results from Global Burden of Disease Study 2019 Open
Comprehensive research on the global burden of CVDs among adolescents and young adults (15-44 years) is lacking. We analyzed the results from the Global Burden of Disease (GBD), Injuries, and Risk Factors Study 2019, and the incidence, mor…
View article: Pregnancy Outcome of Infertile Patients with Uterine Malformation after Hysteroscopic and Laparoscopic Surgery
Pregnancy Outcome of Infertile Patients with Uterine Malformation after Hysteroscopic and Laparoscopic Surgery Open
Background: Uterine malformations can be divided into the dysmorphic uterus (U1); septate uterus (U2); bicorporeal uterus (U3); hemi-uterus (U4) and hypoplastic uterus (U5) with clinical significance ranging from mild to severe. This study…
View article: Comprehensive pan-cancer investigation: unraveling the oncogenic, prognostic, and immunological significance of Abelson interactor family member 3 gene in human malignancies
Comprehensive pan-cancer investigation: unraveling the oncogenic, prognostic, and immunological significance of Abelson interactor family member 3 gene in human malignancies Open
Background: Abelson interactor Family Member 3 (ABI3) encodes protein that not only suppresses the ectopic metastasis of tumor cells but also hinders their migration. Although ABI3 had been found to modulate the advancement of diverse neop…
View article: ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction
ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction Open
Fibroblast ALKBH5 positively regulates post-MI healing by stabilization of ErbB4 mRNA in an m6A-dependent manner. ALKBH5/ErbB4 might be potential therapeutic targets for post-MI cardiac rupture.
View article: Effect of Traditional Chinese Formula Dingkun Pill on Primary Dysmenorrhea: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Effect of Traditional Chinese Formula Dingkun Pill on Primary Dysmenorrhea: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Open
Background: Primary dysmenorrhea (PD) afflicts many childbearing-age women, with a high prevalence ranging from 17% to 90%. The Dingkun pill (DKP), a traditional Chinese medicine formula, has been prescribed for managing menstrual disorder…
View article: Transplantation of mitochondria encapsulated in hydrogel ameliorates myocardial ischemia-reperfusion injury
Transplantation of mitochondria encapsulated in hydrogel ameliorates myocardial ischemia-reperfusion injury Open
Mitochondria play a central role in myocardial ischemia-reperfusion (I/R) injury. Therefore, mitochondrial transplantation (MTP) holds therapeutic potential for treating I/R injury. However, the transplantation environment (TE) could cause…
View article: Investigation on the Needs of Obstetricians & Gynecologists in Different Types of Hospitals for the Content and Forms of Continuing Medical Education and Training
Investigation on the Needs of Obstetricians & Gynecologists in Different Types of Hospitals for the Content and Forms of Continuing Medical Education and Training Open
Background: Medicine is to some extent an empirical science that requires repeated clinical practice. To explore the needs of obstetricians & gynecologists (Ob & Gy) in different kinds of hospitals for continuing medical education (CME) tr…
View article: Metabolism, inflammation, and cardiovascular diseases from basic research to clinical practice
Metabolism, inflammation, and cardiovascular diseases from basic research to clinical practice Open
Cardiovascular diseases (CVDs) affect more than 500 million people worldwide and are associated with high mortality and morbidity[1]. The heart uses a variety of substrates as energy source, including fatty acid, glucose, lactate, ketone b…
View article: Current Situation and Demand for Continuing Medical Education (CME) for Obstetricians and Gynecologists
Current Situation and Demand for Continuing Medical Education (CME) for Obstetricians and Gynecologists Open
The most popular training content for obstetricians and gynecologists with different working years is common gynecological endocrine diseases, of which abnormal uterine bleeding, menopausal syndrome, polycystic ovarian syndrome and cervica…
View article: Effect of Low-Power Visible-Light-Activated Photodynamic Therapy (PDT) on Primary Dysmenorrhea: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Effect of Low-Power Visible-Light-Activated Photodynamic Therapy (PDT) on Primary Dysmenorrhea: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Open
Low-power visible-light-activated PDT is a new type of treatment for primary dysmenorrhea which is safe, effective and does not affect normal pregnancy preparation. It may exert its therapeutic effect by adjusting downward the level of PGE…