Aiman Haider
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View article: Validating the biological origin of in vivo fractional intracellular volume from VERDICT-MRI in the prostate
Validating the biological origin of in vivo fractional intracellular volume from VERDICT-MRI in the prostate Open
Reliable imaging biomarkers are needed to characterize clinically significant prostate cancer (csPCa). The clinically established measure, apparent diffusion coefficient (ADC) from multiparametric (mp)MRI, lacks specificity to key histolog…
View article: Evaluating interobserver variability in reporting of surgical margin status in men undergoing radical prostatectomy: analysis from the IP8-FLUORESCE study
Evaluating interobserver variability in reporting of surgical margin status in men undergoing radical prostatectomy: analysis from the IP8-FLUORESCE study Open
View article: IP8-FLUORESCE: A Prospective Paired Cohort Study Evaluating the Diagnostic Accuracy of Fluorescence Confocal Microscopy for Real-time Assessment of Surgical Margins in Radical Prostatectomy
IP8-FLUORESCE: A Prospective Paired Cohort Study Evaluating the Diagnostic Accuracy of Fluorescence Confocal Microscopy for Real-time Assessment of Surgical Margins in Radical Prostatectomy Open
FCM is a feasible, rapid technique for intraoperative margin assessment in RP. Its diagnostic accuracy is reasonable for clinically significant, longer PSMs, but limited for shorter margins, particularly at the apex. These findings support…
View article: Systematic review of bilateral epididymal leiomyomas
Systematic review of bilateral epididymal leiomyomas Open
Purpose Epididymal leiomyomas (LM) are rare benign tumours. Bilateral LM are even more uncommon and there are no management guidelines on LM. We performed a systematic review to update the number of epididymal LM cases reported, and to sum…
View article: Bacteriological Profile And Antibiotic Resistance Pattern In Patients With Acute Exacerbation Of Bronchiectasis.
Bacteriological Profile And Antibiotic Resistance Pattern In Patients With Acute Exacerbation Of Bronchiectasis. Open
Background: Bacterial infections are a significant contributing factor to acute exacerbations in patients with bronchiectasis, and they have a substantial impact on clinical outcomes. Understanding the variability of causative organisms an…
View article: Frequency of Hepatotoxicity in Pulmonary Tuberculosis Patients Taking Anti-Tuberculous Therapy
Frequency of Hepatotoxicity in Pulmonary Tuberculosis Patients Taking Anti-Tuberculous Therapy Open
Background: Anti-tuberculous therapy (ATT), while effective in treating pulmonary tuberculosis, carries the risk of hepatotoxicity due to drugs such as isoniazid, rifampicin, and pyrazinamide. Objective: To determine the frequency of hepat…
View article: Correction: Squamous cell carcinoma of the neovagina following transgender woman gender-affirming vaginoplasty: a case report and systematic review
Correction: Squamous cell carcinoma of the neovagina following transgender woman gender-affirming vaginoplasty: a case report and systematic review Open
View article: Wnt Signaling in Male Genital Lichen Sclerosus, Differentiated Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma
Wnt Signaling in Male Genital Lichen Sclerosus, Differentiated Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma Open
Wnt signalling plays a role in progression from MGLSc to PeSCC through protein dysregulation. Overexpression and altered interactions in PeSCC highlight its potential as a diagnostic, prognostic, and therapeutic target.
View article: A Direct Comparative Analysis of HPV DNA with Single-Molecule RNA and p16INK4a Protein Expression in Lichen Sclerosus: Implications for Diagnostics and Pathogenesis
A Direct Comparative Analysis of HPV DNA with Single-Molecule RNA and p16INK4a Protein Expression in Lichen Sclerosus: Implications for Diagnostics and Pathogenesis Open
HPV DNA was detected in a mosaic pattern across the prepuce, with no significant differences between MGLSc and non-MGLSc skin. The absence of transcriptional activity suggests that HPV in MGLSc is incidental and may not contribute toward p…
View article: Effect of NeuroSAFE-guided RARP versus standard RARP on erectile function and urinary continence in patients with localised prostate cancer (NeuroSAFE PROOF): a multicentre, patient-blinded, randomised, controlled phase 3 trial
Effect of NeuroSAFE-guided RARP versus standard RARP on erectile function and urinary continence in patients with localised prostate cancer (NeuroSAFE PROOF): a multicentre, patient-blinded, randomised, controlled phase 3 trial Open
National Institute of Healthcare Research, JP Moulton Charitable Foundation, UCLH Charity, St Peters Trust, and Rosetrees Trust.
