Aiko Barsch
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View article: Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems
Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems Open
Ultrahigh resolution mass spectrometry (UHR-MS) coupled with direct infusion (DI) electrospray ionization offers a fast solution for accurate untargeted profiling. Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers have …
View article: Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research
Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research Open
Metabolomics-the endpoint of the omics cascade-is increasingly recognized as a preferred method for understanding the ultimate responses of biological systems to stress. Flow injection electrospray (FIE) mass spectrometry (MS) has advantag…
Olive Oil Quality and Authenticity Assessment Aspects Employing FIA-MRMS and LC-Orbitrap MS Metabolomic Approaches Open
Edible vegetable oils comprise integral components of humans’ daily diet during the lifetime. Therefore, they constitute a central part of dietary-exposome, which among other factors regulates human health. In particular, the regular consu…
Olive Oil Quality and Authenticity Assessment Aspects Employing FIA-MRMS and LC-Orbitrap MS Metabolomic Approaches Open
Edible vegetable oils comprise integral components of humans' daily diet during the lifetime. Therefore, they constitute a central part of dietary-exposome, which among other factors regulates human health. In particular, the regular consu…
Generation of a Collision Cross Section Library for Multi-Dimensional Plant Metabolomics Using UHPLC-Trapped Ion Mobility-MS/MS Open
The utility of metabolomics is well documented; however, its full scientific promise has not yet been realized due to multiple technical challenges. These grand challenges include accurate chemical identification of all observable metaboli…
View article: Feature-based Molecular Networking in the GNPS Analysis Environment
Feature-based Molecular Networking in the GNPS Analysis Environment Open
Molecular networking has become a key method used to visualize and annotate the chemical space in non-targeted mass spectrometry-based experiments. However, distinguishing isomeric compounds and quantitative interpretation are currently li…
Trapped ion mobility spectrometry (TIMS) and parallel accumulation - serial fragmentation (PASEF) enable in-depth lipidomics from minimal sample amounts Open
Lipids form a highly diverse group of biomolecules fulfilling central biological functions, ranging from structural components to intercellular signaling. Yet, a comprehensive characterization of the lipidome from limited starting material…
View article: The Plant Immunity Regulating F-Box Protein CPR1 Supports Plastid Function in Absence of Pathogens
The Plant Immunity Regulating F-Box Protein CPR1 Supports Plastid Function in Absence of Pathogens Open
The redox imbalanced 6 mutant (rimb6) of Arabidopsis thaliana was isolated in a genetic screening approach for mutants with defects in chloroplast-to- nucleus redox signaling. It has an atypically low activation status of the 2-Cys peroxir…
<strong>Increasing arginine production in <em>Corynebacterium glutamicum </em>by rational strain design in combination with metabolomics and proteomics</strong> Open
C. glutamicum is a bacterium used for biotechnological production of amino acids and other metabolites. Arginine is of commercial importance in cosmetic and pharmaceutical industries and as food additive. Here metabolomics and proteomics d…
View article: Using the knowns to discover the unknowns: <scp>MS</scp>‐based dereplication uncovers structural diversity in 17‐hydroxygeranyllinalool diterpene glycoside production in the Solanaceae
Using the knowns to discover the unknowns: <span>MS</span>‐based dereplication uncovers structural diversity in 17‐hydroxygeranyllinalool diterpene glycoside production in the Solanaceae Open
Summary Exploring the diversity of plant secondary metabolism requires efficient methods to obtain sufficient structural insights to discriminate previously known from unknown metabolites. De novo structure elucidation and confirmation of …