Explanipedia

The Overlooked Burden of Atopic Comorbidities in Eosinophilic Esophagitis: Insights from a Real-Life Comprehensive Multidisciplinary Evaluation Open

Marcella Pesce, Mario Ricchiuti, Elena Cantone, Maddalena Napolitano, Aikaterini Detoraki , et al. · 2025

Background/Objectives: Eosinophilic esophagitis (EoE) is a T2-mediated disease characterized by dysphagia and food impaction. It is often associated with other atopic disorders and is considered a late manifestation of the “atopic march”. …

Optimising care for chronic rhinosinusitis with nasal polyps and asthma in multimorbid patients: a multidisciplinary Delphi consensus Open

Eugenio De Corso, Adriano Vaghi, Marco Corbò, Carlotta Pipolo, Alessandra Vultaggio , et al. · 2025

This consensus highlights the value of a multidisciplinary approach for multimorbid CRSwNP and asthma patients, advocating for endotype-driven therapies and standardised pathways in clinical practice.

Clinical and immunological biomarkers in hypereosinophilic syndrome: the second step after diagnostic algorithms Open

David Longhino, Ilaria Baglivo, Maria Antonietta Zavarella, Stefania Colantuono, Chiara Laface , et al. · 2025

Background Idiopathic hypereosinophilic syndrome currently represents a major unmet need for all medical specialties dealing with this disease. Markers capable of characterising the wide variability of its clinical presentation are current…

Trichilemmal Keratinized Lesion of the Upper Palpebral Conjunctiva: A Case Report. Open

Anastasia Papachristou, Andreas Papandroudis, Eleni Lagoudaki, Aikaterini Detoraki, Εfstathios T. Detorakis · 2025

Major presenting symptoms were ocular discomfort and conjunctival hyperemia. Histopathological examination was compatible with a cystic lesion with trichilemmal keratinization. No recurrence was observed during the follow-up period. Conclu…

Transitioning adolescents and young adults with asthma: insights from a severe asthma series Open

Alessandro Dorato, Rosa Buonagura, Melissa Borrelli, Cristina Fontanella, Adele Corcione , et al. · 2025

Thanks to improvements in asthma care and availability of new biologic treatments, a relatively novel population of adolescents and young adults (AYA) with severe asthma (SA) is growing. Transition from pediatric to adult care represents a…

The Potential Role of Nasal Cytology in Respiratory Diseases: Clinical Research and Future Perspectives Open

Giuseppina Marcuccio, Giuseppina Raffio, Pasquale Ambrosino, Claudio Candia, Elena Cantone , et al. · 2025

Nasal cytology is a non-invasive, affordable, and easily executable technique commonly used in research to study rhinitis and, to a lesser extent, chronic rhinosinusitis. It is particularly useful for the differential diagnosis of non-alle…

The Effects of Mepolizumab on CRSwNP: Real-Life Evidence Open

Elena Cantone, Bernardino Cassiano, Paolo Pezzella, Mario Brandon Russo, Aikaterini Detoraki · 2024

Background: This study aims to evaluate the efficacy and safety of mepolizumab in the treatment of severe uncontrolled CRSwNP with or without comorbid asthma in a real-life setting over the first six months of therapy. Methods: A total of …

Asthma severity: the patient’s point of view Open

Gabriella Guarnieri, Bianca Olivieri, Manuela Latorre, Angela Rizzi, Francesco Blasi , et al. · 2024

This study highlights the disparity between clinical categorization and patient perceptions of asthma severity. The prevalence of self reported severe asthma exceeds literature data. The burden of mild asthma remains significant, with trea…

Managing Patients with Hypereosinophilic Syndrome: A Statement from the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC) Open

Marco Caminati, Luisa Brussino, Matilde Carlucci, Palma Carlucci, Lucia Federica Carpagnano , et al. · 2024

Hypereosinophilic syndrome (HES) encompasses a heterogeneous and complex group of different subtypes within the wider group of hypereosinophilic disorders. Despite increasing research interest, several unmet needs in terms of disease ident…