View article: Applying Focal Therapy to Lesions Detected via Magnetic Resonance Imaging: Delivering Cancer Ablation Beyond the Visibility Phenomenon
Applying Focal Therapy to Lesions Detected via Magnetic Resonance Imaging: Delivering Cancer Ablation Beyond the Visibility Phenomenon Open
View article: Validation of in vivo VERDICT fIC against matched histology from whole-mount prostatectomy
Validation of in vivo VERDICT fIC against matched histology from whole-mount prostatectomy Open
Motivation: Intracellular volume fraction (fIC) maps from VERDICT-MRI have shown potential to improve prostate cancer (PCa) stratification, but the microstructural origin of the signal has not yet been investigated in in vivo settings. Goa…
View article: Combining tissue biomarkers with mpMRI to diagnose clinically significant prostate cancer. Analysis of 21 biomarkers in the PICTURE study
Combining tissue biomarkers with mpMRI to diagnose clinically significant prostate cancer. Analysis of 21 biomarkers in the PICTURE study Open
Background Serum PSA and digital rectal examination remain the key diagnostic tools for detecting prostate cancer. However, due to the limited specificity of serum PSA, the applicability of this marker continues to be controversial. Recent…
View article: P029 Surgical planning robotic assisted radical prostatectomy – what is the impact of biparametic vs multiparametic MRI?
P029 Surgical planning robotic assisted radical prostatectomy – what is the impact of biparametic vs multiparametic MRI? Open
View article: Transcriptionally Active Human Papillomavirus in Male Genital Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma
Transcriptionally Active Human Papillomavirus in Male Genital Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma Open
Penile intraepithelial neoplasia (PeIN) and penile squamous cell carcinoma (PeSCC) are both thought to be associated with male genital lichen sclerosus and human papillomavirus (HPV) infection through dichotomous pathways: (i) undifferenti…
View article: The RECONCILE study protocol: Exploiting image-based risk stratification in early prostate cancer to discriminate progressors from non-progressors (RECONCILE)
The RECONCILE study protocol: Exploiting image-based risk stratification in early prostate cancer to discriminate progressors from non-progressors (RECONCILE) Open
Introduction RECONCILE (ClinicalTrials.gov:NCT04340245) will identify molecular and radiomic markers associated with clinical progression and radiological progression events in a cohort of localised, newly diagnosed Gleason 3 + 4 tumours. …
View article: Accuracy of the LaserSAFE technique for detecting positive surgical margins during robot‐assisted radical prostatectomy: blind assessment and inter‐rater agreement analysis
Accuracy of the LaserSAFE technique for detecting positive surgical margins during robot‐assisted radical prostatectomy: blind assessment and inter‐rater agreement analysis Open
Introduction and objectives Fluorescence confocal microscopy (FCM) is a new imaging modality capable of generating digital microscopic resolution scans of fresh surgical specimens, and holds potential as an alternative to frozen section (F…
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Cover Image Open
View article: Comparative Bibliometric Analysis of Established and Emerging Databases on Salivary Biomarkers for Early Oral Cancer Diagnosis
Comparative Bibliometric Analysis of Established and Emerging Databases on Salivary Biomarkers for Early Oral Cancer Diagnosis Open
Background Salivary biomarkers play an important role in the preventive strategy for oral cancer detection at an early stage. The aim of this study was to carry out a comparative quantitative analysis of the research material on the topic …
View article: Intraoperative margin assessment during radical prostatectomy: is microscopy frozen in time or ready for digital defrost?
