Aiko M. Cirone
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View article: Antibiotic use in early life subsequently impairs MAIT cell-mediated immunity 2867
Antibiotic use in early life subsequently impairs MAIT cell-mediated immunity 2867 Open
Description Although an association between antibiotic use in early life and increased susceptibility to infection has been described, the mechanisms behind this remain unclear. The development of mucosal associated invariant T (MAIT) cell…
View article: Antibiotic use in early life subsequently impairs MAIT cell-mediated immunity
Antibiotic use in early life subsequently impairs MAIT cell-mediated immunity Open
Summary Mucosal-associated invariant T (MAIT) cells are predominantly located in barrier tissues where they rapidly respond to pathogens and commensals by recognizing microbial derivatives of riboflavin synthesis. Early-life exposure to th…
View article: Dietary Chitin Particles Called Mimetic Fungi Ameliorate Colitis in Toll-Like Receptor 2/CD14- and Sex-Dependent Manners
Dietary Chitin Particles Called Mimetic Fungi Ameliorate Colitis in Toll-Like Receptor 2/CD14- and Sex-Dependent Manners Open
Chitin is a natural N -acetylglucosamine polymer and a major structural component of fungal cell walls. Dietary chitin is mucoadhesive; anti-inflammatory effects of chitin microparticles (CMPs; 1- to 10-μm diameters) have been demonstrated…
View article: Phagocytosis-mediated M1 activation by chitin but not by chitosan
Phagocytosis-mediated M1 activation by chitin but not by chitosan Open
Chitin particles have been used to understand host response to chitin-containing pathogens and allergens and are known to induce a wide range of polarized macrophage activations, depending, at least in part, on particle size. Nonphagocytos…