Sustained remission induced by 2 years of treatment with benralizumab in patients with severe eosinophilic asthma and nasal polyposis Open

Corrado Pelaia, Claudia Crimi, Alida Benfante, Maria Filomena Caiaffa, Raffaele Campisi , et al. · 2024

Background and Objective Several randomized controlled trials (RCTs) have shown that benralizumab is characterized by a good profile of efficacy and safety, thereby being potentially able to elicit clinical remission on‐treatment of severe…

Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission Open

Giovanna Elisiana Carpagnano, Andrea Portacci, Santi Nolasco, Aikaterini Detoraki, Alessandro Vatrella , et al. · 2024

Introduction Clinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remissio…

Early Ear, Nose and Throat Manifestations in Eosinophilic Granulomatosis with Poliangioitis: Results from Our Cohort Group and Literature Review Open

Mario D’Onofrio, Daniele La Prova, Maria Rosaria Galdiero, Elena Cantone, Eugenio Tremante , et al. · 2023

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, systemic necrotizing vasculitis affecting small-to-medium-sized vessels. EGPA’s clinical manifestations are heterogeneous, affecting different organs and systems, and the uppe…

Exhaled Nitric Oxide as Biomarker of Type 2 Diseases Open

Mauro Maniscalco, Salvatore Fuschillo, Ilaria Mormile, Aikaterini Detoraki, Giovanni Sarnelli , et al. · 2023

Nitric oxide (NO) is a short-lived gas molecule which has been studied for its role as a signaling molecule in the vasculature and later, in a broader view, as a cellular messenger in many other biological processes such as immunity and in…

Early ENT Manifestations in Eosinophilic Granulomatosis with Poliangioitis: Results from Our Cohort Group and Literature Review Open

Mario D’Onofrio, Daniele La Prova, Maria Rosaria Galdiero, Elena Cantone, Eugenio Tremante , et al. · 2023

Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare systemic necrotizing vasculitis, affecting small-to-medium sized vessels. EGPA’s clinical manifestations are heterogeneous affecting different organs and systems and the upper …

Real-world characteristics of “super-responders” to mepolizumab and benralizumab in severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis Open

Andrea Portacci, Raffaele Campisi, Enrico Buonamico, Santi Nolasco, Corrado Pelaia , et al. · 2023

Background The current definition of severe eosinophilic asthma (SEA) super-responders to biologic treatment does not include patients with other eosinophil-based comorbidities. Although eosinophilic granulomatosis with polyangiitis (EGPA)…

Severe Asthma Network Italy Definition of Clinical Remission in Severe Asthma: A Delphi Consensus Open

Giorgio Walter Canonica, Francesco Blasi, Giovanna Elisiana Carpagnano, Giuseppe Guida, Enrico Heffler , et al. · 2023

Severe asthma affects about 10% of the population with asthma and is characterized by low lung function and a high count of blood leukocytes, mainly eosinophils. Various definitions are used in clinical practice and in the literature to id…

Effectiveness and safety of anti-IL-5/Rα biologics in eosinophilic granulomatosis with polyangiitis: a two-year multicenter observational study Open

Santi Nolasco, Andrea Portacci, Raffaele Campisi, Enrico Buonamico, Corrado Pelaia , et al. · 2023

Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis characterized by asthma, systemic manifestations, and blood and tissue eosinophilia. Objective To assess the effectiveness and safety of mepolizumab (anti…

A Multidisciplinary Approach for Type 2 Allergic Diseases: What Do Biologics Teach Us? Open

Mauro Maniscalco, Aikaterini Detoraki, Giovanni Sarnelli, Maria Nolano, Amato de Paulis , et al. · 2023

Patients with atopic/allergic disorders, including atopic dermatitis (AD), allergic rhino-conjunctivitis (AR), chronic rhinosinusitis with/without nasal polyps (CRSwNP/CRSsNP), bronchial asthma, food allergy, and eosinophilic esophagitis (…