Intraoperative margin assessment during radical prostatectomy: is microscopy frozen in time or ready for digital defrost? Open
Intraoperative frozen section (IFS) is used with the intention to improve functional and oncological outcomes for patients undergoing radical prostatectomy (RP). High resource requirements of IFS techniques such as NeuroSAFE may preclude w…
View article: Primary Vulval Melanoma and Genital Lichen Sclerosus
Primary Vulval Melanoma and Genital Lichen Sclerosus Open
Background Lichen sclerosus (LS) is a chronic, inflammatory skin disease with a predilection for the genitalia. Although, the association between squamous cell cancer and genital LS is well established, a link with genital melanoma has not…
View article: A diagnosis of syphilis following a radical circumcision for suspected penile cancer
A diagnosis of syphilis following a radical circumcision for suspected penile cancer Open
We present a case of a 70-year-old gentleman who was referred to our tertiary 2-week-wait penile cancer clinic with a penile mass that was ulcerated, painful and discharging. This was suspicious for penile cancer and a radical circumcision…
View article: Long-term outcomes of penile squamous cell carcinoma in men age ≤50 years old compared with men >50 years old from a single tertiary referral centre: a propensity score matched analysis
Long-term outcomes of penile squamous cell carcinoma in men age ≤50 years old compared with men >50 years old from a single tertiary referral centre: a propensity score matched analysis Open
Penile cancer (PeCa) is rare, and the oncological outcomes in younger men are unclear. We aimed to analyse and compare oncological outcomes of men age ≤50 years (y) and >50 years with PeCa. A retrospective analysis of men ≤50 y with penile…
View article: Improving fluorescence confocal microscopy for margin assessment during robot‐assisted radical prostatectomy: The <scp>LaserSAFE</scp> technique
Improving fluorescence confocal microscopy for margin assessment during robot‐assisted radical prostatectomy: The <span>LaserSAFE</span> technique Open
Figure S1 Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the…
View article: Accuracy of Ex-vivo Fluorescence Confocal Microscopy in Margin Assessment of Solid Tumors: A Systematic Review
Accuracy of Ex-vivo Fluorescence Confocal Microscopy in Margin Assessment of Solid Tumors: A Systematic Review Open
Fluorescence confocal microscopy (FCM) is a novel technology that enables rapid high-resolution digital imaging of non-formalin-fixed tissue specimens and offers real-time positive surgical margin identification. In this systematic review,…
View article: Accuracy of surgical margin analysis during robot-assisted radical prostatectomy (RARP) using the Histolog scanner
Accuracy of surgical margin analysis during robot-assisted radical prostatectomy (RARP) using the Histolog scanner Open
View article: A large dermoid cyst of the spermatic cord
A large dermoid cyst of the spermatic cord Open
Dermoid cysts of the spermatic cord are rare, with only a few adult cases published in the literature. We report a patient with a 10cm inguinal mass referred to us for a suspected paratesticular sarcoma. Imaging suggested a cyst but, due t…
View article: Primary Penile Melanoma and Genital Lichen Sclerosus
Primary Penile Melanoma and Genital Lichen Sclerosus Open
Background There is a well-established association between squamous cell cancer and genital lichen sclerosus (GLSc). Although there have been several reported cases of vulval melanoma (MM) associated with LSc, particularly in the paediatri…
View article: <scp>ST6GAL1</scp>‐mediated aberrant sialylation promotes prostate cancer progression
<span>ST6GAL1</span>‐mediated aberrant sialylation promotes prostate cancer progression Open
Aberrant glycosylation is a universal feature of cancer cells, and cancer‐associated glycans have been detected in virtually every cancer type. A common change in tumour cell glycosylation is an increase in α2,6 sialylation of N ‐glycans, …
View article: Prevalence of MRI lesions in men responding to a GP-led invitation for a prostate health check: a prospective cohort study
Prevalence of MRI lesions in men responding to a GP-led invitation for a prostate health check: a prospective cohort study Open
Objective In men with a raised prostate-specific antigen (PSA), MRI increases the detection of clinically significant cancer and reduces overdiagnosis, with fewer biopsies. MRI as a screening tool has not been assessed independently of PSA…