Local Allergic Rhinitis: A Different Rhinitis Endotype? Literature Overview Open

Elena Cantone, Aikaterini Detoraki, Eugenio De Corso · 2022

Chronic rhinitis (CR) is commonly divided into allergic rhinitis (AR) and nonallergic rhinitis (NAR). AR is triggered by the immunoglobulin E (IgE)-mediated response to allergens, whereas NAR is characterized by the absence of allergic sen…

Functional Modulation of Human Macrophages by Secreted Phospholipases A2: Implications in Cancer Open

Maria Rosaria Galdiero, Ilaria Mormile, Francescopaolo Granata, Stefania Loffredo, Aikaterini Detoraki , et al. · 2022

Cancer-related inflammation has recently emerged as an important component of cancer pathogenesis that is able to promote tumor initiation and progression, and the acquisition of the known hallmark capabilities, including evasion from immu…

The Role of Allergen-Specific Immunotherapy in ENT Diseases: A Systematic Review Open

Elena Cantone, Stefania Gallo, Sara Torretta, Aikaterini Detoraki, Carlo Cavaliere , et al. · 2022

Previous studies have demonstrated that both subcutaneous (SCIT) and sublingual specific immunotherapy (SLIT) are effective in treating allergic rhinitis (AR). Further studies have evaluated the efficacy of allergen-specific immunotherapy …

Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life Open

Eustachio Nettis, Luisa Brussino, Vincenzo Patella, Laura Bonzano, Aikaterini Detoraki , et al. · 2022

Predictive Response to Immunotherapy Score: A Useful Tool for Identifying Eligible Patients for Allergen Immunotherapy Open

Ilaria Mormile, Francescopaolo Granata, Aikaterini Detoraki, Daniela Pacella, Francesca Della Casa , et al. · 2022

A specific predictive tool of allergen immunotherapy (AIT) outcome has not been identified yet. This study aims to evaluate the efficacy of a disease score referred to as Predictive Response to Immunotherapy Score (PRIS) to predict the res…

Quality of life in patients with allergic and immunologic skin diseases: in the eye of the beholder Open

Ester Di Agosta, Lorenzo Salvati, Monica Corazza, Ilaria Baiardini, Francesca Ambrogio , et al. · 2021

Severe asthma: One disease and multiple definitions Open

Diego Bagnasco, Pierluigi Paggiaro, Manuela Latorre, Chiara Folli, Elisa Testino , et al. · 2021

Defining a Severe Asthma Super-Responder: Findings from a Delphi Process Open

John W. Upham, Chantal Le Lievre, David J. Jackson, Matthew Masoli, Michael E. Wechsler , et al. · 2021

Issue Information Open

Erika Tamabuchi, Taku Fujimura, Chunbing Lyu, Setsuya Aiba, Luca Fania , et al. · 2021

Real-life evidence of low-dose mepolizumab efficacy in EGPA: a case series Open

Aikaterini Detoraki, Eugenio Tremante, Remo Poto, Emanuela Morelli, Giuseppe Quaremba , et al. · 2021

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, small vessel, necrotizing vasculitis. The disease is mainly characterized by hypereosinophilia and asthma with frequent sinonasal involvement, although multiple organs can be …

Successful treatment of eruptive pyogenic granuloma with propranolol Open

Davide Fattore, Adriana Di Guida, Aikaterini Detoraki, Gaia De Fata Salvatores, Lucia Gallo , et al. · 2021

Pyogenic granuloma (PG) is a vascular proliferation of skin and mucous membranes.1 PG usually presents as a solitary, red, rapidly growing papule or nodule, with a subtle collarette of scale. The pathogenesis is still unproved; it can appe…

Reply to: Kow CS et al. Are severe asthma patients at higher risk of developing severe outcomes from COVID‐19? Open

Enrico Heffler, Aikaterini Detoraki, Marco Contoli, Alberto Papi, Giovanni Paoletti , et al. · 2021

We read with interest the correspondence letter sent by Kow et al1 and referring to our recently published article about the incidence of CoronaVIrus Disease 19 (COVID-19) in severe asthmatics of our Severe Asthma Network in Italy (SANI) r…

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